FR2800071B1 - Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2800071B1
FR2800071B1 FR9913206A FR9913206A FR2800071B1 FR 2800071 B1 FR2800071 B1 FR 2800071B1 FR 9913206 A FR9913206 A FR 9913206A FR 9913206 A FR9913206 A FR 9913206A FR 2800071 B1 FR2800071 B1 FR 2800071B1
Authority
FR
France
Prior art keywords
tetrahydropyridines
preparation
pharmaceutical compositions
compositions containing
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9913206A
Other languages
English (en)
Other versions
FR2800071A1 (fr
Inventor
Marco Baroni
Bernard Bourrie
Pierre Casellas
Umberto Guzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9913206A priority Critical patent/FR2800071B1/fr
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to PCT/FR2000/002910 priority patent/WO2001029026A1/fr
Priority to MXPA02003979A priority patent/MXPA02003979A/es
Priority to TR2002/01075T priority patent/TR200201075T2/xx
Priority to BR0014871-7A priority patent/BR0014871A/pt
Priority to AT00969646T priority patent/ATE271554T1/de
Priority to EP00969646A priority patent/EP1226137B8/fr
Priority to JP2001531826A priority patent/JP4831908B2/ja
Priority to DE60012355T priority patent/DE60012355T2/de
Priority to MEP-251/08A priority patent/MEP25108A/xx
Priority to CA2386417A priority patent/CA2386417C/fr
Priority to UA2002043167A priority patent/UA72934C2/uk
Priority to HU0204444A priority patent/HUP0204444A3/hu
Priority to CNB008160759A priority patent/CN1158276C/zh
Priority to EEP200200210A priority patent/EE05055B1/xx
Priority to DK00969646T priority patent/DK1226137T3/da
Priority to AU79313/00A priority patent/AU778306B2/en
Priority to SK528-2002A priority patent/SK287098B6/sk
Priority to IL14925000A priority patent/IL149250A0/xx
Priority to CZ20021382A priority patent/CZ301566B6/cs
Priority to PT00969646T priority patent/PT1226137E/pt
Priority to NZ518112A priority patent/NZ518112A/en
Priority to KR1020027005110A priority patent/KR100755115B1/ko
Priority to EA200200352A priority patent/EA004508B1/ru
Priority to SI200030499T priority patent/SI1226137T1/xx
Priority to YUP-289/02A priority patent/RS50399B/sr
Priority to US10/111,045 priority patent/US6509351B1/en
Priority to ES00969646T priority patent/ES2223594T3/es
Priority to PL354922A priority patent/PL198421B1/pl
Priority to ARP000105527A priority patent/AR026188A1/es
Priority to TW089122181A priority patent/TWI224097B/zh
Publication of FR2800071A1 publication Critical patent/FR2800071A1/fr
Application granted granted Critical
Publication of FR2800071B1 publication Critical patent/FR2800071B1/fr
Priority to IS6336A priority patent/IS2308B/is
Priority to BG106613A priority patent/BG65564B1/bg
Priority to ZA200203037A priority patent/ZA200203037B/en
Priority to NO20021872A priority patent/NO322596B1/no
Priority to HR20020347A priority patent/HRP20020347B1/xx
Priority to IL149250A priority patent/IL149250A/en
Priority to HK02108188.3A priority patent/HK1046532B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9913206A 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant Expired - Fee Related FR2800071B1 (fr)

Priority Applications (38)

Application Number Priority Date Filing Date Title
FR9913206A FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
KR1020027005110A KR100755115B1 (ko) 1999-10-22 2000-10-19 Ｔｎｆ 억제 활성을 갖는 페닐- 및피리딜-테트라하이드로피리딘
EA200200352A EA004508B1 (ru) 1999-10-22 2000-10-19 Фенил- и пиридил-тетрагидропиридины, обладающие ингибирующей активностью в отношении фактора некроза опухоли (фно)
BR0014871-7A BR0014871A (pt) 1999-10-22 2000-10-19 Fenil- e piridil-tetrahidro-piridinas que possuem uma atividade inibidora de fnt
AT00969646T ATE271554T1 (de) 1999-10-22 2000-10-19 Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung
EP00969646A EP1226137B8 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
JP2001531826A JP4831908B2 (ja) 1999-10-22 2000-10-19 Ｔｎｆ阻害活性を有するフェニル−およびピリジル−テトラヒドロピリジン類
MXPA02003979A MXPA02003979A (es) 1999-10-22 2000-10-19 Fenil- y piridil-tetrahidro-piridinas que tiene una actividad inhibidora de tnf.
MEP-251/08A MEP25108A (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
CA2386417A CA2386417C (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydropyridines possedant une activite inhibitrice de fnt
UA2002043167A UA72934C2 (uk) 1999-10-22 2000-10-19 Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція
HU0204444A HUP0204444A3 (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydro-pyridines, process for their preparation and pharmaceutical compositions containing them
NZ518112A NZ518112A (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydropyridines having TNF inhibiting activity
EEP200200210A EE05055B1 (et) 1999-10-22 2000-10-19 TNF-i aktiivsust p„rssivad fenl- ja pridltetrahdropridiinid
DK00969646T DK1226137T3 (da) 1999-10-22 2000-10-19 Phenyl- og pyridyltetrahydro-pyridiner med en hæmmende virkning på TNF
AU79313/00A AU778306B2 (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity
SK528-2002A SK287098B6 (sk) 1999-10-22 2000-10-19 Deriváty fenyl- a pyridyl-tetrahydropyridínu, spôsob ich prípravy a farmaceutická kompozícia, ktorá ich obsahuje, a použitie
IL14925000A IL149250A0 (en) 1999-10-22 2000-10-19 Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
CZ20021382A CZ301566B6 (cs) 1999-10-22 2000-10-19 Deriváty fenyl- a pyridyl-tetrahydropyridinu, zpusob jejich prípravy a farmaceutická kompozice, která je obsahuje
PT00969646T PT1226137E (pt) 1999-10-22 2000-10-19 Fenil- e piridinil-tetra-hidro-piridinas que possuem uma actividade inibidora defnt
PCT/FR2000/002910 WO2001029026A1 (fr) 1999-10-22 2000-10-19 Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
DE60012355T DE60012355T2 (de) 1999-10-22 2000-10-19 Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung
TR2002/01075T TR200201075T2 (tr) 1999-10-22 2000-10-19 Fenil-ve piridil-tetrahidropiridinler, bunların preparasyonu için proses ve bunları ihtiva eden farmasötik kompozisyonlar
SI200030499T SI1226137T1 (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
YUP-289/02A RS50399B (sr) 1999-10-22 2000-10-19 Fenil- i piridil-tetrahidro-piridini koji imaju tnf-inhibitorsku aktivnost
US10/111,045 US6509351B1 (en) 1999-10-22 2000-10-19 Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity
ES00969646T ES2223594T3 (es) 1999-10-22 2000-10-19 Fenil- y piridil-tetrahidro-piridinas con una actividad inhibidora de fnt.
PL354922A PL198421B1 (pl) 1999-10-22 2000-10-19 Fenylo- i pirydylo-tetrahydropirydyny, sposób ich wytwarzania, syntetyczne związki pośrednie, środek farmaceutyczny i zastosowanie fenylo- i pirydylo-tetrahydropirydyn
CNB008160759A CN1158276C (zh) 1999-10-22 2000-10-19 具有抑制tnf活性的苯基-和吡啶基-四氢吡啶
ARP000105527A AR026188A1 (es) 1999-10-22 2000-10-20 Fenil- y piridil- tetrahidropiridinas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
TW089122181A TWI224097B (en) 1999-10-22 2000-10-23 Phenyl-and pyridyl-tetrahydropyridines, process for their preparation and pharmaceutical compositions containing them
IS6336A IS2308B (is) 1999-10-22 2002-04-09 Fenýl- og pýridýl-tetrahýdró-pýridín sem hafa TNFletjandi virkni
BG106613A BG65564B1 (bg) 1999-10-22 2002-04-15 Фенил- и пиридил-тетрахидропиридини, притежаващи tnf-инхибираща активност, метод и междинни съединения за получаването им, фармацевтичен състав, който ги съдържа, и използването им
ZA200203037A ZA200203037B (en) 1999-10-22 2002-04-17 Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity.
HR20020347A HRP20020347B1 (en) 1999-10-22 2002-04-19 Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
NO20021872A NO322596B1 (no) 1999-10-22 2002-04-19 Fenyl- og pyridyltetrahydropyridiner, fremgangsmater for deres fremstilling, deres anvendelse, farmasoytisk preparat samt syntesemellomprodukter
IL149250A IL149250A (en) 1999-10-22 2002-04-21 Phenyl and pyridyl tetrahydropyridines, process for their preparation and pharmaceutical preparations containing them
HK02108188.3A HK1046532B (zh) 1999-10-22 2002-11-12 具有抑制tnf活性的苯基-和吡啶基-四氫吡啶

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9913206A FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2800071A1 FR2800071A1 (fr) 2001-04-27
FR2800071B1 true FR2800071B1 (fr) 2002-02-15

Family

ID=9551238

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9913206A Expired - Fee Related FR2800071B1 (fr) 1999-10-22 1999-10-22 Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant

Country Status (2)

Country Link
FR (1) FR2800071B1 (fr)
ZA (1) ZA200203037B (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118691A (en) * 1990-09-20 1992-06-02 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents

Also Published As

Publication number Publication date
ZA200203037B (en) 2003-06-05
FR2800071A1 (fr) 2001-04-27

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Year of fee payment: 18

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Effective date: 20180629