MD4407B1 - Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate - Google Patents
Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrateInfo
- Publication number
- MD4407B1 MD4407B1 MDA20150041A MD20150041A MD4407B1 MD 4407 B1 MD4407 B1 MD 4407B1 MD A20150041 A MDA20150041 A MD A20150041A MD 20150041 A MD20150041 A MD 20150041A MD 4407 B1 MD4407 B1 MD 4407B1
- Authority
- MD
- Moldova
- Prior art keywords
- myeloid leukemia
- human myeloid
- ylmethylidene
- hydrazinecarbothioamide
- prop
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry, namely to a coordinative compound from the class of thiosemicarbazonates of transition metals and may find application in medicine for the prevention and treatment of human myeloid leukemia.Summary of the invention consists in that as an inhibitor of human myeloid leukemia HL-60 cells is proposed the new bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate compound of formula:The claimed compound expands the range of highly active inhibitors of human myeloid leukemia cells.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20150041A MD4407C1 (en) | 2015-04-29 | 2015-04-29 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20150041A MD4407C1 (en) | 2015-04-29 | 2015-04-29 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4407B1 true MD4407B1 (en) | 2016-03-31 |
MD4407C1 MD4407C1 (en) | 2016-10-31 |
Family
ID=55646048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150041A MD4407C1 (en) | 2015-04-29 | 2015-04-29 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4407C1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
MD4520B1 (en) * | 2016-12-16 | 2017-10-31 | Государственный Университет Молд0 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1448295A (en) * | 1974-05-01 | 1976-09-02 | Farmaceutici Italia | Thiosemicarbazones |
US4657903A (en) * | 1982-03-31 | 1987-04-14 | The United States Of America As Represented By The Secretary Of The Army | Transition metal complexes of the selenium analogs of 2-acetyl- and 2-propionylpyridine thiosemicarbazones useful for treating malarial infections and leukemia |
DK383183A (en) * | 1983-08-22 | 1985-02-23 | Cheminova As | BIOCID, NON-FUNGICID AND / OR BACTERICID, AGENT AND THIOSEMIC CARBONZONE AND METAL COMPLEXES THEREOF FOR USE IN THE AGENT |
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
WO2004069801A1 (en) * | 2003-02-05 | 2004-08-19 | Unisearch Limited | Metal ion chelators and therapeutic use thereof |
MD3098G2 (en) * | 2006-01-03 | 2007-02-28 | Государственный Университет Молд0 | Dihydrate of di( -Ophenoxy)-di[N-(2-oxy-1-benzal)-N1- -oxyfuralhydrazine(2-)copper] with properties of inhibitor of the human myeloid leukemia |
MD3655G2 (en) * | 2007-09-03 | 2009-02-28 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper |
MD3890G2 (en) * | 2008-09-08 | 2009-12-31 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides |
MD20110040A1 (en) * | 2011-05-10 | 2012-11-30 | Государственный Университет Молд0 | Inhibitors of human myeloid leukemia based on 2-[2-(pyridine-2-ilmethylidene)hydrazine]-1,3-benzothiazole and 2-[2-(1-pyridine-2-ilethylidene)hydrazine]-1,3-benzothiazole dihydrate |
MD4190C1 (en) * | 2011-06-16 | 2013-07-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on {bis[2-(3,5-dibrom-2-hydroxyphenyl)-2-oxoethyl-piperidin-1-carbodithioato(1-)-O,O′]copper} |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4300C1 (en) * | 2012-12-28 | 2015-03-31 | Государственный Университет Молд0 | Inhibitor of HepG2 cell proliferation in liver cancer based on chloro-[2-phenyl(pyridine-2-yl)methanone-4-(3-methoxyphenyl)thiosemicarbazono]nickel |
CN103951602B (en) * | 2014-03-19 | 2016-06-15 | 河南理工大学 | There is the synthetic method of pyrroles's thiosemicarbazones copper of anti-tumor activity, nickel complex |
-
2015
- 2015-04-29 MD MDA20150041A patent/MD4407C1/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD4434C1 (en) * | 2015-10-09 | 2017-04-30 | Государственный Университет Молд0 | Use of N'-[1-(2-pyridyl)ethylidene]morpholin-4-carbothiohydrazide as a human myeloid leukemia HL-60 cell proliferation inhibitor |
MD4520B1 (en) * | 2016-12-16 | 2017-10-31 | Государственный Университет Молд0 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Also Published As
Publication number | Publication date |
---|---|
MD4407C1 (en) | 2016-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |