ME01969B - Sredstva za lijecenje poremecaja koji ukljucuju modulaciju receptora rijanodina - Google Patents
Sredstva za lijecenje poremecaja koji ukljucuju modulaciju receptora rijanodinaInfo
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- ME01969B ME01969B MEP-2014-147A MEP2014147A ME01969B ME 01969 B ME01969 B ME 01969B ME P2014147 A MEP2014147 A ME P2014147A ME 01969 B ME01969 B ME 01969B
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Claims (23)
1. Spoj, naznačen time, da je predstavljen strukturom Formule (I):pri čemuR je COOH;i njihove farmaceutski prihvatljive soli.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time, da je u obliku soli s farmaceutski prihvatljivom kiselinom ili lužinom.
3. Spoj u skladu s patentnim zahtjevom 2, naznačen time, da je sol odabrana iz skupine koja se sastoji od natrija, kalija, magnezija, hemifumarata, hidroklorida i hidrobromida.
4. Spoj u skladu s patentnim zahtjevom 1, naznačen time, da je odabran izskupine koja se sastoji od:
5. Spoj u skladu s patentnim zahtjevom 1, naznačen time, da je predstavljenstrukturnom Formulom (1):ili njihovom farmaceutski prihvatljivom soli.
6. Spoj u skladu s patentnim zahtjevom 5, naznačen time, da je u obliku solis farmaceutski prihvatljivom kiselinom ili lužinom.
7. Spoj u skladu s patentnim zahtjevom 6, naznačen time, da je sol odabranaiz skupine koja se sastoji od natrija, kalija, magnezija, hemifumarata, hidroklorida i hidrobromida.
8. Spoj u skladu s patentnim zahtjevom 7, naznačen time, da je sol natrijeva sol.
9. Spoj u skladu s patentnim zahtjevom 7, naznačen time, da je sol hemifumaratna sol.
10. Farmaceutski pripravak koji sadrži spoj u skladu s patentnim zahtjevima 1-9, naznačena time, da je u kombinaciji s jednim ili više farmaceutski prihvatljivih ekscipijensa ili nosača.
11. Farmaceutski pripravak u skladu s patentnim zahtjevom 10, naznačen time, da se koristi u liječenju ili prevenciji stanja odabranih is skupine koja se sastoji od srčanih poremećaja i oboljenja, mišićnog umora, poremećaja i bolesti muskuloskeletalnog sustava, poremećaja i bolesti središnjeg živčanog sustava (CNS), kognitivne disfunkcije, nervno-mišićnih poremećaja i oboljenja, poremećaja i bolesti kostiju, tumorske kaheksije, maligne hipertermije, dijabetesa, iznenadne srčane smrti i sindroma iznenadne dječje smrti ili za poboljšanje kognitivne funkcije.
12. Farmaceutski pripravak u skladu s patentnim zahtjevom 10, za uporabu u liječenju ili prevenciji stanja u skladu s patentnim zahtjevom 11, naznačen time, da su srčani poremećaji ili oboljenja odabrani iz skupine koja se sastoji od poremećaja ili bolesti nepravilnog rada srca poput primjerice atrijske i ventrikularne aritmije, atrijske i ventrikularne fibrilacije, atrijske i ventrikularne tahiaritmije, atrijske i ventrikularne tahikardije, kateholaminergičke polimorfne ventrikularne tahikardije (CPVT) te njihovih varijanti izazvanih usljed tjelovježbe; poremećaja i bolesti nepravilnog rada srca izazvanog usljed tjelovježbe; srčanog zatajenja; kongestivnog zatajenja srca; kroničnog zatajenja srca; akutnog zatajenja srca; sistoličkog zatajenja srca; dijastoličkog zatajenja srca; akutne dekompenzacije srca; srčane ishemije/reperfuzijska ozljeda (I/R); kronične opstruktivne plućne bolesti; I/R ozljede usljed srčane angioplastije ili usljed trombolize za liječenje infarkta miokarda (MI); te visokog krvanog tlaka.
13. Farmaceutski pripravak u skladu s patentnim zahtjevom 10 za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11, naznačen time, da je mišićni zamor uzrokovan bolešću, poremećajem ili stanjem skeletnih mišića.
14. Farmaceutski pripravak u skladu s patentnim zahtjevom 10 za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11, naznačen time, da je muskuloskeletalni poremećaj, bolest ili stanje odabrano iz skupine koja se sastoji zamora skeletnih mišića izazvanog usljed tjelovježbe; zamora mišića izazvanog usljed produljene ili intenzivne tjelovježbe; kongenitalne miopatije; mišične distrofije poput primjerice Duchenne-ove distrofije mišića (DMD), Becker-ove distrofije mišića (BMD), Limb-Girdle distrofije mišića (LGMD), facioskapulohumeralne mišićne distrofije, miotonične mišične distrofije, kongenitalne mišične distrofije (CMD), distalne mišične distrofije, Emery-Dreifuss-ove mišične distrofije i okulofaringealne mišićne distrofije; spinalne mišićne atrofije (SMA), spinalne i bulbarne mišićne atrofije (SBMA), Zamora mišića povezanog sa starosnom dobi; sarkopenije, bolesti središnje jezgre; tumorske kaheksije; poremećaje mjehura i inkontinencije.
15. Farmaceutski pripravak u skladu s patentnim zahtjevom 10 za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11, naznačen time, da su poremećaj ili bolesti središnjeg živčanog sustava (CNS) odabrani iz skupine koja se sastoji od Alzheimer-ove bolesti (AD), neuropatije, napadaja, Parkinson-ove bolesti (PD) i Huntington-ove bolesti (HD); i nervno-mišićnih poremećaja i bolesti koje su odabrane iz skupine koja se sastoji od spinocerebelarne ataksije (SCA) i amiotrofna lateralna skleroza (ALS, Lou Gehrig-ova bolest).
16. Farmaceutski pripravak u skladu s patentnim zahtjevom za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11, naznačen time, da je kognitivna disfunkcija povezana sa stresom ili sa starosnom dobi, ili gdje kognitivna funkcija treba biti poboljšana zbog kratkog pamćenja, dugotrajnog pamćenja, pažnje ili učenja, ili gdje je kognitivna disfunkcija povezana s bolesti ili poremećajem koji je odabran iz skupine koja se sastoji od Alzheimer-ove bolesti (AD), poremećaja pažnje uzrokovanog hiperaktivnošću (ADHD), poremećaja autističnog spektra (ASD), generaliziranog anksioznog poremećaja (GAD), opsesivno-kompulzivnog poremećaja (OCD), Parkinsonove bolesti (PD), post-traumatskog stresnog poremećaja (PTSD), Schizophrenije, bipolarnog poremećaja i unipolarne velike depresije.
17. Farmaceutski pripravak u skladu s patentnim zahtjevom 10 za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11, naznačen time, da je stanje tumorska kaheksija.
18. Farmaceutski pripravak u skladu s patentnim zahtjevom 17, naznačen time, da je tumorska kaheksija uzrokovana usljed metastaziranja tumora kosti.
19. Spoj u skladu s bilo kojim od patentnih zahtjeva 1-9, ili njihove soli, naznačen time, da se koristi za liječenje ili prevenciju stanja odabranih iz skupine koja se sastoji od srčanih poremećaja ili oboljenja, zamora mišića, poremećaja muskuloskeletalnog sustava, poremećaja i bolesti središnjeg živčanog sustava (CNS), kognitivne disfunkcije, nervno-mišićnih poremećaja i bolesti, poremećaja i bolesti kosti, tumorske kaheksije, maligne hipertermije, dijabetesa, iznenadne srčane smrti i sindroma iznenadne dječje smrti ili za poboljšanje kognitivne funkcije.
20. Farmaceutski pripravak u skladu s patentnim zahtjevom 10 u kombinaciji s antisens-oligonukleotidom (AO) koji je specifičan za upletanje odsječka u ciljanoj mRNK za bolje preskakanje egzona u rečenoj ciljanoj mRNK, naznačen time, da se koristi za uporabu u liječenju ili prevenciji u skladu s patentnim zahtjevom 11.
21. Farmaceutski pripravak u skladu s patentnim zahtjevom 20, naznačen time, da se koristi u liječenju Duchenne-ove mišićne distrofije (DMD), pri čemu je antisens-oligonukleotid (AO) specifičan za upletanje odsječka od najmanje jednog od egzona DMD gena.
22. Farmaceutski pripravak u skladu s patentnim zahtjevom 21, naznačen time, da je antisens-oligonukleotid specifičan za upletanje odsječka egzona 23, 45, 44, 50, 51, 52 i /ili 53 DMD gena.
23. Postupak priprave u skladu s bilo kojim od patentnih zahtjeva 1-9, naznačen time, da se sastoji od koraka reakcije spojeva formule sa spojem formulesa spojem formulepri čemu Ra je COOR1 ili CN; R1 je C1-C4 alkil, a L je odlazeća skupina kako bi se dobio spoj formule:ipretvaranjem skupine Ra u skupinu R kako bi se dobio spoj formule (I).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625890P | 2012-04-18 | 2012-04-18 | |
| EP12167732.2A EP2708535A1 (en) | 2012-05-11 | 2012-05-11 | Agents for treating disorders involving modulation of ryanodine receptors |
| EP20130164051 EP2653466B1 (en) | 2012-04-18 | 2013-04-17 | Agents for treating disorders involving modulation of ryanodine receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01969B true ME01969B (me) | 2015-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2014-147A ME01969B (me) | 2012-04-18 | 2013-04-17 | Sredstva za lijecenje poremecaja koji ukljucuju modulaciju receptora rijanodina |
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| US9725429B2 (en) | 2013-03-15 | 2017-08-08 | Rosalind Franklin University Of Medicine And Science | Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release |
| CN105209030B (zh) | 2013-03-15 | 2018-06-12 | 罗莎琳德富兰克林医科大学 | 用于稳定兰尼碱受体使其免于异常水平的钙释放的化合物 |
| AU2014290368B2 (en) | 2013-07-18 | 2019-07-11 | Baylor College Of Medicine | Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia |
| WO2015197562A1 (en) * | 2014-06-23 | 2015-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of disorders or diseases associated with ryanodine receptor dysfunction |
| WO2016017448A1 (ja) * | 2014-07-30 | 2016-02-04 | 株式会社アエタスファルマ | １，４－ベンゾチアゼピン－１－オキシド誘導体の光学異性体、及びそれを用いた医薬組成物 |
| US20160207893A1 (en) * | 2014-12-30 | 2016-07-21 | Myotherix, Inc. | Novel calcium modulators |
| ES2643856B1 (es) | 2016-05-24 | 2018-08-03 | Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea | Triazoles para la regulación de la homeostasis de calcio intracelular |
| US11426415B2 (en) | 2017-03-06 | 2022-08-30 | Washington University | Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders |
| JP7282332B2 (ja) * | 2017-10-25 | 2023-05-29 | 学校法人順天堂 | リアノジン受容体阻害薬 |
| US11826315B2 (en) | 2018-04-19 | 2023-11-28 | Tvardi Therapeutics | STAT3 inhibitors |
| US11026905B2 (en) | 2018-04-19 | 2021-06-08 | Tvardi Therapeutics, Inc. | STAT3 inhibitors |
| CA3159181A1 (en) | 2020-01-24 | 2021-07-29 | Imran ALIBHAI | Therapeutic compounds, formulations, and uses thereof |
| WO2022099011A1 (en) * | 2020-11-06 | 2022-05-12 | Cytokinetics, Inc. | Bicyclic 1,4-diazepanones and therapeutic uses thereof |
| KR20230129267A (ko) | 2021-01-08 | 2023-09-07 | 암고 파마, 인크. | 리아노딘 수용체 조정제의 결정질 형태 및 그의 용도 |
| CN115369163A (zh) * | 2021-05-17 | 2022-11-22 | 中国科学院上海营养与健康研究所 | Ryr2及其下调剂在治疗转移性结直肠癌中的应用 |
| CN117750966A (zh) * | 2021-05-20 | 2024-03-22 | 阿姆果制药有限公司 | 包含兰尼定受体调节剂的药物组合物及其用途 |
| WO2022246114A2 (en) * | 2021-05-20 | 2022-11-24 | Armgo Pharma, Inc. | Pharmaceutical compositions comprising a ryanodine receptor modulator and uses thereof |
| WO2023091524A1 (en) * | 2021-11-16 | 2023-05-25 | Armgo Pharma, Inc. | Therapeutic compounds |
| US20230302013A1 (en) * | 2022-02-09 | 2023-09-28 | The Trustees Of Columbia University In The City Of New York | METHOD OF TREATING VIRAL-INDUCED COGNITIVE DYSFUNCTION BY TARGETING LEAKY RyR2 CHANNELS |
| EP4230196A1 (en) | 2022-02-21 | 2023-08-23 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of dystrophinopathies |
| WO2023244946A1 (en) | 2022-06-15 | 2023-12-21 | Tvardi Therapeutics, Inc. | Prodrugs of stat3 inhibitors |
| EP4548971A1 (en) * | 2023-11-06 | 2025-05-07 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | 1,4-benzothiazepines and related compounds with cyclopropanol groups as multi-targeted drugs |
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| DE58901634D1 (de) * | 1988-11-05 | 1992-07-16 | Bayer Ag | Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen. |
| GB9021813D0 (en) * | 1990-10-08 | 1990-11-21 | Ici Plc | Tricyclic heterocycles |
| AU666318B2 (en) | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| KR100313649B1 (ko) * | 1992-11-09 | 2002-02-28 | 더 부츠 캄파니 피엘씨 | 신경계질환치료제로서유용한1,4-벤조티아제핀,이의제조방법및이를포함하는약제학적조성물 |
| FR2752017B1 (fr) | 1996-08-01 | 1998-10-16 | Hispano Suiza Sa | Inverseur de poussee de turboreacteur a portes formant ecopes |
| GB9914745D0 (en) | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| US7879840B2 (en) * | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US8022058B2 (en) * | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US20020183307A1 (en) | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| CN100400040C (zh) | 2000-10-30 | 2008-07-09 | 詹森药业有限公司 | 三肽酶抑制剂 |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| EP1603450A4 (en) | 2003-03-07 | 2009-07-29 | Univ Columbia | PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR |
| US20090292119A1 (en) * | 2003-10-07 | 2009-11-26 | The Trustees Of Columbia University In The City Of New York | Methods for synthesizing benzothiazepine compounds |
| WO2006101495A1 (en) | 2005-03-23 | 2006-09-28 | Battelle Memorial Institute | Advanced capability rfid system |
| US7704990B2 (en) * | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| WO2007127145A2 (en) | 2006-04-25 | 2007-11-08 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treatment of cardiac arrhythmia in non-human animals |
| WO2008060332A2 (en) | 2006-06-02 | 2008-05-22 | The Trustees Of Columbia University In The City Of New York | Methods for treating or reducing muscle fatigue |
| WO2008021432A2 (en) | 2006-08-17 | 2008-02-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treatment of conditions affecting the nervous system |
| WO2008021439A2 (en) * | 2006-08-17 | 2008-02-21 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for treatment of cardiac hypertrophy |
| WO2008064264A2 (en) | 2006-11-20 | 2008-05-29 | Armgo Pharma, Inc. | In vivo methods for identifying and screening compounds that modulate calstabin binding to a ryanodine receptor |
| KR101260859B1 (ko) | 2008-03-03 | 2013-05-06 | 르 라보레또레 쎄르비에르 | 감마-아미노알킬벤젠으로부터 벤조티아제핀을 제조하는 방법 |
| CN101891706B (zh) * | 2010-04-09 | 2013-05-29 | 复旦大学 | 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途 |
| WO2012019076A1 (en) | 2010-08-06 | 2012-02-09 | The Trustees Of Columbia University In The City Of New York | Compositions and methods for preventing and treating cardiac ischemia/reperfusion injury |
| WO2012019071A1 (en) | 2010-08-06 | 2012-02-09 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating sarcopenia |
| WO2012037105A1 (en) | 2010-09-14 | 2012-03-22 | The Trustees Of Columbia University In The City Of New York | Methods of treating, ameliorating or preventing stress-induced neuronal disorders and diseases |
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