UA108753C2 - 5,6-Dihydro-2H- [1,4] OXASINE-3-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE INHIBITORS (BACE) - Google Patents

5,6-Dihydro-2H- [1,4] OXASINE-3-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE INHIBITORS (BACE)

Info

Publication number
UA108753C2
UA108753C2 UAA201212485A UAA201212485A UA108753C2 UA 108753 C2 UA108753 C2 UA 108753C2 UA A201212485 A UAA201212485 A UA A201212485A UA A201212485 A UAA201212485 A UA A201212485A UA 108753 C2 UA108753 C2 UA 108753C2
Authority
UA
Ukraine
Prior art keywords
beta
dementia
bace
dihydro
secretase inhibitors
Prior art date
Application number
UAA201212485A
Other languages
Russian (ru)
Ukrainian (uk)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2011/059441 external-priority patent/WO2011154431A1/en
Application filed filed Critical
Publication of UA108753C2 publication Critical patent/UA108753C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Abstract

Даний винахід стосується нових похідних 5,6-дигідро-2Н-[1,4]оксазин-3-іламіну як інгібіторів бета-секретази, також відомих як фермент, що розщеплює амілоїд у бета-ділянці, ВАСЕ, ВАСЕ1, Asp2 або мемапсин 2.Винахід також стосується фармацевтичних композицій, що містять такі сполуки, способів отримання таких сполук і композицій, а також застосування таких сполук і композицій для запобігання і лікування порушень, в які залучена бета-секретаза, таких як хвороба Альцгеймера (AD), помірне когнітивне порушення, старість, деменція, деменція з тільцями Леві, синдром Дауна, деменція, що асоціюється з інсультом, деменція, що асоціюється з хворобою Паркінсона, і деменція, що асоціюється з бета-амілоїдом.The present invention relates to novel derivatives of 5,6-dihydro-2H- [1,4] oxazin-3-ylamine as beta-secretase inhibitors, also known as the amyloid cleavage enzyme in beta, BACE, VACE, Asp2 or memapsin 2 . The invention also relates to pharmaceutical compositions containing such compounds, methods of producing such compounds and compositions, and the use of such compounds and compositions for the prevention and treatment of disorders involving beta-secretase, such as Alzheimer's disease (AD), a moderate cognitive impairment. , old age, dementia, dementia with calves Levy, p Down syndrome, stroke-related dementia, Parkinson's-associated dementia, and beta-amyloid-associated dementia.

UAA201212485A 2010-06-09 2011-08-06 5,6-Dihydro-2H- [1,4] OXASINE-3-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE INHIBITORS (BACE) UA108753C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10165335 2010-06-09
PCT/EP2011/059441 WO2011154431A1 (en) 2010-06-09 2011-06-08 5,6-dihydro-2h-[1,4]oxazin-3-yl-amine derivatives useful as inhibitors of beta-secretase (bace)

Publications (1)

Publication Number Publication Date
UA108753C2 true UA108753C2 (en) 2015-06-10

Family

ID=42938341

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201212485A UA108753C2 (en) 2010-06-09 2011-08-06 5,6-Dihydro-2H- [1,4] OXASINE-3-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE INHIBITORS (BACE)

Country Status (1)

Country Link
UA (1) UA108753C2 (en)

Similar Documents

Publication Publication Date Title
EA201291366A1 (en) DERIVATIVES 5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-SHE AS BETA SECRETASE INHIBITORS (BACE)
UA109459C2 (en) 5,6-Dihydroimidazo derivatives [1,2-a] Pyrazine-8-ylamine, Suitable as BACE-SECRETASE INHIBITORS (BACE)
UA109800C2 (en) 6,7-DIHYDROPYRAZOLO$1,5-a]PYRAZINE-4-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE (BACE) INHIBITORS
UA109687C2 (en) 3,4-DIHYDROPYRROLO$1,2-a]PYRAZINE-1-YLAMINE DERIVATIVES USEFUL AS BETA-SECRETASE (BACE) INHIBITORS
EA201291435A1 (en) DERIVATIVES 5,6-DIGIDRO-2H- [1,4] OXAZIN-3-ILAMINE AS BETA SECRETASE INHIBITORS (BACE)
EA201291413A1 (en) DERIVATIVES 3-AMINO-5,6-DIHYDRO-1H-PYRAZIN-2-SHE, APPLICABLE FOR THE TREATMENT OF ALCHEIMER'S Disease And Other Forms Of Dementia
EA201491116A1 (en) DERIVATIVES 6-DIFTORMETYL-5,6-DIGIDRO-2H- [1,4] OXAZIN-3-AMINE
MX2013003246A (en) 4,7-DIHYDRO-PYRAZOLO[1,5-a]PYRAZIN-6-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE).
MX357383B (en) 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives.
BR112012018386A2 (en) "phosphatidylinositol 3-kinase isoindolinone inhibitors"
MY148558A (en) Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use
CY1111070T1 (en) 2-AMINE-QUINAZOLINE DERIVATIVE USEFUL FOR B-SECRETARISE INHIBITORS (BACE)
CY1111086T1 (en) 2-AMINO-KINAZOLIN DERIVATIVE USEFUL FOR BETA-SECRETARISE INHIBITORS (BACE)
MX2009012608A (en) Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use.
BR112014006763A2 (en) n- (3- (2-amino-6,6-difluoro-4,4a, 5,6,7,7a-hexahydro-cyclopenta [e] [1,3] oxazin-4-yl) -phenyl) -amides as bace1 inhibitors
MX2012010658A (en) Spiro-tetracyclic ring compounds as beta - secretase modulators.
EA201592277A1 (en) DERIVATIVES 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO [1,5-A] PYRAZINE AS BETA SECRETASE INHIBITORS
EA201592307A1 (en) DERIVATIVES 4-AMINO-6-PHENYL-6,7-DIHYDRO [1,2,3] TRIAZOLO [1,5-A] PIRAZINE AS BETA SECRETASE INHIBITORS (BACE)
UA108753C2 (en) 5,6-Dihydro-2H- [1,4] OXASINE-3-YLAMINE DERIVATIVES USEFUL AS BETA SECRETASE INHIBITORS (BACE)