MD4520C1 - N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor - Google Patents
N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitorInfo
- Publication number
- MD4520C1 MD4520C1 MDA20160141A MD20160141A MD4520C1 MD 4520 C1 MD4520 C1 MD 4520C1 MD A20160141 A MDA20160141 A MD A20160141A MD 20160141 A MD20160141 A MD 20160141A MD 4520 C1 MD4520 C1 MD 4520C1
- Authority
- MD
- Moldova
- Prior art keywords
- breast cancer
- cancer cells
- ylmethylidene
- hydrazinecarbothioamide
- butoxyphenyl
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 4
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 4
- UUOPJNVEEGYJRI-UHFFFAOYSA-N 1-(4-butoxyphenyl)-3-(pyridin-2-ylmethylideneamino)thiourea Chemical compound C(CCC)OC1=CC=C(C=C1)NC(=S)NN=CC1=NC=CC=C1 UUOPJNVEEGYJRI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003966 growth inhibitor Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003583 thiosemicarbazides Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to chemistry and medicine, namely to a biologically active organic compound of the thiosemicarbazide class and can be used in medicine as a cytotoxic drug in the prevention and treatment of breast cancer.Summary of the invention consists in the use of a novel compound N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide of formula:as T-47D breast cancer cells growth and reproduction inhibitor, which at a concentration of 10-7 mol/l inhibits the growth and multiplication of 44.2% of T-47D breast cancer cells.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160141A MD4520C1 (en) | 2016-12-16 | 2016-12-16 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MDA20160141A MD4520C1 (en) | 2016-12-16 | 2016-12-16 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
MD4520B1 MD4520B1 (en) | 2017-10-31 |
MD4520C1 true MD4520C1 (en) | 2018-05-31 |
Family
ID=60243236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160141A MD4520C1 (en) | 2016-12-16 | 2016-12-16 | N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor |
Country Status (1)
Country | Link |
---|---|
MD (1) | MD4520C1 (en) |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5281715A (en) * | 1992-05-13 | 1994-01-25 | Yale University | 2-formylpyridine thiosemicarbazone compounds |
AU2009213153A1 (en) * | 2008-02-11 | 2009-08-20 | Institute Of Enzymology, Biological Research Center, Hungarian Academy Of Sciences | Compounds with MDR1-inverse activity |
MD3995C2 (en) * | 2009-05-11 | 2010-07-31 | Государственный Университет Молд0 | Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation |
WO2012033601A1 (en) * | 2010-08-20 | 2012-03-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Thiosemicarbazones with mdr1 - inverse activity |
MD4132C1 (en) * | 2010-12-13 | 2012-05-31 | Государственный Университет Молд0 | Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells |
MD4215C1 (en) * | 2012-07-09 | 2013-11-30 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia based on N-(4-(5-(pyridin-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-2-(pyridin-2-ylmethylen)-hydrazinecarbothioamide |
MD4349C1 (en) * | 2014-06-23 | 2015-12-31 | Государственный Университет Молд0 | N-(3-methoxyphenyl)-2-(pyridine-2-ylmethylene)-hydrazinecarbothioamide compound - inhibitor of human melanoma MeW-164 cell proliferation |
MD4407C1 (en) * | 2015-04-29 | 2016-10-31 | Государственный Университет Молд0 | Inhibitor of human myeloid leukemia HL-60 cells based on bis[N-(prop-2-en-1-yl)-2-(pyridine-2-ylmethylidene)hydrazinecarbothioamide]nickel(II) chloride hydrate |
-
2016
- 2016-12-16 MD MDA20160141A patent/MD4520C1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MD4520B1 (en) | 2017-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |