TN2014000424A1 - Agents pour le traitement de troubles impliquant la modulation des recepteurs de la ryanodine - Google Patents

Agents pour le traitement de troubles impliquant la modulation des recepteurs de la ryanodine

Info

Publication number
TN2014000424A1
TN2014000424A1 TN2014000424A TN2014000424A TN2014000424A1 TN 2014000424 A1 TN2014000424 A1 TN 2014000424A1 TN 2014000424 A TN2014000424 A TN 2014000424A TN 2014000424 A TN2014000424 A TN 2014000424A TN 2014000424 A1 TN2014000424 A1 TN 2014000424A1
Authority
TN
Tunisia
Prior art keywords
agents
treatment
disorders involving
ryanodine receptors
involving modulation
Prior art date
Application number
TN2014000424A
Other languages
English (en)
Inventor
Jiaming Yan
Sandro Belvedere
Yael Webb
Marc Bertrand
Nicole Villeneuve
Original Assignee
Servier Lab
Armgo Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Armgo Pharma Inc filed Critical Servier Lab
Publication of TN2014000424A1 publication Critical patent/TN2014000424A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/841—Muscles; heart

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
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  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
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Abstract

La présente invention concerne des dérivés 1,4-benzothiazépines et leur utilisation pour traiter des états, des troubles et des maladies associés à des récepteurs de ryanodine (RyRs) qui régulent la fonction des canaux calciques dans les cellules. L'invention concerne également des compositions pharmaceutiques comprenant les composés et leurs utilisations pour traiter des maladies et des états associés à RyRs, en particulier des troubles cardiaques, musculo-squelettiques et du système nerveux central (SNC).
TN2014000424A 2012-04-18 2014-10-10 Agents pour le traitement de troubles impliquant la modulation des recepteurs de la ryanodine TN2014000424A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261625890P 2012-04-18 2012-04-18
EP12167732.2A EP2708535A1 (fr) 2012-05-11 2012-05-11 Agents pour le traitement de troubles impliquant la modulation de récepteurs de la ryanodine
PCT/EP2013/057958 WO2013156505A1 (fr) 2012-04-18 2013-04-17 Agents pour le traitement de troubles mettant en jeu la modulation de récepteurs de ryanodine

Publications (1)

Publication Number Publication Date
TN2014000424A1 true TN2014000424A1 (fr) 2016-03-30

Family

ID=49165460

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2014000424A TN2014000424A1 (fr) 2012-04-18 2014-10-10 Agents pour le traitement de troubles impliquant la modulation des recepteurs de la ryanodine

Country Status (48)

Country Link
US (3) US20130281512A1 (fr)
EP (2) EP2708535A1 (fr)
JP (1) JP5965542B2 (fr)
KR (1) KR101731459B1 (fr)
CN (1) CN104350045B (fr)
AP (1) AP3591A (fr)
AR (1) AR090712A1 (fr)
AU (1) AU2013248313B2 (fr)
BR (1) BR112014025670B1 (fr)
CA (1) CA2870599C (fr)
CL (1) CL2014002756A1 (fr)
CO (1) CO7091184A2 (fr)
CR (1) CR20140476A (fr)
CU (1) CU24327B1 (fr)
CY (1) CY1115826T1 (fr)
DK (1) DK2653466T3 (fr)
DO (1) DOP2014000230A (fr)
EA (1) EA027922B1 (fr)
EC (1) ECSP14027564A (fr)
ES (1) ES2529890T3 (fr)
GT (1) GT201400222A (fr)
HK (2) HK1192537A1 (fr)
HR (1) HRP20141113T8 (fr)
HU (1) HUE024284T2 (fr)
IL (1) IL235043A (fr)
JO (1) JO3070B1 (fr)
MA (1) MA37525B1 (fr)
MD (1) MD4489C1 (fr)
ME (1) ME01969B (fr)
MX (1) MX350890B (fr)
MY (1) MY167783A (fr)
NI (1) NI201400123A (fr)
NZ (1) NZ701122A (fr)
PE (1) PE20142193A1 (fr)
PH (1) PH12014502256A1 (fr)
PL (1) PL2653466T3 (fr)
PT (1) PT2653466E (fr)
RS (1) RS53711B1 (fr)
RU (1) RU2644350C2 (fr)
SA (1) SA113340479B1 (fr)
SG (1) SG11201406404YA (fr)
SI (1) SI2653466T1 (fr)
TN (1) TN2014000424A1 (fr)
TW (1) TWI507399B (fr)
UA (1) UA113759C2 (fr)
UY (1) UY34742A (fr)
WO (1) WO2013156505A1 (fr)
ZA (1) ZA201407499B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2906168C (fr) 2013-03-15 2018-07-24 Rosalind Franklin University Of Medicine And Science Composes pour stabiliser des recepteurs de ryanodine a partir de niveaux aberrants de liberation de calcium
US9725429B2 (en) 2013-03-15 2017-08-08 Rosalind Franklin University Of Medicine And Science Furanyl-imine and thiofuranyl-imine compounds for stabilizing ryanodine receptors from aberrant levels of calcium release
ES2934319T3 (es) 2013-07-18 2023-02-21 Baylor College Medicine Métodos y composiciones para el tratamiento de la atrofia muscular, la debilidad muscular y/o la caquexia
WO2015197562A1 (fr) * 2014-06-23 2015-12-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de troubles ou de maladies associées au dysfonctionnement du récepteur de la ryanodine
KR102091211B1 (ko) * 2014-07-30 2020-03-19 가부시키가이샤 아에타스 파루마 1,4-벤조티아제핀-1-옥사이드 유도체의 광학 이성질체, 및 그것을 사용한 의약 조성물
US20160207893A1 (en) * 2014-12-30 2016-07-21 Myotherix, Inc. Novel calcium modulators
ES2643856B1 (es) * 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles para la regulación de la homeostasis de calcio intracelular
US11426415B2 (en) 2017-03-06 2022-08-30 Washington University Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders
WO2019082940A1 (fr) * 2017-10-25 2019-05-02 学校法人順天堂 Inhibiteur du récepteur de la ryanodine
AU2019255755A1 (en) 2018-04-19 2020-12-03 Baylor College Of Medicine STAT3 inhibitors
US11026905B2 (en) 2018-04-19 2021-06-08 Tvardi Therapeutics, Inc. STAT3 inhibitors
JP2023520273A (ja) 2020-01-24 2023-05-17 トゥヴァルディ セラピューティクス，インク． 治療化合物、製剤、およびその使用
CA3176635A1 (fr) * 2020-11-06 2022-05-12 Cytokinetics, Inc. 1,4-diazepanones bicycliques et leurs utilisations therapeutiques
EP4274580A1 (fr) * 2021-01-08 2023-11-15 Armgo Pharma, Inc. Formes cristallines d'un modulateur du récepteur de la ryanodine et leurs utilisations
WO2022246114A2 (fr) * 2021-05-20 2022-11-24 Armgo Pharma, Inc. Compositions pharmaceutiques comprenant un modulateur du récepteur de la ryanodine et leurs utilisations
WO2023091524A1 (fr) * 2021-11-16 2023-05-25 Armgo Pharma, Inc. Composés thérapeutiques
EP4230196A1 (fr) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Composés à utiliser dans le traitement des dystrophinopathies

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE58901634D1 (de) * 1988-11-05 1992-07-16 Bayer Ag Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen.
GB9021813D0 (en) * 1990-10-08 1990-11-21 Ici Plc Tricyclic heterocycles
ES2190428T3 (es) 1991-06-28 2003-08-01 Smithkline Beecham Corp Antagonistas biciclicos de fibrinogeno.
DE69317436T2 (de) * 1992-11-09 1998-07-02 Knoll Ag 1,4-benzothiazepine verwendbar als neurologische mittel
FR2752017B1 (fr) 1996-08-01 1998-10-16 Hispano Suiza Sa Inverseur de poussee de turboreacteur a portes formant ecopes
GB9914745D0 (en) 1999-06-24 1999-08-25 Knoll Ag Therapeutic agents
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) * 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20020183307A1 (en) 2000-07-26 2002-12-05 Tremont Samuel J. Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake
CA2422617C (fr) 2000-10-30 2011-07-12 Janssen Pharmaceutica N.V. Inhibiteurs de tripeptidyl peptidase
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
WO2004080283A2 (fr) 2003-03-07 2004-09-23 The Trustees Of Columbia University, In The City Of New York Procedes utilisant le recepteur de la ryanodine de type 1
US20090292119A1 (en) * 2003-10-07 2009-11-26 The Trustees Of Columbia University In The City Of New York Methods for synthesizing benzothiazepine compounds
DE112005003511T5 (de) 2005-03-23 2008-04-17 Battelle Memorial Institute, Richland RFID-System mit verbesserter Leistungsfähigkeit
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
WO2007127145A2 (fr) 2006-04-25 2007-11-08 The Trustees Of Columbia University In The City Of New York Procédés et compositions de traitement de l'arythmie cardiaque chez des animaux non humains
WO2008060332A2 (fr) 2006-06-02 2008-05-22 The Trustees Of Columbia University In The City Of New York Méthodes pour traiter ou réduire la fatigue musculaire
WO2008021439A2 (fr) * 2006-08-17 2008-02-21 The Trustees Of Columbia University In The City Of New York Compositions et méthodes de traitement de l'hypertrophie cardiaque
WO2008021432A2 (fr) 2006-08-17 2008-02-21 The Trustees Of Columbia University In The City Of New York Compositions et méthodes de traitement d'états affectant le système nerveux
WO2008064264A2 (fr) 2006-11-20 2008-05-29 Armgo Pharma, Inc. Procédés in vivo d'identification et de criblage de composés qui modulent la liaison de calstabine à un récepteur de ryanodine
KR101260859B1 (ko) * 2008-03-03 2013-05-06 르 라보레또레 쎄르비에르 감마-아미노알킬벤젠으로부터 벤조티아제핀을 제조하는 방법
CN101891706B (zh) * 2010-04-09 2013-05-29 复旦大学 3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
WO2012019071A1 (fr) 2010-08-06 2012-02-09 The Trustees Of Columbia University In The City Of New York Méthodes de traitement prophylactique et thérapeutique de la sarcopénie
WO2012019076A1 (fr) 2010-08-06 2012-02-09 The Trustees Of Columbia University In The City Of New York Compositions et méthodes de traitement prophylactique ou thérapeutique d'une lésion d'ischémie/reperfusion cardiaque
WO2012037105A1 (fr) 2010-09-14 2012-03-22 The Trustees Of Columbia University In The City Of New York Procédés de traitement, d'amélioration ou de prévention de troubles et de maladies neuronaux induits par le stress

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