MD4132B1 - Di(µ-S)-bis{cloro-¢fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar - Google Patents

Di(µ-S)-bis{cloro-¢fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Info

Publication number
MD4132B1
MD4132B1 MDA20100137A MD20100137A MD4132B1 MD 4132 B1 MD4132 B1 MD 4132B1 MD A20100137 A MDA20100137 A MD A20100137A MD 20100137 A MD20100137 A MD 20100137A MD 4132 B1 MD4132 B1 MD 4132B1
Authority
MD
Moldova
Prior art keywords
copper
mammary cancer
thiosemicarbazonato
manifesting
methanone
Prior art date
Application number
MDA20100137A
Other languages
English (en)
Moldavian (mo)
Other versions
MD4132C1 (ro
Inventor
Aurelian Gulea
Victor Tapcov
Tatiana Straistari
Donald Poirier
Victor Ţapcov
Original Assignee
Univ De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ De Stat Din Moldova filed Critical Univ De Stat Din Moldova
Priority to MDA20100137A priority Critical patent/MD4132C1/ro
Publication of MD4132B1 publication Critical patent/MD4132B1/ro
Publication of MD4132C1 publication Critical patent/MD4132C1/ro

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la chimie şi medicină, şi anume la o combinaţie complexă biologic activă a cuprului cu tiosemicarbazone; care poate găsi aplicare în medicină ca preparat citostatic la profilaxia şi tratarea cancerului mamar.Esenţa invenţiei constă în sinteza unui compus coordinativ nou al cuprului cu tiosemicarbazona2-benzoilpiridinei, di(µ-S)-bis{cloro¢fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} cu formula:care manifestă proprietăţi de inhibitor al proliferării celulelor T-47D ale cancerului mamar.Rezultatul tehnic constă în extinderea gamei de compuşi coordinativi cu activitate anticancerigenă, care la o concentraţie de 10-6 mol/L depăşeşte aproximativ de 4 ori caracteristicele similare ale analogului proxim din clasa tiosemicarbazonaţilor de cupru.
MDA20100137A 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar MD4132C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Publications (2)

Publication Number Publication Date
MD4132B1 true MD4132B1 (ro) 2011-10-31
MD4132C1 MD4132C1 (ro) 2012-05-31

Family

ID=45815291

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Country Status (1)

Country Link
MD (1) MD4132C1 (ro)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (ro) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxifenil)-2-(piridin-2-ilmetiliden)hidrazincarbotioamida în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
CN109694391A (zh) * 2018-12-20 2019-04-30 广西师范大学 一种以2-氨基-5-氯二苯甲酮缩氨基硫脲为配体的铂配合物及其合成方法和应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4326C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul N-(D8,13-biciclohomofarnesenoilamino)carbazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
MD4327C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul 1-(D8,13-biciclohomofarnesenoil)-3-amino-1,2,4-triazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
CN112028911A (zh) * 2020-09-22 2020-12-04 广西师范大学 一种以2-苯甲酰吡啶缩氨基硫脲为配体的锌配合物及其合成方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723270A (en) * 1950-03-29 1955-11-08 Nepera Chemical Co Inc Thiosemicarbazones of pyridylaldehydes and pyridylketones
US2695911A (en) * 1951-08-14 1954-11-30 American Home Prod Preparation of copper compounds of thiosemicarbazones
SU1059870A1 (ru) * 1981-09-04 1991-04-30 Институт Неорганической Химии Со Ан Ссср Комплексное соединение меди (П) с тиосемикарбазоновым производным стабильного нитроксильного радикала имидазолина, про вл ющие противоопухолевую активность
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
DE69232911T2 (de) * 1991-10-31 2003-11-13 For Health Inc Molecules Verwendung eines polyhydroxybenzamids oder dessen Derivat zur Herstellung eines Medikaments für die Behandlung von viralen Infektionen
MD195C2 (ro) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecsuri ale cuprului cu proprietăţi antistafilococice
US5869676A (en) * 1997-05-15 1999-02-09 Vion Pharmaceuticals, Inc. Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP
DE60033830T2 (de) * 1999-10-04 2007-11-15 John Harrow Carter Pharmazeutische zusammensetzung, die kupfer, salicylsäure und vitamin c enthält
UA34404C2 (en) * 2000-06-02 2004-06-15 Ltd Liability Company Res And Inlet roll-type box (its variants)
MXPA03003656A (es) * 2000-10-26 2005-01-25 Wave7 Optics Inc Metodo y sistema para procesar paquetes corriente abajo de una red optica.
MD1812C2 (ro) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecşi de cupru ca inhibitori de bacterii şi fungi
MD2942C2 (ro) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromsalicilidentiosemicarbazonatocupru)
RU2358721C1 (ru) * 2005-04-15 2009-06-20 Виктор Павлович Кутняк Антинеопластический препарат (варианты)
AU2006292482A1 (en) * 2005-09-16 2007-03-29 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing cancer using pyridine carboxaldehyde pyridine thiosemicarbazone radiosensitizing agents
US20070122843A1 (en) * 2005-09-23 2007-05-31 Fazlul Sarkar Isoflavonoid analogs and their metal complexes as anti-cancer agents
CN100506819C (zh) * 2005-10-12 2009-07-01 卡南吉医药科技（上海）有限公司 N,n－二甲基－n’－[2－(2－噻吩基)－2－(2－吡啶基)－1－氮杂烯基]－硫脲
CN101260121A (zh) * 2007-03-07 2008-09-10 卡南吉医药科技（上海）有限公司 杂芳环缩氨基硫脲与过渡金属的络合物及其在制备抗肿瘤药物中的应用
AT505367A1 (de) * 2007-05-29 2008-12-15 Faustus Forschung Translationa Tumorhemmende ruthenium und osmium- thiosemicarbazonatokomplexe
MD3655G2 (ro) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de bis(2-hidroxi-8-fenil-triciclo/7.3.1.0.2,7/tridecan-13-on-tiosemicarbazonato)cupru
MD3771G2 (ro) * 2008-04-30 2009-07-31 Государственный Университет Молд0 Inhibitori ai enzimei 17β-HSD, stimulatoare a multiplicării celulelor cancerului prostatei
EP2318406B1 (en) * 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
MD3995C2 (ro) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
MD3996C2 (ro) * 2009-05-25 2010-07-31 Государственный Университет Молд0 Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (ro) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxifenil)-2-(piridin-2-ilmetiliden)hidrazincarbotioamida în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
CN109694391A (zh) * 2018-12-20 2019-04-30 广西师范大学 一种以2-氨基-5-氯二苯甲酮缩氨基硫脲为配体的铂配合物及其合成方法和应用
CN109694391B (zh) * 2018-12-20 2021-03-23 广西师范大学 一种以2-氨基-5-氯二苯甲酮缩氨基硫脲为配体的铂配合物及其合成方法和应用

Also Published As

Publication number Publication date
MD4132C1 (ro) 2012-05-31

Similar Documents

Publication Publication Date Title
EA201391626A1 (ru) Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
EA201490407A1 (ru) Содержащие гидразид модуляторы нуклеарного транспорта и их применения
UA110943C2 (uk) N-ацилсульфонамідні промотори апоптозу
EA201100136A1 (ru) 2,4'-бипиридинилы в качестве ингибиторов протеинкиназы d, применимые для лечения сердечной недостаточности и рака
WO2012061557A3 (en) Chemical compounds
PH12015501074A1 (en) Triazolopyrazine
EA201591753A1 (ru) 3-пиримидин-4-илоксазолидин-2-оны в качестве ингибиторов мутантного idh
EA201500394A1 (ru) Ингибиторы деметилаз гистонов
EA201201159A1 (ru) Дейтерированные соединения пирролопиримидина в качестве ингибиторов cdk4/6
MD4132B1 (ro) Di(µ-S)-bis{cloro-¢fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar
MX2013000821A (es) Nuevas aminopirazoloquinazolinas.
EA201391644A1 (ru) Частично насыщенные трициклические соединения и способы их получения и применения
PH12016500225A1 (en) Novel quinoline-substituted compound
MX2012013274A (es) Novedosos derivados de la pirimidina.
MD4133C1 (ro) [(2-Carbamotioilhidrazon)propionato(2-)]-(4-aminobenzensulfamid)cupru, care manifestă activitate antimicrobiană faţă de bacteriile din genul Bacillus cereus
EA201290840A1 (ru) Антагонисты ванилоидного рецептора trpv1 с бициклической частью
MX2011008899A (es) Nuevas orto-aminoamidas para el tratamiento del cancer.
MD4194C1 (ro) Compus coordinativ trinuclear al cuprului: tris{µ-[3,5-dibromo-2-hidroxibenziliden-4′-(piridin-2-il)-tiosemicarbazido(2-)]cupru} hidrat, care manifestă activitate antimicotică faţă de Candida albicans
EA201400339A1 (ru) Новые имидазоламины в качестве модуляторов киназной активности
MD4127C1 (ro) Utilizare a di(µ-S)-bis{cloro-[1-(piridin-2-il)etanon-4-metiltiosemicarbazonato(1-)]cupru} în calitate de substanţă cu activitate antimicrobiană faţă de Staphylococcus aureus
UA112769C2 (uk) Аміноінданові сполуки і їх застосування при лікуванні болю
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
HK1165797A1 (en) Imidazolidine-2,4-dione derivatives, and use thereof as a cancer drug
UA106884C2 (uk) Похідні імідазолідин-2,4-діону та їх застосування як медикаменту
MD3996C2 (ro) Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)

Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees