MA43580A - L-valinate d'un dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants - Google Patents

L-valinate d'un dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants

Info

Publication number
MA43580A
MA43580A MA043580A MA43580A MA43580A MA 43580 A MA43580 A MA 43580A MA 043580 A MA043580 A MA 043580A MA 43580 A MA43580 A MA 43580A MA 43580 A MA43580 A MA 43580A
Authority
MA
Morocco
Prior art keywords
valinate
salt
crystalline form
polymorphic crystalline
corresponding polymorphic
Prior art date
Application number
MA043580A
Other languages
English (en)
Inventor
Catherine Jorand-Lebrun
Page Patrick Naxos
Vincent Pomel
Anna Quattropani
Matthias Schwarz
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/987,586 external-priority patent/US9447055B1/en
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of MA43580A publication Critical patent/MA43580A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/095Oxytocins; Vasopressins; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Emergency Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA043580A 2016-01-04 2017-01-04 L-valinate d'un dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants MA43580A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662274674P 2016-01-04 2016-01-04
US14/987,586 US9447055B1 (en) 2016-01-04 2016-01-04 α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
US201662395664P 2016-09-16 2016-09-16
US201662407918P 2016-10-13 2016-10-13

Publications (1)

Publication Number Publication Date
MA43580A true MA43580A (fr) 2021-05-26

Family

ID=57799697

Family Applications (2)

Application Number Title Priority Date Filing Date
MA043549A MA43549A (fr) 2016-01-04 2017-01-04 Alpha-amino esters de dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants
MA043580A MA43580A (fr) 2016-01-04 2017-01-04 L-valinate d'un dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA043549A MA43549A (fr) 2016-01-04 2017-01-04 Alpha-amino esters de dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants

Country Status (23)

Country Link
EP (4) EP4140988A1 (fr)
JP (5) JP6933322B2 (fr)
KR (2) KR20180100120A (fr)
CN (1) CN108779087A (fr)
AU (4) AU2017205670B2 (fr)
CA (2) CA3009576A1 (fr)
DK (2) DK3400217T3 (fr)
EA (1) EA036990B1 (fr)
ES (2) ES2916835T3 (fr)
HR (2) HRP20220673T1 (fr)
HU (2) HUE058871T2 (fr)
IL (4) IL284912B (fr)
LT (2) LT3397622T (fr)
MA (2) MA43549A (fr)
MX (3) MX2018008304A (fr)
PL (2) PL3397622T3 (fr)
PT (2) PT3397622T (fr)
RS (2) RS63286B1 (fr)
SG (4) SG10202009723PA (fr)
SI (2) SI3397622T1 (fr)
UA (2) UA125377C2 (fr)
WO (2) WO2017118639A1 (fr)
ZA (1) ZA201903769B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA43549A (fr) * 2016-01-04 2021-05-26 ObsEva SA Alpha-amino esters de dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants
RU2711615C1 (ru) * 2019-09-12 2020-01-17 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ лечения эндометриоза на основании экспериментальной модели у крыс
JP2022548314A (ja) * 2019-09-23 2022-11-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 妊娠を遷延させるためおよび月経または妊娠の合併症の処置の方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835175A (en) 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
US3839396A (en) 1971-07-15 1974-10-01 Shionogi & Co 9-lower alkyl-9-fluorenyl carbonates
US4108846A (en) 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
SE430885B (sv) 1980-03-24 1983-12-19 Ferring Ab Oxytocin-derivat
US4508657A (en) 1982-01-19 1985-04-02 Research Corporation Peptide synthesis and amino acid blocking agents
US4581167A (en) 1982-01-19 1986-04-08 Research Corporation Peptide synthesis and amino acid blocking agents
DE10075020I2 (de) 1982-12-21 2003-01-09 Ferring Ab Vasotocinderivate
US4460501A (en) 1983-08-30 1984-07-17 Research Corporation Process for the synthesis of peptides utilizing thioxanthylmethyloxycarbonyl dioxides
US5370135A (en) * 1993-10-13 1994-12-06 Biex, Inc. Use of estriol measurement to monitor tocolytic therapy
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
SE9604341D0 (sv) 1996-11-26 1996-11-26 Ferring Bv Hepta-peptide oxytocin analogue
IN188411B (fr) * 1997-03-27 2002-09-21 Yuhan Corp
WO2001092267A2 (fr) * 2000-05-30 2001-12-06 Ortho-Mcneil Pharmaceutical, Inc. Medicaments a base de dihydropyridine, compositions et procedes associes
GB0130677D0 (en) 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
EP1480998B1 (fr) 2002-02-27 2006-11-22 Ferring BV Intermediaires et procedes destines a fabriquer des analogues d'oxytocine heptapeptide
CA2477265A1 (fr) * 2002-03-28 2003-10-09 Applied Research Systems Ars Holding N.V. Derives de thiazolidine carboxamide utiles en tant que modulateurs du recepteur de prostaglandine f
GB0208785D0 (en) * 2002-04-17 2002-05-29 Medical Res Council Treatment methtods
US7521530B2 (en) * 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
UA78058C2 (en) 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists
WO2004052899A2 (fr) * 2002-12-12 2004-06-24 Idenix (Cayman) Limited Procede de production de nucleosides ramifies en position 2'
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
GB0414093D0 (en) 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
EP2493874A1 (fr) 2009-10-30 2012-09-05 Glaxo Group Limited Nouvelles formes cristallines de (3r,6r) -3- (2, 3 -dihydro- 1h- inden- 2 -yl) - 1 - [ (1r) - 1 - (2, 6 - diméthyl - 3 - pyridinyl) - 2 - (4 -morpholinyl) -2-oxoéthyl]-6- [(1s) - 1 -méthylpropyl]-2,5- pipérazinedione
EP2845850A1 (fr) 2013-09-10 2015-03-11 ObsEva S.A. Dérivés de pyrrolidine comme antagonistes des récepteurs V1a de vasopressine/oxytocine
EP2886107A1 (fr) 2013-12-17 2015-06-24 ObsEva S.A. Formules orales de dérivés de pyrrolydine
AU2014397706A1 (en) * 2014-06-16 2016-12-22 Glaxosmithkline Intellectual Property Development Limited Retosiban for the treatment of pre-term labour
JP2017519015A (ja) 2014-07-02 2017-07-13 オブセヴァ エス.エー. Ot−r活性に関する疾患を治療するための方法に有用な結晶質の(3z,5s)−5−(ヒドロキシメチル)−1−[(2’−メチル−1,1’−ビフェニル−4−イル)カルボニル]ピロリジン−3−オン о−メチルオキシム
ES2716862T3 (es) 2014-12-22 2019-06-17 Ferring Bv Terapia con antagonistas del receptor de oxitocina en la fase lútea para la implantación y embarazo en mujeres que se someten a tecnologías de reproducción asistida
MA43549A (fr) * 2016-01-04 2021-05-26 ObsEva SA Alpha-amino esters de dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants
US9447055B1 (en) * 2016-01-04 2016-09-20 Merck Serono S.A. α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof

Also Published As

Publication number Publication date
DK3400217T3 (da) 2022-06-07
AU2017205670B2 (en) 2021-05-20
EP3397622A1 (fr) 2018-11-07
JP7169573B2 (ja) 2022-11-11
HRP20220674T1 (hr) 2022-07-22
UA125118C2 (uk) 2022-01-12
KR20180100120A (ko) 2018-09-07
AU2017205254B2 (en) 2021-05-20
LT3400217T (lt) 2022-06-27
CA3009576A1 (fr) 2017-07-13
PT3397622T (pt) 2022-06-15
HUE058871T2 (hu) 2022-09-28
SI3400217T1 (sl) 2022-07-29
IL259742B (en) 2021-08-31
LT3397622T (lt) 2022-06-27
SG11201804594YA (en) 2018-06-28
ZA201903769B (en) 2023-03-29
MX2018008304A (es) 2019-01-24
EP3397622B1 (fr) 2022-03-09
JP2024012376A (ja) 2024-01-30
JP2019501897A (ja) 2019-01-24
AU2017205670A1 (en) 2018-08-16
SG11201804789QA (en) 2018-07-30
SG10202009723PA (en) 2020-11-27
ES2916835T3 (es) 2022-07-06
IL289256A (en) 2022-02-01
HUE058872T2 (hu) 2022-09-28
EP4144351A1 (fr) 2023-03-08
CN108779087A (zh) 2018-11-09
WO2017118639A1 (fr) 2017-07-13
AU2017205254A1 (en) 2018-08-16
IL260286B (en) 2022-02-01
PT3400217T (pt) 2022-06-15
KR20180099708A (ko) 2018-09-05
WO2017118641A1 (fr) 2017-07-13
JP7377588B2 (ja) 2023-11-10
AU2023233151A1 (en) 2023-10-12
JP6933322B2 (ja) 2021-09-08
CA3009573A1 (fr) 2017-07-13
HRP20220673T1 (hr) 2022-07-08
PL3397622T3 (pl) 2022-07-04
JP7432284B2 (ja) 2024-02-16
SI3397622T1 (sl) 2022-07-29
AU2021218009A1 (en) 2021-09-09
AU2021218003A1 (en) 2021-09-02
EP3400217A1 (fr) 2018-11-14
JP2021178858A (ja) 2021-11-18
IL260286A (en) 2018-07-31
PL3400217T3 (pl) 2022-07-04
UA125377C2 (uk) 2022-03-02
EP3400217B1 (fr) 2022-03-09
AU2021218009B2 (en) 2023-06-22
RS63286B1 (sr) 2022-06-30
IL284912B (en) 2022-07-01
JP2019500351A (ja) 2019-01-10
IL284912A (en) 2021-08-31
RS63285B1 (sr) 2022-06-30
ES2915948T3 (es) 2022-06-27
JP2023002668A (ja) 2023-01-10
EA036990B1 (ru) 2021-01-25
MX2018008157A (es) 2018-09-03
SG10202009769WA (en) 2020-11-27
EP4140988A1 (fr) 2023-03-01
IL259742A (en) 2018-07-31
DK3397622T3 (en) 2022-06-07
MA43549A (fr) 2021-05-26
MX2022000154A (es) 2022-02-21
EA201891095A1 (ru) 2019-01-31

Similar Documents

Publication Publication Date Title
IL272555A (en) New sulfonamide carboxamide compounds
IL273786A (en) New sulfonamide carboxamide compounds
IL272550A (en) New sulfonamide carboxamide compounds
IL271716A (en) New sulfonamide carboxamide compounds
MA46866A (fr) Une forme cristalline d'un inhibiteur de magl
MA46972A (fr) Forme polymorphe de sépiaptérine
IL248277A0 (en) Compounds of the type: 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl amides
IL271399A (en) Methods for the preparation of heterocyclic 3,1-benzodioxole compounds
HK1258964A1 (zh) 用於製備1,3-苯並間二氧雜環戊烯雜環化合物的方法
MA46567A (fr) Formes cristallines de l'éravacycline
MA43580A (fr) L-valinate d'un dérivé d'hydroxypropylthiazolidine carboxamide, sel et forme cristalline polymorphe correspondants
GB201702610D0 (en) Trial head
MA48944A (fr) Forme cristalline de n-butyldéoxygalactonojirimycine
FR3036312B1 (fr) Patte de derailleur
PL3515454T3 (pl) Krystaliczna polimorficzna postać 3-hydroksy-4,5-bis-benzyloksy- 6-benzyloksymetylo-2-fenylo-2-okso-2lambda5-[1,2]oksafosfinanu
EP3665144C0 (fr) Procédé de récupération de 3-methylbut-3-en-1-ol
MA45685A (fr) Formes cristallines de 4-cyano-n-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2h-pyran-4-yl)pyridin-3-yl)-1h-imidazole-2-carboxamide
ITUB20169994A1 (it) Nuove forme cristalline di farmaci immunomodulatori
MA44471A (fr) Forme cristalline
MA52458A (fr) Nouvelles formes cristallines
GB201814433D0 (en) Cyclists etc clothes etc
ZA201802361B (en) Pitting head
GB201716349D0 (en) Dvs
HUP1700542A2 (en) Nucleosides modified by 5'-linker
FR3050651B3 (fr) Reacteur de cristallisation