MX2009004433A - Suspensiones farmaceuticas acuosas que contienen rebamipide y su procedimiento de fabricacion. - Google Patents

Suspensiones farmaceuticas acuosas que contienen rebamipide y su procedimiento de fabricacion.

Info

Publication number
MX2009004433A
MX2009004433A MX2009004433A MX2009004433A MX2009004433A MX 2009004433 A MX2009004433 A MX 2009004433A MX 2009004433 A MX2009004433 A MX 2009004433A MX 2009004433 A MX2009004433 A MX 2009004433A MX 2009004433 A MX2009004433 A MX 2009004433A
Authority
MX
Mexico
Prior art keywords
rebamipide
aqueous pharmaceutical
manufacturing process
suspensions containing
pharmaceutical suspensions
Prior art date
Application number
MX2009004433A
Other languages
English (en)
Inventor
Yoshito Masuda
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of MX2009004433A publication Critical patent/MX2009004433A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención proporciona una suspensión farmacéutica acuosa que contiene rebamipide que se puede preparar por un procedimiento simple y mantener el estado de partículas finas dispersas de rebamipide estable sin presentar aglutinación de las partículas finas; la suspensión farmacéutica acuosa que contiene rebamipide de la invención se prepara por mezclado de alcohol polivinílico y además un compuesto tipo sal sódica con rebamipide.
MX2009004433A 2006-10-26 2007-10-24 Suspensiones farmaceuticas acuosas que contienen rebamipide y su procedimiento de fabricacion. MX2009004433A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006291535 2006-10-26
PCT/JP2007/071167 WO2008050896A1 (en) 2006-10-26 2007-10-24 Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof

Publications (1)

Publication Number Publication Date
MX2009004433A true MX2009004433A (es) 2009-05-08

Family

ID=39324676

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004433A MX2009004433A (es) 2006-10-26 2007-10-24 Suspensiones farmaceuticas acuosas que contienen rebamipide y su procedimiento de fabricacion.

Country Status (20)

Country Link
US (1) US8772317B2 (es)
EP (1) EP2077840A4 (es)
JP (1) JP5250551B2 (es)
KR (2) KR20090073248A (es)
CN (1) CN101528229B (es)
AR (1) AR063366A1 (es)
AU (1) AU2007309968B2 (es)
BR (1) BRPI0718429A2 (es)
CA (1) CA2665024C (es)
HK (1) HK1133188A1 (es)
IL (1) IL197950A0 (es)
MX (1) MX2009004433A (es)
MY (1) MY148303A (es)
NZ (1) NZ576224A (es)
RU (1) RU2467751C2 (es)
SG (1) SG175628A1 (es)
TW (1) TWI415629B (es)
UA (1) UA95989C2 (es)
WO (1) WO2008050896A1 (es)
ZA (1) ZA200902778B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200808375A (en) 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof
DK2285413T3 (da) * 2008-06-19 2012-08-27 Otsuka Pharma Co Ltd Farmaceutisk sammensætning
US20140010882A1 (en) * 2011-03-24 2014-01-09 Takakuni Matsuda Pharmaceutical composition for treating a disease in the oral cavity comprising rebamipide
CN102240260B (zh) * 2011-05-17 2012-05-23 山东省医疗器械研究所 一种治疗阴道干涩症的药物及其制备方法
TW201322982A (zh) 2011-11-01 2013-06-16 Otsuka Pharma Co Ltd 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑
NZ628126A (en) * 2012-02-16 2016-10-28 Atyr Pharma Inc Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
WO2015034008A1 (ja) * 2013-09-05 2015-03-12 大塚製薬株式会社 レバミピドの局所止血用途
CN104586762A (zh) * 2014-04-11 2015-05-06 广州仁恒医药科技有限公司 含有瑞巴派特的药物组合物及其制备方法
CN103976946A (zh) * 2014-05-20 2014-08-13 广州艾格生物科技有限公司 一种含有水溶性高分子聚合物的瑞巴派特混悬滴眼液及其制备方法
JP6854587B2 (ja) * 2015-04-17 2021-04-07 ロート製薬株式会社 医薬製剤
WO2016190306A1 (ja) * 2015-05-28 2016-12-01 ロート製薬株式会社 水性眼科組成物
CN105147606A (zh) * 2015-08-18 2015-12-16 广州仁恒医药科技有限公司 一种瑞巴派特水悬浮液的制备方法
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
KR102307958B1 (ko) 2015-10-01 2021-10-05 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
KR20170039347A (ko) * 2015-10-01 2017-04-11 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
JP2017109996A (ja) * 2015-12-11 2017-06-22 日本合成化学工業株式会社 結晶成長抑制剤
CN107349181B (zh) * 2016-05-09 2021-02-19 四川科伦药物研究院有限公司 含有瑞巴派特和聚维酮的眼科水悬浮液及其制备方法
KR101923519B1 (ko) * 2018-06-26 2019-02-27 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
KR20200019451A (ko) 2018-08-14 2020-02-24 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
KR102659338B1 (ko) 2023-05-18 2024-04-19 국제약품 주식회사 안구건조증 치료용 약제학적 조성물

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3856173D1 (de) * 1987-10-21 1998-06-10 Siemens Ag Verfahren zum Herstellen eines Bipolartransistors mit isolierter Gateelektrode
US5188826A (en) * 1988-02-08 1993-02-23 Insite Vision Incorporated Topical ophthalmic suspensions
RU2098094C1 (ru) * 1991-03-27 1997-12-10 Сендзю Фармасьютикал Ко., Лтд. Способ приготовления водной суспензии и водный глазной препарат
US5540930A (en) 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
AU684115B2 (en) 1993-12-27 1997-12-04 Mitsubishi Chemical Corporation Ophthalmic suspension containing diflupredonate
JP3781792B2 (ja) 1993-12-27 2006-05-31 千寿製薬株式会社 ジフルプレドナート含有点眼用懸濁液剤
US5576311A (en) 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
JP3093661B2 (ja) * 1995-10-12 2000-10-03 大塚製薬株式会社 眼疾患治療剤
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
JP3402195B2 (ja) * 1997-05-14 2003-04-28 千寿製薬株式会社 再分散性の良い水性懸濁液剤
KR20010012188A (ko) * 1997-05-14 2001-02-15 요시다 쇼지 재분산성이 양호한 수성 현탁액제
KR100994221B1 (ko) * 2001-06-14 2010-11-12 오츠카 세이야쿠 가부시키가이샤 의약 조성물
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
JP2005008625A (ja) * 2003-05-23 2005-01-13 Santen Pharmaceut Co Ltd キノロン系抗菌化合物を含有する点眼液
WO2004103373A1 (ja) 2003-05-23 2004-12-02 Santen Pharmaceutical Co.,Ltd. キノロン系抗菌化合物を含有する点眼液
TW200613006A (en) 2004-09-10 2006-05-01 Otsuka Pharma Co Ltd Rebamipide preparation for rectal administration to be prepared before using
TWI363626B (en) * 2004-11-15 2012-05-11 Otsuka Pharma Co Ltd Aqueous ophthalmic suspension of crystalline rebamipide
TW200808375A (en) * 2006-05-12 2008-02-16 Otsuka Pharma Co Ltd Hydrogel suspension and manufacturing process thereof

Also Published As

Publication number Publication date
EP2077840A4 (en) 2010-08-11
KR101491965B1 (ko) 2015-02-10
IL197950A0 (en) 2009-12-24
KR20140088228A (ko) 2014-07-09
JP5250551B2 (ja) 2013-07-31
MY148303A (en) 2013-03-29
RU2009119717A (ru) 2010-12-10
UA95989C2 (uk) 2011-09-26
US20100029714A1 (en) 2010-02-04
US8772317B2 (en) 2014-07-08
EP2077840A1 (en) 2009-07-15
ZA200902778B (en) 2010-02-24
CN101528229B (zh) 2012-07-04
WO2008050896A1 (en) 2008-05-02
HK1133188A1 (en) 2010-03-19
KR20090073248A (ko) 2009-07-02
SG175628A1 (en) 2011-11-28
AR063366A1 (es) 2009-01-21
CA2665024A1 (en) 2008-05-02
AU2007309968B2 (en) 2012-09-06
NZ576224A (en) 2010-12-24
TWI415629B (zh) 2013-11-21
RU2467751C2 (ru) 2012-11-27
BRPI0718429A2 (pt) 2013-11-12
TW200822936A (en) 2008-06-01
JP2010507566A (ja) 2010-03-11
CA2665024C (en) 2015-04-07
AU2007309968A1 (en) 2008-05-02
CN101528229A (zh) 2009-09-09

Similar Documents

Publication Publication Date Title
MY148303A (en) Aqueous pharmaceutical suspensions containing rebamipide and manufacturing process thereof
CL2008001349A1 (es) Proceso de preparacion de particulas pigmentarias autoligantes, secas o en suspension o dispersion acuosa, particulas pigmentarias autoligantes secas; y suspension acuosa de dichas particulas.
HRP20180629T1 (hr) Vodene suspenzije tmc278
EA200800891A1 (ru) Композиции суспензий и способы их получения
UA88317C2 (ru) Бемит, способ его получения и способ получения затравки, применение бемита
WO2010059913A3 (en) Preparation of rasagiline and salts thereof
AR061087A1 (es) Suspension de hidrogel y su proceso de fabricacion
MX2014004667A (es) Concentracion de suspensiones.
IN2014MN02002A (es)
EP2205613A4 (en) BIOCOMPATIBLE SUSPENSION STABILIZER FOR DISPERSING INORGANIC NANOPARTICLES IN AQUEOUS SOLUTION
CY1112917T1 (el) Υγρες στοματικες συνθεσεις
AP2008004691A0 (en) Stable aqueous suspension
WO2011068872A8 (en) Carboxyvinyl polymer-containing nanoparticle suspensions
GB2496089B (en) Improved process for the preparation of stable suspension of nano silver particles having antibacterial activity
GB0818894D0 (en) Additives for controlled dispersion of aqueous suspensions and suspension comprising such additives
WO2007092510A3 (en) Stabilized and freeze-protected polymer drag reducing agent suspensions
EP2213621A3 (en) Aqueous dispersion of aggregate alumina particles
CL2007002291A1 (es) Composicion para tratamiento de bebidas que comprende particulas de xerogel con volumen de poros entre 0,2-2 ml/g y tamano medio de particula 5-40 micrones, donde la composicion comprende hasta 20% de finos; metodo para elaborar composicion; y metodo
IL188971A0 (en) Process for the preparation of a stable dispersion of sub-micron particles in an aqueous medium
WO2007014566A3 (en) Microcapsules and their use
TH112261A (th) สารแขวนลอยแอคเควียสทางเภสัชกรรมที่มีรีบามิพายด์อยู่ด้วย และกรรมวิธีการผลิตของมัน
TH112261B (th) สารแขวนลอยแอคเควียสทางเภสัชกรรมที่มีรีบามิพายด์อยู่ด้วย และกรรมวิธีการผลิตของมัน
GB2429716A9 (en) Colloid/suspension of particulates and biofuel
TH92487A (th) การตั้งสูตรยาน้ำแขวนตะกอนของฟีโซฟีนาดีน
TH117391A (th) องค์ประกอบและวิธีการสำหรับการเตรียมสารแขวนตะกอนไลโปโซมชั้นเดียวที่มีความเสถียร

Legal Events

Date Code Title Description
FG Grant or registration