DE60012355D1 - Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung - Google Patents

Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung

Info

Publication number
DE60012355D1
DE60012355D1 DE60012355T DE60012355T DE60012355D1 DE 60012355 D1 DE60012355 D1 DE 60012355D1 DE 60012355 T DE60012355 T DE 60012355T DE 60012355 T DE60012355 T DE 60012355T DE 60012355 D1 DE60012355 D1 DE 60012355D1
Authority
DE
Germany
Prior art keywords
inhibitoral
tnf
tetrahydro
pyridyl
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60012355T
Other languages
English (en)
Other versions
DE60012355T2 (de
Inventor
Marco Baroni
Bernard Bourrie
Rosanna Cardamone
Pierre Casellas
Umberto Guzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9913206A external-priority patent/FR2800071B1/fr
Priority claimed from FR0008328A external-priority patent/FR2810984B1/fr
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of DE60012355D1 publication Critical patent/DE60012355D1/de
Application granted granted Critical
Publication of DE60012355T2 publication Critical patent/DE60012355T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A43—FOOTWEAR
    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B7/00—Footwear with health or hygienic arrangements
    • A43B7/12—Special watertight footwear
    • A43B7/125—Special watertight footwear provided with a vapour permeable member, e.g. a membrane
    • A—HUMAN NECESSITIES
    • A43—FOOTWEAR
    • A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
    • A43B9/00—Footwear characterised by the assembling of the individual parts
    • A43B9/02—Footwear stitched or nailed through
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
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    • B29D35/0009—Producing footwear by injection moulding; Apparatus therefor
    • B29D35/0018—Moulds
    • B29D35/0045—Sealing means for the mould cavity
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    • B29D35/061—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding
    • B29D35/062—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding using means to bond the moulding material to the preformed uppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/122—Soles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/128—Moulds or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D35/00—Producing footwear
    • B29D35/12—Producing parts thereof, e.g. soles, heels, uppers, by a moulding technique
    • B29D35/14—Multilayered parts
    • B29D35/142—Soles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
    • B29C45/14836—Preventing damage of inserts during injection, e.g. collapse of hollow inserts, breakage
    • B29C2045/14844—Layers protecting the insert from injected material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Mechanical Engineering (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
DE60012355T 1999-10-22 2000-10-19 Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung Expired - Lifetime DE60012355T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9913206 1999-10-22
FR9913206A FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR0008328A FR2810984B1 (fr) 2000-06-28 2000-06-28 Pyridyl-tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR0008328 2000-06-28
PCT/FR2000/002910 WO2001029026A1 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt

Publications (2)

Publication Number Publication Date
DE60012355D1 true DE60012355D1 (de) 2004-08-26
DE60012355T2 DE60012355T2 (de) 2005-12-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60012355T Expired - Lifetime DE60012355T2 (de) 1999-10-22 2000-10-19 Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung

Country Status (35)

Country Link
US (1) US6509351B1 (de)
EP (1) EP1226137B8 (de)
JP (1) JP4831908B2 (de)
KR (1) KR100755115B1 (de)
CN (1) CN1158276C (de)
AR (1) AR026188A1 (de)
AT (1) ATE271554T1 (de)
AU (1) AU778306B2 (de)
BG (1) BG65564B1 (de)
BR (1) BR0014871A (de)
CA (1) CA2386417C (de)
CZ (1) CZ301566B6 (de)
DE (1) DE60012355T2 (de)
DK (1) DK1226137T3 (de)
EA (1) EA004508B1 (de)
EE (1) EE05055B1 (de)
ES (1) ES2223594T3 (de)
HK (1) HK1046532B (de)
HR (1) HRP20020347B1 (de)
HU (1) HUP0204444A3 (de)
IL (2) IL149250A0 (de)
IS (1) IS2308B (de)
ME (1) MEP25108A (de)
MX (1) MXPA02003979A (de)
NO (1) NO322596B1 (de)
NZ (1) NZ518112A (de)
PL (1) PL198421B1 (de)
PT (1) PT1226137E (de)
RS (1) RS50399B (de)
SI (1) SI1226137T1 (de)
SK (1) SK287098B6 (de)
TR (1) TR200201075T2 (de)
TW (1) TWI224097B (de)
UA (1) UA72934C2 (de)
WO (1) WO2001029026A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
FR2832405B1 (fr) * 2001-11-19 2004-12-10 Sanofi Synthelabo Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1657240A4 (de) 2003-08-18 2009-04-08 Fujifilm Finechemicals Co Ltd Pyridyltetrahydropyridine, pyridylpiperidine, und verfahren zu deren herstellung
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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US3991061A (en) 1975-07-16 1976-11-09 G. D. Searle & Co. Azanaphthaleneacetic acid derivatives
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ME01727B (de) 2010-05-07
NZ518112A (en) 2003-11-28
ES2223594T3 (es) 2005-03-01
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NO20021872L (no) 2002-06-21
EP1226137B8 (de) 2004-12-15
HK1046532A1 (en) 2003-01-17
IL149250A (en) 2007-08-19
RS50399B (sr) 2009-12-31
EP1226137B1 (de) 2004-07-21
UA72934C2 (uk) 2005-05-16
DK1226137T3 (da) 2004-11-22
AU778306B2 (en) 2004-11-25
PL354922A1 (en) 2004-03-22
EE05055B1 (et) 2008-08-15
PT1226137E (pt) 2004-11-30
IL149250A0 (en) 2002-11-10
HK1046532B (zh) 2005-03-18
JP4831908B2 (ja) 2011-12-07
MEP25108A (en) 2011-12-20
SK5282002A3 (en) 2002-08-06
AR026188A1 (es) 2003-01-29
EA200200352A1 (ru) 2002-10-31
BR0014871A (pt) 2002-06-11
CA2386417C (en) 2010-09-28
EE200200210A (et) 2003-06-16
CZ20021382A3 (cs) 2002-07-17
HUP0204444A2 (en) 2003-05-28
AU7931300A (en) 2001-04-30
ATE271554T1 (de) 2004-08-15
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