MD3995C2 - Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation - Google Patents

Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

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Publication number
MD3995C2
MD3995C2 MDA20090050A MD20090050A MD3995C2 MD 3995 C2 MD3995 C2 MD 3995C2 MD A20090050 A MDA20090050 A MD A20090050A MD 20090050 A MD20090050 A MD 20090050A MD 3995 C2 MD3995 C2 MD 3995C2
Authority
MD
Moldova
Prior art keywords
inhibitor
cell proliferation
mammary cancer
dibromosalicylidenethiosemicarbazonato
aminobenzenesulfamido
Prior art date
Application number
MDA20090050A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD3995B1 (en
Inventor
Аурелиан ГУЛЯ
Виктор ЦАПКОВ
Дональд ПОЙРИЕР
Валериу РУДИК
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20090050A priority Critical patent/MD3995C2/en
Publication of MD3995B1 publication Critical patent/MD3995B1/en
Publication of MD3995C2 publication Critical patent/MD3995C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to chemistry, namely to the use of coordinative compound from the class of thiosemicarbazonates of transition metals as inhibitor of mammary cancer T-47D cell proliferation.Summary of the invention consists in the use as inhibitor of mammary cancer T-47D cell proliferation of di(µ-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} of formula:
MDA20090050A 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation MD3995C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Publications (2)

Publication Number Publication Date
MD3995B1 MD3995B1 (en) 2009-12-31
MD3995C2 true MD3995C2 (en) 2010-07-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20090050A MD3995C2 (en) 2009-05-11 2009-05-11 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation

Country Status (1)

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MD (1) MD3995C2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4520C1 (en) * 2016-12-16 2018-05-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

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JPH01156930A (en) * 1987-08-12 1989-06-20 Immunomedics Inc Production of radioactively labelled composite
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
MD195C2 (en) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова The copper complexes with antistaphylococcus properties
RU2049789C1 (en) * 1988-11-25 1995-12-10 Сис Био Интернасьональ С.А. Nitride complex of transient metal
SU639252A1 (en) * 1975-07-09 1999-12-27 РќРѕСЃРєРѕРІ Р¤.РЎ. PHOSPHORYLATED THIOSEMICARBAZONES WITH ANTI-VIRUS ACTIVITY
MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
RU2198875C2 (en) * 1997-05-15 2003-02-20 Вион Фармасьютикалз, Инк. Methods of synthesis of pyridine-2-carboxaldehyde thiosemicarbazones and intermediate pyridine-2-carboxaldehydes
RU2199531C2 (en) * 1997-05-15 2003-02-27 Вион Фармасьютикалз, Инк. Pyridine-2-carboxaldehyde thiosemicarbazones and pharmaceutical composition based on thereof
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
US20040014647A1 (en) * 2000-12-22 2004-01-22 Lee Hyang Woo Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them
MD2942C2 (en) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper)
EA007179B1 (en) * 2000-10-02 2006-08-25 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си New thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors
CN1891701A (en) * 2005-07-07 2007-01-10 桑迪亚医药技术（上海）有限责任公司 Heteraromatic ring thiosemicarbazone compound, and its derivatives and their use forpreparing antitumour medicine
MD3124C2 (en) * 2005-05-25 2007-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II)
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
EA200870405A1 (en) * 2006-04-03 2009-04-28 Глэксо Груп Лимитед METHOD FOR OBTAINING HETEROCYCLIC DERIVATIVES
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB897870A (en) * 1959-06-15 1962-05-30 Ici Ltd s-triazolo[2, 3-c]pyrimidine derivatives
SU639252A1 (en) * 1975-07-09 1999-12-27 РќРѕСЃРєРѕРІ Р¤.РЎ. PHOSPHORYLATED THIOSEMICARBAZONES WITH ANTI-VIRUS ACTIVITY
JPH01156930A (en) * 1987-08-12 1989-06-20 Immunomedics Inc Production of radioactively labelled composite
RU2049789C1 (en) * 1988-11-25 1995-12-10 Сис Био Интернасьональ С.А. Nitride complex of transient metal
US5124351A (en) * 1989-02-27 1992-06-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pharmaceutical compositions for the treatment of cancers susceptible to treatment with the copper complex of S-(methylthio)-DL-homocysteine or the L-enantimorph thereof
MD195C2 (en) * 1994-12-05 1995-11-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова The copper complexes with antistaphylococcus properties
RU2199531C2 (en) * 1997-05-15 2003-02-27 Вион Фармасьютикалз, Инк. Pyridine-2-carboxaldehyde thiosemicarbazones and pharmaceutical composition based on thereof
RU2198875C2 (en) * 1997-05-15 2003-02-20 Вион Фармасьютикалз, Инк. Methods of synthesis of pyridine-2-carboxaldehyde thiosemicarbazones and intermediate pyridine-2-carboxaldehydes
EA007179B1 (en) * 2000-10-02 2006-08-25 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си New thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors
US20040014647A1 (en) * 2000-12-22 2004-01-22 Lee Hyang Woo Apicidin-derivatives, their synthetic methods and anti-tumor compositions containing them
MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
MD2942C2 (en) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper)
MD3124C2 (en) * 2005-05-25 2007-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II)
CN1891701A (en) * 2005-07-07 2007-01-10 桑迪亚医药技术（上海）有限责任公司 Heteraromatic ring thiosemicarbazone compound, and its derivatives and their use forpreparing antitumour medicine
EA200870405A1 (en) * 2006-04-03 2009-04-28 Глэксо Груп Лимитед METHOD FOR OBTAINING HETEROCYCLIC DERIVATIVES
MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
MD3890G2 (en) * 2008-09-08 2009-12-31 Государственный Университет Молд0 Inhibitors of human myeloid leukemia on base of coordinative compounds of copper(II) with salicylidene thiocarbazides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Горбунова В. А. Новые цитостатики в лечении злокачественных опухолей. Москва, Медицина, 1998, с. 128 *

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees