ATE539063T1 - Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolen - Google Patents
Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolenInfo
- Publication number
- ATE539063T1 ATE539063T1 AT08759158T AT08759158T ATE539063T1 AT E539063 T1 ATE539063 T1 AT E539063T1 AT 08759158 T AT08759158 T AT 08759158T AT 08759158 T AT08759158 T AT 08759158T AT E539063 T1 ATE539063 T1 AT E539063T1
- Authority
- AT
- Austria
- Prior art keywords
- regioselective
- azabenzimidazoles
- benzimidazoles
- copper
- catalyzed synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07290800 | 2007-06-26 | ||
| PCT/EP2008/004639 WO2009000413A1 (en) | 2007-06-26 | 2008-06-11 | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE539063T1 true ATE539063T1 (de) | 2012-01-15 |
Family
ID=38646504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08759158T ATE539063T1 (de) | 2007-06-26 | 2008-06-11 | Regioselektive, kupferkatalysierte synthese von benzimidazolen und azabenzimidazolen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8735586B2 (enExample) |
| EP (1) | EP2173721B1 (enExample) |
| JP (1) | JP5492770B2 (enExample) |
| KR (1) | KR20100023907A (enExample) |
| CN (1) | CN101687815A (enExample) |
| AT (1) | ATE539063T1 (enExample) |
| AU (1) | AU2008267444A1 (enExample) |
| BR (1) | BRPI0813271A2 (enExample) |
| CA (1) | CA2691857A1 (enExample) |
| IL (1) | IL202823A0 (enExample) |
| MX (1) | MX2009013753A (enExample) |
| WO (1) | WO2009000413A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| CA2785536C (en) | 2009-12-30 | 2018-02-27 | Arqule, Inc. | Substituted imidazopyridinyl-aminopyridine compounds |
| US8809541B2 (en) | 2010-08-25 | 2014-08-19 | Neopharm Co., Ltd. | Heterocyclic compound, and composition for treating inflammatory diseases using same |
| KR101594002B1 (ko) | 2010-10-06 | 2016-02-15 | 글락소스미스클라인 엘엘씨 | Ｐｉ３ 키나제 억제제로서의 벤즈이미다졸 유도체 |
| CA2831710A1 (en) | 2011-03-31 | 2012-10-04 | Bayer Intellectual Property Gmbh | Substituted benzimidazoles as mps-1 kinase inhibitors |
| DK2723741T3 (en) | 2011-06-24 | 2016-06-06 | Arqule Inc | SUBSTITUTED imidazopyridinyl-aminopyridine compounds |
| WO2012177852A1 (en) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| EP2865672A4 (en) * | 2012-06-22 | 2015-12-16 | Sumitomo Chemical Co | CONDENSED HETEROCYCLIC COMPOUND |
| CN102924460B (zh) * | 2012-11-05 | 2015-12-16 | 南京师范大学 | 一种4H-吡咯并[1,2-a]苯并咪唑衍生物及其合成方法和应用 |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
| JP2016507496A (ja) | 2012-12-21 | 2016-03-10 | ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． | ブロモドメイン阻害剤としての新規複素環式化合物 |
| CN103130811B (zh) * | 2013-03-11 | 2015-02-25 | 河南师范大学 | 一种5,6-二氢吡唑并[1,5-c]喹唑啉类化合物的合成方法 |
| US9067917B2 (en) | 2013-03-15 | 2015-06-30 | Janssen Pharmaceutica Nv | 1,2,5-substituted benzimidazoles as FLAP modulators |
| US9695149B2 (en) | 2013-03-15 | 2017-07-04 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as flap modulators |
| AR095604A1 (es) | 2013-03-15 | 2015-10-28 | Syngenta Participations Ag | Derivados de imidazopiridina útiles como microbicidas |
| KR102307566B1 (ko) | 2013-06-21 | 2021-10-05 | 제니쓰 에피제네틱스 리미티드 | 신규한 바이사이클릭 브로모도메인 억제제 |
| CN105473581B (zh) | 2013-06-21 | 2019-04-23 | 齐尼思表观遗传学有限公司 | 作为溴结构域抑制剂的新取代的双环化合物 |
| CA2919948C (en) | 2013-07-31 | 2020-07-21 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
| RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
| CN103965136B (zh) * | 2014-05-07 | 2016-09-07 | 苏州波菲特新材料科技有限公司 | 一种制备n-甲基噻唑啉-2-酮类化合物的方法 |
| US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| HK1245246A1 (zh) | 2014-12-01 | 2018-08-24 | 恒翼生物医药科技(上海)有限公司 | 作为溴域抑制剂的取代吡啶酮 |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| CN107406438B (zh) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
| CN114702495A (zh) | 2015-11-20 | 2022-07-05 | 福马治疗有限公司 | 作为泛素-特异性蛋白酶1抑制剂的嘌呤酮 |
| CN106519250A (zh) * | 2016-09-29 | 2017-03-22 | 辽宁石油化工大学 | 含氮小分子有机配体调节荧光发射性质的一维链状铜配位聚合物的制备方法 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2018125799A2 (en) | 2016-12-29 | 2018-07-05 | Viamet Pharmaceuticals (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| CA3055292A1 (en) | 2016-12-29 | 2018-07-05 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| CA3058695A1 (en) | 2017-04-26 | 2018-11-01 | Basilea Pharmaceutica International AG | Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof |
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2019055877A1 (en) | 2017-09-15 | 2019-03-21 | Forma Therapeutics, Inc. | TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300 |
| GB201800688D0 (en) | 2018-01-16 | 2018-02-28 | Redag Crop Prot Ltd | Agricultural chemicals |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| IL279734B2 (en) | 2018-06-29 | 2024-11-01 | Forma Therapeutics Inc | Inhibiting creb binding protein (cbp) |
| LT3860998T (lt) | 2018-10-05 | 2024-06-25 | Annapurna Bio Inc. | Junginiai ir kompozicijos, skirti gydyti būkles, susijusias su apj receptoriaus aktyvumu |
| CA3126224A1 (en) | 2019-01-08 | 2020-07-16 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| TW202102494A (zh) | 2019-03-15 | 2021-01-16 | 美商弗瑪治療公司 | 抑制環amp-反應元件-結合蛋白(creb) |
| CN110982806B (zh) * | 2019-08-30 | 2022-09-02 | 浙江工业大学 | 一种蛋白质芳基衍生物及其制备方法 |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| CN111206260B (zh) * | 2020-02-12 | 2022-03-22 | 齐鲁工业大学 | 一种吡啶并[1,2-a]苯并咪唑类化合物的电化学合成方法 |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| SI4347031T1 (sl) | 2021-06-04 | 2026-01-30 | Vertex Pharmaceuticals Incorporated | N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007072146A1 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Chromane substituted benzimidazoles and their use as acid pump inhibitors |
| MX2009005264A (es) * | 2006-12-06 | 2009-05-28 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
-
2008
- 2008-06-11 WO PCT/EP2008/004639 patent/WO2009000413A1/en not_active Ceased
- 2008-06-11 BR BRPI0813271-2A2A patent/BRPI0813271A2/pt not_active IP Right Cessation
- 2008-06-11 CN CN200880021896A patent/CN101687815A/zh active Pending
- 2008-06-11 MX MX2009013753A patent/MX2009013753A/es active IP Right Grant
- 2008-06-11 KR KR1020097027120A patent/KR20100023907A/ko not_active Withdrawn
- 2008-06-11 EP EP08759158A patent/EP2173721B1/en not_active Not-in-force
- 2008-06-11 CA CA002691857A patent/CA2691857A1/en not_active Abandoned
- 2008-06-11 AU AU2008267444A patent/AU2008267444A1/en not_active Abandoned
- 2008-06-11 JP JP2010513710A patent/JP5492770B2/ja not_active Expired - Fee Related
- 2008-06-11 AT AT08759158T patent/ATE539063T1/de active
-
2009
- 2009-12-17 IL IL202823A patent/IL202823A0/en unknown
- 2009-12-22 US US12/644,401 patent/US8735586B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL202823A0 (en) | 2010-06-30 |
| CA2691857A1 (en) | 2008-12-31 |
| WO2009000413A1 (en) | 2008-12-31 |
| JP5492770B2 (ja) | 2014-05-14 |
| US20100261909A1 (en) | 2010-10-14 |
| EP2173721B1 (en) | 2011-12-28 |
| MX2009013753A (es) | 2010-01-26 |
| CN101687815A (zh) | 2010-03-31 |
| EP2173721A1 (en) | 2010-04-14 |
| JP2010531313A (ja) | 2010-09-24 |
| BRPI0813271A2 (pt) | 2014-12-30 |
| KR20100023907A (ko) | 2010-03-04 |
| US8735586B2 (en) | 2014-05-27 |
| AU2008267444A1 (en) | 2008-12-31 |
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