TN2011000105A1 - Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use - Google Patents

Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use

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Publication number
TN2011000105A1
TN2011000105A1 TN2011000105A TN2011000105A TN2011000105A1 TN 2011000105 A1 TN2011000105 A1 TN 2011000105A1 TN 2011000105 A TN2011000105 A TN 2011000105A TN 2011000105 A TN2011000105 A TN 2011000105A TN 2011000105 A1 TN2011000105 A1 TN 2011000105A1
Authority
TN
Tunisia
Prior art keywords
compounds
formula
beta
betasecretase
spiro
Prior art date
Application number
TN2011000105A
Other languages
French (fr)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2009/056748 external-priority patent/WO2010030954A1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of TN2011000105A1 publication Critical patent/TN2011000105A1/en

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I); wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula (I) are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula (I).
TN2011000105A 2009-09-11 2011-03-01 Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use TN2011000105A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/056748 WO2010030954A1 (en) 2008-09-11 2009-09-11 Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use

Publications (1)

Publication Number Publication Date
TN2011000105A1 true TN2011000105A1 (en) 2012-09-05

Family

ID=55024400

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2011000105A TN2011000105A1 (en) 2009-09-11 2011-03-01 Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use

Country Status (1)

Country Link
TN (1) TN2011000105A1 (en)

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