MD3996C2 - Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) - Google Patents
Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1)Info
- Publication number
- MD3996C2 MD3996C2 MDA20090055A MD20090055A MD3996C2 MD 3996 C2 MD3996 C2 MD 3996C2 MD A20090055 A MDA20090055 A MD A20090055A MD 20090055 A MD20090055 A MD 20090055A MD 3996 C2 MD3996 C2 MD 3996C2
- Authority
- MD
- Moldova
- Prior art keywords
- phenylthiosemicarbazonato
- aquacopper
- salicylidene
- inhibitors
- enzyme activity
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals that can find their application in medicine for prophylaxis and treatment of prostate cancer.Summary of the invention consists in the synthesis of perchlorate of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) of general formula:where R=Br, NO2.The coordinative compounds possess properties of inhibitors of 17β-HSD enzyme activity (type 1), stimulator for prostate cancer cell proliferation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20090055A MD3996C2 (en) | 2009-05-25 | 2009-05-25 | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20090055A MD3996C2 (en) | 2009-05-25 | 2009-05-25 | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) |
Publications (2)
Publication Number | Publication Date |
---|---|
MD3996B1 MD3996B1 (en) | 2009-12-31 |
MD3996C2 true MD3996C2 (en) | 2010-07-31 |
Family
ID=43568860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20090055A MD3996C2 (en) | 2009-05-25 | 2009-05-25 | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1) |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD3996C2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4126C1 (en) * | 2010-11-15 | 2012-04-30 | Государственный Университет Молд0 | N,N'-[4,4'-(perfluoro-1,4-phenylenedioxy)-bis(4,1-phenylene)]-bis[2-(pyridine-2-ilmethylene)hydrazinecarbothioamide] and use thereof as prostate cancer LNCaP cell proliferation inhibitor |
MD4132C1 (en) * | 2010-12-13 | 2012-05-31 | Государственный Университет Молд0 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4025C2 (en) * | 2009-08-25 | 2010-10-31 | Владимир КАРАУШ | Remedy for treating prostatitis and prostate hyperplasia |
MD4349C1 (en) * | 2014-06-23 | 2015-12-31 | Государственный Университет Молд0 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2695911A (en) * | 1951-08-14 | 1954-11-30 | American Home Prod | Preparation of copper compounds of thiosemicarbazones |
RU2265014C1 (en) * | 2004-05-13 | 2005-11-27 | Открытое Акционерное Общество "Фармасинтез" | Method for preparing 4-thioureidoiminimethyl-pyridinium perchlorate possessing tuberculostatic activity |
MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
-
2009
- 2009-05-25 MD MDA20090055A patent/MD3996C2/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2695911A (en) * | 1951-08-14 | 1954-11-30 | American Home Prod | Preparation of copper compounds of thiosemicarbazones |
RU2265014C1 (en) * | 2004-05-13 | 2005-11-27 | Открытое Акционерное Общество "Фармасинтез" | Method for preparing 4-thioureidoiminimethyl-pyridinium perchlorate possessing tuberculostatic activity |
MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4126C1 (en) * | 2010-11-15 | 2012-04-30 | Государственный Университет Молд0 | N,N'-[4,4'-(perfluoro-1,4-phenylenedioxy)-bis(4,1-phenylene)]-bis[2-(pyridine-2-ilmethylene)hydrazinecarbothioamide] and use thereof as prostate cancer LNCaP cell proliferation inhibitor |
MD4132C1 (en) * | 2010-12-13 | 2012-05-31 | Государственный Университет Молд0 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
Also Published As
Publication number | Publication date |
---|---|
MD3996B1 (en) | 2009-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |