MD3890G2 - Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides - Google Patents
Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazidesInfo
- Publication number
- MD3890G2 MD3890G2 MDA20080237A MD20080237A MD3890G2 MD 3890 G2 MD3890 G2 MD 3890G2 MD A20080237 A MDA20080237 A MD A20080237A MD 20080237 A MD20080237 A MD 20080237A MD 3890 G2 MD3890 G2 MD 3890G2
- Authority
- MD
- Moldova
- Prior art keywords
- myeloid leukemia
- inhibitors
- human myeloid
- copper
- thiocarbazides
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals that can be applied in medicine for prophylaxis and treatment of human myeloid leukemia.Summary of the invention consists in that as inhibitors of human myeloid leukemia are proposed coordinative compounds of copper sulphate and nitrate with the salicylaldehyde thiosemicarbazones of general formula:where X = NO3 ¯(I - VII); ½ SO4 2¯ (VIII- XIV)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20080237A MD3890G2 (en) | 2008-09-08 | 2008-09-08 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20080237A MD3890G2 (en) | 2008-09-08 | 2008-09-08 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
Publications (2)
Publication Number | Publication Date |
---|---|
MD3890F1 MD3890F1 (en) | 2009-04-30 |
MD3890G2 true MD3890G2 (en) | 2009-12-31 |
Family
ID=40901724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20080237A MD3890G2 (en) | 2008-09-08 | 2008-09-08 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD3890G2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4190C1 (en) * | 2011-06-16 | 2013-07-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4349C1 (en) * | 2014-06-23 | 2015-12-31 | Государственный Университет Молд0 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
MD4393C1 (en) * | 2015-09-04 | 2016-08-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
RU2739317C1 (en) * | 2020-02-17 | 2020-12-22 | Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук | Mono- and binuclear n,o-complexes of copper (ii) diacetate with 1-[(dimethylamino) methyl]-2-naphthol, having anti-tumour activity |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4407C1 (en) * | 2015-04-29 | 2016-10-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
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2008
- 2008-09-08 MD MDA20080237A patent/MD3890G2/en not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4190C1 (en) * | 2011-06-16 | 2013-07-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4349C1 (en) * | 2014-06-23 | 2015-12-31 | Государственный Университет Молд0 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
MD4393C1 (en) * | 2015-09-04 | 2016-08-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
RU2739317C1 (en) * | 2020-02-17 | 2020-12-22 | Федеральное государственное бюджетное научное учреждение Уфимский федеральный исследовательский центр Российской академии наук | Mono- and binuclear n,o-complexes of copper (ii) diacetate with 1-[(dimethylamino) methyl]-2-naphthol, having anti-tumour activity |
Also Published As
Publication number | Publication date |
---|---|
MD3890F1 (en) | 2009-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |