PT3400217T - Derivado de l-valinato de hidroxipropiltiazolidina, seu sal e forma cristalina deste - Google Patents

Derivado de l-valinato de hidroxipropiltiazolidina, seu sal e forma cristalina deste

Info

Publication number
PT3400217T
PT3400217T PT177003928T PT17700392T PT3400217T PT 3400217 T PT3400217 T PT 3400217T PT 177003928 T PT177003928 T PT 177003928T PT 17700392 T PT17700392 T PT 17700392T PT 3400217 T PT3400217 T PT 3400217T
Authority
PT
Portugal
Prior art keywords
valinate
salt form
carboxamide derivative
crystal polymorph
hydroxypropylthiazolidine
Prior art date
Application number
PT177003928T
Other languages
English (en)
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/987,586 external-priority patent/US9447055B1/en
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of PT3400217T publication Critical patent/PT3400217T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
PT177003928T 2016-01-04 2017-01-04 Derivado de l-valinato de hidroxipropiltiazolidina, seu sal e forma cristalina deste PT3400217T (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662274674P 2016-01-04 2016-01-04
US14/987,586 US9447055B1 (en) 2016-01-04 2016-01-04 α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
US201662395664P 2016-09-16 2016-09-16
US201662407918P 2016-10-13 2016-10-13

Publications (1)

Publication Number Publication Date
PT3400217T true PT3400217T (pt) 2022-06-15

Family

ID=57799697

Family Applications (2)

Application Number Title Priority Date Filing Date
PT177003928T PT3400217T (pt) 2016-01-04 2017-01-04 Derivado de l-valinato de hidroxipropiltiazolidina, seu sal e forma cristalina deste
PT177003910T PT3397622T (pt) 2016-01-04 2017-01-04 Co-administração de alfa-amino éster de derivado de hidroxipropiltiazolidina e carboxamida e um agente tocolítico

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT177003910T PT3397622T (pt) 2016-01-04 2017-01-04 Co-administração de alfa-amino éster de derivado de hidroxipropiltiazolidina e carboxamida e um agente tocolítico

Country Status (23)

Country Link
EP (4) EP3400217B1 (pt)
JP (5) JP6933322B2 (pt)
KR (2) KR20180099708A (pt)
CN (1) CN108779087A (pt)
AU (4) AU2017205670B2 (pt)
CA (2) CA3009576A1 (pt)
DK (2) DK3397622T3 (pt)
EA (1) EA036990B1 (pt)
ES (2) ES2915948T3 (pt)
HR (2) HRP20220673T1 (pt)
HU (2) HUE058871T2 (pt)
IL (4) IL284912B (pt)
LT (2) LT3397622T (pt)
MA (2) MA43549A (pt)
MX (3) MX2018008157A (pt)
PL (2) PL3400217T3 (pt)
PT (2) PT3400217T (pt)
RS (2) RS63286B1 (pt)
SG (4) SG10202009769WA (pt)
SI (2) SI3400217T1 (pt)
UA (2) UA125377C2 (pt)
WO (2) WO2017118641A1 (pt)
ZA (1) ZA201903769B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6933322B2 (ja) * 2016-01-04 2021-09-08 メルク セローノ エス．エー． ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形
RU2711615C1 (ru) * 2019-09-12 2020-01-17 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" Способ лечения эндометриоза на основании экспериментальной модели у крыс
EP4034129A4 (en) * 2019-09-23 2023-11-01 The Board of Trustees of the Leland Stanford Junior University TREATMENT PROCEDURES FOR GESTATIONAL EXTENSION AND FOR MENSTRUAL OR GESTATIONAL COMPLICATIONS

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835175A (en) 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
US3839396A (en) 1971-07-15 1974-10-01 Shionogi & Co 9-lower alkyl-9-fluorenyl carbonates
US4108846A (en) 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
SE430885B (sv) 1980-03-24 1983-12-19 Ferring Ab Oxytocin-derivat
US4581167A (en) 1982-01-19 1986-04-08 Research Corporation Peptide synthesis and amino acid blocking agents
US4508657A (en) 1982-01-19 1985-04-02 Research Corporation Peptide synthesis and amino acid blocking agents
DE10075020I2 (de) 1982-12-21 2003-01-09 Ferring Ab Vasotocinderivate
US4460501A (en) 1983-08-30 1984-07-17 Research Corporation Process for the synthesis of peptides utilizing thioxanthylmethyloxycarbonyl dioxides
US5370135A (en) * 1993-10-13 1994-12-06 Biex, Inc. Use of estriol measurement to monitor tocolytic therapy
DE4434488A1 (de) * 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
SE9604341D0 (sv) 1996-11-26 1996-11-26 Ferring Bv Hepta-peptide oxytocin analogue
IN188411B (pt) * 1997-03-27 2002-09-21 Yuhan Corp
EP1296990A2 (en) * 2000-05-30 2003-04-02 Ortho-McNeil Pharmaceutical, Inc. Dihydropyridine compounds for the inhibition of calcium-influx
GB0130677D0 (en) 2001-12-21 2002-02-06 Glaxo Group Ltd Medicaments and novel compounds
JP4615221B2 (ja) 2002-02-27 2011-01-19 フェリング ベスローテン フェンノートシャップ ヘプタペプチドオキシトシンアナログを製造するための中間体及び方法
ZA200406763B (en) * 2002-03-28 2005-09-30 Applied Research Systems Thiazolidine carboxamide derivatives as modulatorsof the prostaglandin F receptor.
GB0208785D0 (en) 2002-04-17 2002-05-29 Medical Res Council Treatment methtods
US7521530B2 (en) 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
UA78058C2 (en) 2002-07-05 2007-02-15 Applied Research Systems Pyrrolidine derivative as oxitocin antagonists
AU2003300901A1 (en) * 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
GB0414093D0 (en) 2004-06-23 2004-07-28 Glaxo Group Ltd Novel compounds
US8716286B2 (en) 2009-10-30 2014-05-06 Glaxo Group Limited Crystalline forms of (3R, 6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione
EP2845850A1 (en) 2013-09-10 2015-03-11 ObsEva S.A. Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists
EP2886107A1 (en) 2013-12-17 2015-06-24 ObsEva S.A. Oral formulations of pyrrolydine derivatives
BR112016029661A2 (pt) 2014-06-16 2017-08-22 Glaxosmithkline Ip Dev Ltd retosiban para tratamento de parto prematuro
MX371068B (es) 2014-07-02 2020-01-15 ObsEva SA ((3z,5s)-5-(hidroximetil)-1-[(2'-metil-1,1'-bifenil-4-il)carbonil ]pirrolidin-3-ona o-metiloxima cristalina y métodos de uso de la misma.
EP3501533A1 (en) 2014-12-22 2019-06-26 Ferring B.V. Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies
US9447055B1 (en) * 2016-01-04 2016-09-20 Merck Serono S.A. α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
JP6933322B2 (ja) 2016-01-04 2021-09-08 メルク セローノ エス．エー． ヒドロキシプロピルチアゾリジンカルボキサミド誘導体のｌ−バリネート及びその塩形態、結晶多形

Also Published As

Publication number Publication date
UA125118C2 (uk) 2022-01-12
IL260286B (en) 2022-02-01
JP2019500351A (ja) 2019-01-10
SI3400217T1 (sl) 2022-07-29
MA43549A (fr) 2021-05-26
EP4140988A1 (en) 2023-03-01
ES2915948T3 (es) 2022-06-27
IL284912B (en) 2022-07-01
IL259742A (en) 2018-07-31
ES2916835T3 (es) 2022-07-06
ZA201903769B (en) 2023-03-29
CA3009573A1 (en) 2017-07-13
EP3397622A1 (en) 2018-11-07
MX2018008157A (es) 2018-09-03
AU2017205670B2 (en) 2021-05-20
HRP20220674T1 (hr) 2022-07-22
IL259742B (en) 2021-08-31
IL289256A (en) 2022-02-01
JP6933322B2 (ja) 2021-09-08
SG10202009723PA (en) 2020-11-27
EP3400217B1 (en) 2022-03-09
SG11201804789QA (en) 2018-07-30
IL284912A (en) 2021-08-31
MA43580A (fr) 2021-05-26
LT3400217T (lt) 2022-06-27
HRP20220673T1 (hr) 2022-07-08
EP3400217A1 (en) 2018-11-14
JP2019501897A (ja) 2019-01-24
AU2021218009A1 (en) 2021-09-09
AU2017205254A1 (en) 2018-08-16
KR20180100120A (ko) 2018-09-07
AU2017205254B2 (en) 2021-05-20
CA3009576A1 (en) 2017-07-13
WO2017118639A1 (en) 2017-07-13
PT3397622T (pt) 2022-06-15
HUE058872T2 (hu) 2022-09-28
AU2021218009B2 (en) 2023-06-22
SI3397622T1 (sl) 2022-07-29
EP4144351A1 (en) 2023-03-08
AU2021218003A1 (en) 2021-09-02
MX2018008304A (es) 2019-01-24
RS63285B1 (sr) 2022-06-30
LT3397622T (lt) 2022-06-27
MX2022000154A (es) 2022-02-21
JP7432284B2 (ja) 2024-02-16
WO2017118641A1 (en) 2017-07-13
AU2023233151A1 (en) 2023-10-12
PL3397622T3 (pl) 2022-07-04
EA036990B1 (ru) 2021-01-25
KR20180099708A (ko) 2018-09-05
DK3397622T3 (en) 2022-06-07
SG11201804594YA (en) 2018-06-28
JP7377588B2 (ja) 2023-11-10
HUE058871T2 (hu) 2022-09-28
EA201891095A1 (ru) 2019-01-31
CN108779087A (zh) 2018-11-09
DK3400217T3 (da) 2022-06-07
JP2023002668A (ja) 2023-01-10
AU2017205670A1 (en) 2018-08-16
SG10202009769WA (en) 2020-11-27
EP3397622B1 (en) 2022-03-09
PL3400217T3 (pl) 2022-07-04
JP2024012376A (ja) 2024-01-30
RS63286B1 (sr) 2022-06-30
JP7169573B2 (ja) 2022-11-11
IL260286A (en) 2018-07-31
JP2021178858A (ja) 2021-11-18
UA125377C2 (uk) 2022-03-02

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