MD4434C1 - Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor - Google Patents
Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitorInfo
- Publication number
- MD4434C1 MD4434C1 MDA20150097A MD20150097A MD4434C1 MD 4434 C1 MD4434 C1 MD 4434C1 MD A20150097 A MDA20150097 A MD A20150097A MD 20150097 A MD20150097 A MD 20150097A MD 4434 C1 MD4434 C1 MD 4434C1
- Authority
- MD
- Moldova
- Prior art keywords
- myeloid leukemia
- cell proliferation
- human myeloid
- carbothiohydrazide
- morpholin
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry and medicine, namely to the use of an organic compound from the class of thiosemicarbazones as a human myeloid leukemia HL-60 cell proliferation inhibitor and can be used in medicine in the prevention and treatment of leukoses.Summary of the invention consists in the use as a human myeloid leukemia HL-60 cell proliferation inhibitor of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide of formula:This compound has a significant cytostatic activity, inclusively at a concentration of 10-7 mol/L, with respect to human myeloid leukemia HL-60 cells.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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MDA20150097A MD4434C1 (en) | 2015-10-09 | 2015-10-09 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20150097A MD4434C1 (en) | 2015-10-09 | 2015-10-09 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4434B1 MD4434B1 (en) | 2016-09-30 |
MD4434C1 true MD4434C1 (en) | 2017-04-30 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MDA20150097A MD4434C1 (en) | 2015-10-09 | 2015-10-09 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
Country Status (1)
Country | Link |
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MD (1) | MD4434C1 (en) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1985000955A1 (en) * | 1983-08-22 | 1985-03-14 | A/S Cheminova | A biocidal, particularly fungicidal and/or bactericidal composition and thiosemicarbazones and metal complexes thereof for use in the composition |
US4596798A (en) * | 1982-03-30 | 1986-06-24 | The United States Of America As Represented By The Secretary Of The Army | 2-acetylpyridine thiosemicarbazones as antiviral agents |
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
US20030166658A1 (en) * | 2000-06-05 | 2003-09-04 | Johann Hofmann | Heterocyclic hydrazones for use as anti-cancer agents |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4393B1 (en) * | 2015-09-04 | 2016-01-31 | Universitatea De Stat Din Moldova | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
MD4407B1 (en) * | 2015-04-29 | 2016-03-31 | Universitatea De Stat Din Moldova | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
-
2015
- 2015-10-09 MD MDA20150097A patent/MD4434C1/en not_active IP Right Cessation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4596798A (en) * | 1982-03-30 | 1986-06-24 | The United States Of America As Represented By The Secretary Of The Army | 2-acetylpyridine thiosemicarbazones as antiviral agents |
WO1985000955A1 (en) * | 1983-08-22 | 1985-03-14 | A/S Cheminova | A biocidal, particularly fungicidal and/or bactericidal composition and thiosemicarbazones and metal complexes thereof for use in the composition |
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
US5721259A (en) * | 1992-05-13 | 1998-02-24 | Yale University | Method of using 2-formylpyridine thiosemicarbazone compounds |
US20030166658A1 (en) * | 2000-06-05 | 2003-09-04 | Johann Hofmann | Heterocyclic hydrazones for use as anti-cancer agents |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4407B1 (en) * | 2015-04-29 | 2016-03-31 | Universitatea De Stat Din Moldova | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
MD4393B1 (en) * | 2015-09-04 | 2016-01-31 | Universitatea De Stat Din Moldova | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
Non-Patent Citations (5)
Title |
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Amandha KAISER DA SILVA. Complexos Heterolepticos de Ouro(III) como Potenciais Antitumorais e Anti-Trypanosoma cruzi// Dissertacao apresentada ao Instituto de Quimica de Sao Carlos. P. 31 // Sao Carlos, 2015, Data publicare: 2015-05-22, regasit la 2016.07.18, url: http://www.teses.usp.br/teses/disponiveis/75/75135/tde-20052015-154103/publico/AmandhaKaiserdaSilvarevisado.pdf pag. 31 * |
ARORA Sh., AGARVAL Sh., SINGHAL Sh. Anticancer activities of thiosemicarbazides/thiosemicarbazones: a Review. Int. J. Pharmacy and Pharmaceutical sciences, vol. 6, Issuie 9, 2014. Regăsit în Internet la 2016.07.21, url: http://innovareacademics.in/journals/index.php/ijpps/article/view/1837 pag.1-2 * |
D.KOVALA-DEMERTZI et al. In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: synthesis, spectroscopical study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents. Eur. J. Med. Chem., v. 44, p. 1296-1302, 2009. Regăsit în Internet la 2016.07.20, url: https://www.researchgate.net/profile/Alexandros_Alexandratos2/publication/230792819_In_vitro_and_in_vivo_antitumor_activity_of_platinum(II)_complexes_withthiosemicarbazones_derived_from_2-formyl_and_2-acetyl_pyridine_andcontaining_ring_incorporated_at_N(4)-position_Synthesis_spectroscopicstudy_and_crystal_structure_of_platinum(II)_complexes_with_thiosemicarbazonespotential_anticancer_agents/links/0912f504724d66065a000000.pdf pag.1299, Table 4, compound (2). * |
Kasuga N.C., Onodera K., Nakano S., Hazashi K., Nomiya K. Synthesis, crystal structures and antimicrobial activities of 6-coordinate antimony(III) complexes with tridentate 2-acetylpyridine thiosemicarbazone, bis(thiosemicarbazone) and semicarbazone ligands. J. Inorg. Biochem. 2006 July, 100, p. 1176-1186 DOI: 10.1016/j.inorbio.2006.01.037 * |
Serda M. et al. (2014) Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships. PLOS ONE 9(10): e110291. doi: 10.1371/journal.pone.0110291. Published October 16, 2014. Regăsit în Internet la 2016.07.18 url: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110291 page 6 Figure5, chelator 1c; pag. 7 Table 1, chelator 1c * |
Also Published As
Publication number | Publication date |
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MD4434B1 (en) | 2016-09-30 |
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Legal Events
Date | Code | Title | Description |
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FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |