MA54093A - Procédé de culture cellulaire par perfusion intensifiée avec récolte continue et sans purge cellulaire - Google Patents

Procédé de culture cellulaire par perfusion intensifiée avec récolte continue et sans purge cellulaire

Info

Publication number
MA54093A
MA54093A MA054093A MA54093A MA54093A MA 54093 A MA54093 A MA 54093A MA 054093 A MA054093 A MA 054093A MA 54093 A MA54093 A MA 54093A MA 54093 A MA54093 A MA 54093A
Authority
MA
Morocco
Prior art keywords
cell
culture process
purge
cell culture
continuous harvest
Prior art date
Application number
MA054093A
Other languages
English (en)
Inventor
Mingyue Fang
Siyuan Tang
Hang Zhou
Weichang Zhou
Original Assignee
Wuxi Biologics Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi Biologics Ireland Ltd filed Critical Wuxi Biologics Ireland Ltd
Publication of MA54093A publication Critical patent/MA54093A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
MA054093A 2018-11-02 2019-09-29 Procédé de culture cellulaire par perfusion intensifiée avec récolte continue et sans purge cellulaire MA54093A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018113776 2018-11-02
CN2019089993 2019-06-04

Publications (1)

Publication Number Publication Date
MA54093A true MA54093A (fr) 2021-09-08

Family

ID=70463469

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054093A MA54093A (fr) 2018-11-02 2019-09-29 Procédé de culture cellulaire par perfusion intensifiée avec récolte continue et sans purge cellulaire

Country Status (10)

Country Link
US (1) US20220364034A1 (fr)
EP (1) EP3874023A4 (fr)
JP (2) JP2022506413A (fr)
KR (1) KR102597919B1 (fr)
CN (1) CN111406105B (fr)
CA (1) CA3118398A1 (fr)
MA (1) MA54093A (fr)
SG (1) SG11202104417UA (fr)
TW (1) TW202035681A (fr)
WO (1) WO2020088180A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230330055A1 (en) * 2020-07-10 2023-10-19 Tsingtao A-Smart Medical Technology Co., Ltd. Method for activating follicles by means of using small-molecule compound, and preparation thereof
EP4228794A1 (fr) * 2020-10-15 2023-08-23 AGC Biologics, Inc. Culture continue à haute densité cellulaire avec filtration tangentielle à deux récipients
CN112592948B (zh) * 2020-12-16 2023-05-09 广州汉腾生物科技有限公司 动物细胞的灌流培养方法
WO2022180260A1 (fr) * 2021-02-25 2022-09-01 Securecell Ag Système d'échantillonnage de fluide pour applications biotechnologiques, son procédé de fonctionnement et son utilisation
CN114230669B (zh) * 2021-12-24 2024-01-30 天士力生物医药股份有限公司 一种双特异性抗体的生产方法
WO2024006893A1 (fr) * 2022-06-30 2024-01-04 Genentech, Inc. Systèmes, appareil et procédés de culture cellulaire
WO2024040519A1 (fr) * 2022-08-25 2024-02-29 Wuxi Biologics Co., Ltd. Culture discontinue alimentée par perfusion intermittente
CN115747055A (zh) * 2022-11-16 2023-03-07 四川至善唯新生物科技有限公司 一种细胞灌流培养的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2507552B2 (ja) * 1988-08-29 1996-06-12 株式会社ニッショー 細胞培養産生物の取出しおよび培地の交換方法
MX340242B (es) * 2006-07-14 2016-07-01 Dpx Holdings Bv Proceso mejorado para el cultivo de celulas.
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2188371B1 (fr) * 2007-08-09 2017-12-20 Wyeth LLC Utilisation de la perfusion pour améliorer la production d'une culture cellulaire en mode semi-continu dans des bioréacteurs
DE102008064279A1 (de) * 2008-12-20 2010-06-24 Bayer Technology Services Gmbh Bioreaktor
CN103305417A (zh) * 2012-03-07 2013-09-18 无锡药明康德生物技术有限公司 进行蛋白生产的高产量反应器及其生产方法和应用
SG11201601899TA (en) * 2013-09-16 2016-04-28 Genzyme Corp Methods and systems for processing a cell culture
EP3071682A1 (fr) * 2013-11-20 2016-09-28 CMC Biologics A/S Système de bioréacteur et procédé de production d'un biopolymère
US20160312168A1 (en) * 2013-12-30 2016-10-27 Ge Healthcare Bio-Sciences Corp. Apparatus for cell cultivation
US10106829B2 (en) * 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
ES2909630T3 (es) * 2014-06-04 2022-05-09 Amgen Inc Métodos de recolección en cultivos de células de mamífero
TW202340452A (zh) * 2015-08-04 2023-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
KR102613876B1 (ko) * 2015-11-10 2023-12-15 리플리겐 코포레이션 일회용 교번 접방향 유동 여과 유닛
HRP20221071T1 (hr) * 2016-12-23 2022-11-11 Serum Institute Of India Private Limited Postupci za povećanje produktivnosti antitijela u kulturi stanica sisavaca i smanjenje agregacije tokom nizvodne obrade, postupci formulacije i rezultirajuće stabilne formulacije antitijela
CN106987559A (zh) * 2017-03-22 2017-07-28 上海药明生物技术有限公司 一种重组chok1细胞株的构建方法及其应用
KR102604988B1 (ko) * 2017-03-31 2023-11-24 베링거 인겔하임 인터내셔날 게엠베하 관류 배지
EP3601584A1 (fr) * 2017-03-31 2020-02-05 Boehringer Ingelheim International GmbH Milieu de perfusion
CN108504562A (zh) * 2018-06-21 2018-09-07 江苏澳创生物科技有限公司 一种发酵生产l-苏氨酸的系统及其应用

Also Published As

Publication number Publication date
CN111406105B (zh) 2024-08-30
EP3874023A1 (fr) 2021-09-08
SG11202104417UA (en) 2021-05-28
CA3118398A1 (fr) 2020-05-07
TW202035681A (zh) 2020-10-01
KR102597919B1 (ko) 2023-11-06
US20220364034A1 (en) 2022-11-17
CN111406105A (zh) 2020-07-10
EP3874023A4 (fr) 2022-08-17
KR20210086655A (ko) 2021-07-08
JP2023109835A (ja) 2023-08-08
WO2020088180A1 (fr) 2020-05-07
JP2022506413A (ja) 2022-01-17

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