MD3890G2 - Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides - Google Patents

Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

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Publication number
MD3890G2
MD3890G2 MDA20080237A MD20080237A MD3890G2 MD 3890 G2 MD3890 G2 MD 3890G2 MD A20080237 A MDA20080237 A MD A20080237A MD 20080237 A MD20080237 A MD 20080237A MD 3890 G2 MD3890 G2 MD 3890G2
Authority
MD
Moldova
Prior art keywords
myeloid leukemia
inhibitors
human myeloid
copper
thiocarbazides
Prior art date
Application number
MDA20080237A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD3890F1 (en
Inventor
Аурелиан ГУЛЯ
Дональд ПОЙРИЕР
Елена-Михаела ПАХОНЦУ
Виктор ЦАПКОВ
Наталия БЕЖЕНАРЬ
Дженни РОЙ
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20080237A priority Critical patent/MD3890G2/en
Publication of MD3890F1 publication Critical patent/MD3890F1/en
Publication of MD3890G2 publication Critical patent/MD3890G2/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals that can be applied in medicine for prophylaxis and treatment of human myeloid leukemia.Summary of the invention consists in that as inhibitors of human myeloid leukemia are proposed coordinative compounds of copper sulphate and nitrate with the salicylaldehyde thiosemicarbazones of general formula:where X = NO3 ¯(I - VII); ½ SO4 2¯ (VIII- XIV)
MDA20080237A 2008-09-08 2008-09-08 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides MD3890G2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20080237A MD3890G2 (en) 2008-09-08 2008-09-08 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20080237A MD3890G2 (en) 2008-09-08 2008-09-08 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

Publications (2)

Publication Number Publication Date
MD3890F1 MD3890F1 (en) 2009-04-30
MD3890G2 true MD3890G2 (en) 2009-12-31

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MDA20080237A MD3890G2 (en) 2008-09-08 2008-09-08 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

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MD (1) MD3890G2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4393C1 (en) * 2015-09-04 2016-08-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor
RU2739317C1 (en) * 2020-02-17 2020-12-22 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук Mono- and binuclear n,o-complexes of copper (ii) diacetate with 1-[(dimethylamino) methyl]-2-naphthol, having anti-tumour activity

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4393C1 (en) * 2015-09-04 2016-08-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor
RU2739317C1 (en) * 2020-02-17 2020-12-22 Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук Mono- and binuclear n,o-complexes of copper (ii) diacetate with 1-[(dimethylamino) methyl]-2-naphthol, having anti-tumour activity

Also Published As

Publication number Publication date
MD3890F1 (en) 2009-04-30

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees