MX2009013753A - Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles. - Google Patents
Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles.Info
- Publication number
- MX2009013753A MX2009013753A MX2009013753A MX2009013753A MX2009013753A MX 2009013753 A MX2009013753 A MX 2009013753A MX 2009013753 A MX2009013753 A MX 2009013753A MX 2009013753 A MX2009013753 A MX 2009013753A MX 2009013753 A MX2009013753 A MX 2009013753A
- Authority
- MX
- Mexico
- Prior art keywords
- regioselective
- azabenzimidazoles
- benzimidazoles
- copper catalyzed
- catalyzed synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290800 | 2007-06-26 | ||
| PCT/EP2008/004639 WO2009000413A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009013753A true MX2009013753A (es) | 2010-01-26 |
Family
ID=38646504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009013753A MX2009013753A (es) | 2007-06-26 | 2008-06-11 | Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8735586B2 (enExample) |
| EP (1) | EP2173721B1 (enExample) |
| JP (1) | JP5492770B2 (enExample) |
| KR (1) | KR20100023907A (enExample) |
| CN (1) | CN101687815A (enExample) |
| AT (1) | ATE539063T1 (enExample) |
| AU (1) | AU2008267444A1 (enExample) |
| BR (1) | BRPI0813271A2 (enExample) |
| CA (1) | CA2691857A1 (enExample) |
| IL (1) | IL202823A0 (enExample) |
| MX (1) | MX2009013753A (enExample) |
| WO (1) | WO2009000413A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| CA2785536C (en) | 2009-12-30 | 2018-02-27 | Arqule, Inc. | Substituted imidazopyridinyl-aminopyridine compounds |
| JP5894161B2 (ja) * | 2010-08-25 | 2016-03-23 | ネオファーム カンパニー， リミテッド | 新規の複素環化合物及びこれを用いた炎症性疾患治療用組成物 |
| ES2616238T3 (es) | 2010-10-06 | 2017-06-12 | Glaxosmithkline Llc, Corporation Service Company | Derivados de bencimidazol como inhibidores de PI3 quinasa |
| CN103582632B (zh) | 2011-03-31 | 2015-08-19 | 拜耳知识产权有限责任公司 | 取代的苯并咪唑 |
| JP6046710B2 (ja) | 2011-06-24 | 2016-12-21 | アーキュール，インコーポレイティド | 置換されたイミダゾピリジニル−アミノピリジン化合物 |
| US8815854B2 (en) | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
| US9156838B2 (en) * | 2012-06-22 | 2015-10-13 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound |
| CN102924460B (zh) * | 2012-11-05 | 2015-12-16 | 南京师范大学 | 一种4H-吡咯并[1,2-a]苯并咪唑衍生物及其合成方法和应用 |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
| CN103130811B (zh) * | 2013-03-11 | 2015-02-25 | 河南师范大学 | 一种5,6-二氢吡唑并[1,5-c]喹唑啉类化合物的合成方法 |
| AR095604A1 (es) | 2013-03-15 | 2015-10-28 | Syngenta Participations Ag | Derivados de imidazopiridina útiles como microbicidas |
| WO2014151367A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,5-substituted benzimidazoles as flap modulators |
| WO2014151380A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as flap modulators |
| SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
| CA2915622C (en) | 2013-06-21 | 2020-08-18 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| US9855271B2 (en) | 2013-07-31 | 2018-01-02 | Zenith Epigenetics Ltd. | Quinazolinones as bromodomain inhibitors |
| WO2015077572A1 (en) | 2013-11-22 | 2015-05-28 | CL BioSciences LLC | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
| CN103965136B (zh) * | 2014-05-07 | 2016-09-07 | 苏州波菲特新材料科技有限公司 | 一种制备n-甲基噻唑啉-2-酮类化合物的方法 |
| EP3227281A4 (en) | 2014-12-01 | 2018-05-30 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| HK1245248B (en) | 2014-12-11 | 2020-05-15 | 恒翼生物医药(上海)股份有限公司 | Substituted heterocycles as bromodomain inhibitors |
| HK1245247A1 (zh) | 2014-12-17 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| SG11201804098TA (en) | 2015-11-20 | 2018-06-28 | Forma Therapeutics Inc | Purinones as ubiquitin-specific protease 1 inhibitors |
| CN106519250A (zh) * | 2016-09-29 | 2017-03-22 | 辽宁石油化工大学 | 含氮小分子有机配体调节荧光发射性质的一维链状铜配位聚合物的制备方法 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| EP3562487B1 (en) | 2016-12-29 | 2023-11-29 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| WO2018125799A2 (en) | 2016-12-29 | 2018-07-05 | Viamet Pharmaceuticals (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| JP7277431B2 (ja) | 2017-07-11 | 2023-05-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | ナトリウムチャネルのモジュレーターとしてのカルボキサミド |
| AU2018334272B2 (en) | 2017-09-15 | 2023-06-15 | Forma Therapeutics, Inc. | Tetrahydro-imidazo quinoline compositions as CBP/p300 inhibitors |
| GB201800688D0 (en) | 2018-01-16 | 2018-02-28 | Redag Crop Prot Ltd | Agricultural chemicals |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| KR102805503B1 (ko) | 2018-06-29 | 2025-05-09 | 포르마 세라퓨틱스 인크. | Creb 결합 단백질(cbp)의 저해 |
