MD4349C1 - N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation - Google Patents
N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferationInfo
- Publication number
- MD4349C1 MD4349C1 MDA20140062A MD20140062A MD4349C1 MD 4349 C1 MD4349 C1 MD 4349C1 MD A20140062 A MDA20140062 A MD A20140062A MD 20140062 A MD20140062 A MD 20140062A MD 4349 C1 MD4349 C1 MD 4349C1
- Authority
- MD
- Moldova
- Prior art keywords
- human melanoma
- compound
- hydrazinecarbothioamide
- ylmethylene
- mew
- Prior art date
Links
Abstract
The invention relates to chemistry and medicine, namely to an organic compound from the class of thioamides, which may find application in medicine as a cytostatic agent for the prophylaxis and treatment of human melanoma.Summary of the invention consists in the synthesis of N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound of formula:,exhibiting the human melanoma MeW-164 cell proliferation inhibition property.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20140062A MD4349C1 (en) | 2014-06-23 | 2014-06-23 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20140062A MD4349C1 (en) | 2014-06-23 | 2014-06-23 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4349B1 MD4349B1 (en) | 2015-05-31 |
MD4349C1 true MD4349C1 (en) | 2015-12-31 |
Family
ID=53190461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20140062A MD4349C1 (en) | 2014-06-23 | 2014-06-23 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
Country Status (1)
Country | Link |
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MD (1) | MD4349C1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4520C1 (en) * | 2016-12-16 | 2018-05-31 | Государственный Университет Молд0 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Citations (11)
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---|---|---|---|---|
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
CN101260121A (en) * | 2007-03-07 | 2008-09-10 | 卡南吉医药科技(上海)有限公司 | Complex compound of heteroaromatic thiosemicarbazone and transition metal, and application thereof in preparing antineoplastic medicine |
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
MD3995B1 (en) * | 2009-05-11 | 2009-12-31 | Universitatea De Stat Din Moldova | Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD3996B1 (en) * | 2009-05-25 | 2009-12-31 | Universitatea De Stat Din Moldova | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17Beta-HSD enzyme activity (type 1) |
WO2010006438A1 (en) * | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
CN102210698A (en) * | 2004-01-02 | 2011-10-12 | 维奥恩药品公司 | Use of composition containing 3-aminopyridine-2-formaldehyde thiosemicarbazone in treatment of cancers |
MD4190B1 (en) * | 2011-06-16 | 2012-12-31 | Univ De Stat Din Moldova | Inhibitor of human myeloid leukemia based on {bis¢2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215B1 (en) * | 2012-07-09 | 2013-04-30 | Univ De Stat Din Moldova | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
-
2014
- 2014-06-23 MD MDA20140062A patent/MD4349C1/en not_active IP Right Cessation
Patent Citations (12)
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US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
US5721259A (en) * | 1992-05-13 | 1998-02-24 | Yale University | Method of using 2-formylpyridine thiosemicarbazone compounds |
CN102210698A (en) * | 2004-01-02 | 2011-10-12 | 维奥恩药品公司 | Use of composition containing 3-aminopyridine-2-formaldehyde thiosemicarbazone in treatment of cancers |
CN101260121A (en) * | 2007-03-07 | 2008-09-10 | 卡南吉医药科技(上海)有限公司 | Complex compound of heteroaromatic thiosemicarbazone and transition metal, and application thereof in preparing antineoplastic medicine |
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
MD3771G2 (en) * | 2008-04-30 | 2009-07-31 | Государственный Университет Молд0 | Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication |
WO2010006438A1 (en) * | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD3995B1 (en) * | 2009-05-11 | 2009-12-31 | Universitatea De Stat Din Moldova | Use of di(Á-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
MD3996B1 (en) * | 2009-05-25 | 2009-12-31 | Universitatea De Stat Din Moldova | Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17Beta-HSD enzyme activity (type 1) |
MD4190B1 (en) * | 2011-06-16 | 2012-12-31 | Univ De Stat Din Moldova | Inhibitor of human myeloid leukemia based on {bis¢2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215B1 (en) * | 2012-07-09 | 2013-04-30 | Univ De Stat Din Moldova | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
Non-Patent Citations (4)
Title |
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Anuszewska E., Chlopkiewicz B., Gruber B., Marczewska J., Priebe W., Skurzak H. Estimation of DNA damage and cytotoxicity of anthracycline analogs in human melanoma cells on early and late passages. Acta Poloniae Pharmaceutica - Drug Research, 2006, vol. 63, nr. 4, p. 321-324 * |
Douglas West, Jack Ingram, Nicole Kozub, Gordon Bain, Anthony Liberta. Copper(II) complexes of 2-formyl-, 2-acetyl- and 2-benzoyl-pyridine N(4)-phenyl-, N(4)-o-methoxyphenyl-, N(4)-p-methoxy-phenyl- and N(4)-p-nitrophenylthiosemicarbazones. Transition Metal Chemistry, June 1996, vol. 21, issue 3, p. 213-218 (regăsit în Internet la 2015.02.10 URL:<http://link.springer.com/content/pdf/10.1007/BF00165969.pdf#>) * |
Douglas X. West et al. Copper(II) complexes of 2- formyl-, 6-methyl-2-formyl- and 2- benzoylpyridine N(4)-(2-methylpyridinyl)-, N(4)- (2-ethylpyridinyl)- and N(4)-methyl(2- ethylpyridinyl)thiosemicarbazones. Transition Metal Chemistry, 1996, 21, 289-295; (regăsit în Internet la 2015.02.11 URL: <http://www.springerlink.com/content/g90np851733v87lk/>) * |
Giorgio Pelosi. Thiosemicarbazone Metal Complexes: from structure to activity. The Open Crystallography Journal, 2010, 3, pag. 16-28, (regăsit în Internet la 2015.02.10 URL: < <http://benthamopen.com/contents/pdf/TOCRYJ/TOCRYJ-3-16.pdf>>) * |
Also Published As
Publication number | Publication date |
---|---|
MD4349B1 (en) | 2015-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |