MD4194C1 - Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans - Google Patents
Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicansInfo
- Publication number
- MD4194C1 MD4194C1 MDA20120009A MD20120009A MD4194C1 MD 4194 C1 MD4194 C1 MD 4194C1 MD A20120009 A MDA20120009 A MD A20120009A MD 20120009 A MD20120009 A MD 20120009A MD 4194 C1 MD4194 C1 MD 4194C1
- Authority
- MD
- Moldova
- Prior art keywords
- copper
- thiosemicarbazido
- hydroxybenzylidene
- dibromo
- pyridin
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry and medicine, in particular to biologically active polynuclear coordinative compounds of copper from the class of thiosemicarbazonates of transition metals.Summary of the invention consists in the synthesis of a new compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate of the formula:The compound exhibits antifungal activity against Candida albicans and can be used in medicine and veterinary medicine for the prevention and treatment of mycoses.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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MDA20120009A MD4194C1 (en) | 2012-01-23 | 2012-01-23 | Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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MDA20120009A MD4194C1 (en) | 2012-01-23 | 2012-01-23 | Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans |
Publications (2)
Publication Number | Publication Date |
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MD4194B1 MD4194B1 (en) | 2013-01-31 |
MD4194C1 true MD4194C1 (en) | 2013-08-31 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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MDA20120009A MD4194C1 (en) | 2012-01-23 | 2012-01-23 | Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans |
Country Status (1)
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MD (1) | MD4194C1 (en) |
Families Citing this family (11)
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---|---|---|---|---|
MD4255C1 (en) * | 2012-11-05 | 2014-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Tetraisothiocyanatocobaltate of bis(nicotinoylhydrazone)-2,6-diformil-4-methylphenol(methanol)(aqua)cobalt(II) and process for cultivation of microalga Porphyridium cruentum with the use thereof |
MD4253C1 (en) * | 2012-11-05 | 2014-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Sulphato-bis(nicotinoylhydrazone)-2,6-diacetylpyridin-cobalt(II )monomethanol trihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof |
MD4254C1 (en) * | 2012-11-05 | 2014-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Hexafluorotitanate-bis[(dimethylglyoximato)-di-(thiocarbamide)cobalt(III)] dihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof |
MD4303C1 (en) * | 2013-07-05 | 2015-04-30 | Институт Химии Академии Наук Молдовы | Bis(dimethylglyoximato)chloro(isonicotinoylhydrazone-2-hydroxy-1-naphthaldehyde)cobalt(III) and process for cultivation of Porphyridium cruentum microalga with the use thereof |
MD4326C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
MD4327C1 (en) * | 2013-10-22 | 2015-09-30 | Институт Химии Академии Наук Молдовы | N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use |
MD4366C1 (en) * | 2014-07-09 | 2016-03-31 | Институт Химии Академии Наук Молдовы | Bis[1-phenyl-3-methyl-6-(pyridinium-4-il)-4,5-diaza-hexa-1,3,5-triene-1-hydroxy-6-olato-O1,N4,O6]iron(II)sulphate tetrahydrate and process for cultivation of microalga Porphyridium cruentum with its use |
MD4367C1 (en) * | 2014-07-09 | 2016-03-31 | Институт Химии Академии Наук Молдовы | Bis[N'-(2-hydroxy-kO-3-carboxybenzilidene)pyridine-3-carbohydrazidate(-1)-k2N',O]iron(III) perchlorate - water (4/5) and process for cultivation of microalga Porphyridium cruentum with its use |
MD4365C1 (en) * | 2014-07-09 | 2016-03-31 | Институт Химии Академии Наук Молдовы | Bis[1-phenyl-3-methyl-6-(pyridinium-4-yl)-4,5-diaza-hexa-1,3,5-triene-1,6-diolato-O1,N4,O6]iron(III) nitrate and process for cultivation of microalga Porphyridium cruentum with its use |
MD4356C1 (en) * | 2014-07-09 | 2016-02-29 | Институт Химии Академии Наук Молдовы | Bis[N'-(2-hydroxy-kO-benzylidene)pyridine-4-carbohydrazidate(-1)-k2N',O]iron(III) nitrate - water (2/3) and process for cultivation of microalga Porphyridium cruentum with its use |
MD4402C1 (en) * | 2015-09-04 | 2016-09-30 | Государственный Университет Молд0 | Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD1812C2 (en) * | 2000-12-29 | 2002-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Copper complexes as bacteria and fungi inhibitors |
MD2003C2 (en) * | 2001-01-10 | 2003-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Copper chelate compounds (II) with antimicrobial and antimycotic activity |
MD2861G2 (en) * | 2004-09-20 | 2006-04-30 | Государственный Университет Молд0 | (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity |
MD2942C2 (en) * | 2004-04-27 | 2006-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
MD3484G2 (en) * | 2007-02-12 | 2008-08-31 | Государственный Университет Молд0 | Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity |
-
2012
- 2012-01-23 MD MDA20120009A patent/MD4194C1/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD1812C2 (en) * | 2000-12-29 | 2002-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Copper complexes as bacteria and fungi inhibitors |
MD2003C2 (en) * | 2001-01-10 | 2003-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Copper chelate compounds (II) with antimicrobial and antimycotic activity |
MD2942C2 (en) * | 2004-04-27 | 2006-06-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper) |
MD2861G2 (en) * | 2004-09-20 | 2006-04-30 | Государственный Университет Молд0 | (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity |
MD3484G2 (en) * | 2007-02-12 | 2008-08-31 | Государственный Университет Молд0 | Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity |
Non-Patent Citations (2)
Title |
---|
Candida albicans, Wikipedia, the free enciclopedia, (regăsit în Internet la 2012.11.09, url: http://en.wikipedia.org/wiki/Candida_albicans ) * |
November 2011 release of the Cambridge Structural Database System (version 5.32) * |
Also Published As
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FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |