MEP25108A - Phenyl- and pyridyl-tetrahydro-pyridines having tnf inhibiting activity - Google Patents
Phenyl- and pyridyl-tetrahydro-pyridines having tnf inhibiting activityInfo
- Publication number
- MEP25108A MEP25108A MEP-251/08A MEP25108A MEP25108A ME P25108 A MEP25108 A ME P25108A ME P25108 A MEP25108 A ME P25108A ME P25108 A MEP25108 A ME P25108A
- Authority
- ME
- Montenegro
- Prior art keywords
- group
- hydrogen
- pyridines
- tetrahydro
- pyridyl
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A43—FOOTWEAR
- A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
- A43B7/00—Footwear with health or hygienic arrangements
- A43B7/12—Special watertight footwear
- A43B7/125—Special watertight footwear provided with a vapour permeable member, e.g. a membrane
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- A—HUMAN NECESSITIES
- A43—FOOTWEAR
- A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
- A43B9/00—Footwear characterised by the assembling of the individual parts
- A43B9/02—Footwear stitched or nailed through
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/0009—Producing footwear by injection moulding; Apparatus therefor
- B29D35/0018—Moulds
- B29D35/0045—Sealing means for the mould cavity
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/06—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/06—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising
- B29D35/061—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding
- B29D35/062—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding using means to bond the moulding material to the preformed uppers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
- B29D35/122—Soles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
- B29D35/128—Moulds or apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D35/00—Producing footwear
- B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
- B29D35/14—Multilayered parts
- B29D35/142—Soles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
- B29C45/14836—Preventing damage of inserts during injection, e.g. collapse of hollow inserts, breakage
- B29C2045/14844—Layers protecting the insert from injected material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Mechanical Engineering (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9913206A FR2800071B1 (fr) | 1999-10-22 | 1999-10-22 | Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR0008328A FR2810984B1 (fr) | 2000-06-28 | 2000-06-28 | Pyridyl-tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| PCT/FR2000/002910 WO2001029026A1 (fr) | 1999-10-22 | 2000-10-19 | Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ME01727B ME01727B (me) | 2010-05-07 |
| MEP25108A true MEP25108A (en) | 2011-12-20 |
Family
ID=26212500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-251/08A MEP25108A (en) | 1999-10-22 | 2000-10-19 | Phenyl- and pyridyl-tetrahydro-pyridines having tnf inhibiting activity |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6509351B1 (ru) |
| EP (1) | EP1226137B8 (ru) |
| JP (1) | JP4831908B2 (ru) |
| KR (1) | KR100755115B1 (ru) |
| CN (1) | CN1158276C (ru) |
| AR (1) | AR026188A1 (ru) |
| AT (1) | ATE271554T1 (ru) |
| AU (1) | AU778306B2 (ru) |
| BG (1) | BG65564B1 (ru) |
| BR (1) | BR0014871A (ru) |
| CA (1) | CA2386417C (ru) |
| CZ (1) | CZ301566B6 (ru) |
| DE (1) | DE60012355T2 (ru) |
| DK (1) | DK1226137T3 (ru) |
| EA (1) | EA004508B1 (ru) |
| EE (1) | EE05055B1 (ru) |
| ES (1) | ES2223594T3 (ru) |
| HK (1) | HK1046532B (ru) |
| HR (1) | HRP20020347B1 (ru) |
| HU (1) | HUP0204444A3 (ru) |
| IL (2) | IL149250A0 (ru) |
| IS (1) | IS2308B (ru) |
| ME (1) | MEP25108A (ru) |
| MX (1) | MXPA02003979A (ru) |
| NO (1) | NO322596B1 (ru) |
| NZ (1) | NZ518112A (ru) |
| PL (1) | PL198421B1 (ru) |
| PT (1) | PT1226137E (ru) |
| RS (1) | RS50399B (ru) |
| SI (1) | SI1226137T1 (ru) |
| SK (1) | SK287098B6 (ru) |
| TR (1) | TR200201075T2 (ru) |
| TW (1) | TWI224097B (ru) |
| UA (1) | UA72934C2 (ru) |
| WO (1) | WO2001029026A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823748B1 (fr) * | 2001-04-20 | 2004-02-20 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR2831166B1 (fr) * | 2001-10-18 | 2004-02-27 | Sanofi Synthelabo | Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant |
| FR2832405B1 (fr) * | 2001-11-19 | 2004-12-10 | Sanofi Synthelabo | Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant |
| FR2840896B1 (fr) * | 2002-06-18 | 2005-04-08 | Sanofi Synthelabo | Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| JP4866610B2 (ja) | 2003-08-18 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類 |
| FR2883285B1 (fr) * | 2005-03-17 | 2007-05-18 | Sanofi Aventis Sa | Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3991061A (en) | 1975-07-16 | 1976-11-09 | G. D. Searle & Co. | Azanaphthaleneacetic acid derivatives |
| US4704390A (en) * | 1986-02-13 | 1987-11-03 | Warner-Lambert Company | Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
| US5118691A (en) * | 1990-09-20 | 1992-06-02 | Warner-Lambert Co. | Substituted tetrahydropyridines as central nervous system agents |
| US5045550A (en) * | 1990-09-20 | 1991-09-03 | Warner-Lambert Co. | Substituted tetrahydropyridines as central nervous system agents |
| US5273977A (en) * | 1990-11-05 | 1993-12-28 | Warner-Lambert Company | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents |
| WO1997038992A1 (en) * | 1996-04-12 | 1997-10-23 | Sumitomo Pharmaceuticals Company, Limited | Piperidinylpyramidine derivatives |
| US5776939A (en) * | 1997-06-12 | 1998-07-07 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
| US6281216B1 (en) * | 1998-02-09 | 2001-08-28 | Duphar International Research B.V. | 2-aminoquinoline derivatives having d4-agonistic activity |
| FR2803593B1 (fr) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
2000
- 2000-10-19 CN CNB008160759A patent/CN1158276C/zh not_active Expired - Fee Related
- 2000-10-19 US US10/111,045 patent/US6509351B1/en not_active Expired - Lifetime
- 2000-10-19 RS YUP-289/02A patent/RS50399B/sr unknown
- 2000-10-19 HU HU0204444A patent/HUP0204444A3/hu unknown
- 2000-10-19 CA CA2386417A patent/CA2386417C/en not_active Expired - Fee Related
- 2000-10-19 UA UA2002043167A patent/UA72934C2/ru unknown
- 2000-10-19 ES ES00969646T patent/ES2223594T3/es not_active Expired - Lifetime
- 2000-10-19 PT PT00969646T patent/PT1226137E/pt unknown
- 2000-10-19 DE DE60012355T patent/DE60012355T2/de not_active Expired - Lifetime
- 2000-10-19 CZ CZ20021382A patent/CZ301566B6/cs not_active IP Right Cessation
- 2000-10-19 EE EEP200200210A patent/EE05055B1/xx not_active IP Right Cessation
- 2000-10-19 AU AU79313/00A patent/AU778306B2/en not_active Ceased
- 2000-10-19 NZ NZ518112A patent/NZ518112A/en not_active IP Right Cessation
- 2000-10-19 SK SK528-2002A patent/SK287098B6/sk not_active IP Right Cessation
- 2000-10-19 JP JP2001531826A patent/JP4831908B2/ja not_active Expired - Fee Related
- 2000-10-19 WO PCT/FR2000/002910 patent/WO2001029026A1/fr active IP Right Grant
- 2000-10-19 ME MEP-251/08A patent/MEP25108A/xx unknown
- 2000-10-19 MX MXPA02003979A patent/MXPA02003979A/es active IP Right Grant
- 2000-10-19 KR KR1020027005110A patent/KR100755115B1/ko active IP Right Grant
- 2000-10-19 AT AT00969646T patent/ATE271554T1/de active
- 2000-10-19 BR BR0014871-7A patent/BR0014871A/pt active Search and Examination
- 2000-10-19 SI SI200030499T patent/SI1226137T1/xx unknown
- 2000-10-19 TR TR2002/01075T patent/TR200201075T2/xx unknown
- 2000-10-19 DK DK00969646T patent/DK1226137T3/da active
- 2000-10-19 PL PL354922A patent/PL198421B1/pl unknown
- 2000-10-19 EP EP00969646A patent/EP1226137B8/fr not_active Expired - Lifetime
- 2000-10-19 EA EA200200352A patent/EA004508B1/ru not_active IP Right Cessation
- 2000-10-19 IL IL14925000A patent/IL149250A0/xx active IP Right Grant
- 2000-10-20 AR ARP000105527A patent/AR026188A1/es not_active Application Discontinuation
- 2000-10-23 TW TW089122181A patent/TWI224097B/zh not_active IP Right Cessation
-
2002
- 2002-04-09 IS IS6336A patent/IS2308B/is unknown
- 2002-04-15 BG BG106613A patent/BG65564B1/bg unknown
- 2002-04-19 HR HR20020347A patent/HRP20020347B1/xx not_active IP Right Cessation
- 2002-04-19 NO NO20021872A patent/NO322596B1/no not_active IP Right Cessation
- 2002-04-21 IL IL149250A patent/IL149250A/en not_active IP Right Cessation
- 2002-11-12 HK HK02108188.3A patent/HK1046532B/zh not_active IP Right Cessation
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