ME02258B - Modulatori farmakokinetičkih svojstava terapeutika - Google Patents

Modulatori farmakokinetičkih svojstava terapeutika

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Publication number
ME02258B
ME02258B MEP-2015-590A MEP59015A ME02258B ME 02258 B ME02258 B ME 02258B ME P59015 A MEP59015 A ME P59015A ME 02258 B ME02258 B ME 02258B
Authority
ME
Montenegro
Prior art keywords
alkyl
compound
pharmaceutically acceptable
independently
unsubstituted
Prior art date
Application number
MEP-2015-590A
Other languages
English (en)
French (fr)
Inventor
Manoj C Desai
Hongtao Liu
Lianhong Xu
Allen Yu Hong
Randall W Vivian
Original Assignee
Gilead Sciences Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38729072&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02258(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ME02258B publication Critical patent/ME02258B/me

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/78—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton from carbonyl compounds, e.g. from formaldehyde, and amines having amino groups bound to carbon atoms of six-membered aromatic rings, with formation of methylene-diarylamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
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  • Immunology (AREA)
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  • Biophysics (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Claims (12)

1. Jedinjenje formule IIB: ili njena farmaceutski prihvatljiva so, solvat, stereoizomer i/ili ester, đe: R10a i R10b su svaki nezavisno H ili -C1-4 alkil; R12 je H ili -CH3; R13 je H, -C1-4 alkil, -(CH2)0-1CR17R18OR19, -(CH2)O-3CR17R18NR20R21, -(CH2)0- 3CR17R18NR17C(O)NR20R21, -(CH2)1-3C(O)R22, -(CH2)1-3S(O)2R22 ili -(CH2)1-3-R23; R14 i R15 su svaki nezavisno H, -C1-4 alkil ili arilalkil; R17 i R18 su svaki nezavisno H ili -C1-3 alkil; R19 je H, -Cm alkil ili arilalkil; R20 i R21 su svaki nezavisno H, -C1-3 alkil, -C(O)R17 ili -S(O)2R17; ili R20 i R21, kada uzeti zajedno sa atomom azota sa kojim su spojeni, formiraju nesupstituisani ili supstituisani 5-6-člani heterociklil prsten koji sadrži 1-2 heteroatoma izabrana iz grupe koja se sastoji iz N i O; R22 je H, -C1-3 alkil, -OR19 ili -NR20R21; i R23 je nesupstituisani ili supstituisani 5-6-člani heterociklil prsten koji sadrži 1-2 heteroatoma izabrana iz grupe koja se sastoji iz N i O; gde je pomenuti nesupstituisani ili supstituisani 5-6-člani heterociklil prsten formiran od R20 i R21 inesupstituisani ili supstituisani 5-6-člani heterociklil prsten od R23 pri čemu je svaki nezavisno nesupstituisan ili supstituisan sa C1-2 alkilom.
2. Jedinjenje patentnog zahteva 1 gde: R13 je -(CH2)1-3CR17R18NR20R21, -(CH2)0-3CR17R18NR]7C(0)NR20R21 ili -(CH2)1-3-R23.
3. Jedinjenje patentnog zahteva 2, gde: R13 je -(CH2)0-3CR17R, 8NR20R21 ili -(CH2)0-3CR17R18NR17C(0)-NR20R21.
4.Jedinjenje patentnog zahteva 1 formule IIC: ili njena farmaceutski prihvatljiva so, solvat, stereoizomer i/ili ester, gde: R13 je H, -Cm alkil, -(CH2)0-1CRl7R18OR19, -(CH2)o-3CR17R18NR20R21, -(CH2)0-3CR17R18NR17C(O)NR20R21, -(CH2)1-3C(O)R22 ili -(CH2)1-3-R23; R17 i R18 su svaki nezavisno H ili C1-3 alkil; R19 je H, -Cm alkil ili arilalkil; R20 i R21 su svaki nezavisno H, -Ci-3 alkil, -C(O)R17 ili -S(0)2R17; ili R20 i R21, kada uzeti zajedno sa azotovim atomom za koji su vezani, formiraju 5-6-člani heterociklil prsten koji sadrži 1-2 heteroatoma izabrana iz grupe koja se sastoji iz N i O; R22 je H, -C1-3alkil, -OR19 ili -NR20R21; i R23 je nesupstituisani ili supstituisani 5-6-člani heterociklil prsten koji sadrži 1-2 heteroatoma izabrana iz grupe koja se sastoji iz N i O.
5. Jedinjenje patentnog zahteva 1 formule ili njena farmaceutski prihvatljiva so, stereoizomer i/ili solvat.
6. Jedinjenje patentnog zahteva 5 koje je: ili njegova farmaceutski prihvatljiva so.
7. Jedinjenje patentnog zahteva 1 izabrano iz grupe koja se sastoji od ili njegovih farmaceutski prihvatljivih soli, solvata, estera, i/ili stereoizomera.
8. Jedinjenje patentnog zahteva 1 izabrano iz grupe koja se sastoji od i ili njegovih farmaceutski prihvatljivih soli, solvata, estera, i/ili stereoizomera.
9. Farmaceutska kompozicija koja sadrži jedinjenje bilo kog patentnog zahteva od 1 do 8, ili njegove farmaceutski prihvatljive soli, solvate, i/ili estere, i farmaceutski prihvatljiv nosač ili ekscipijens.
10. Jedinjenje bilo kog patentnog zahteva od 1 do 8 za primenu pri lečenju.
11. Jedinjenje bilo kog patentnog zahteva od 1 do 8 za primenu u poboljšanju farmakokinetike leka koji je metabolisan od strane citohroma P450 monooksigenaze, povećavanju nivoa krvne plazme leka koja je metabolisana od strane citohroma P450 monooksigenaze, inhibiranju citohrom P450 monooksigenaze, lečenju HIV infekcije, ili lečenju HCV infekcije kod pacijenta.
12. Jedinjenje za primenu prema patentnom zahtevu 11, gde citohrom P450 monooksigenaze je citohrom P450 monooksigenaze 3A.
MEP-2015-590A 2006-07-07 2007-07-06 Modulatori farmakokinetičkih svojstava terapeutika ME02258B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US81931506P 2006-07-07 2006-07-07
US83237106P 2006-07-21 2006-07-21
US90322807P 2007-02-23 2007-02-23
PCT/US2007/015604 WO2008010921A2 (en) 2006-07-07 2007-07-06 Modulators of pharmacokinetic properties of therapeutics

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JP4881433B2 (ja) 2012-02-22
RS54237B9 (sr) 2019-07-31
US20080108617A1 (en) 2008-05-08
CY2015046I2 (el) 2016-06-22
SG183007A1 (en) 2012-08-30
EP4566670A3 (en) 2025-08-27
KR20090028821A (ko) 2009-03-19
US20130123311A1 (en) 2013-05-16
AU2007275860B2 (en) 2013-11-14
IL195488A (en) 2017-04-30
EP3112355A1 (en) 2017-01-04
FR15C0078I1 (me) 2016-01-08
US9139541B2 (en) 2015-09-22
JP2009542696A (ja) 2009-12-03
WO2008010921A2 (en) 2008-01-24
EP2049506A2 (en) 2009-04-22
EA200900155A1 (ru) 2009-06-30
NO2019027I1 (no) 2019-07-04
US20110212964A1 (en) 2011-09-01
CA2653374A1 (en) 2008-01-24
BRPI0714055A2 (pt) 2012-12-18
EP3696171C0 (en) 2025-02-19
FIC20150052I1 (fi) 2015-11-06
ES2546378T5 (es) 2024-09-25
RS54237B1 (sr) 2015-12-31
NO343776B1 (no) 2019-06-03
PL2049506T3 (pl) 2015-11-30
RS54237B2 (sr) 2024-08-30
ZA200810399B (en) 2026-04-29
EP3696171A1 (en) 2020-08-19
KR20140004808A (ko) 2014-01-13
NL300780I2 (me) 2016-03-15
AP2008004720A0 (en) 2008-12-31
EP2049506B1 (en) 2015-06-17
KR20150042869A (ko) 2015-04-21
TWI411613B (zh) 2013-10-11
HK1232217A1 (en) 2018-01-05
KR101636221B1 (ko) 2016-07-04
HRP20150744T1 (en) 2015-10-09
US20160303088A1 (en) 2016-10-20
WO2008010921A3 (en) 2008-07-10
US20140105859A1 (en) 2014-04-17
US20160067360A1 (en) 2016-03-10
EA201270738A1 (ru) 2013-07-30
US8067449B2 (en) 2011-11-29
EP2487165B1 (en) 2016-09-14
AU2007275860C1 (en) 2014-06-12
HK1126485A1 (en) 2009-09-04
EP2049506B2 (en) 2024-05-08
KR101477822B1 (ko) 2015-01-02
EA025845B1 (ru) 2017-02-28
AU2007275860A1 (en) 2008-01-24
US8383655B2 (en) 2013-02-26
EA020489B1 (ru) 2014-11-28
EP2487165A1 (en) 2012-08-15
NO20090593L (no) 2009-04-07
EP3112355B1 (en) 2020-04-29
LU92864I2 (fr) 2016-01-06
TW201412733A (zh) 2014-04-01
US20150225448A1 (en) 2015-08-13
DK2049506T4 (da) 2024-06-10
ES2546378T9 (es) 2016-01-26
US20180221348A1 (en) 2018-08-09
BE2015C058I2 (me) 2026-07-10
FI2049506T4 (fi) 2024-06-12
AP2985A (en) 2014-09-30
CN101490023A (zh) 2009-07-22
HUE025565T4 (en) 2017-01-30
US20090291952A1 (en) 2009-11-26
BRPI0714055B8 (pt) 2021-05-25
TWI496778B (zh) 2015-08-21
DK2049506T5 (en) 2016-02-15
MX2009000234A (es) 2009-01-23
US7939553B2 (en) 2011-05-10
SI2049506T2 (sl) 2024-07-31
FR15C0078I2 (fr) 2016-04-22
JP2012051933A (ja) 2012-03-15
US20170143680A1 (en) 2017-05-25
AR061838A1 (es) 2008-09-24
NZ573060A (en) 2012-02-24
CY1116688T1 (el) 2016-06-22
HRP20090077A2 (en) 2009-06-30
PL2049506T5 (pl) 2024-09-09
DK2049506T3 (en) 2015-09-14
HRP20090077B1 (hr) 2016-04-08
CN101490023B (zh) 2013-05-29
TW200811167A (en) 2008-03-01
ES2796275T3 (es) 2020-11-26
NO20190528A1 (no) 2009-04-07
ES2546378T3 (es) 2015-09-23
EP2049506B9 (en) 2016-01-13
IL195488A0 (en) 2009-09-01
NO345343B1 (no) 2020-12-21
HUE025565T2 (en) 2016-03-29
ES3026665T3 (en) 2025-06-11
CN103275033B (zh) 2015-04-29
EP4566670A2 (en) 2025-06-11
HRP20150744T4 (hr) 2024-09-27
US20150011775A1 (en) 2015-01-08
PT2487165T (pt) 2016-11-18
IL232320A0 (en) 2014-06-30
PL3696171T3 (pl) 2025-05-19
NL300780I1 (me) 2016-03-15
LTPA2015040I1 (lt) 2015-12-28
HRP20150744T2 (hr) 2016-02-26
ES2611308T3 (es) 2017-05-08
SI2049506T1 (sl) 2015-08-31
BRPI0714055B1 (pt) 2019-05-21
NO2019031I1 (no) 2019-07-19
PT2049506E (pt) 2015-10-09
EP3696171B1 (en) 2025-02-19
CN103275033A (zh) 2013-09-04
LTC2049506I2 (lt) 2019-05-10

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