MD4393B1 - Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper - Google Patents
Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copperInfo
- Publication number
- MD4393B1 MD4393B1 MDA20150083A MD20150083A MD4393B1 MD 4393 B1 MD4393 B1 MD 4393B1 MD A20150083 A MDA20150083 A MD A20150083A MD 20150083 A MD20150083 A MD 20150083A MD 4393 B1 MD4393 B1 MD 4393B1
- Authority
- MD
- Moldova
- Prior art keywords
- myeloid leukemia
- human myeloid
- carbothiohydrazido
- ylmethylidene
- nitrato
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry, namely to the synthesis of coordinative compounds from the class of thiosemicarbazonates of transition metals and can find application in medicine for the prevention and treatment of human myeloid leukemia.Summary of the invention consists in that as an inhibitor of human myeloid leukemia (HL-60 cells) is proposed nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper of Formula:The claimed compound inhibits the growth and reproduction of 72% of human myeloid leukemia HL-60 cells at a concentration of 10-7 mol/L.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20150083A MD4393C1 (en) | 2015-09-04 | 2015-09-04 | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20150083A MD4393C1 (en) | 2015-09-04 | 2015-09-04 | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4393B1 true MD4393B1 (en) | 2016-01-31 |
MD4393C1 MD4393C1 (en) | 2016-08-31 |
Family
ID=55235455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150083A MD4393C1 (en) | 2015-09-04 | 2015-09-04 | Inhibitor of human myeloid leukemia HL-60 cells based on nitrato-[N′-(1-pyridine-2-ylmethylidene)-morpholine-4-carbothiohydrazido(1-)]copper |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4393C1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH465607A (en) * | 1965-08-28 | 1968-11-30 | Bayer Ag | Process for the production of thiosemicarbazones |
GB1448295A (en) * | 1974-05-01 | 1976-09-02 | Farmaceutici Italia | Thiosemicarbazones |
DK383183A (en) * | 1983-08-22 | 1985-02-23 | Cheminova As | BIOCID, NON-FUNGICID AND / OR BACTERICID, AGENT AND THIOSEMIC CARBONZONE AND METAL COMPLEXES THEREOF FOR USE IN THE AGENT |
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
MD3098G2 (en) * | 2006-01-03 | 2007-02-28 | Государственный Университет Молд0 | Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia |
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4190C1 (en) * | 2011-06-16 | 2013-07-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
-
2015
- 2015-09-04 MD MDA20150083A patent/MD4393C1/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
Also Published As
Publication number | Publication date |
---|---|
MD4393C1 (en) | 2016-08-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |