ME02113B - Parazitocidni spojevi dihidroizoksazola - Google Patents

Parazitocidni spojevi dihidroizoksazola

Info

Publication number
ME02113B
ME02113B MEP-2015-73A MEP201573A ME02113B ME 02113 B ME02113 B ME 02113B ME P201573 A MEP201573 A ME P201573A ME 02113 B ME02113 B ME 02113B
Authority
ME
Montenegro
Prior art keywords
parasiticidal
dihydroisoxazole compounds
dihydroisoxazole
compounds
parasiticidal dihydroisoxazole
Prior art date
Application number
MEP-2015-73A
Other languages
English (en)
Inventor
Zengyun An
Yang Zhang
Liang Chen
Shuhui Chen
Jean Marie Defauw
Scott Dale Holmstrom
Ping Hu
Chongzhi Tang
William Hunter White
Wentao Wu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME02113B publication Critical patent/ME02113B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MEP-2015-73A 2011-05-19 2012-05-08 Parazitocidni spojevi dihidroizoksazola ME02113B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CN2011/074294 WO2012155352A1 (en) 2011-05-19 2011-05-19 Dihydroisoxazole compounds, parasiticidal uses and formulations thereof
PCT/CN2012/072878 WO2012155676A1 (en) 2011-05-19 2012-03-23 Parasiticidal compounds, methods, and formulations
EP20120721146 EP2710000B1 (en) 2011-05-19 2012-05-08 Parasiticidal dihydroisoxazole compounds
PCT/US2012/036883 WO2012158396A1 (en) 2011-05-19 2012-05-08 Parasiticidal dihydroisoxazole compounds

Publications (1)

Publication Number Publication Date
ME02113B true ME02113B (me) 2015-10-20

Family

ID=47176150

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2015-73A ME02113B (me) 2011-05-19 2012-05-08 Parazitocidni spojevi dihidroizoksazola

Country Status (30)

Country Link
US (3) US8648081B2 (me)
EP (2) EP2710000B1 (me)
JP (1) JP5989099B2 (me)
KR (1) KR101586553B1 (me)
CN (1) CN103547576B (me)
AR (1) AR086296A1 (me)
AU (1) AU2012256220B2 (me)
BR (1) BR112013028132B1 (me)
CA (1) CA2835436C (me)
CL (1) CL2013003287A1 (me)
CO (1) CO6811873A2 (me)
CR (1) CR20130486A (me)
CY (1) CY1116450T1 (me)
DK (1) DK2710000T3 (me)
EA (1) EA023711B1 (me)
ES (1) ES2543392T3 (me)
HK (1) HK1191337A1 (me)
HR (1) HRP20150588T1 (me)
IL (1) IL229007A (me)
ME (1) ME02113B (me)
MX (1) MX341739B (me)
PE (1) PE20141041A1 (me)
PL (1) PL2710000T3 (me)
PT (1) PT2710000E (me)
RS (1) RS54048B1 (me)
SG (1) SG194836A1 (me)
SI (1) SI2710000T1 (me)
TW (1) TWI554508B (me)
UA (1) UA110519C2 (me)
WO (3) WO2012155352A1 (me)

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UY33403A (es) * 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
WO2012155352A1 (en) 2011-05-19 2012-11-22 Eli Lilly And Company Dihydroisoxazole compounds, parasiticidal uses and formulations thereof
ES2699246T3 (es) * 2012-12-11 2019-02-08 Bracco Imaging Spa Proceso continuo para la preparación de ácido (S)-2-acetiloxipropionico
CA2900029C (en) 2013-02-06 2021-03-02 Bayer Cropscience Aktiengesellschaft Halogen-substituted pyrazol derivatives as pest-control agents
CA2935646A1 (en) 2014-01-03 2015-07-09 Bayer Animal Health Gmbh Novel pyrazolyl-heteroarylamides as pesticides
CN106456615B (zh) 2014-05-09 2020-10-27 奇尼塔公司 抗病毒化合物、医药组合物及其使用方法
PL3154928T3 (pl) * 2014-06-10 2020-08-24 Bracco Imaging S.P.A Sposób wytwarzania kwasu (S)-2-acetyloksypropionowego i jego pochodnych
RU2017104717A (ru) 2014-07-15 2018-08-15 Байер Энимэл Хельс ГмбХ Арилтриазолилпиридины в качестве средств для борьбы с вредителями
WO2016207234A1 (en) 2015-06-23 2016-12-29 Intervet International B.V. Isoxazoline solution containing vitamin e for use with sanitized drinking water
CN109328017A (zh) * 2016-05-10 2019-02-12 瑞士伊兰科动物保健有限公司 用于控制海虱的二氢异噁唑化合物
WO2018081733A1 (en) * 2016-10-31 2018-05-03 The California Institute For Biomedical Research Methods and compositions for preventing vector-borne disease transmission
EP3573978A1 (en) 2017-01-25 2019-12-04 Basf Se Process for preparation of benzylic amides
WO2018166855A1 (en) * 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
CN112955426A (zh) * 2018-10-29 2021-06-11 巴斯夫欧洲公司 制备光学富集的羟醛化合物的方法
KR20220119085A (ko) 2019-12-20 2022-08-26 남미 테라퓨틱스, 인크. 암의 치료에 유용한 톨-유사 수용체 (“tlr”) 효능제 전구약물을 함유하는 제제화된 및/또는 공동-제제화된 리포솜 조성물 및 그의 방법
BR112023017446A2 (pt) * 2021-03-11 2023-11-07 In The Bowl Animal Health Inc Ração canina oral e métodos para controle de infestações de pulgas em um canino
WO2022192631A1 (en) * 2021-03-11 2022-09-15 In The Bowl Animal Health, Inc. Oral canine feed and methods for controlling tick infestations in a canine
JP2024522989A (ja) * 2021-06-02 2024-06-25 エフ エム シー コーポレーション 無脊椎有害生物を防除するための縮合ピリジン
CN117915782A (zh) * 2021-06-25 2024-04-19 碗中动物健康公司 猫科动物口服饲料和在猫科动物中控制蚤侵袭的方法
JP2024524996A (ja) * 2021-06-25 2024-07-09 イン ザ ボウル アニマル ヘルス,インコーポレーテッド 経口のネコ科動物の飼料およびネコ科動物におけるダニの侵入を制御する方法
CN114085159B (zh) * 2021-11-25 2023-04-07 浙江大学 一种1,3-环己二酮还原胺化制备3-氨基环己酮的方法
WO2023208447A1 (en) 2022-04-25 2023-11-02 Basf Se An emulsifiable concentrate having a (substituted) benzaldehyde-based solvent system
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
EP4389210A1 (en) 2022-12-21 2024-06-26 Basf Se Heteroaryl compounds for the control of invertebrate pests

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CN101768129B (zh) * 2004-03-05 2012-05-23 日产化学工业株式会社 异*唑啉取代苯甲酰胺化合物的制备中间体
HUP0501170A2 (en) 2005-12-20 2007-09-28 Richter Gedeon Nyrt 2-heteroaryl-3-phenyl-thieno[2,3-b]pyridines, process for their preparation, their use and pharmaceutical compositions containing them
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
JP2008044880A (ja) * 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
RU2009141185A (ru) 2007-04-10 2011-05-20 Байер КропСайенс АГ (DE) Инсектицидные производные арилизоксазолина
ES2445651T3 (es) * 2007-06-13 2014-03-04 E. I. Du Pont De Nemours And Company Insecticidas de isoxazolina
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
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JP2012501989A (ja) * 2008-09-04 2012-01-26 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト 殺虫化合物
WO2010079077A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
RU2518462C2 (ru) 2008-12-19 2014-06-10 Новартис Аг Органические соединения
JP2011098956A (ja) * 2009-10-09 2011-05-19 Sumitomo Chemical Co Ltd イソオキサゾリン化合物及びその用途
WO2011073098A1 (de) * 2009-12-15 2011-06-23 Bayer Cropscience Ag 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren
NZ606194A (en) 2010-08-05 2013-12-20 Zoetis Services Llc Isoxazoline derivatives as antiparasitic agents
ES2793481T3 (es) 2010-09-24 2020-11-16 Zoetis Services Llc Oximas de isoxazolina como agentes antiparasitarios
CA2826067A1 (en) * 2011-02-10 2012-08-16 Novartis Ag Isoxazoline derivatives for controlling invertebrate pests
WO2012155352A1 (en) 2011-05-19 2012-11-22 Eli Lilly And Company Dihydroisoxazole compounds, parasiticidal uses and formulations thereof

Also Published As

Publication number Publication date
BR112013028132A2 (pt) 2016-08-09
JP2014515347A (ja) 2014-06-30
CA2835436A1 (en) 2012-11-22
US8648081B2 (en) 2014-02-11
CR20130486A (es) 2014-03-12
PE20141041A1 (es) 2014-08-27
BR112013028132B1 (pt) 2021-05-04
SG194836A1 (en) 2013-12-30
WO2012158396A1 (en) 2012-11-22
CN103547576B (zh) 2016-06-08
US20130217699A1 (en) 2013-08-22
HK1191337A1 (en) 2014-07-25
IL229007A0 (en) 2013-12-31
RS54048B1 (en) 2015-10-30
UA110519C2 (uk) 2016-01-12
SI2710000T1 (sl) 2015-06-30
NZ616409A (en) 2015-11-27
WO2012155676A1 (en) 2012-11-22
JP5989099B2 (ja) 2016-09-07
AU2012256220B2 (en) 2016-12-15
EA023711B1 (ru) 2016-07-29
MX2013013446A (es) 2014-07-14
HRP20150588T1 (hr) 2015-07-03
EA201391542A1 (ru) 2014-03-31
CN103547576A (zh) 2014-01-29
US9255111B2 (en) 2016-02-09
KR101586553B1 (ko) 2016-01-18
TWI554508B (zh) 2016-10-21
PL2710000T3 (pl) 2015-10-30
PT2710000E (pt) 2015-07-06
EP2710000B1 (en) 2015-04-29
DK2710000T3 (en) 2015-05-26
CO6811873A2 (es) 2013-12-16
CY1116450T1 (el) 2017-02-08
CA2835436C (en) 2015-12-22
CL2013003287A1 (es) 2014-07-25
US20140107149A1 (en) 2014-04-17
MX341739B (es) 2016-08-31
KR20140002054A (ko) 2014-01-07
WO2012155352A1 (en) 2012-11-22
TW201307337A (zh) 2013-02-16
US8889710B2 (en) 2014-11-18
EP2918583A1 (en) 2015-09-16
ES2543392T3 (es) 2015-08-18
IL229007A (en) 2016-07-31
US20150072993A1 (en) 2015-03-12
EP2710000A1 (en) 2014-03-26
AU2012256220A1 (en) 2013-10-10
AR086296A1 (es) 2013-12-04

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GB201115829D0 (en) Compounds