MD195C2 - Complecsuri ale cuprului cu proprietăţi antistafilococice - Google Patents
Complecsuri ale cuprului cu proprietăţi antistafilocociceInfo
- Publication number
- MD195C2 MD195C2 MD95-0041A MD950041A MD195C2 MD 195 C2 MD195 C2 MD 195C2 MD 950041 A MD950041 A MD 950041A MD 195 C2 MD195 C2 MD 195C2
- Authority
- MD
- Moldova
- Prior art keywords
- antistaphylococcus
- prototype
- theirs
- active
- properties
- Prior art date
Links
- 230000000941 anti-staphylcoccal effect Effects 0.000 title abstract 2
- 150000001879 copper Chemical class 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- MPTQRFCYZCXJFQ-UHFFFAOYSA-L copper(II) chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Cu+2] MPTQRFCYZCXJFQ-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la tiosemicarbazonaţii cuprului cu liganzi micşti, care posedă activitate antistafilococică şi poate găsi aplicare în medicină.Compusul su formula generală CuA(Z-2H), în carese obţine la interacţiunea în decurs de 15-20 minute a soluţiilor etanolice fierbinţi (t=50°C) de clorură de cupru (2+) dihidratată şi de tiosemicarbazonă a aldehidei 2-oxi-1-naftalice în raport molar de 1:1 în prezent piridinei, 3-sau 4-picolinei (pH=8).Aceste complexuri sunt de 4-24 ori mai active faţă de bacteriile din genul Staphylococcus în comparaţie cu analogul lor structural care se aplică în medicina practică şi de 1,2-2,5 ori mai activ decât prototipul, iar toxicitatea este mai mică de 5,2-9 ori decât a analogului structural şi de 1,02-1,2 ori mai mică faţă de cea a prototipului.Tabele: 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0041A MD195C2 (ro) | 1994-12-05 | 1994-12-05 | Complecsuri ale cuprului cu proprietăţi antistafilococice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD95-0041A MD195C2 (ro) | 1994-12-05 | 1994-12-05 | Complecsuri ale cuprului cu proprietăţi antistafilococice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD195B1 MD195B1 (ro) | 1995-05-31 |
| MD195C2 true MD195C2 (ro) | 1995-11-30 |
Family
ID=19738616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0041A MD195C2 (ro) | 1994-12-05 | 1994-12-05 | Complecsuri ale cuprului cu proprietăţi antistafilococice |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD195C2 (ro) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3995C2 (ro) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar |
| MD4112C1 (ro) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Compuşi coordinativi ai cuprului cu 4-(dimetilfenil)-tiosemicarbazonele 2-formilpiridinei |
| MD4127C1 (ro) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Utilizare a di(µ-S)-bis{cloro-[1-(piridin-2-il)etanon-4-metiltiosemicarbazonato(1-)]cupru} în calitate de substanţă cu activitate antimicrobiană faţă de Staphylococcus aureus |
| MD4132C1 (ro) * | 2010-12-13 | 2012-05-31 | Государственный Университет Молд0 | Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1650G2 (ro) * | 1999-12-06 | 2001-11-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | 3,5-Dibromsalicilidentiosemicarbazidopiridincupru care manifestă activitate antistafilococică şi antistreptococică |
| MD4252C1 (ro) * | 2012-05-31 | 2014-05-31 | Государственный Университет Молд0 | Catena-(µ-nitrato)[µ-(2-hidroxibenziliden)-4-prop-2-en-1-iltiosemicarbazon-S]argint cu activitate antimicrobiană faţă de bacteriile Salmonella abony |
| MD4383C1 (ro) * | 2015-03-06 | 2016-06-30 | Государственный Университет Молд0 | Compusul acetato-(8-formilchinolintiosemicarbazono)cupru(II) care manifestă activitate antibacteriană |
-
1994
- 1994-12-05 MD MD95-0041A patent/MD195C2/ro active IP Right Grant
Non-Patent Citations (3)
| Title |
|---|
| Машковский М.Д. Лекарственные средства. т. 2. Минск, 1987. * |
| Фурацилин и опыт его применения. Под ред. Гиллера С.А. Рига. 1953. АН Латвийской ССР. * |
| Цапков В.И., Кетруш П.М., Шляхов Э.Н., Наузат А.Н., Бурденко Т.А., Бурлаку Н.Я., Гылка В.В., Стан В.В., Самусь Н.М. Тез. докл. на XVII Всес. Чугаевск. сов. по хим. компл. оед. Минск, 1990, т. 4, с. 651. * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3995C2 (ro) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar |
| MD4112C1 (ro) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Compuşi coordinativi ai cuprului cu 4-(dimetilfenil)-tiosemicarbazonele 2-formilpiridinei |
| MD4127C1 (ro) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Utilizare a di(µ-S)-bis{cloro-[1-(piridin-2-il)etanon-4-metiltiosemicarbazonato(1-)]cupru} în calitate de substanţă cu activitate antimicrobiană faţă de Staphylococcus aureus |
| MD4132C1 (ro) * | 2010-12-13 | 2012-05-31 | Государственный Университет Молд0 | Di(µ-S)-bis{cloro-[fenil(piridin-2-il)metanon-tiosemicarbazonato(1-)]cupru} care manifestă proprietatea de inhibare a proliferării celulelor T-47D ale cancerului mamar |
Also Published As
| Publication number | Publication date |
|---|---|
| MD195B1 (ro) | 1995-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20091205 |