MD3124C2 - Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II) - Google Patents
Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II) Download PDFInfo
- Publication number
- MD3124C2 MD3124C2 MDA20050150A MD20050150A MD3124C2 MD 3124 C2 MD3124 C2 MD 3124C2 MD A20050150 A MDA20050150 A MD A20050150A MD 20050150 A MD20050150 A MD 20050150A MD 3124 C2 MD3124 C2 MD 3124C2
- Authority
- MD
- Moldova
- Prior art keywords
- copper
- medicine
- sulfanilamide
- viii
- vii
- Prior art date
Links
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 title abstract 2
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 title abstract 2
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention refers to chemistry and medicine, namely to the synthesis of a series of biologically active chelate compounds of copper from the class of thiosemicarbazidates of the transition metals and may find its application in medicine and veterinary medicine.Summary of the invention consists in that as antimicrobial preparations there are proposed the sulfanilamide-containing salcicylidenethiosemicarbazidates of copper(II) of formula:where X=H(I-VI, VIII-XI), Br(VII); R=H(I-VII), C6H3-(VIII-XI);The result of the invention consists in the synthesis of compounds I-XI, having low toxicity, manifesting antimicrobial activity about the majority of microorganisms, and in the case of gram-positive strains manifest bacteriostatic and bactericidal activity 2…160 times higher than their structural analogue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20050150A MD3124C2 (en) | 2005-05-25 | 2005-05-25 | Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20050150A MD3124C2 (en) | 2005-05-25 | 2005-05-25 | Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD3124B1 MD3124B1 (en) | 2006-08-31 |
| MD3124C2 true MD3124C2 (en) | 2007-03-31 |
Family
ID=36992836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20050150A MD3124C2 (en) | 2005-05-25 | 2005-05-25 | Sulfanilamide-containing salicylidenethiosemicarbazidates of copper(II) |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD3124C2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
| MD4112C1 (en) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
| MD4127C1 (en) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Use of di(m-S)-bis{chloro-[1-(pyridine-2-yl)ethanone-4-methylthiosemicarbazonato(1-)]copper} as substance with antimicrobial activity against Staphylococcus aureus |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4133C1 (en) * | 2010-07-19 | 2012-05-31 | Государственный Университет Молд0 | [(2-Carbamotioylhydrazone)propionato(2-)]-(4-aminobenzenesulfonamide)copper, manifesting antimicrobial activity against bacteria of the genus Bacillus cereus |
| MD4179C1 (en) * | 2011-05-23 | 2013-02-28 | Государственный Университет Молд0 | Coordinative compounds of copper(II), containing 4-phenylthiosemicarbazone 2-formylpyridine and sulfonylamides, exhibiting antimicrobial activity against bacteria of Bacillus cereus species |
| MD4252C1 (en) * | 2012-05-31 | 2014-05-31 | Государственный Университет Молд0 | Catena-(µ-nitrato)[µ-(2-hydroxybenzylidene)-4-prop-2-en-1-ylthiocarbazone-S]silver with antimicrobial activity against bacteria Salmonella abony |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2942B2 (en) * | 2004-04-27 | 2005-12-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Di(-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
-
2005
- 2005-05-25 MD MDA20050150A patent/MD3124C2/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2942B2 (en) * | 2004-04-27 | 2005-12-31 | Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova | Di(-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
| MD4112C1 (en) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
| MD4127C1 (en) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Use of di(m-S)-bis{chloro-[1-(pyridine-2-yl)ethanone-4-methylthiosemicarbazonato(1-)]copper} as substance with antimicrobial activity against Staphylococcus aureus |
Also Published As
| Publication number | Publication date |
|---|---|
| MD3124B1 (en) | 2006-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |