MD4194C1 - Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans - Google Patents

Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans

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Publication number
MD4194C1
MD4194C1 MDA20120009A MD20120009A MD4194C1 MD 4194 C1 MD4194 C1 MD 4194C1 MD A20120009 A MDA20120009 A MD A20120009A MD 20120009 A MD20120009 A MD 20120009A MD 4194 C1 MD4194 C1 MD 4194C1
Authority
MD
Moldova
Prior art keywords
copper
thiosemicarbazido
hydroxybenzylidene
dibromo
pyridin
Prior art date
Application number
MDA20120009A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4194B1 (en
Inventor
Аурелиан ГУЛЯ
Татьяна КЭПЭЦЫНЭ
Юрие ЧУМАКОВ
Каролина ЛОЗАН-ТЫРШУ
Петр ПЕТРЕНКО
Георге КОДИЦЭ
Виктор ЦАПКОВ
Валериу РУДИК
Original Assignee
Государственный Университет Молд0
Институт Прикладной Физики Академии Наук Молдовы
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0, Институт Прикладной Физики Академии Наук Молдовы filed Critical Государственный Университет Молд0
Priority to MDA20120009A priority Critical patent/MD4194C1/en
Publication of MD4194B1 publication Critical patent/MD4194B1/en
Publication of MD4194C1 publication Critical patent/MD4194C1/en

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Abstract

The invention relates to chemistry and medicine, in particular to biologically active polynuclear coordinative compounds of copper from the class of thiosemicarbazonates of transition metals.Summary of the invention consists in the synthesis of a new compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate of the formula:The compound exhibits antifungal activity against Candida albicans and can be used in medicine and veterinary medicine for the prevention and treatment of mycoses.
MDA20120009A 2012-01-23 2012-01-23 Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans MD4194C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120009A MD4194C1 (en) 2012-01-23 2012-01-23 Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120009A MD4194C1 (en) 2012-01-23 2012-01-23 Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans

Publications (2)

Publication Number Publication Date
MD4194B1 MD4194B1 (en) 2013-01-31
MD4194C1 true MD4194C1 (en) 2013-08-31

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MDA20120009A MD4194C1 (en) 2012-01-23 2012-01-23 Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans

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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4255C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Tetraisothiocyanatocobaltate of bis(nicotinoylhydrazone)-2,6-diformil-4-methylphenol(methanol)(aqua)cobalt(II) and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4253C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Sulphato-bis(nicotinoylhydrazone)-2,6-diacetylpyridin-cobalt(II )monomethanol trihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4254C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Hexafluorotitanate-bis[(dimethylglyoximato)-di-(thiocarbamide)cobalt(III)] dihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4303C1 (en) * 2013-07-05 2015-04-30 Институт Химии Академии Наук Молдовы Bis(dimethylglyoximato)chloro(isonicotinoylhydrazone-2-hydroxy-1-naphthaldehyde)cobalt(III) and process for cultivation of Porphyridium cruentum microalga with the use thereof
MD4326C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4327C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4366C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-il)-4,5-diaza-hexa-1,3,5-triene-1-hydroxy-6-olato-O1,N4,O6]iron(II)sulphate tetrahydrate and process for cultivation of microalga Porphyridium cruentum with its use
MD4367C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-3-carboxybenzilidene)pyridine-3-carbohydrazidate(-1)-k2N',O]iron(III) perchlorate - water (4/5) and process for cultivation of microalga Porphyridium cruentum with its use
MD4365C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-yl)-4,5-diaza-hexa-1,3,5-triene-1,6-diolato-O1,N4,O6]iron(III) nitrate and process for cultivation of microalga Porphyridium cruentum with its use
MD4356C1 (en) * 2014-07-09 2016-02-29 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-benzylidene)pyridine-4-carbohydrazidate(-1)-k2N',O]iron(III) nitrate - water (2/3) and process for cultivation of microalga Porphyridium cruentum with its use
MD4402C1 (en) * 2015-09-04 2016-09-30 Государственный Университет Молд0 Methyl-N'-[(2-hydroxynaphthalene-1-il)methylidene]-N-prop-2-en-1-ylhydrazonothioate, exhibiting antifungal activity against Candida albicans

Citations (5)

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Publication number Priority date Publication date Assignee Title
MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
MD2861G2 (en) * 2004-09-20 2006-04-30 Государственный Университет Молд0 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity
MD2942C2 (en) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper)
MD3484G2 (en) * 2007-02-12 2008-08-31 Государственный Университет Молд0 Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
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MD1812C2 (en) * 2000-12-29 2002-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper complexes as bacteria and fungi inhibitors
MD2003C2 (en) * 2001-01-10 2003-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Copper chelate compounds (II) with antimicrobial and antimycotic activity
MD2942C2 (en) * 2004-04-27 2006-06-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Di(µ-O)-bis(3,5-dibromosalicylidene thiosemicarbazonatocopper)
MD2861G2 (en) * 2004-09-20 2006-04-30 Государственный Университет Молд0 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity
MD3484G2 (en) * 2007-02-12 2008-08-31 Государственный Университет Молд0 Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity

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Title
Candida albicans, Wikipedia, the free enciclopedia, (regăsit în Internet la 2012.11.09, url: http://en.wikipedia.org/wiki/Candida_albicans ) *
November 2011 release of the Cambridge Structural Database System (version 5.32) *

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