MEP58708A - Biciklična heterociklična jedinjenja, ljekovi koji sadrže ova jedinjenja, njihova primjena i postupak za njihovo dobijanje - Google Patents

Biciklična heterociklična jedinjenja, ljekovi koji sadrže ova jedinjenja, njihova primjena i postupak za njihovo dobijanje

Info

Publication number
MEP58708A
MEP58708A MEP-587/08A MEP58708A MEP58708A ME P58708 A MEP58708 A ME P58708A ME P58708 A MEP58708 A ME P58708A ME P58708 A MEP58708 A ME P58708A
Authority
ME
Montenegro
Prior art keywords
production
compounds
methods
medicaments containing
bicyclic heterocycles
Prior art date
Application number
MEP-587/08A
Other languages
English (en)
Inventor
Frank Himmelsbach
Elke Langkopf
Birgit Jung
Stefan Blech
Flavio Solca
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP58708A publication Critical patent/MEP58708A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Prdmetni pronalazak se odnosi na biciklična hweterociklična jedinjenja opšte formule (I), u kojoj su Ra do Rc definisani kao što je navedeno u zahtjevima 1 do 7, na njihove teutomere, njihove stereoizomere i njihove soli, a naročito na njihove fiziološki prihvatljive soli sa neorganskim ili orgasnskim kisjelinama ili bazama koje imaju vrijedna farmakološka svojstva, a naqročito inhibitorno dejstvo na transdukciju signala podsredstvom tirozin kinaza, na njihovu primjenu za liječenje bolesti, a naročito tumora, bolesti pluća i disajnih puteva, i na njihovo dobijanje.
MEP-587/08A 2000-08-26 2001-08-18 Biciklična heterociklična jedinjenja, ljekovi koji sadrže ova jedinjenja, njihova primjena i postupak za njihovo dobijanje MEP58708A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10042058A DE10042058A1 (de) 2000-08-26 2000-08-26 Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP2001/009532 WO2002018351A1 (de) 2000-08-26 2001-08-18 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
MEP58708A true MEP58708A (bs) 2011-05-10

Family

ID=7653945

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-587/08A MEP58708A (bs) 2000-08-26 2001-08-18 Biciklična heterociklična jedinjenja, ljekovi koji sadrže ova jedinjenja, njihova primjena i postupak za njihovo dobijanje

Country Status (30)

Country Link
EP (1) EP1315705A1 (bs)
JP (1) JP4834282B2 (bs)
KR (1) KR100862873B1 (bs)
CN (1) CN100404517C (bs)
AR (1) AR033562A1 (bs)
AU (2) AU2001287694B2 (bs)
BG (1) BG107559A (bs)
BR (1) BR0113519A (bs)
CA (1) CA2417897C (bs)
CZ (1) CZ302567B6 (bs)
DE (1) DE10042058A1 (bs)
EA (1) EA005679B1 (bs)
EC (1) ECSP034464A (bs)
EE (1) EE05269B1 (bs)
HR (1) HRP20030138A2 (bs)
HU (1) HUP0300819A3 (bs)
IL (2) IL154602A0 (bs)
ME (1) MEP58708A (bs)
MX (1) MXPA03001483A (bs)
MY (1) MY126132A (bs)
NO (1) NO324866B1 (bs)
NZ (1) NZ524668A (bs)
PL (1) PL360248A1 (bs)
RS (1) RS52279B (bs)
SK (1) SK287747B6 (bs)
TW (1) TWI294422B (bs)
UA (1) UA73004C2 (bs)
UY (1) UY26903A1 (bs)
WO (1) WO2002018351A1 (bs)
ZA (1) ZA200300991B (bs)

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DE10334226A1 (de) * 2003-07-28 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse
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KR101317809B1 (ko) 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR20140096571A (ko) 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
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Also Published As

Publication number Publication date
MY126132A (en) 2006-09-29
IL154602A (en) 2008-07-08
HUP0300819A2 (hu) 2003-09-29
UY26903A1 (es) 2002-03-22
RS52279B (sr) 2012-10-31
CZ302567B6 (cs) 2011-07-13
ECSP034464A (es) 2003-03-31
AU8769401A (en) 2002-03-13
EA005679B1 (ru) 2005-04-28
BG107559A (bg) 2003-10-31
BR0113519A (pt) 2003-07-01
TWI294422B (en) 2008-03-11
KR20030024914A (ko) 2003-03-26
HK1057557A1 (zh) 2004-04-08
SK287747B6 (sk) 2011-08-04
MXPA03001483A (es) 2003-06-06
AR033562A1 (es) 2003-12-26
EP1315705A1 (de) 2003-06-04
AU2001287694B2 (en) 2007-09-06
NZ524668A (en) 2006-06-30
ZA200300991B (en) 2004-04-16
CA2417897C (en) 2009-03-31
EE200300077A (et) 2004-12-15
IL154602A0 (en) 2003-09-17
HRP20030138A2 (en) 2005-04-30
UA73004C2 (uk) 2005-05-16
CN1449390A (zh) 2003-10-15
DE10042058A1 (de) 2002-03-07
WO2002018351A1 (de) 2002-03-07
NO20030870L (no) 2003-02-25
PL360248A1 (en) 2004-09-06
JP4834282B2 (ja) 2011-12-14
NO324866B1 (no) 2007-12-17
NO20030870D0 (no) 2003-02-25
HUP0300819A3 (en) 2008-03-28
JP2004507529A (ja) 2004-03-11
EA200300219A1 (ru) 2003-08-28
EE05269B1 (et) 2010-02-15
CN100404517C (zh) 2008-07-23
SK2312003A3 (en) 2003-10-07
CA2417897A1 (en) 2003-01-30
KR100862873B1 (ko) 2008-10-15
YU14003A (sh) 2006-01-16

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