MA51528A - Procédé de détection d'un analogue dérivé de la trifluridine - Google Patents
Procédé de détection d'un analogue dérivé de la trifluridineInfo
- Publication number
- MA51528A MA51528A MA051528A MA51528A MA51528A MA 51528 A MA51528 A MA 51528A MA 051528 A MA051528 A MA 051528A MA 51528 A MA51528 A MA 51528A MA 51528 A MA51528 A MA 51528A
- Authority
- MA
- Morocco
- Prior art keywords
- trifluridine
- detection
- analogue derived
- analogue
- derived
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
- G01N2030/8845—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds involving halogenated organic compounds
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018000881 | 2018-01-05 | ||
| US16/040,734 US10816517B2 (en) | 2018-01-05 | 2018-07-20 | Method for detecting trifluridine-related substance by high-performance liquid chromatography |
| CN201810821041.5A CN110007010A (zh) | 2018-01-05 | 2018-07-24 | 源自曲氟尿苷的类似物质的检测方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51528A true MA51528A (fr) | 2020-11-11 |
Family
ID=67139109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051528A MA51528A (fr) | 2018-01-05 | 2019-01-04 | Procédé de détection d'un analogue dérivé de la trifluridine |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10816517B2 (fr) |
| EP (1) | EP3736568A4 (fr) |
| JP (1) | JP7257969B2 (fr) |
| MA (1) | MA51528A (fr) |
| TW (1) | TWI759575B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10866219B2 (en) | 2017-12-22 | 2020-12-15 | Taiho Pharmaceutical Co., Ltd. | Method for detecting trifluridine- and/or tipiracil-related substance |
| US10816517B2 (en) | 2018-01-05 | 2020-10-27 | Taiho Pharmaceutical Co., Ltd. | Method for detecting trifluridine-related substance by high-performance liquid chromatography |
| CN111505159A (zh) * | 2020-05-09 | 2020-08-07 | 石家庄格瑞药业有限公司 | 盐酸阿罗洛尔中有关物质的检测方法 |
| CN112630313A (zh) * | 2020-11-06 | 2021-04-09 | 天地恒一制药股份有限公司 | 一种(s)-3-羟基四氢呋喃对映异构体的高效液相拆分方法 |
| CN112362791B (zh) * | 2020-12-10 | 2023-06-06 | 国药一心制药有限公司 | 一种曲氟尿苷与其异构体的hplc分离方法 |
| CN112595793B (zh) * | 2020-12-31 | 2022-03-22 | 华南理工大学 | 一种基于苯酚测定的地龙注射液检测方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056996A (ja) | 1983-09-07 | 1985-04-02 | Taiho Yakuhin Kogyo Kk | ２′―デオキシ―５―トリフルオロメチルウリジン誘導体及びそれを含有する抗腫瘍剤 |
| JPS6110565A (ja) | 1984-06-26 | 1986-01-18 | Takeda Chem Ind Ltd | ウラシル−５−カルボン酸エステル類の製造法 |
| ATE245631T1 (de) | 1995-03-29 | 2003-08-15 | Taiho Pharmaceutical Co Ltd | Uracilderivate und diese enthaltende antitumoreffekt-verstärker sowie antitumormittel |
| US20070212763A1 (en) | 2003-11-11 | 2007-09-13 | Mitsui Chemicals, Inc. | Process For Producing Pentose-5-Phosphate Ester |
| JP4603274B2 (ja) | 2004-02-24 | 2010-12-22 | 三井化学株式会社 | ２’−デオキシ−５−トリフルオロメチルウリジンの製造方法 |
| JP4441313B2 (ja) | 2004-04-02 | 2010-03-31 | 三井化学株式会社 | ２’−デオキシ−５−パーフルオロアルキルウリジンの製造法 |
| RU2394581C2 (ru) | 2005-01-26 | 2010-07-20 | Тайхо Фармасьютикал Ко., Лтд. | ПРОТИВОРАКОВОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО, СОДЕРЖАЩЕЕ α,α,α-ТРИФТОРТИМИДИН И ИНГИБИТОР ТИМИДИНФОСФОРИЛАЗЫ |
| WO2013012213A2 (fr) | 2011-07-15 | 2013-01-24 | 엘지전자 주식회사 | Procédé de communication et dispositif sans fil à bande passante variable |
| TWI526210B (zh) | 2012-02-15 | 2016-03-21 | Taiho Pharmaceutical Co Ltd | Oral pharmaceutical composition |
| TWI503122B (zh) * | 2012-02-15 | 2015-10-11 | Taiho Pharmaceutical Co Ltd | Oral administration of pharmaceutical compositions |
| CN106333952A (zh) | 2014-02-19 | 2017-01-18 | 齐鲁制药有限公司 | 一种胸苷磷酸化酶抑制剂的结晶形式及其制备方法 |
| CN105198947B (zh) | 2014-06-27 | 2019-05-14 | 江苏奥赛康药业股份有限公司 | 一种Trifluridine化合物及其药物组合物 |
| CN105461772B (zh) | 2015-11-23 | 2018-01-12 | 国药一心制药有限公司 | 一种曲氟尿苷中间体及曲氟尿苷的制备方法 |
| JP6380369B2 (ja) | 2015-12-25 | 2018-08-29 | トヨタ自動車株式会社 | 車両用ピラー構造 |
| CN106220699A (zh) * | 2016-07-21 | 2016-12-14 | 嘉实（湖南）医药科技有限公司 | 高纯度曲氟尿苷的制备方法 |
| CN108203437B (zh) | 2016-12-20 | 2022-05-13 | 海南先声药业有限公司 | 两种替吡嘧啶杂质制备方法与应用 |
| CN106749194B (zh) | 2017-01-23 | 2019-05-07 | 齐鲁天和惠世制药有限公司 | 一种替匹嘧啶的制备方法 |
| US10866219B2 (en) | 2017-12-22 | 2020-12-15 | Taiho Pharmaceutical Co., Ltd. | Method for detecting trifluridine- and/or tipiracil-related substance |
| WO2019124544A1 (fr) | 2017-12-22 | 2019-06-27 | 大鵬薬品工業株式会社 | Procédé de détection d'analogues dérivés de trifluridine et/ou de tipiracil |
| US10816517B2 (en) | 2018-01-05 | 2020-10-27 | Taiho Pharmaceutical Co., Ltd. | Method for detecting trifluridine-related substance by high-performance liquid chromatography |
| WO2019135405A1 (fr) | 2018-01-05 | 2019-07-11 | 大鵬薬品工業株式会社 | Procédé de détection d'un analogue dérivé de la trifluridine |
-
2018
- 2018-07-20 US US16/040,734 patent/US10816517B2/en active Active
-
2019
- 2019-01-04 TW TW108100350A patent/TWI759575B/zh active
- 2019-01-04 MA MA051528A patent/MA51528A/fr unknown
- 2019-01-04 EP EP19736109.0A patent/EP3736568A4/fr active Pending
- 2019-01-04 JP JP2019563983A patent/JP7257969B2/ja active Active
- 2019-06-17 US US16/442,993 patent/US10809237B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10816517B2 (en) | 2020-10-27 |
| US20190212309A1 (en) | 2019-07-11 |
| JP7257969B2 (ja) | 2023-04-14 |
| EP3736568A4 (fr) | 2021-11-17 |
| JPWO2019135405A1 (ja) | 2021-01-21 |
| US10809237B2 (en) | 2020-10-20 |
| US20190369063A1 (en) | 2019-12-05 |
| TWI759575B (zh) | 2022-04-01 |
| TW201930333A (zh) | 2019-08-01 |
| EP3736568A1 (fr) | 2020-11-11 |
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