MD2003C2 - Copper chelate compounds (II) with antimicrobial and antimycotic activity - Google Patents
Copper chelate compounds (II) with antimicrobial and antimycotic activity Download PDFInfo
- Publication number
- MD2003C2 MD2003C2 MDA20010012A MD20010012A MD2003C2 MD 2003 C2 MD2003 C2 MD 2003C2 MD A20010012 A MDA20010012 A MD A20010012A MD 20010012 A MD20010012 A MD 20010012A MD 2003 C2 MD2003 C2 MD 2003C2
- Authority
- MD
- Moldova
- Prior art keywords
- antimicrobial
- ch3py
- chelate compounds
- copper chelate
- medicine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 239000013522 chelant Substances 0.000 title abstract 2
- 229910052802 copper Inorganic materials 0.000 title abstract 2
- 239000010949 copper Substances 0.000 title abstract 2
- 230000001857 anti-mycotic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 230000000843 anti-fungal effect Effects 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 229940042396 direct acting antivirals thiosemicarbazones Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- -1 metals thiosemicarbazones Chemical class 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry and medicine, namely to the co-ordinative compounds of the transient metals thiosemicarbazones class.Summary of the invention consists in obtaining copper chelate compounds of the formula:where A=NH3 (I), 2-CH3Py(II), 3-CH3Py (III), 4-CH3Py (IV), 2-NH2Py (V), 5-nitrofurfurylidene-2-isonicotinoilhydrazone (VI); n = 0 (II, III, V), 1 (IV), 2 (I), 3 (VI) with antimicrobial and antifungal activity.They may be applied in medicine and veterinary medicine in the capacity of antibacterial and antifungal preparations with wide spectrum of biological activity or in the capacity of ingredients for obtaining of selective nutrient media.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20010012A MD2003C2 (en) | 2001-01-10 | 2001-01-10 | Copper chelate compounds (II) with antimicrobial and antimycotic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20010012A MD2003C2 (en) | 2001-01-10 | 2001-01-10 | Copper chelate compounds (II) with antimicrobial and antimycotic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD2003B1 MD2003B1 (en) | 2002-09-30 |
| MD2003C2 true MD2003C2 (en) | 2003-03-31 |
Family
ID=19739725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20010012A MD2003C2 (en) | 2001-01-10 | 2001-01-10 | Copper chelate compounds (II) with antimicrobial and antimycotic activity |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD2003C2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2942C2 (en) * | 2004-04-27 | 2006-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
| MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
| MD4112C1 (en) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
| MD4127C1 (en) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Use of di(m-S)-bis{chloro-[1-(pyridine-2-yl)ethanone-4-methylthiosemicarbazonato(1-)]copper} as substance with antimicrobial activity against Staphylococcus aureus |
| MD4194C1 (en) * | 2012-01-23 | 2013-08-31 | Государственный Университет Молд0 | Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4133C1 (en) * | 2010-07-19 | 2012-05-31 | Государственный Университет Молд0 | [(2-Carbamotioylhydrazone)propionato(2-)]-(4-aminobenzenesulfonamide)copper, manifesting antimicrobial activity against bacteria of the genus Bacillus cereus |
| MD4258C1 (en) * | 2012-05-31 | 2014-06-30 | Государственный Университет Молд0 | The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans |
| MD4252C1 (en) * | 2012-05-31 | 2014-05-31 | Государственный Университет Молд0 | Catena-(µ-nitrato)[µ-(2-hydroxybenzylidene)-4-prop-2-en-1-ylthiocarbazone-S]silver with antimicrobial activity against bacteria Salmonella abony |
| MD4383C1 (en) * | 2015-03-06 | 2016-06-30 | Государственный Университет Молд0 | Acetato-(8-formylquinolinethiosemicarbazono)copper(II) compound, exhibiting antibacterial activity |
| MD4402C1 (en) * | 2015-09-04 | 2016-09-30 | Государственный Университет Молд0 | Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
-
2001
- 2001-01-10 MD MDA20010012A patent/MD2003C2/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1812B1 (en) * | 2000-12-29 | 2001-12-31 | Univ Nicolae Testemitanu | Copper complexes as bacteria and fungi inhibitors |
| MD1812C2 (en) * | 2000-12-29 | 2002-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Copper complexes as bacteria and fungi inhibitors |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2942C2 (en) * | 2004-04-27 | 2006-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
| MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
| MD4112C1 (en) * | 2010-05-17 | 2011-12-31 | Государственный Университет Молд0 | Coordinative compounds of copper with 4-(dimethylphenyl)-thiosemicarbazones of 2-formylpyridine |
| MD4127C1 (en) * | 2010-10-06 | 2012-04-30 | Государственный Университет Молд0 | Use of di(m-S)-bis{chloro-[1-(pyridine-2-yl)ethanone-4-methylthiosemicarbazonato(1-)]copper} as substance with antimicrobial activity against Staphylococcus aureus |
| MD4194C1 (en) * | 2012-01-23 | 2013-08-31 | Государственный Университет Молд0 | Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans |
Also Published As
| Publication number | Publication date |
|---|---|
| MD2003B1 (en) | 2002-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |