MD4520C1 - N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor - Google Patents

N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

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Publication number
MD4520C1
MD4520C1 MDA20160141A MD20160141A MD4520C1 MD 4520 C1 MD4520 C1 MD 4520C1 MD A20160141 A MDA20160141 A MD A20160141A MD 20160141 A MD20160141 A MD 20160141A MD 4520 C1 MD4520 C1 MD 4520C1
Authority
MD
Moldova
Prior art keywords
breast cancer
cancer cells
ylmethylidene
hydrazinecarbothioamide
butoxyphenyl
Prior art date
Application number
MDA20160141A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD4520B1 (en
Inventor
Аурелиан ГУЛЯ
Наталия МИТКЕВИЧ
Виктор ЦАПКОВ
Валентин ГУДУМАК
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20160141A priority Critical patent/MD4520C1/en
Publication of MD4520B1 publication Critical patent/MD4520B1/en
Publication of MD4520C1 publication Critical patent/MD4520C1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to chemistry and medicine, namely to a biologically active organic compound of the thiosemicarbazide class and can be used in medicine as a cytotoxic drug in the prevention and treatment of breast cancer.Summary of the invention consists in the use of a novel compound N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide of formula:as T-47D breast cancer cells growth and reproduction inhibitor, which at a concentration of 10-7 mol/l inhibits the growth and multiplication of 44.2% of T-47D breast cancer cells.
MDA20160141A 2016-12-16 2016-12-16 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor MD4520C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20160141A MD4520C1 (en) 2016-12-16 2016-12-16 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20160141A MD4520C1 (en) 2016-12-16 2016-12-16 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

Publications (2)

Publication Number Publication Date
MD4520B1 MD4520B1 (en) 2017-10-31
MD4520C1 true MD4520C1 (en) 2018-05-31

Family

ID=60243236

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20160141A MD4520C1 (en) 2016-12-16 2016-12-16 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor

Country Status (1)

Country Link
MD (1) MD4520C1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281715A (en) * 1992-05-13 1994-01-25 Yale University 2-formylpyridine thiosemicarbazone compounds
AU2009213153A1 (en) * 2008-02-11 2009-08-20 Institute Of Enzymology, Biological Research Center, Hungarian Academy Of Sciences Compounds with MDR1-inverse activity
MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
WO2012033601A1 (en) * 2010-08-20 2012-03-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Thiosemicarbazones with mdr1 - inverse activity
MD4132C1 (en) * 2010-12-13 2012-05-31 Государственный Университет Молд0 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells
MD4215C1 (en) * 2012-07-09 2013-11-30 Государственный Университет Молд0 Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide
MD4349C1 (en) * 2014-06-23 2015-12-31 Государственный Университет Молд0 N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation
MD4407C1 (en) * 2015-04-29 2016-10-31 Государственный Университет Молд0 Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate

Also Published As

Publication number Publication date
MD4520B1 (en) 2017-10-31

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees