MD4300B1 - Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel - Google Patents
Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickelInfo
- Publication number
- MD4300B1 MD4300B1 MDA20120128A MD20120128A MD4300B1 MD 4300 B1 MD4300 B1 MD 4300B1 MD A20120128 A MDA20120128 A MD A20120128A MD 20120128 A MD20120128 A MD 20120128A MD 4300 B1 MD4300 B1 MD 4300B1
- Authority
- MD
- Moldova
- Prior art keywords
- liver cancer
- cell proliferation
- inhibitor
- hepg2 cell
- thiosemicarbazono
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals and can be used in medicine as cytostatic agent in the prophylaxis and treatment of liver cancer.Summary of the invention consists in the fact that as inhibitor of HepG2 cell proliferation in liver cancer is proposed the use of a new compound, chloro-¢2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel of formula:The claimed compound exhibits itself as an effective inhibitor of HepG2 cell proliferation in liver cancer at concentrations of 10-5 - 10-6 mol/L.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120128A MD4300C1 (en) | 2012-12-28 | 2012-12-28 | Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20120128A MD4300C1 (en) | 2012-12-28 | 2012-12-28 | Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4300B1 true MD4300B1 (en) | 2014-08-31 |
MD4300C1 MD4300C1 (en) | 2015-03-31 |
Family
ID=51485231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20120128A MD4300C1 (en) | 2012-12-28 | 2012-12-28 | Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4300C1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4407C1 (en) * | 2015-04-29 | 2016-10-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD890G2 (en) * | 1996-06-24 | 1998-07-31 | Николае ЕРЕМИЯ | Method for animals immunologic system potetiation |
CN102038934B (en) * | 2005-11-03 | 2012-08-29 | 福建医科大学 | Application of cucurmosin in preparation of drug for treating breast cancer |
CA2649324A1 (en) * | 2006-04-12 | 2007-10-25 | Jean-Damien Charrier | Tetrahydropteridines useful as inhibitors of protein kinases |
CN101204401B (en) * | 2007-12-14 | 2010-05-19 | 中国科学院南海海洋研究所 | Sea hedgehog extractive, preparation method and anticancer application thereof |
CN100569781C (en) * | 2007-12-14 | 2009-12-16 | 中国科学院南海海洋研究所 | A kind of dimeric flavones compound and preparation method thereof and the application in the preparation cancer therapy drug |
CN101333236A (en) * | 2008-08-05 | 2008-12-31 | 浙江大学 | Method for preparing clitocine and applications in antineoplastic medicaments |
CN102219822B (en) * | 2011-03-24 | 2013-01-09 | 上海交通大学 | Ganoderic acid T amide derivative TLTO-A and synthetic method and application thereof |
-
2012
- 2012-12-28 MD MDA20120128A patent/MD4300C1/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4407C1 (en) * | 2015-04-29 | 2016-10-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Also Published As
Publication number | Publication date |
---|---|
MD4300C1 (en) | 2015-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |