EA201391542A1 - Антипаразитарные соединения, способы и составы - Google Patents

Антипаразитарные соединения, способы и составы

Info

Publication number
EA201391542A1
EA201391542A1 EA201391542A EA201391542A EA201391542A1 EA 201391542 A1 EA201391542 A1 EA 201391542A1 EA 201391542 A EA201391542 A EA 201391542A EA 201391542 A EA201391542 A EA 201391542A EA 201391542 A1 EA201391542 A1 EA 201391542A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compounds
compositions
animal
antiparasitic compounds
Prior art date
Application number
EA201391542A
Other languages
English (en)
Other versions
EA023711B1 (ru
Inventor
Цзенъюнь Ань
Лянь Чэнь
Шухуй Чэнь
Джин Мари Дефо
Скотт Дейл Холмстром
Пин Ху
Чунчжи Тан
Уильям Хантер Уайт
Вэньтао У
Ян Чзан
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201391542A1 publication Critical patent/EA201391542A1/ru
Publication of EA023711B1 publication Critical patent/EA023711B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

В настоящем изобретении предложены дигидроизоксазольные соединения, подходящие для борьбы с паразитами как у животных, так и у сельскохозяйственных культур. Также предложены способы борьбы с паразитарными инвазиями у животного посредством введения животному эффективного количества соединения, описанного выше, или его фармацевтически приемлемой соли, а также составы для борьбы с паразитарными инвазиями с применением соединений, описанных выше, или их приемлемой соли и приемлемого носителя. Также предложены соединения и способы, подходящие для получения дигидроизоксазольных соединений.
EA201391542A 2011-05-19 2012-05-08 Антипаразитарные соединения, способы и составы EA023711B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2011/074294 WO2012155352A1 (en) 2011-05-19 2011-05-19 Dihydroisoxazole compounds, parasiticidal uses and formulations thereof
PCT/CN2012/072878 WO2012155676A1 (en) 2011-05-19 2012-03-23 Parasiticidal compounds, methods, and formulations
PCT/US2012/036883 WO2012158396A1 (en) 2011-05-19 2012-05-08 Parasiticidal dihydroisoxazole compounds

Publications (2)

Publication Number Publication Date
EA201391542A1 true EA201391542A1 (ru) 2014-03-31
EA023711B1 EA023711B1 (ru) 2016-07-29

Family

ID=47176150

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201391542A EA023711B1 (ru) 2011-05-19 2012-05-08 Антипаразитарные соединения, способы и составы

Country Status (30)

Country Link
US (3) US8648081B2 (ru)
EP (2) EP2710000B1 (ru)
JP (1) JP5989099B2 (ru)
KR (1) KR101586553B1 (ru)
CN (1) CN103547576B (ru)
AR (1) AR086296A1 (ru)
AU (1) AU2012256220B2 (ru)
BR (1) BR112013028132B1 (ru)
CA (1) CA2835436C (ru)
CL (1) CL2013003287A1 (ru)
CO (1) CO6811873A2 (ru)
CR (1) CR20130486A (ru)
CY (1) CY1116450T1 (ru)
DK (1) DK2710000T3 (ru)
EA (1) EA023711B1 (ru)
ES (1) ES2543392T3 (ru)
HK (1) HK1191337A1 (ru)
HR (1) HRP20150588T1 (ru)
IL (1) IL229007A (ru)
ME (1) ME02113B (ru)
MX (1) MX341739B (ru)
PE (1) PE20141041A1 (ru)
PL (1) PL2710000T3 (ru)
PT (1) PT2710000E (ru)
RS (1) RS54048B1 (ru)
SG (1) SG194836A1 (ru)
SI (1) SI2710000T1 (ru)
TW (1) TWI554508B (ru)
UA (1) UA110519C2 (ru)
WO (3) WO2012155352A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2703275C2 (ru) * 2014-06-10 2019-10-16 Бракко Имэджинг Спа Способ получения (s)-2-ацетилоксипропионовой кислоты и ее производных

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33403A (es) * 2010-06-17 2011-12-30 Novartis Ag Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales
WO2012155352A1 (en) 2011-05-19 2012-11-22 Eli Lilly And Company Dihydroisoxazole compounds, parasiticidal uses and formulations thereof
WO2014090650A1 (en) * 2012-12-11 2014-06-19 Bracco Imaging Spa Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride
AU2014214140B2 (en) 2013-02-06 2017-08-31 Vetoquinol Sa Halogen-substituted pyrazol derivatives as pest-control agents
CR20160311A (es) 2014-01-03 2016-08-16 Bayer Animal Health Gmbh Nuevas pirazolil-heteroarilamidas como agentes plaguicidas
MX2016014642A (es) * 2014-05-09 2017-05-25 Kineta Inc Compuestos y composiciones farmaceuticas antivirales, asi como metodos de uso de los mismos.
ES2864083T3 (es) 2014-07-15 2021-10-13 Bayer Animal Health Gmbh Aril-triazolil-piridinas como pesticidas
CN107750159B (zh) 2015-06-23 2021-10-29 英特维特国际股份有限公司 用于消毒的饮用水的含有维生素的异噁唑啉溶液
US10537549B2 (en) * 2016-05-10 2020-01-21 Elanco Tiergesundheit Ag Dihydroisoxazole compound for use in controlling sea lice
CA3042306A1 (en) * 2016-10-31 2018-05-03 The Scripps Research Institute Methods and compositions for preventing vector-borne disease transmission
US10961213B2 (en) 2017-01-25 2021-03-30 Basf Se Process for preparation of benzylic amides
WO2018166855A1 (en) * 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
AU2019369659A1 (en) * 2018-10-29 2021-04-29 Basf Se Process for preparation of optically enriched aldol compounds
CA3161668A1 (en) 2019-12-20 2021-06-24 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof
CN117412673A (zh) * 2021-03-11 2024-01-16 碗中动物健康公司 犬科动物口服饲料和在犬科动物中控制蚤侵袭的方法
AU2022232440A1 (en) * 2021-03-11 2023-09-21 In The Bowl Animal Health, Inc. Oral canine feed and methods for controlling tick infestations in a canine
WO2022256284A1 (en) * 2021-06-02 2022-12-08 Fmc Corporation Fused pyridines for controlling invertebrate pests
WO2022271961A1 (en) * 2021-06-25 2022-12-29 In The Bowl Animal Health, Inc. Oral feline feed and methods for controlling tick infestations in a feline
CN117915782A (zh) * 2021-06-25 2024-04-19 碗中动物健康公司 猫科动物口服饲料和在猫科动物中控制蚤侵袭的方法
CN114085159B (zh) * 2021-11-25 2023-04-07 浙江大学 一种1,3-环己二酮还原胺化制备3-氨基环己酮的方法
WO2023208447A1 (en) 2022-04-25 2023-11-02 Basf Se An emulsifiable concentrate having a (substituted) benzaldehyde-based solvent system
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
EP4389210A1 (en) 2022-12-21 2024-06-26 Basf Se Heteroaryl compounds for the control of invertebrate pests

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2558848C (en) * 2004-03-05 2013-11-19 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
HUP0501170A2 (en) * 2005-12-20 2007-09-28 Richter Gedeon Nyrt 2-heteroaryl-3-phenyl-thieno[2,3-b]pyridines, process for their preparation, their use and pharmaceutical compositions containing them
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
JP2008044880A (ja) * 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
NZ580241A (en) 2007-04-10 2011-02-25 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
WO2008154528A2 (en) * 2007-06-13 2008-12-18 E. I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
KR101680912B1 (ko) 2008-07-09 2016-11-29 바스프 에스이 이속사졸린 화합물 ⅰ을 포함하는 살충 활성 혼합물
CA2732217A1 (en) * 2008-09-04 2010-03-11 Peter Renold Insecticidal compounds
WO2010079077A1 (en) * 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
MX2011006568A (es) 2008-12-19 2011-08-03 Novartis Ag Compuestos organicos.
JP2011098956A (ja) * 2009-10-09 2011-05-19 Sumitomo Chemical Co Ltd イソオキサゾリン化合物及びその用途
WO2011073098A1 (de) * 2009-12-15 2011-06-23 Bayer Cropscience Ag 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren
EP2601190B1 (en) 2010-08-05 2018-07-04 Zoetis Services LLC Isoxazoline derivatives as antiparasitic agents
ES2793481T3 (es) * 2010-09-24 2020-11-16 Zoetis Services Llc Oximas de isoxazolina como agentes antiparasitarios
CN103347880B (zh) * 2011-02-10 2015-11-25 瑞士诺华动物保健有限公司 用于控制无脊椎害虫的异噁唑啉衍生物
WO2012155352A1 (en) 2011-05-19 2012-11-22 Eli Lilly And Company Dihydroisoxazole compounds, parasiticidal uses and formulations thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2703275C2 (ru) * 2014-06-10 2019-10-16 Бракко Имэджинг Спа Способ получения (s)-2-ацетилоксипропионовой кислоты и ее производных
US10738000B2 (en) 2014-06-10 2020-08-11 Bracco Imaging Spa Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof

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RS54048B1 (en) 2015-10-30
UA110519C2 (ru) 2016-01-12
HRP20150588T1 (hr) 2015-07-03
EA023711B1 (ru) 2016-07-29
PL2710000T3 (pl) 2015-10-30
KR20140002054A (ko) 2014-01-07
MX341739B (es) 2016-08-31
US9255111B2 (en) 2016-02-09
AR086296A1 (es) 2013-12-04
WO2012158396A1 (en) 2012-11-22
DK2710000T3 (en) 2015-05-26
JP5989099B2 (ja) 2016-09-07
US8889710B2 (en) 2014-11-18
MX2013013446A (es) 2014-07-14
ES2543392T3 (es) 2015-08-18
US20140107149A1 (en) 2014-04-17
CN103547576A (zh) 2014-01-29
AU2012256220A1 (en) 2013-10-10
BR112013028132A2 (pt) 2016-08-09
WO2012155676A1 (en) 2012-11-22
US20130217699A1 (en) 2013-08-22
US8648081B2 (en) 2014-02-11
SI2710000T1 (sl) 2015-06-30
HK1191337A1 (en) 2014-07-25
CO6811873A2 (es) 2013-12-16
TW201307337A (zh) 2013-02-16
WO2012155352A1 (en) 2012-11-22
CR20130486A (es) 2014-03-12
EP2710000B1 (en) 2015-04-29
EP2918583A1 (en) 2015-09-16
CA2835436C (en) 2015-12-22
EP2710000A1 (en) 2014-03-26
BR112013028132B1 (pt) 2021-05-04
CA2835436A1 (en) 2012-11-22
AU2012256220B2 (en) 2016-12-15
CL2013003287A1 (es) 2014-07-25
PE20141041A1 (es) 2014-08-27
IL229007A (en) 2016-07-31
IL229007A0 (en) 2013-12-31
TWI554508B (zh) 2016-10-21
CY1116450T1 (el) 2017-02-08
CN103547576B (zh) 2016-06-08
SG194836A1 (en) 2013-12-30
NZ616409A (en) 2015-11-27
KR101586553B1 (ko) 2016-01-18
JP2014515347A (ja) 2014-06-30
ME02113B (me) 2015-10-20
PT2710000E (pt) 2015-07-06
US20150072993A1 (en) 2015-03-12

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