| IL316875A (en) | 2018-10-05 | 2025-01-01 | Annapurna Bio Inc | Compounds and compositions for treating conditions associated with APJ receptor activity |
| US12358893B2 (en) | 2019-01-08 | 2025-07-15 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| CN110982806B (zh) * | 2019-08-30 | 2022-09-02 | 浙江工业大学 | 一种蛋白质芳基衍生物及其制备方法 |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| CN111206260B (zh) * | 2020-02-12 | 2022-03-22 | 齐鲁工业大学 | 一种吡啶并[1,2-a]苯并咪唑类化合物的电化学合成方法 |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101088247B1 (ko) * | 2005-12-19 | 2011-11-30 | 라퀄리아 파마 인코포레이티드 | 크로메인 치환된 벤즈이미다졸 및 이들의 산 펌프억제제로서의 용도 |
| KR20090097908A (ko) * | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
-
2008
- 2008-06-11 CN CN200880021896A patent/CN101687815A/zh active Pending
- 2008-06-11 JP JP2010513710A patent/JP5492770B2/ja not_active Expired - Fee Related
- 2008-06-11 KR KR1020097027120A patent/KR20100023907A/ko not_active Withdrawn
- 2008-06-11 CA CA002691857A patent/CA2691857A1/en not_active Abandoned
- 2008-06-11 EP EP08759158A patent/EP2173721B1/en not_active Not-in-force
- 2008-06-11 BR BRPI0813271-2A2A patent/BRPI0813271A2/pt not_active IP Right Cessation
- 2008-06-11 MX MX2009013753A patent/MX2009013753A/es active IP Right Grant
- 2008-06-11 AT AT08759158T patent/ATE539063T1/de active
- 2008-06-11 WO PCT/EP2008/004639 patent/WO2009000413A1/en not_active Ceased
- 2008-06-11 AU AU2008267444A patent/AU2008267444A1/en not_active Abandoned
-
2009
- 2009-12-17 IL IL202823A patent/IL202823A0/en unknown
- 2009-12-22 US US12/644,401 patent/US8735586B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100023907A (ko) | 2010-03-04 |
| IL202823A0 (en) | 2010-06-30 |
| CA2691857A1 (en) | 2008-12-31 |
| JP5492770B2 (ja) | 2014-05-14 |
| ATE539063T1 (de) | 2012-01-15 |
| BRPI0813271A2 (pt) | 2014-12-30 |
| US20100261909A1 (en) | 2010-10-14 |
| AU2008267444A1 (en) | 2008-12-31 |
| EP2173721B1 (en) | 2011-12-28 |
| WO2009000413A1 (en) | 2008-12-31 |
| JP2010531313A (ja) | 2010-09-24 |
| CN101687815A (zh) | 2010-03-31 |
| EP2173721A1 (en) | 2010-04-14 |
| US8735586B2 (en) | 2014-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009013753A (es) | Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles. | |
| IL196431A0 (en) | A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles | |
| IL201253A0 (en) | A transition metal catalyzed synthesis of n - aminoindoles | |
| MX2009014203A (es) | Una sintesis de 2h-indazoles catalizada por un metal de transicion. | |
| BRPI0813273A2 (pt) | Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados | |
| MX2009013591A (es) | Proceso para la preparacion de pirazoles. | |
| MX342850B (es) | Proceso para la preparacion de triazolonas quirales. | |
| MX2009013738A (es) | Un procedimiento catalizado por paladio para el acoplamiento de alquinos terminales con tosilatos de arilo. | |
| MY162033A (en) | New process for the synthesis of agomelatine | |
| MX2009007713A (es) | Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas. | |
| MX2009008772A (es) | Derivado piridil-triazolopirimidina o su sal, pesticida que lo contiene y proceso para su produccion. | |
| Joshi et al. | Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents | |
| MY149070A (en) | 1h-quinazoline-2,4-diones | |
| MY144746A (en) | Process for the preparation of agomelatine | |
| IL200323A0 (en) | Synthesis of glyt-1 inhibitors | |
| WO2011012620A3 (en) | Processes for the alkylation of pyrazoles | |
| GB201104203D0 (en) | Chemical process | |
| UA102816C2 (ru) | Способ синтеза кристаллической формы v агомелатина | |
| MY151461A (en) | A process for the palladium-catalyzed coupling of terminal alkynes with heteroayl tosylates and heteroaryl benzenesulfonates | |
| MX2009011926A (es) | Metodo para la sintesis del acido (z)-3-[2-butoxi-3´-(3-heptil-1-m etil-ureido)-bifenil-4-il]-2-metoxi-acrilico. | |
| WO2008087736A1 (ja) | アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法 | |
| TH138122A (th) | กรรมวิธีการสังเคราะห์สารอนุพันธ์ของไกลโคซิลไตรอะโซล (Glycosyl Triazole) โดยปฏิกิริยาวันพอทโอไกลโคซิเลชั่นคลิกเคมิสทรี (One-pot O-Glycosylation Click Chemistry) (One-pot synthetic method of Glycosyl triazole derivatives) | |
| NO20075687L (no) | Fremgangsmate for fremstilling av bicykliske forbindelser | |
| GB0713566D0 (en) | The Synthesis of,N-alkylbis(orciny)phenox AZinones;N-alkyl 3,6-D1(1'3'-Dihydroxy-5'-methylbenzene 6')4,5-Dimethylphenoxazin-2-one-7-oxides | |
| TN2009000302A1 (fr) | Nouveau procede de synthese de l'agomelatine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |