MD3229816T2 - Polimeri de legare a protonilor pentru administrare orală - Google Patents
Polimeri de legare a protonilor pentru administrare oralăInfo
- Publication number
- MD3229816T2 MD3229816T2 MDE20170179T MDE20170179T MD3229816T2 MD 3229816 T2 MD3229816 T2 MD 3229816T2 MD E20170179 T MDE20170179 T MD E20170179T MD E20170179 T MDE20170179 T MD E20170179T MD 3229816 T2 MD3229816 T2 MD 3229816T2
- Authority
- MD
- Moldova
- Prior art keywords
- proton
- oral administration
- binding polymers
- animal
- methods
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000010606 normalization Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/02—Alkylation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
- C08F226/04—Diallylamine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F26/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F26/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a single or double bond to nitrogen
- C08F26/04—Diallylamine
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2810/00—Chemical modification of a polymer
- C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2333/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2333/24—Homopolymers or copolymers of amides or imides
- C08J2333/26—Homopolymers or copolymers of acrylamide or methacrylamide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compoziţii farmaceutice pentru metode de tratare a unui animal, incluzȃnd omul, şi metode de preparare a unor astfel de compoziţii. Compoziţiile farmaceutice conţin polimeri amină reticulaţi şi pot fi folosiţi, de exemplu, pentru tratarea bolilor sau a altor afecţiuni metabolice în care îndepărtarea protonilor şi/sau a ionilor clorură din tractul gastrointestinal va furniza beneficii fiziologice cum ar fi normalizarea concentraţiilor de bicarbonat seric şi pH-ul sȃngelui la un animal, incluzȃnd un om.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462090287P | 2014-12-10 | 2014-12-10 | |
PCT/US2015/065041 WO2016094685A1 (en) | 2014-12-10 | 2015-12-10 | Proton-binding polymers for oral administration |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3229816T2 true MD3229816T2 (ro) | 2020-07-31 |
Family
ID=55080167
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20170179T MD3229816T2 (ro) | 2014-12-10 | 2015-12-10 | Polimeri de legare a protonilor pentru administrare orală |
MDE20200240T MD3593808T2 (ro) | 2014-12-10 | 2015-12-10 | Polimeri de legare a protonilor pentru administrare orală |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20200240T MD3593808T2 (ro) | 2014-12-10 | 2015-12-10 | Polimeri de legare a protonilor pentru administrare orală |
Country Status (26)
Country | Link |
---|---|
US (3) | US11311571B2 (ro) |
EP (3) | EP3229816B1 (ro) |
JP (4) | JP6903576B2 (ro) |
KR (2) | KR20240008418A (ro) |
CN (2) | CN107428955B (ro) |
AU (2) | AU2015360413B2 (ro) |
BR (2) | BR112017011838B1 (ro) |
CA (3) | CA3164664A1 (ro) |
CY (2) | CY1122928T1 (ro) |
DK (2) | DK3229816T3 (ro) |
ES (2) | ES2857177T3 (ro) |
HK (1) | HK1243952A1 (ro) |
HR (2) | HRP20200689T1 (ro) |
HU (2) | HUE052736T2 (ro) |
IL (3) | IL252439B (ro) |
LT (2) | LT3593808T (ro) |
MA (3) | MA48486B1 (ro) |
MD (2) | MD3229816T2 (ro) |
ME (1) | ME03783B (ro) |
MX (3) | MX2017007497A (ro) |
PL (2) | PL3593808T3 (ro) |
PT (2) | PT3593808T (ro) |
RS (2) | RS60208B1 (ro) |
RU (2) | RU2020102937A (ro) |
SI (2) | SI3229816T1 (ro) |
