MD4132C1 - Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar - Google Patents

Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Info

Publication number
MD4132C1
MD4132C1 MDA20100137A MD20100137A MD4132C1 MD 4132 C1 MD4132 C1 MD 4132C1 MD A20100137 A MDA20100137 A MD A20100137A MD 20100137 A MD20100137 A MD 20100137A MD 4132 C1 MD4132 C1 MD 4132C1
Authority
MD
Moldova
Prior art keywords
copper
mammary cancer
thiosemicarbazonato
manifesting
methanone
Prior art date
Application number
MDA20100137A
Other languages
English (en)
Russian (ru)
Other versions
MD4132B1 (ro
Inventor
Aurelian Gulea
Tatiana Straistari
Donald Poirier
Victor Ţapcov
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20100137A priority Critical patent/MD4132C1/ro
Publication of MD4132B1 publication Critical patent/MD4132B1/ro
Publication of MD4132C1 publication Critical patent/MD4132C1/ro

Links

Landscapes

  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Invenţia se referă la chimie şi medicină, şi anume la o combinaţie complexă biologic activă a cuprului cu tiosemicarbazone, care poate găsi aplicare în medicină ca preparat citostatic la profilaxia şi tratarea cancerului mamar.Esenţa invenţiei constă în sinteza unui compus coordinativ nou al cuprului cu tiosemicarbazona2-benzoilpiridinei, di(µ-S)-bis{cloro[fenil-(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} cu formula:care manifestă proprietăţi de inhibitor al proliferării celulelor T-47D ale cancerului mamar.Rezultatul tehnic constă în extinderea gamei de compuşi coordinativi cu activitate anticancerigenă, care la o concentraţie de 10-6 mol/L depăşeşte aproximativ de 4 ori caracteristicile similare ale analogului proxim din clasa tiosemicarbazonaţilor de cupru.
MDA20100137A 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar MD4132C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Publications (2)

Publication Number Publication Date
MD4132B1 MD4132B1 (ro) 2011-10-31
MD4132C1 true MD4132C1 (ro) 2012-05-31

Family

ID=45815291

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20100137A MD4132C1 (ro) 2010-12-13 2010-12-13 Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar

Country Status (1)

Country Link
MD (1) MD4132C1 (ro)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4327C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul 1-(D8,13-biciclohomofarnesenoil)-3-amino-1,2,4-triazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
MD4326C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul N-(D8,13-biciclohomofarnesenoilamino)carbazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
CN112028911A (zh) * 2020-09-22 2020-12-04 广西师范大学 一种以2-苯甲酰吡啶缩氨基硫脲为配体的锌配合物及其合成方法和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520C1 (ro) * 2016-12-16 2018-05-31 Государственный Университет Молд0 N-(4-butoxifenil)-2-(piridin-2-ilmetiliden)hidrazincarbotioamida în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar
CN109694391B (zh) * 2018-12-20 2021-03-23 广西师范大学 一种以2-氨基-5-氯二苯甲酮缩氨基硫脲为配体的铂配合物及其合成方法和应用

Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695911A (en) * 1951-08-14 1954-11-30 American Home Prod Preparation of copper compounds of thiosemicarbazones
US2723270A (en) * 1950-03-29 1955-11-08 Nepera Chemical Co Inc Thiosemicarbazones of pyridylaldehydes and pyridylketones
EP0135713A2 (en) * 1983-07-28 1985-04-03 The Wellcome Foundation Limited Antiviral combinations
SU1059870A1 (ru) * 1981-09-04 1991-04-30 Институт Неорганической Химии Со Ан Ссср Комплексное соединение меди (П) с тиосемикарбазоновым производным стабильного нитроксильного радикала имидазолина, про вл ющие противоопухолевую активность
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
WO1993012782A1 (en) * 1991-10-31 1993-07-08 Elford Howard L Method of treating viral diseases
MD195C2 (ro) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecsuri ale cuprului cu proprietăţi antistafilococice
WO1998051670A1 (en) * 1997-05-15 1998-11-19 Vion Pharmaceuticals, Inc. Process for the synthesis of ribonucleotide reductase inhibitors 3-ap and 3-amp
WO2001024803A2 (en) * 1999-10-04 2001-04-12 John Carter Pharmaceutical compositions containing copper, salicylic acid and vitamines c
MD1812C2 (ro) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecşi de cupru ca inhibitori de bacterii şi fungi
US20030016692A1 (en) * 2000-10-26 2003-01-23 Wave7 Optics, Inc. Method and system for processing upstream packets of an optical network
MD2002G2 (ro) * 2000-06-02 2003-03-31 Сайентифик Энд Прэдакшэн Ентерпрайз "Еталон", Л.Т.Д. Cutie de intrare cu role (variante)
MD2942C2 (ro) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromsalicilidentiosemicarbazonatocupru)
WO2006110119A1 (fr) * 2005-04-15 2006-10-19 Victor Pavlovich Kutnyak Produit antineoplasique (et variantes)
WO2007035489A2 (en) * 2005-09-16 2007-03-29 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing cancer using pyridine carboxaldehyde pyridine thiosemicarbazone radiosensitizing agents
WO2007035927A2 (en) * 2005-09-23 2007-03-29 Wayne State University Isoflavonoid analogs and their metal conjugates as anti-cancer agents
CN1948304A (zh) * 2005-10-12 2007-04-18 桑迪亚医药技术（上海）有限责任公司 杂芳环缩氨基硫脲类化合物及其衍生物
CN101260121A (zh) * 2007-03-07 2008-09-10 卡南吉医药科技（上海）有限公司 杂芳环缩氨基硫脲与过渡金属的络合物及其在制备抗肿瘤药物中的应用
AT505367A1 (de) * 2007-05-29 2008-12-15 Faustus Forschung Translationa Tumorhemmende ruthenium und osmium- thiosemicarbazonatokomplexe
MD3655G2 (ro) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de bis(2-hidroxi-8-fenil-triciclo/7.3.1.0.2,7/tridecan-13-on-tiosemicarbazonato)cupru
MD3771G2 (ro) * 2008-04-30 2009-07-31 Государственный Университет Молд0 Inhibitori ai enzimei 17β-HSD, stimulatoare a multiplicării celulelor cancerului prostatei
MD3995B1 (ro) * 2009-05-11 2009-12-31 Universitatea De Stat Din Moldova Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} in calitate de inhibitor al proliferarii celulelor T-47D ale cancerului mamar
WO2010006438A1 (en) * 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
MD3996C2 (ro) * 2009-05-25 2010-07-31 Государственный Университет Молд0 Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)

Patent Citations (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2723270A (en) * 1950-03-29 1955-11-08 Nepera Chemical Co Inc Thiosemicarbazones of pyridylaldehydes and pyridylketones
US2695911A (en) * 1951-08-14 1954-11-30 American Home Prod Preparation of copper compounds of thiosemicarbazones
SU1059870A1 (ru) * 1981-09-04 1991-04-30 Институт Неорганической Химии Со Ан Ссср Комплексное соединение меди (П) с тиосемикарбазоновым производным стабильного нитроксильного радикала имидазолина, про вл ющие противоопухолевую активность
EP0135713A2 (en) * 1983-07-28 1985-04-03 The Wellcome Foundation Limited Antiviral combinations
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
WO1993012782A1 (en) * 1991-10-31 1993-07-08 Elford Howard L Method of treating viral diseases
MD195C2 (ro) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecsuri ale cuprului cu proprietăţi antistafilococice
WO1998051670A1 (en) * 1997-05-15 1998-11-19 Vion Pharmaceuticals, Inc. Process for the synthesis of ribonucleotide reductase inhibitors 3-ap and 3-amp
WO2001024803A2 (en) * 1999-10-04 2001-04-12 John Carter Pharmaceutical compositions containing copper, salicylic acid and vitamines c
MD2002G2 (ro) * 2000-06-02 2003-03-31 Сайентифик Энд Прэдакшэн Ентерпрайз "Еталон", Л.Т.Д. Cutie de intrare cu role (variante)
US20030016692A1 (en) * 2000-10-26 2003-01-23 Wave7 Optics, Inc. Method and system for processing upstream packets of an optical network
MD1812C2 (ro) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Complecşi de cupru ca inhibitori de bacterii şi fungi
MD2942C2 (ro) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromsalicilidentiosemicarbazonatocupru)
WO2006110119A1 (fr) * 2005-04-15 2006-10-19 Victor Pavlovich Kutnyak Produit antineoplasique (et variantes)
WO2007035489A2 (en) * 2005-09-16 2007-03-29 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of treating or preventing cancer using pyridine carboxaldehyde pyridine thiosemicarbazone radiosensitizing agents
WO2007035927A2 (en) * 2005-09-23 2007-03-29 Wayne State University Isoflavonoid analogs and their metal conjugates as anti-cancer agents
CN1948304A (zh) * 2005-10-12 2007-04-18 桑迪亚医药技术（上海）有限责任公司 杂芳环缩氨基硫脲类化合物及其衍生物
CN101260121A (zh) * 2007-03-07 2008-09-10 卡南吉医药科技（上海）有限公司 杂芳环缩氨基硫脲与过渡金属的络合物及其在制备抗肿瘤药物中的应用
AT505367A1 (de) * 2007-05-29 2008-12-15 Faustus Forschung Translationa Tumorhemmende ruthenium und osmium- thiosemicarbazonatokomplexe
MD3655G2 (ro) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor al leucemiei mieloide umane în bază de bis(2-hidroxi-8-fenil-triciclo/7.3.1.0.2,7/tridecan-13-on-tiosemicarbazonato)cupru
MD3771G2 (ro) * 2008-04-30 2009-07-31 Государственный Университет Молд0 Inhibitori ai enzimei 17β-HSD, stimulatoare a multiplicării celulelor cancerului prostatei
WO2010006438A1 (en) * 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
MD3995B1 (ro) * 2009-05-11 2009-12-31 Universitatea De Stat Din Moldova Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} in calitate de inhibitor al proliferarii celulelor T-47D ale cancerului mamar
MD3996C2 (ro) * 2009-05-25 2010-07-31 Государственный Университет Молд0 Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Chumakov Iu. M., Tsapkov V. I., Jeanneau E., Bairac N. N., Bocelli G., Poirier D., Roy J., Gulea A. Crystal structures of copper(II) chloride, copper(II) bromide and copper(II) nitrate complexes with pyridin-2-carbaldehyde thiosemicarbazone. Cryst. Report. 2008, Vol.53, N 5, P. 786-792 *
Douglas X. West et al. Copper(II) complexes of 2-formyl-, 6-methyl-2-formyl- and 2-benzoylpyridine N(4)-(2-methylpyridinyl)-, N(4)-(2-ethylpyridinyl)- and N(4)-methyl(2-ethylpyridinyl)thiosemicarbazones. Transition Met. Chem., 21, 289-295 (1996); (regăsit în Internet la 2011.08.10, url: http://www.springerlink.com/content/g90np851733v87lk/) *
Giorgio Pelosi. Thiosemicarbazone Metal Complexes: from Structure to Activity. The Open Crystallography Journal, 2010, 3, pag. 16-28 *
Prostate cancer (the page was last modified on 08 August 2011), (regăsit în Internet la 2011.08.10, url: http://en.wikipedia.org/wiki/Prostate_cancer ) *
Tarlok S. Lobana et al. Mono- and di-nuclear complexes of thiosemicarbazones with copper(II): Synthesis, spectroscopy and structures. Polyhedron, Vol. 28, Issue 18, December 2009, Pages 3899-3906. doi:10.1016/j.poly.2009.08.028 <http://dx.doi.org/10.1016/j.poly.2009.08.028> (Rezumat regăsit în Internet la 2011.08.11 (abstract+graphical abstract), url: http://www.sciencedirect.com/science/article/pii/S0277538709005890 ) *
Tripathi Laxmi et al. Role of chelates in treatment of cancer. Indian Journal of Cancer, April-June 2007, vol. 44, issue 2, pag. 62-71 (regăsit în Internet la 2011.08.11, url: http://www.bioline.org.br/pdf?cn07011 ) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4327C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul 1-(D8,13-biciclohomofarnesenoil)-3-amino-1,2,4-triazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
MD4326C1 (ro) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы Compusul N-(D8,13-biciclohomofarnesenoilamino)carbazol şi procedeu de cultivare a cianobacteriei Nostoc linckia cu utilizarea acestuia
CN112028911A (zh) * 2020-09-22 2020-12-04 广西师范大学 一种以2-苯甲酰吡啶缩氨基硫脲为配体的锌配合物及其合成方法和应用

Also Published As

Publication number Publication date
MD4132B1 (ro) 2011-10-31

Similar Documents

Publication Publication Date Title
EA201391626A1 (ru) Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
EA201490407A1 (ru) Содержащие гидразид модуляторы нуклеарного транспорта и их применения
UA110943C2 (uk) N-ацилсульфонамідні промотори апоптозу
EA201100136A1 (ru) 2,4&#39;-бипиридинилы в качестве ингибиторов протеинкиназы d, применимые для лечения сердечной недостаточности и рака
WO2012061557A3 (en) Chemical compounds
PH12015501074A1 (en) Triazolopyrazine
EA201591753A1 (ru) 3-пиримидин-4-илоксазолидин-2-оны в качестве ингибиторов мутантного idh
EA201500394A1 (ru) Ингибиторы деметилаз гистонов
EA201201159A1 (ru) Дейтерированные соединения пирролопиримидина в качестве ингибиторов cdk4/6
MD4132C1 (ro) Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar
MX2013000821A (es) Nuevas aminopirazoloquinazolinas.
EA201391644A1 (ru) Частично насыщенные трициклические соединения и способы их получения и применения
PH12016500225A1 (en) Novel quinoline-substituted compound
MX2012013274A (es) Novedosos derivados de la pirimidina.
MD4133C1 (ro) [(2-Carbamotioilhidrazon)propionato(2-)]-(4-aminobenzensulfamid)cupru, care manifestă activitate antimicrobiană faţă de bacteriile din genul Bacillus cereus
EA201290840A1 (ru) Антагонисты ванилоидного рецептора trpv1 с бициклической частью
MX2011008899A (es) Nuevas orto-aminoamidas para el tratamiento del cancer.
MD4194C1 (ro) Compus coordinativ trinuclear al cuprului: tris{µ-[3,5-dibromo-2-hidroxibenziliden-4′-(piridin-2-il)-tiosemicarbazido(2-)]cupru} hidrat, care manifestă activitate antimicotică faţă de Candida albicans
EA201400339A1 (ru) Новые имидазоламины в качестве модуляторов киназной активности
MD4127C1 (ro) Utilizare a di(µ-S)-bis{cloro-[1-(piridin-2-il)etanon-4-metiltiosemicarbazonato(1-)]cupru} în calitate de substanţă cu activitate antimicrobiană faţă de Staphylococcus aureus
UA112769C2 (uk) Аміноінданові сполуки і їх застосування при лікуванні болю
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
HK1165797A1 (en) Imidazolidine-2,4-dione derivatives, and use thereof as a cancer drug
UA106884C2 (uk) Похідні імідазолідин-2,4-діону та їх застосування як медикаменту
MD3996C2 (ro) Percloraţi de 5-R-saliciliden-4-feniltiosemicarbazonato(1-)-aquacupru(II) ce posedă proprietăţi de inhibitori ai activităţii enzimei 17 b-HSD (tipul 1)

Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees