MD4132B1 - Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells - Google Patents

Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells

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Publication number
MD4132B1
MD4132B1 MDA20100137A MD20100137A MD4132B1 MD 4132 B1 MD4132 B1 MD 4132B1 MD A20100137 A MDA20100137 A MD A20100137A MD 20100137 A MD20100137 A MD 20100137A MD 4132 B1 MD4132 B1 MD 4132B1
Authority
MD
Moldova
Prior art keywords
copper
mammary cancer
thiosemicarbazonato
manifesting
methanone
Prior art date
Application number
MDA20100137A
Other languages
Moldavian (mo)
Romanian (ro)
Other versions
MD4132C1 (en
Inventor
Aurelian Gulea
Victor Tapcov
Tatiana Straistari
Donald Poirier
Victor Ţapcov
Original Assignee
Univ De Stat Din Moldova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ De Stat Din Moldova filed Critical Univ De Stat Din Moldova
Priority to MDA20100137A priority Critical patent/MD4132C1/en
Publication of MD4132B1 publication Critical patent/MD4132B1/en
Publication of MD4132C1 publication Critical patent/MD4132C1/en

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  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to chemistry and medicine, namely to a biologically active complex combination of copper with thiosemicarbazone, which can be used in medicine as a cytostatic preparation in the prevention and treatment of mammary cancer.Summary of the invention consists in the synthesis of a new coordinative compound of copper with 2-benzoylpyridine thiosemicarbazone, di(µ-S)-bis{chloro-¢phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} of formula:manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells.The technical result is to increase the range of coordinative compounds with anticancer activity, which at a concentration of 10-6 mol/L is about 4 times higher than the similar characteristics of the closest analogue from the class of copper thiosemicarbazonates.
MDA20100137A 2010-12-13 2010-12-13 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells MD4132C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (en) 2010-12-13 2010-12-13 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20100137A MD4132C1 (en) 2010-12-13 2010-12-13 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells

Publications (2)

Publication Number Publication Date
MD4132B1 true MD4132B1 (en) 2011-10-31
MD4132C1 MD4132C1 (en) 2012-05-31

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MDA20100137A MD4132C1 (en) 2010-12-13 2010-12-13 Di(µ-S)-bis{chloro-[phenyl(pyridine-2-yl)methanone-thiosemicarbazonato(1-)]-copper} manifesting the property of inhibiting the proliferation of mammary cancer T-47D cells

Country Status (1)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor
CN109694391A (en) * 2018-12-20 2019-04-30 广西师范大学 It is a kind of using 2- amino -5- chlorobenzophenone thiosemicarbazones as the platinum complex of ligand and its synthetic method and application

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* Cited by examiner, † Cited by third party
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MD4326C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4327C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
CN112028911A (en) * 2020-09-22 2020-12-04 广西师范大学 Zinc complex taking 2-benzoylpyridine thiosemicarbazone as ligand and synthetic method and application thereof

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MD3655G2 (en) * 2007-09-03 2009-02-28 Государственный Университет Молд0 Inhibitor of human myeloid leukemia on base of bis(2-hydroxy-8-phenyl-tricyclo/7.3.1.0.2,7/-tridecane-13-on-thiosemicarbazonato)copper
MD3771G2 (en) * 2008-04-30 2009-07-31 Государственный Университет Молд0 Inhibitors of 17β-HSD enzyme, stimulator for prostate cancer cell multiplication
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MD3995C2 (en) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Use of di(m-Ophenoxy)-di{[2-(4-aminobenzenesulfamido)-5-ethyl-1,3,4-thiadiazole]-3,5-dibromosalicylidenethiosemicarbazonato(-1)-copper} as inhibitor of mammary cancer T-47D cell proliferation
MD3996C2 (en) * 2009-05-25 2010-07-31 Государственный Университет Молд0 Perchlorates of 5-R-salicylidene-4-phenylthiosemicarbazonato(1-)-aquacopper(II) possessing properties of inhibitors of 17b-HSD enzyme activity (type 1)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD4520B1 (en) * 2016-12-16 2017-10-31 Государственный Университет Молд0 N-(4-butoxyphenyl)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide as T-47D breast cancer cells growth inhibitor
CN109694391A (en) * 2018-12-20 2019-04-30 广西师范大学 It is a kind of using 2- amino -5- chlorobenzophenone thiosemicarbazones as the platinum complex of ligand and its synthetic method and application
CN109694391B (en) * 2018-12-20 2021-03-23 广西师范大学 Platinum complex taking 2-amino-5-chlorobenzophenone thiosemicarbazone as ligand and synthetic method and application thereof

Also Published As

Publication number Publication date
MD4132C1 (en) 2012-05-31

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees