MD4132C1 - Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells - Google Patents
Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cellsInfo
- Publication number
- MD4132C1 MD4132C1 MDA20100137A MD20100137A MD4132C1 MD 4132 C1 MD4132 C1 MD 4132C1 MD A20100137 A MDA20100137 A MD A20100137A MD 20100137 A MD20100137 A MD 20100137A MD 4132 C1 MD4132 C1 MD 4132C1
- Authority
- MD
- Moldova
- Prior art keywords
- copper
- mammary cancer
- thiosemicarbazonato
- manifesting
- methanone
- Prior art date
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry and medicine, namely to a biologically active complex combination of copper with thiosemicarbazone, which can be used in medicine as a cytostatic preparation in the prevention and treatment of mammary cancer.Summary of the invention consists in the synthesis of a new coordinative compound of copper with 2-benzoylpyridine thiosemicarbazone, di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} of formula:manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells.The technical result is to increase the range of coordinative compounds with anticancer activity, which at a concentration of 10-6 mol/L is about 4 times higher than the similar characteristics of the closest analogue from the class of copper thiosemicarbazonates.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20100137A MD4132C1 (en) | 2010-12-13 | 2010-12-13 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20100137A MD4132C1 (en) | 2010-12-13 | 2010-12-13 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4132B1 MD4132B1 (en) | 2011-10-31 |
MD4132C1 true MD4132C1 (en) | 2012-05-31 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MDA20100137A MD4132C1 (en) | 2010-12-13 | 2010-12-13 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
Country Status (1)
Country | Link |
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MD (1) | MD4132C1 (en) |
Cited By (3)
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MD4326C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
MD4327C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
CN112028911A (en) * | 2020-09-22 | 2020-12-04 | 广西师范大学 | Zinc complex taking 2-benzoylpyridine thiosemicarbazone as ligand and synthetic method and application thereof |
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MD4520C1 (en) * | 2016-12-16 | 2018-05-31 | Государственный Университет Молд0 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
CN109694391B (en) * | 2018-12-20 | 2021-03-23 | 广西师范大学 | Platinum complex taking 2-amino-5-chlorobenzophenone thiosemicarbazone as ligand and synthetic method and application thereof |
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MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
MD3995B1 (en) * | 2009-05-11 | 2009-12-31 | Universitatea De Stat Din Moldova | Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
WO2010006438A1 (en) * | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
MD3996C2 (en) * | 2009-05-25 | 2010-07-31 | Государственный Университет Молд0 | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) |
-
2010
- 2010-12-13 MD MDA20100137A patent/MD4132C1/en not_active IP Right Cessation
Patent Citations (24)
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EP0135713A2 (en) * | 1983-07-28 | 1985-04-03 | The Wellcome Foundation Limited | Antiviral combinations |
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MD195C2 (en) * | 1994-12-05 | 1995-11-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | The copper complexes with antistaphylococcus properties |
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MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
WO2010006438A1 (en) * | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
MD3995B1 (en) * | 2009-05-11 | 2009-12-31 | Universitatea De Stat Din Moldova | Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
MD3996C2 (en) * | 2009-05-25 | 2010-07-31 | Государственный Университет Молд0 | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4326C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
MD4327C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
CN112028911A (en) * | 2020-09-22 | 2020-12-04 | 广西师范大学 | Zinc complex taking 2-benzoylpyridine thiosemicarbazone as ligand and synthetic method and application thereof |
Also Published As
Publication number | Publication date |
---|---|
MD4132B1 (en) | 2011-10-31 |
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Legal Events
Date | Code | Title | Description |
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FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |