ME00074B - Benzotiofeni, formulacije koje ih sadrže i proizvod - Google Patents

Benzotiofeni, formulacije koje ih sadrže i proizvod

Info

Publication number
ME00074B
ME00074B MEP-2008-183A MEP2008183A ME00074B ME 00074 B ME00074 B ME 00074B ME P2008183 A MEP2008183 A ME P2008183A ME 00074 B ME00074 B ME 00074B
Authority
ME
Montenegro
Prior art keywords
compounds
formula
present
compound
benzothiophenes
Prior art date
Application number
MEP-2008-183A
Other languages
English (en)
Inventor
Gordon N Arbuthnot
Brian W Dalder
Kerry J Hartauer
Wayne D Luke
Robert E Stratford Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00074(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9607110.5A external-priority patent/GB9607110D0/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ME00074B publication Critical patent/ME00074B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Thin Film Transistor (AREA)

Abstract

          Ovaj pronalazak izlaže jedinjenja formule (I) i farmaceutski prihvatljive soli injihove solvate čija je karakteristika što je jedinjenje u obliku čestica i imaspecifičan raspon veličina. Ovaj pronalazak dalje izlaže farmaceutske smešekoje sadrže ili su formulisane korišćenjem jedinjenja formule (I) i korišćenjetakvih jedinjenja za ublažavanje ljudskih patologija, uključujući osteoporozu,smanjivanje seruma lipida i raka dojke.              Ovaj pronalazak izlaže jedinjenja formule (I) i farmaceutski prihvatljive soli injihove solvate čija je karakteristika što je jedinjenje u obliku čestica i imaspecifičan raspon veličina. Ovaj pronalazak dalje izlaže farmaceutske smešekoje sadrže ili su formulisane korišćenjem jedinjenja formule (I) i korišćenjetakvih jedinjenja za ublažavanje ljudskih patologija, uključujući osteoporozu,smanjivanje seruma lipida i raka dojke.       
MEP-2008-183A 1996-03-26 1997-03-20 Benzotiofeni, formulacije koje ih sadrže i proizvod ME00074B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1416796P 1996-03-26 1996-03-26
GBGB9607110.5A GB9607110D0 (en) 1996-04-04 1996-04-04 Benzothiopenes formulations containing same and methods
PCT/US1997/004259 WO1997035571A1 (en) 1996-03-26 1997-03-20 Benzothiophenes, formulations containing same, and methods

Publications (1)

Publication Number Publication Date
ME00074B true ME00074B (me) 2010-10-10

Family

ID=26309061

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-183/08A MEP18308A (en) 1996-03-26 1997-03-20 Benzothiophenes, formulations containing same, and methods
MEP-2008-183A ME00074B (me) 1996-03-26 1997-03-20 Benzotiofeni, formulacije koje ih sadrže i proizvod

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-183/08A MEP18308A (en) 1996-03-26 1997-03-20 Benzothiophenes, formulations containing same, and methods

Country Status (30)

Country Link
EP (2) EP2266560A1 (me)
JP (5) JP2000507268A (me)
CN (1) CN1162153C (me)
AR (1) AR006387A1 (me)
AT (1) ATE464897T1 (me)
AU (1) AU723797B2 (me)
BR (1) BR9708248A (me)
CA (1) CA2250191C (me)
CO (1) CO4780022A1 (me)
CZ (1) CZ300341B6 (me)
DE (1) DE69739855D1 (me)
DK (1) DK0910369T3 (me)
EA (1) EA001257B1 (me)
ES (1) ES2341399T3 (me)
HK (1) HK1020671A1 (me)
ID (1) ID19813A (me)
IL (2) IL126320A (me)
ME (2) MEP18308A (me)
MY (1) MY115533A (me)
NO (1) NO320894B1 (me)
NZ (1) NZ332036A (me)
PL (1) PL191148B1 (me)
PT (1) PT910369E (me)
RO (1) RO121117B1 (me)
SI (1) SI0910369T1 (me)
TR (1) TR199801915T2 (me)
TW (1) TW513421B (me)
UA (1) UA57596C2 (me)
WO (1) WO1997035571A1 (me)
YU (1) YU41898A (me)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001257B1 (ru) * 1996-03-26 2000-12-25 Эли Лилли Энд Компани Бензотиофены, содержащие их фармацевтические композиции и способы лечения патологических состояний с их использованием
ZA979720B (en) 1996-10-30 1999-04-29 Lilly Co Eli Prophylaxis of breast cancer
CZ300261B6 (cs) * 1996-10-30 2009-04-01 Eli Lilly And Company Použití hydrochloridové soli raloxifenu pro prípravu léciva pro prevenci rakoviny prsu
CA2499819A1 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
GB2456096B (en) 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
EP2242483B1 (en) * 2007-12-21 2013-02-20 Synthon B.V. Raloxifene composition
EP3202420B1 (en) * 2008-12-11 2020-03-04 Besins Healthcare Luxembourg SARL Transdermal pharmaceutical compositions comprising a serm
WO2011000581A2 (en) 2009-07-02 2011-01-06 Synthon B.V. Raloxifene composition
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
GB201515391D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
GB201515387D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
EP3251661B1 (en) * 2016-05-30 2020-12-23 Sun Pharmaceutical Industries Limited Raloxifene sprinkle composition

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
JPS63112519A (ja) * 1986-10-28 1988-05-17 Shin Etsu Chem Co Ltd ニフエジピン製剤の製造方法
NL9000634A (nl) * 1990-03-20 1991-10-16 Catharina Ziekenhuis Stichting Suspensie-injectiepreparaat op waterbasis, werkwijze voor de bereiding daarvan en toepassing van dit preparaat voor pijnbestrijding.
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
DE69322764T2 (de) * 1992-10-09 1999-05-06 Kanegafuchi Chemical Ind Herstellungsmethode für feines granulat
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
JPH09506898A (ja) * 1993-12-21 1997-07-08 イーライ・リリー・アンド・カンパニー 非ペプチドタキキニン受容体アンタゴニスト
ZA951497B (en) * 1994-03-02 1996-08-23 Lilly Co Eli Orally administerable pharmaceutical formulations
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5567820A (en) 1994-05-20 1996-10-22 Eli Lilly And Company Glucopyranoside benzothiophenes
US5494920A (en) * 1994-08-22 1996-02-27 Eli Lilly And Company Methods of inhibiting viral replication
CO4410190A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US5494929A (en) * 1995-01-12 1996-02-27 Eli Lilly And Company Methods of inhibiting growth hormone effects
US5532254A (en) 1995-06-07 1996-07-02 Eli Lilly And Company Modulation of calcium channels using benzothiophenes
EA001257B1 (ru) * 1996-03-26 2000-12-25 Эли Лилли Энд Компани Бензотиофены, содержащие их фармацевтические композиции и способы лечения патологических состояний с их использованием

Also Published As

Publication number Publication date
NO984444L (no) 1998-11-26
MEP18308A (en) 2010-06-10
TR199801915T2 (xx) 1998-12-21
PL191148B1 (pl) 2006-03-31
EA001257B1 (ru) 2000-12-25
PT910369E (pt) 2010-06-04
EP2266560A1 (en) 2010-12-29
AU2215497A (en) 1997-10-17
EP0910369A1 (en) 1999-04-28
NO320894B1 (no) 2006-02-06
RO121117B1 (ro) 2006-12-29
EP0910369A4 (en) 2001-03-21
ID19813A (id) 1998-08-06
CZ305398A3 (cs) 1999-05-12
IL140742A (en) 2012-02-29
BR9708248A (pt) 1999-07-27
JP2013166797A (ja) 2013-08-29
IL126320A0 (en) 1999-05-09
AU723797B2 (en) 2000-09-07
IL126320A (en) 2001-08-08
TW513421B (en) 2002-12-11
IL140742A0 (en) 2002-02-10
CA2250191C (en) 2005-11-15
JP2015157865A (ja) 2015-09-03
CA2250191A1 (en) 1997-10-02
JP6095725B2 (ja) 2017-03-15
MY115533A (en) 2003-07-31
CO4780022A1 (es) 1999-05-26
CN1162153C (zh) 2004-08-18
UA57596C2 (uk) 2003-06-16
ATE464897T1 (de) 2010-05-15
EA199800865A1 (ru) 1999-02-25
HK1020671A1 (en) 2000-05-19
CZ300341B6 (cs) 2009-04-22
SI0910369T1 (sl) 2010-08-31
DK0910369T3 (da) 2010-07-26
WO1997035571A1 (en) 1997-10-02
ES2341399T3 (es) 2010-06-18
NO984444D0 (no) 1998-09-24
AR006387A1 (es) 1999-08-25
DE69739855D1 (de) 2010-06-02
YU41898A (sh) 1999-07-28
JP2016106159A (ja) 2016-06-16
PL329051A1 (en) 1999-03-01
NZ332036A (en) 1999-04-29
JP6095821B2 (ja) 2017-03-15
CN1213967A (zh) 1999-04-14
EP0910369B1 (en) 2010-04-21
JP2000507268A (ja) 2000-06-13
JP2009019057A (ja) 2009-01-29

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