DK3036320T3 - Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre - Google Patents
Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre Download PDFInfo
- Publication number
- DK3036320T3 DK3036320T3 DK14761736.9T DK14761736T DK3036320T3 DK 3036320 T3 DK3036320 T3 DK 3036320T3 DK 14761736 T DK14761736 T DK 14761736T DK 3036320 T3 DK3036320 T3 DK 3036320T3
- Authority
- DK
- Denmark
- Prior art keywords
- management
- cell culture
- process parameters
- culture process
- protein glycosylation
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/40—Nucleotides, nucleosides, bases
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361867592P | 2013-08-19 | 2013-08-19 | |
PCT/US2014/051727 WO2015026846A1 (en) | 2013-08-19 | 2014-08-19 | Control of protein glycosylation by culture medium supplementation and cell culture process parameters |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3036320T3 true DK3036320T3 (da) | 2021-07-12 |
Family
ID=51494503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14761736.9T DK3036320T3 (da) | 2013-08-19 | 2014-08-19 | Styring af proteinglycosylering ved hjælp af dyrkningsmedietilsætning og cellekulturprocesparametre |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP3916081A3 (da) |
DK (1) | DK3036320T3 (da) |
PL (1) | PL3036320T3 (da) |
WO (1) | WO2015026846A1 (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
DK3122869T3 (da) | 2014-03-24 | 2019-09-09 | Biogen Ma Inc | Fremgangsmåder til afhjælpning af glutamindeprivation under pattedyrecellekultur |
MA41685A (fr) | 2014-10-17 | 2017-08-22 | Biogen Ma Inc | Supplémentation en cuivre pour la régulation de la glycosylation dans un procédé de culture cellulaire de mammifère |
KR102007930B1 (ko) * | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
EP3072957B1 (en) * | 2015-03-23 | 2019-07-10 | Lonza Ltd | Methods for controlling protein glycosylation |
WO2016162514A1 (en) * | 2015-04-10 | 2016-10-13 | Ares Trading S.A. | Methods for modulating protein glycosylation profiles of recombinant proteins |
CN116731147A (zh) | 2015-11-02 | 2023-09-12 | 豪夫迈·罗氏有限公司 | 制备岩藻糖基化和去岩藻糖基化形式的蛋白质的方法 |
AU2016374304A1 (en) * | 2015-12-15 | 2018-06-14 | CSL Behring Lengnau AG | Method for increasing the heterogeneity of O-glycosylation of recombinant factor VII |
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US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
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JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
AU4308689A (en) | 1988-09-02 | 1990-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
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DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
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US9062106B2 (en) * | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
-
2014
- 2014-08-19 WO PCT/US2014/051727 patent/WO2015026846A1/en active Application Filing
- 2014-08-19 EP EP21170805.2A patent/EP3916081A3/en active Pending
- 2014-08-19 DK DK14761736.9T patent/DK3036320T3/da active
- 2014-08-19 EP EP14761736.9A patent/EP3036320B2/en active Active
- 2014-08-19 PL PL14761736T patent/PL3036320T3/pl unknown
Also Published As
Publication number | Publication date |
---|---|
EP3916081A2 (en) | 2021-12-01 |
EP3916081A3 (en) | 2022-03-23 |
EP3036320B2 (en) | 2024-04-03 |
EP3036320A1 (en) | 2016-06-29 |
WO2015026846A1 (en) | 2015-02-26 |
EP3036320B1 (en) | 2021-04-28 |
PL3036320T3 (pl) | 2021-11-02 |
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