MD4393B1 - Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper - Google Patents

Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper

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Publication number
MD4393B1
MD4393B1 MDA20150083A MD20150083A MD4393B1 MD 4393 B1 MD4393 B1 MD 4393B1 MD A20150083 A MDA20150083 A MD A20150083A MD 20150083 A MD20150083 A MD 20150083A MD 4393 B1 MD4393 B1 MD 4393B1
Authority
MD
Moldova
Prior art keywords
myeloid leukemia
human myeloid
carbothiohydrazido
ylmethylidene
nitrato
Prior art date
Application number
MDA20150083A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4393C1 (en
Inventor
Aurelian Gulea
Anastasia PAHOLNIŢCAIA
Donald Poirier
Victor Ţapcov
Original Assignee
Universitatea De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatea De Stat Din Moldova filed Critical Universitatea De Stat Din Moldova
Priority to MDA20150083A priority Critical patent/MD4393C1/en
Publication of MD4393B1 publication Critical patent/MD4393B1/en
Publication of MD4393C1 publication Critical patent/MD4393C1/en

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Abstract

The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals and can find application in medicine for the prevention and treatment of human myeloid leukemia.Summary of the invention consists in that as an inhibitor of human myeloid leukemia (HL-60 cells) is proposed nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper of Formula:The claimed compound inhibits the growth and reproduction of 72% of human myeloid leukemia HL-60 cells at a concentration of 10-7 mol/L.
MDA20150083A 2015-09-04 2015-09-04 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper MD4393C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20150083A MD4393C1 (en) 2015-09-04 2015-09-04 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20150083A MD4393C1 (en) 2015-09-04 2015-09-04 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper

Publications (2)

Publication Number Publication Date
MD4393B1 true MD4393B1 (en) 2016-01-31
MD4393C1 MD4393C1 (en) 2016-08-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20150083A MD4393C1 (en) 2015-09-04 2015-09-04 Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper

Country Status (1)

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MD (1) MD4393C1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465607A (en) * 1965-08-28 1968-11-30 Bayer Ag Process for the production of thiosemicarbazones
GB1448295A (en) * 1974-05-01 1976-09-02 Farmaceutici Italia Thiosemicarbazones
DK383183A (en) * 1983-08-22 1985-02-23 Cheminova As BIOCID, NON-FUNGICID AND / OR BACTERICID, AGENT AND THIOSEMIC CARBONZONE AND METAL COMPLEXES THEREOF FOR USE IN THE AGENT
US5281715A (en) * 1992-05-13 1994-01-25 Yale University 2-formylpyridine thiosemicarbazone compounds
MD3098G2 (en) * 2006-01-03 2007-02-28 Государственный Университет Молд0 Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides
MD20110040A1 (en) * 2011-05-10 2012-11-30 Государственный Университет Молд0 Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate
MD4190C1 (en) * 2011-06-16 2013-07-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper}
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4434C1 (en) * 2015-10-09 2017-04-30 Государственный Университет Молд0 Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor

Also Published As

Publication number Publication date
MD4393C1 (en) 2016-08-31

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees