ATE539063T1 - Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolen - Google Patents
Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolenInfo
- Publication number
- ATE539063T1 ATE539063T1 AT08759158T AT08759158T ATE539063T1 AT E539063 T1 ATE539063 T1 AT E539063T1 AT 08759158 T AT08759158 T AT 08759158T AT 08759158 T AT08759158 T AT 08759158T AT E539063 T1 ATE539063 T1 AT E539063T1
- Authority
- AT
- Austria
- Prior art keywords
- regioselective
- azabenzimidazoles
- benzimidazoles
- copper
- catalyzed synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290800 | 2007-06-26 | ||
| PCT/EP2008/004639 WO2009000413A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539063T1 true ATE539063T1 (de) | 2012-01-15 |
Family
ID=38646504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08759158T ATE539063T1 (de) | 2007-06-26 | 2008-06-11 | Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8735586B2 (enExample) |
| EP (1) | EP2173721B1 (enExample) |
| JP (1) | JP5492770B2 (enExample) |
| KR (1) | KR20100023907A (enExample) |
| CN (1) | CN101687815A (enExample) |
| AT (1) | ATE539063T1 (enExample) |
| AU (1) | AU2008267444A1 (enExample) |
| BR (1) | BRPI0813271A2 (enExample) |
| CA (1) | CA2691857A1 (enExample) |
| IL (1) | IL202823A0 (enExample) |
| MX (1) | MX2009013753A (enExample) |
| WO (1) | WO2009000413A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| MX2012007367A (es) | 2009-12-30 | 2013-04-03 | Arqule Inc | Compuestos substituidos de imidazopiridinilo-aminopiridina. |
| KR101477156B1 (ko) * | 2010-08-25 | 2014-12-29 | (주)네오팜 | 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물 |
| EP3170813B1 (en) | 2010-10-06 | 2018-12-12 | GlaxoSmithKline LLC | Benzimidazole derivatives as pi3 kinase inhibitors |
| CN103582632B (zh) | 2011-03-31 | 2015-08-19 | 拜耳知识产权有限责任公司 | 取代的苯并咪唑 |
| WO2012177852A1 (en) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| KR101974673B1 (ko) | 2011-06-24 | 2019-05-02 | 아르퀼 인코포레이티드 | 치환된 이미다조피리디닐-아미노피리딘 화합물 |
| EP2865672A4 (en) * | 2012-06-22 | 2015-12-16 | Sumitomo Chemical Co | CONDENSED HETEROCYCLIC COMPOUND |
| CN102924460B (zh) * | 2012-11-05 | 2015-12-16 | 南京师范大学 | 一种4H-吡咯并[1,2-a]苯并咪唑衍生物及其合成方法和应用 |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| CN103130811B (zh) * | 2013-03-11 | 2015-02-25 | 河南师范大学 | 一种5,6-二氢吡唑并[1,5-c]喹唑啉类化合物的合成方法 |
| WO2014151367A1 (en) | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 1,2,5-substituted benzimidazoles as flap modulators |
| US9695149B2 (en) | 2013-03-15 | 2017-07-04 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as flap modulators |
| US9512120B2 (en) | 2013-03-15 | 2016-12-06 | Syngenta Participations Ag | Microbicidally active imidazopyridine derivatives |
| SG11201510409QA (en) | 2013-06-21 | 2016-01-28 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
| WO2015004533A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
| WO2015015318A2 (en) | 2013-07-31 | 2015-02-05 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
| KR102254957B1 (ko) | 2013-11-22 | 2021-05-25 | 씨엘 바이오사이언시즈 엘엘씨 | 골다공증 치료 및 예방을 위한 가스트린 길항제(ｅｇ ｙｆ476, 네타제피드) |
| CN103965136B (zh) * | 2014-05-07 | 2016-09-07 | 苏州波菲特新材料科技有限公司 | 一种制备n-甲基噻唑啉-2-酮类化合物的方法 |
| EP3227280B1 (en) | 2014-12-01 | 2019-04-24 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| JP2017537946A (ja) | 2014-12-11 | 2017-12-21 | ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｌｔｄ． | ブロモドメイン阻害剤としての置換複素環 |
| HK1245247A1 (zh) | 2014-12-17 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| RU2750151C2 (ru) | 2015-11-20 | 2021-06-22 | Форма Терапьютикс, Инк. | Гипоксантины в качестве ингибиторов убиквитин-специфической протеазы 1 |
| CN106519250A (zh) * | 2016-09-29 | 2017-03-22 | 辽宁石油化工大学 | 含氮小分子有机配体调节荧光发射性质的一维链状铜配位聚合物的制备方法 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| EP3562487B1 (en) | 2016-12-29 | 2023-11-29 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| CA3069720A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| TWI846350B (zh) | 2017-09-15 | 2024-06-21 | 美商佛瑪治療公司 | 作為ＣＢＰ／ｐ３００抑制劑之四氫－咪唑並喹啉化合物 |
| GB201800688D0 (en) | 2018-01-16 | 2018-02-28 | Redag Crop Prot Ltd | Agricultural chemicals |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| MX2023013508A (es) | 2018-06-29 | 2023-12-13 | Forma Therapeutics Inc | Inhibicion de la proteina de union a creb (cbp). |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| US12358893B2 (en) | 2019-01-08 | 2025-07-15 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| CN110982806B (zh) * | 2019-08-30 | 2022-09-02 | 浙江工业大学 | 一种蛋白质芳基衍生物及其制备方法 |
| DK4069691T3 (da) | 2019-12-06 | 2024-10-28 | Vertex Pharma | Substituerede tetrahydrofuraner som modulatorer af natriumkanaler |
| CN111206260B (zh) * | 2020-02-12 | 2022-03-22 | 齐鲁工业大学 | 一种吡啶并[1,2-a]苯并咪唑类化合物的电化学合成方法 |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| MA64853B1 (fr) | 2021-06-04 | 2025-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101088247B1 (ko) * | 2005-12-19 | 2011-11-30 | 라퀄리아 파마 인코포레이티드 | 크로메인 치환된 벤즈이미다졸 및 이들의 산 펌프억제제로서의 용도 |
| WO2008070507A2 (en) * | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
-
2008
- 2008-06-11 KR KR1020097027120A patent/KR20100023907A/ko not_active Withdrawn
- 2008-06-11 CA CA002691857A patent/CA2691857A1/en not_active Abandoned
- 2008-06-11 MX MX2009013753A patent/MX2009013753A/es active IP Right Grant
- 2008-06-11 AU AU2008267444A patent/AU2008267444A1/en not_active Abandoned
- 2008-06-11 AT AT08759158T patent/ATE539063T1/de active
- 2008-06-11 CN CN200880021896A patent/CN101687815A/zh active Pending
- 2008-06-11 JP JP2010513710A patent/JP5492770B2/ja not_active Expired - Fee Related
- 2008-06-11 EP EP08759158A patent/EP2173721B1/en not_active Not-in-force
- 2008-06-11 BR BRPI0813271-2A2A patent/BRPI0813271A2/pt not_active IP Right Cessation
- 2008-06-11 WO PCT/EP2008/004639 patent/WO2009000413A1/en not_active Ceased
-
2009
- 2009-12-17 IL IL202823A patent/IL202823A0/en unknown
- 2009-12-22 US US12/644,401 patent/US8735586B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100023907A (ko) | 2010-03-04 |
| CA2691857A1 (en) | 2008-12-31 |
| US8735586B2 (en) | 2014-05-27 |
| US20100261909A1 (en) | 2010-10-14 |
| CN101687815A (zh) | 2010-03-31 |
| WO2009000413A1 (en) | 2008-12-31 |
| IL202823A0 (en) | 2010-06-30 |
| BRPI0813271A2 (pt) | 2014-12-30 |
| AU2008267444A1 (en) | 2008-12-31 |
| MX2009013753A (es) | 2010-01-26 |
| JP2010531313A (ja) | 2010-09-24 |
| JP5492770B2 (ja) | 2014-05-14 |
| EP2173721A1 (en) | 2010-04-14 |
| EP2173721B1 (en) | 2011-12-28 |
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