WO (1) | WO2016094685A1 (ro) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2728778C2 (ru) | 2013-06-05 | 2020-07-31 | Трисида, Инк. | Протон-связывающие полимеры для перорального введения |
JP6903576B2 (ja) | 2014-12-10 | 2021-07-14 | トリシダ・インコーポレイテッドTricida, Inc. | 経口投与用プロトン結合ポリマー |
MX2018013476A (es) * | 2016-05-06 | 2019-03-28 | Tricida Inc | Composiciones para tratar trastornos acido-base. |
AU2017388956A1 (en) | 2016-12-28 | 2019-07-11 | Fujifilm Corporation | Emulsion of nitrogen atom-containing polymer or salt thereof, production method therefor, and production method for particles |
US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
EP3698799B1 (en) | 2017-10-16 | 2022-01-26 | FUJIFILM Corporation | Hyperphosphatemia treatment agent |
CA3080651A1 (en) | 2017-11-03 | 2019-05-09 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
MA51628A (fr) * | 2018-06-04 | 2021-03-17 | Tricida Inc | Méthode de traitement de troubles de l'équilibre acido-basique |
WO2019236124A1 (en) * | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
EP4053179A1 (en) | 2021-03-01 | 2022-09-07 | Tricida Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01100164A (ja) * | 1987-10-12 | 1989-04-18 | Shionogi & Co Ltd | スルファモイル−2−ベンゾフランカルボン酸誘導体 |
US20050090553A1 (en) | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
US6444221B1 (en) | 1992-06-30 | 2002-09-03 | Howard K. Shapiro | Methods of treating chronic inflammatory diseases using carbonyl trapping agents |
US5556619A (en) * | 1992-08-20 | 1996-09-17 | The Du Pont Merck Pharmaceutical Company | Crosslinked polymeric ammonium salts |
CA2202397C (en) | 1994-10-17 | 2002-07-16 | Peter W. Stacpoole | Compositions comprising carbonate/bicarbonate buffered dichloroacetic acid and methods for treatment of metabolic and cardiovascular disorders |
US5496545A (en) | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
US5667775A (en) | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
US5648355A (en) | 1994-02-09 | 1997-07-15 | Kos Pharmaceutical, Inc. | Method of treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin |
TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
US20020006899A1 (en) | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
US5753706A (en) | 1996-12-16 | 1998-05-19 | Hsu; Chen Hsing | Methods for treating renal failure |
JP3952223B2 (ja) * | 1997-05-28 | 2007-08-01 | 日東紡績株式会社 | アリルアミン重合体 |
AUPO758297A0 (en) | 1997-06-27 | 1997-07-24 | Rowe, James Baber | Control of acidic gut syndrome |
US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
WO1999040990A1 (en) | 1998-02-17 | 1999-08-19 | University Of Maryland | Anion binding polymers and the use thereof |
US6485703B1 (en) | 1998-07-31 | 2002-11-26 | The Texas A&M University System | Compositions and methods for analyte detection |
US6271264B1 (en) | 1998-12-01 | 2001-08-07 | Geltex Pharmaceuticals, Inc. | Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants |
US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
GB9927088D0 (en) | 1999-11-17 | 2000-01-12 | Secr Defence | Use of poly(diallylamine) polymers |
US6844372B2 (en) | 2000-03-09 | 2005-01-18 | Hisamitsu Pharmaceutical Co., Inc. | Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same |
US20040059065A1 (en) | 2000-03-09 | 2004-03-25 | Takeshi Goto | Crosslinked anion-exchange resin or salt thereof |
WO2001068106A1 (fr) | 2000-03-13 | 2001-09-20 | Hisamitsu Pharmaceutical Co., Inc. | Prophylactiques et/ou remedes pour hyperphosphatemie |
JP2002028737A (ja) | 2000-07-07 | 2002-01-29 | Fujitsu Ltd | プレス打ち抜き加工方法及びプレス打ち抜き加工装置 |
NZ528829A (en) * | 2001-04-18 | 2006-06-30 | Genzyme Corp | Low salt forms of polyallylamine |
JP2004528332A (ja) | 2001-04-18 | 2004-09-16 | ジェンザイム コーポレーション | 痛風を治療する方法および尿酸を結合する方法 |
TW200304813A (en) | 2002-03-11 | 2003-10-16 | Novartis Ag | Salts of organic acid |
JP2007523599A (ja) | 2003-02-10 | 2007-08-23 | オートゲン リサーチ ピーティーワイ エルティーディー. | 治療用分子 |
TWI335218B (en) | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
US7767768B2 (en) | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
US7335795B2 (en) | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
US7385012B2 (en) | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
US7608674B2 (en) | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
US7449605B2 (en) | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
US7459502B2 (en) | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
AU2004311849B2 (en) | 2003-12-31 | 2009-04-02 | Genzyme Corporation | Enteric coated aliphatic amine polymer bile acid sequestrants |
EP1723968A1 (en) | 2004-01-29 | 2006-11-22 | Keio University | Erythrocyte function modifying substance |
US7854924B2 (en) | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
JP4964122B2 (ja) | 2004-03-30 | 2012-06-27 | レリプサ, インコーポレイテッド | イオン結合組成物 |
US8192758B2 (en) | 2004-03-30 | 2012-06-05 | Relypsa, Inc. | Ion binding compositions |
US7429394B2 (en) | 2004-03-30 | 2008-09-30 | Relypsa, Inc. | Ion binding compositions |
US8282960B2 (en) | 2004-03-30 | 2012-10-09 | Relypsa, Inc. | Ion binding compositions |
US7556799B2 (en) | 2004-03-30 | 2009-07-07 | Relypsa, Inc. | Ion binding polymers and uses thereof |
US8399025B2 (en) | 2004-06-04 | 2013-03-19 | Board Of Regents, The University Of Texas System | Polyamine modified particles |
DK1771191T3 (da) | 2004-07-19 | 2014-06-10 | Nutricia Nv | Præparat til anvendelse af aspartat og B12-vitamin eller biotin til regulering af ketonstoffer |
DE102004035808A1 (de) | 2004-07-21 | 2006-03-16 | Kasch, Helmut, Dr. | Ammoniumsalze und Ammoniumsalz-Mineralsalzchlatrate als Transport- und Wirkform für pharmazeutische-medizinische und als Phasentransfermittel für chemische Anwendungen |
US8569277B2 (en) | 2004-08-11 | 2013-10-29 | Palo Alto Investors | Methods of treating a subject for a condition |
US20070293429A1 (en) | 2004-10-08 | 2007-12-20 | Therapei Pharmaceuticals, Inc. | Vasoactive Intestinal Polypeptide Compositions |
US20080214440A1 (en) | 2004-10-08 | 2008-09-04 | Forbes Medi-Tech (Research), Inc. | Vasoactive intestinal polypeptide compositions |
US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
ITME20040015A1 (it) | 2004-12-07 | 2005-03-07 | Vincenzo Savica | Chewing gum, caramelle gommose, pastiglie, compresse a lento rilascio di chelanti fosfato e/o fosforo salivare e capsule a lento rilascio di chelanti fosfato e/o fosforo a livello gastroenterico. |
WO2007004236A2 (en) | 2005-07-04 | 2007-01-11 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
NZ566743A (en) | 2005-08-18 | 2010-07-30 | Globoasia Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same |
US8986669B2 (en) | 2005-09-02 | 2015-03-24 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
KR20080057319A (ko) | 2005-09-30 | 2008-06-24 | 일립사, 인코포레이티드 | 가교 쉘을 갖는 코어-쉘 복합체의 제조 방법, 및 이로부터수득되는 코어-쉘 복합체 |
WO2007038801A2 (en) | 2005-09-30 | 2007-04-05 | Ilypsa, Inc. | Monovalent cation-binding compositions comprising core-shell particles having crosslinked poly-vinylic shells, and methods of use thereof |
WO2007041569A1 (en) | 2005-09-30 | 2007-04-12 | Ilypsa, Inc. | Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal |
WO2007055044A1 (ja) | 2005-11-08 | 2007-05-18 | Ajinomoto Co., Inc. | 麻酔覚醒促進剤 |
BRPI0618352A2 (pt) | 2005-11-08 | 2011-08-23 | Genzyme Corp | composições farmacêuticas e métodos de tratamento da hiperfosfatemia em um paciente |
ITMI20052461A1 (it) | 2005-12-22 | 2007-06-23 | Univ Degli Studi Milano | Sistemi microparticellari per la somministrazione orale di sostanze biologicamente attive |
RU2008136081A (ru) | 2006-02-14 | 2010-03-20 | Тева Фармасьютикл Индастриес Лтд. (Il) | Фармацевтические составы с алифатическими аминными полимерами и способы их производства |
EP2016114A2 (en) | 2006-05-05 | 2009-01-21 | Genzyme Corporation | Amine condensation polymers as phosphate sequestrants |
US20100135950A1 (en) | 2006-07-05 | 2010-06-03 | Genzyme Corporation | Iron(II)-Containing Treatments for Hyperphosphatemia |
BRPI0715053A2 (pt) | 2006-07-18 | 2013-03-19 | Genzyme Corp | composiÇço farmacÊutica, mÉtodo para tratar doenÇas, e, polÍmero |
CA2660029A1 (en) | 2006-08-04 | 2008-02-07 | Nastech Pharmaceutical Company Inc. | Compositions for intranasal delivery of human insulin and uses thereof |
JP2010504285A (ja) | 2006-09-01 | 2010-02-12 | ゲンズイメ コーポレーション | デンドリマー組成物 |
US7964182B2 (en) | 2006-09-01 | 2011-06-21 | USV, Ltd | Pharmaceutical compositions comprising phosphate-binding polymer |
BRPI0717008A2 (pt) | 2006-09-01 | 2014-01-21 | Usv Ltd | Processo para o preparo de cloridrato de sevelamer e formulação do mesmo |
JP5427029B2 (ja) | 2006-09-06 | 2014-02-26 | スキャンポ・アーゲー | 消化管の重炭酸分泌を促進するための方法および組成物 |
WO2008042222A2 (en) | 2006-09-29 | 2008-04-10 | Genzyme Corporation | Amide dendrimer compositions |
US8163799B2 (en) | 2006-12-14 | 2012-04-24 | Genzyme Corporation | Amido-amine polymer compositions |
JP2010519298A (ja) | 2007-02-23 | 2010-06-03 | ゲンズイメ コーポレーション | アミンポリマー組成物 |
US20080207766A1 (en) | 2007-02-27 | 2008-08-28 | Agi Therapeutics Research Ltd. | Methods and compositions for treating at least one upper gastrointestinal symptom |
EP2131820A1 (en) | 2007-03-08 | 2009-12-16 | Genzyme Corporation | Sulfone polymer compositions |
TWI445540B (zh) | 2007-04-20 | 2014-07-21 | Ajinomoto Kk | 抗低體溫組成物 |
EP2152277A1 (en) | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amine dendrimer compositions |
WO2009005838A2 (en) | 2007-07-02 | 2009-01-08 | Cognate3 Llc | Process for the preparation of a non-corrosive base solution and methods of using same |
RU2010104673A (ru) | 2007-07-11 | 2011-08-20 | Торэй Индастриз, Инк. (Jp) | Сшитый полиаллиламин или его соль присоединения кислоты и его применение для медицинских целей |
EP2016947A1 (en) | 2007-07-17 | 2009-01-21 | Chemo Ibérica, S.A. | Novel one step process for preparing cross-linked poly(allylamine) polymers |
WO2009023544A2 (en) | 2007-08-10 | 2009-02-19 | Ilypsa, Inc. | Dosage unit anion-exchange polymer pharmaceutical compositions |
US20090125433A1 (en) * | 2007-11-13 | 2009-05-14 | Franck Rene Mikulecz | Best pre-match routing (of foreign exchange orders) |
US20090156647A1 (en) | 2007-12-12 | 2009-06-18 | Iovate T. & P. Inc. | Method for maintaining physiological pH levels during intensive physical exercise |
PA8807201A1 (es) | 2007-12-14 | 2009-07-23 | Genzyme Corp | Composiciones farmaceuticas |
EP2217215A1 (en) | 2007-12-14 | 2010-08-18 | Genzyme Corporation | Coated pharmaceutical compositions |
JP2009179724A (ja) * | 2008-01-31 | 2009-08-13 | Toray Ind Inc | 架橋ポリビニルアミン又はその酸付加塩、及びその医薬用途 |
WO2009097127A1 (en) | 2008-01-31 | 2009-08-06 | Genzyme Corporation | Pharmaceutical compositions |
AU2009223063A1 (en) | 2008-03-11 | 2009-09-17 | Livionex Inc. | Methods and compositions for treating inflammation and inflammation-related pathologies |
WO2009125433A2 (en) * | 2008-04-08 | 2009-10-15 | Usv Limited | Process for preparation of amine polymer salt |
US20110112445A1 (en) | 2008-04-11 | 2011-05-12 | GP Investmenti S.r.l | Handpiece for Ultrasound Treatments of Human Tissue |
US20110142952A1 (en) | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
DE102008030046A1 (de) | 2008-06-25 | 2009-12-31 | Ratiopharm Gmbh | Kompaktiertes Polyallylamin-Polymer |
US20100008988A1 (en) | 2008-07-14 | 2010-01-14 | Glenmark Generics, Ltd. | Tablet compositions of amine polymers |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
WO2010022381A1 (en) | 2008-08-22 | 2010-02-25 | Relypsa, Inc. | Treating hyperkalemia with crosslinked cation exchange polymers of improved physical properties |
US8337824B2 (en) | 2008-08-22 | 2012-12-25 | Relypsa, Inc. | Linear polyol stabilized polyfluoroacrylate compositions |
MX342439B (es) | 2008-09-25 | 2016-09-29 | Vive Nano Inc * | Metodos para producir nanoparticulas polimericas y formulaciones de ingredientes activos. |
US20110268666A1 (en) | 2008-09-29 | 2011-11-03 | Yissum Research Development Company of the Research University of Jerusalem, Ltd. | Novel gastroretentive delivery system |
WO2010059384A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Process for the preparation of tri-substituted pyridine and tri-substituted pyrimidine derivatives useful as gdir agonists |
US20100166861A1 (en) | 2008-12-29 | 2010-07-01 | Kelly Noel Lynch | Pharmaceutical formulations of sevalamer, or salts thereof, and copovidone |
KR20110119714A (ko) | 2009-01-22 | 2011-11-02 | 유에스브이 리미티드 | 포스페이트 결합 폴리머를 포함하는 약학적 조성물 |
US8945508B2 (en) | 2009-10-13 | 2015-02-03 | The Regents Of The University Of Michigan | Dendrimer compositions and methods of synthesis |
EA024699B1 (ru) | 2009-10-22 | 2016-10-31 | Синтон Б. В. | Фармацевтическая таблетка с немедленным высвобождением, содержащая севеламера карбонат |
US8735360B2 (en) | 2009-12-07 | 2014-05-27 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
JP5964247B2 (ja) | 2010-02-24 | 2016-08-03 | レリプサ, インコーポレイテッド | 胆汁酸捕捉剤として使用するためのポリイミダゾール |
BR112012021444A2 (pt) | 2010-02-24 | 2016-05-31 | Relypsa Inc | polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas. |
IT1406068B1 (it) | 2010-07-22 | 2014-02-06 | Medestea Int Spa | Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
KR101238210B1 (ko) | 2011-06-30 | 2013-03-04 | 엘지전자 주식회사 | 이동 단말기 |
US20130137772A1 (en) | 2011-11-29 | 2013-05-30 | Raymond J. Bergeron | Hydroxypolyamine salts |
JP2015535209A (ja) | 2012-06-21 | 2015-12-10 | ケリク バイオファーマシューティカルス, インコーポレーテッド | 慢性腎臓病患者の治療におけるクエン酸第二鉄の使用 |
BR112015007749A2 (pt) | 2012-10-08 | 2017-07-04 | Relypsa Inc | métodos para tratamento de hipertensão , de hipercaliemia , e de doença renal crônica. |
RU2728778C2 (ru) * | 2013-06-05 | 2020-07-31 | Трисида, Инк. | Протон-связывающие полимеры для перорального введения |
EP3747432A1 (en) | 2013-11-04 | 2020-12-09 | Keryx Biopharmaceuticals, Inc. | Ferric citrate for reducing cardiac failure in chronic kidney disease patients |
JP6903576B2 (ja) | 2014-12-10 | 2021-07-14 | トリシダ・インコーポレイテッドTricida, Inc. | 経口投与用プロトン結合ポリマー |
MX2018013476A (es) | 2016-05-06 | 2019-03-28 | Tricida Inc | Composiciones para tratar trastornos acido-base. |
US10934380B1 (en) | 2017-09-25 | 2021-03-02 | Tricida, Inc. | Crosslinked poly(allylamine) polymer pharmaceutical compositions |
AU2018360868A1 (en) | 2017-11-03 | 2020-04-30 | Tricida, Inc. | Method of treating acid-base disorders |
CA3080651A1 (en) | 2017-11-03 | 2019-05-09 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
WO2019236124A1 (en) | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
MA51628A (fr) | 2018-06-04 | 2021-03-17 | Tricida Inc | Méthode de traitement de troubles de l'équilibre acido-basique |
WO2019236639A1 (en) | 2018-06-04 | 2019-12-12 | Tricida, Inc. | Method of treating acid-base disorders |
US20200306209A1 (en) | 2019-03-27 | 2020-10-01 | Tricida, Inc. | Method of treating acid-base disorders |
-
2015
- 2015-12-10 JP JP2017531176A patent/JP6903576B2/ja active Active
- 2015-12-10 SI SI201531167T patent/SI3229816T1/sl unknown
- 2015-12-10 US US15/533,705 patent/US11311571B2/en active Active
- 2015-12-10 MA MA48486A patent/MA48486B1/fr unknown
- 2015-12-10 RU RU2020102937A patent/RU2020102937A/ru unknown
- 2015-12-10 EP EP15823049.0A patent/EP3229816B1/en active Active
- 2015-12-10 CN CN201580075741.9A patent/CN107428955B/zh active Active
- 2015-12-10 CA CA3164664A patent/CA3164664A1/en active Pending
- 2015-12-10 SI SI201531470T patent/SI3593808T1/sl unknown
- 2015-12-10 ES ES19191396T patent/ES2857177T3/es active Active
- 2015-12-10 PL PL19191396T patent/PL3593808T3/pl unknown
- 2015-12-10 MD MDE20170179T patent/MD3229816T2/ro unknown
- 2015-12-10 LT LTEP19191396.1T patent/LT3593808T/lt unknown
- 2015-12-10 KR KR1020247000875A patent/KR20240008418A/ko active Application Filing
- 2015-12-10 BR BR112017011838-6A patent/BR112017011838B1/pt active IP Right Grant
- 2015-12-10 HU HUE19191396A patent/HUE052736T2/hu unknown
- 2015-12-10 RU RU2017124157A patent/RU2713416C2/ru active
- 2015-12-10 WO PCT/US2015/065041 patent/WO2016094685A1/en active Application Filing
- 2015-12-10 MA MA41150A patent/MA41150B1/fr unknown
- 2015-12-10 AU AU2015360413A patent/AU2015360413B2/en active Active
- 2015-12-10 LT LTEP15823049.0T patent/LT3229816T/lt unknown
- 2015-12-10 RS RS20200504A patent/RS60208B1/sr unknown
- 2015-12-10 KR KR1020177018413A patent/KR102625115B1/ko active IP Right Grant
- 2015-12-10 BR BR122021001914-2A patent/BR122021001914B1/pt active IP Right Grant
- 2015-12-10 EP EP19191396.1A patent/EP3593808B1/en active Active
- 2015-12-10 EP EP20154562.1A patent/EP3718551A1/en active Pending
- 2015-12-10 HU HUE15823049A patent/HUE049057T2/hu unknown
- 2015-12-10 CN CN202111132616.0A patent/CN113855703A/zh active Pending
- 2015-12-10 ES ES15823049T patent/ES2787218T3/es active Active
- 2015-12-10 RS RS20210136A patent/RS61409B1/sr unknown
- 2015-12-10 MA MA053106A patent/MA53106A/fr unknown
- 2015-12-10 MX MX2017007497A patent/MX2017007497A/es active IP Right Grant
- 2015-12-10 ME MEP-2020-85A patent/ME03783B/me unknown
- 2015-12-10 PL PL15823049T patent/PL3229816T3/pl unknown
- 2015-12-10 DK DK15823049.0T patent/DK3229816T3/da active
- 2015-12-10 CA CA3205149A patent/CA3205149A1/en active Pending
- 2015-12-10 MD MDE20200240T patent/MD3593808T2/ro unknown
- 2015-12-10 PT PT191913961T patent/PT3593808T/pt unknown
- 2015-12-10 PT PT158230490T patent/PT3229816T/pt unknown
- 2015-12-10 DK DK19191396.1T patent/DK3593808T3/da active
- 2015-12-10 CA CA2969238A patent/CA2969238C/en active Active
-
2017
- 2017-05-22 IL IL252439A patent/IL252439B/en active IP Right Grant
- 2017-06-08 MX MX2021004558A patent/MX2021004558A/es unknown
- 2017-06-08 MX MX2019014711A patent/MX2019014711A/es unknown
-
2018
- 2018-03-14 HK HK18103560.4A patent/HK1243952A1/zh unknown
-
2020
- 2020-04-29 HR HRP20200689TT patent/HRP20200689T1/hr unknown
- 2020-04-30 CY CY20201100400T patent/CY1122928T1/el unknown
- 2020-06-18 JP JP2020104945A patent/JP6921276B2/ja active Active
- 2020-10-13 IL IL278034A patent/IL278034B/en unknown
-
2021
- 2021-02-05 HR HRP20210204TT patent/HRP20210204T1/hr unknown
- 2021-02-19 CY CY20211100141T patent/CY1124073T1/el unknown
- 2021-07-27 JP JP2021122260A patent/JP7258087B2/ja active Active
- 2021-10-06 AU AU2021245144A patent/AU2021245144B2/en active Active
-
2022
- 2022-02-20 IL IL290729A patent/IL290729A/en unknown
- 2022-04-19 US US17/724,105 patent/US11738041B2/en active Active
-
2023
- 2023-04-04 JP JP2023060573A patent/JP7536343B2/ja active Active
- 2023-08-28 US US18/238,665 patent/US20230405043A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD3229816T2 (ro) | Polimeri de legare a protonilor pentru administrare orală | |
MX2019005300A (es) | Polimeros enlazados al proton para administracion oral. | |
MY197091A (en) | Compositions for treating acid-base disorders | |
MA52909A (fr) | Procédés d'augmentation des taux de globules rouges et de traitement de la drépanocytose | |
JOP20200231A1 (ar) | ناهضات ppar (مستقبل ناشر بيروكسيزوم منشط)، ومركبات، ومكونات أدوية، وطرق استعمالها | |
PH12017500444A1 (en) | Pharmaceutical compositions comprising a dextromethorphan compound and quinidine for the treatment of agitation in dementia | |
MY179105A (en) | Methods of treating alzheimer's disease | |
NZ721500A (en) | Use of halogen compounds for the treatment and prevention of heart attack and ischemic injury | |
WO2014197816A8 (en) | Stimulus responsive nanocomplexes and methods of use thereof | |
PH12016502233A1 (en) | (s)-pirlindole or its pharmaceutically acceptable salts for use in medicine | |
MA42611A (fr) | Traitement combiné comprenant l'administration de 2-amino-3,5,5-trifluoro-3,4,5,6-tétrahydropyridines | |
UA112488C2 (uk) | Три(гетеро)арилпіразоли і їх застосування | |
PH12018502195A1 (en) | Inhaled preparation of isoglycyrrhizic acid or salt thereof, and use in preparing drugs for treating respiratory system diseases | |
UA125728U (uk) | Спосіб лікування атопічного дерматиту | |
EA201692163A1 (ru) | Лекарственное средство для лечения пациентов с тиннитусом | |
MX2018004295A (es) | Compuestos, composiciones farmáceuticas y métodos de uso de agonistas de ppar. | |
EA201692164A1 (ru) | Лекарственное средство для лечения пациентов с тиннитусом | |
UA112357C2 (uk) | Спосіб індивідуальної цільової терапії дефіциту вітаміну d у пацієнтів із захворюваннями кістково-м'язової системи | |
UA100955C2 (ru) | Производные оксазина и их применение в лечении неврологических расстройств |