HRP20220674T1 - Zajednička primjena alfa-amino estera derivata hidroksipropiltiazolidin karboksamida i tokolitičkog sredstva - Google Patents
Zajednička primjena alfa-amino estera derivata hidroksipropiltiazolidin karboksamida i tokolitičkog sredstva Download PDFInfo
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- HRP20220674T1 HRP20220674T1 HRP20220674TT HRP20220674T HRP20220674T1 HR P20220674 T1 HRP20220674 T1 HR P20220674T1 HR P20220674T T HRP20220674T T HR P20220674TT HR P20220674 T HRP20220674 T HR P20220674T HR P20220674 T1 HRP20220674 T1 HR P20220674T1
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- Prior art keywords
- compound
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- patient
- ppm
- tocolytic agent
- Prior art date
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- 229940125712 tocolytic agent Drugs 0.000 title claims 9
- 239000003675 tocolytic agent Substances 0.000 title claims 9
- MFYNLGQKRUZXHD-UHFFFAOYSA-N 2-(3-hydroxypropyl)-1,3-thiazolidine-2-carboxamide Chemical class OCCCC1(SCCN1)C(=O)N MFYNLGQKRUZXHD-UHFFFAOYSA-N 0.000 title 1
- 238000011260 co-administration Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 30
- 229940122828 Oxytocin receptor antagonist Drugs 0.000 claims 3
- 108090000312 Calcium Channels Proteins 0.000 claims 2
- 102000003922 Calcium Channels Human genes 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- 238000005481 NMR spectroscopy Methods 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- VWXRQYYUEIYXCZ-OBIMUBPZSA-N atosiban Chemical group C1=CC(OCC)=CC=C1C[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)CSSCCC(=O)N1 VWXRQYYUEIYXCZ-OBIMUBPZSA-N 0.000 claims 2
- 229960002403 atosiban Drugs 0.000 claims 2
- 108700007535 atosiban Proteins 0.000 claims 2
- 230000003454 betamimetic effect Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229940125400 channel inhibitor Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 229950000801 hydroxyprogesterone caproate Drugs 0.000 claims 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 1
- PTGXAUBQBSGPKF-UHFFFAOYSA-N 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol Chemical compound C=1C=C(O)C=CC=1C(O)C(C)NC(C)CCC1=CC=CC=C1 PTGXAUBQBSGPKF-UHFFFAOYSA-N 0.000 claims 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims 1
- UWHCWRQFNKUYCG-QUZACWSFSA-N Epelsiban Chemical compound O=C([C@H](N1[C@@H](C(N[C@@H](C1=O)C1CC2=CC=CC=C2C1)=O)[C@@H](C)CC)C=1C(=NC(C)=CC=1)C)N1CCOCC1 UWHCWRQFNKUYCG-QUZACWSFSA-N 0.000 claims 1
- DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 claims 1
- ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 claims 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims 1
- 239000000006 Nitroglycerin Substances 0.000 claims 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 claims 1
- 206010036600 Premature labour Diseases 0.000 claims 1
- PLVGDGRBPMVYPB-FDUHJNRSSA-N Retosiban Chemical compound O=C([C@H](N1[C@@H](C(N[C@@H](C1=O)C1CC2=CC=CC=C2C1)=O)[C@@H](C)CC)C=1N=C(C)OC=1)N1CCOCC1 PLVGDGRBPMVYPB-FDUHJNRSSA-N 0.000 claims 1
- OLUJSZLBWZWGJT-HGBKYHTQSA-N [(2s,4z)-2-(hydroxymethyl)-4-methoxyiminopyrrolidin-1-yl]-[4-(2-methylphenyl)phenyl]methanone Chemical compound C1C(=N/OC)\C[C@@H](CO)N1C(=O)C1=CC=C(C=2C(=CC=CC=2)C)C=C1 OLUJSZLBWZWGJT-HGBKYHTQSA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- UGNGRKKDUVKQDF-IHOMMZCZSA-N barusiban Chemical compound N1C(=O)CCSCC[C@@H](C(=O)N(C)[C@H](CO)CCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H]1CC1=CNC2=CC=CC=C12 UGNGRKKDUVKQDF-IHOMMZCZSA-N 0.000 claims 1
- 229950009748 barusiban Drugs 0.000 claims 1
- 108010040145 barusiban Proteins 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 229960003455 buphenine Drugs 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229950009963 epelsiban Drugs 0.000 claims 1
- 229960001022 fenoterol Drugs 0.000 claims 1
- 229960003711 glyceryl trinitrate Drugs 0.000 claims 1
- 229960000708 hexoprenaline Drugs 0.000 claims 1
- OXLZNBCNGJWPRV-UHFFFAOYSA-N hexoprenaline Chemical compound C=1C=C(O)C(O)=CC=1C(O)CNCCCCCCNCC(O)C1=CC=C(O)C(O)=C1 OXLZNBCNGJWPRV-UHFFFAOYSA-N 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 239000006193 liquid solution Substances 0.000 claims 1
- 239000006194 liquid suspension Substances 0.000 claims 1
- 159000000003 magnesium salts Chemical class 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 235000019341 magnesium sulphate Nutrition 0.000 claims 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 claims 1
- 229960001783 nicardipine Drugs 0.000 claims 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical group COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 1
- 229960001597 nifedipine Drugs 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 229950000833 nolasiban Drugs 0.000 claims 1
- 229960002657 orciprenaline Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000026440 premature labor Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 229950010622 retosiban Drugs 0.000 claims 1
- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 claims 1
- 229960001634 ritodrine Drugs 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960000195 terbutaline Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Emergency Medicine (AREA)
Claims (18)
1. Spoj, naznačen time, da je predstavljen formulom (I)
[image]
ili njegova farmaceutski prihvatljiva sol, koji je za uporabu u liječenju ili prevenciji prijevremenog poroda kod ljudskog pacijenta, pri čemu se spoj primjenjuje kod pacijenta uz dodatno tokolitičko sredstvo.
2. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da dodatno tokolitičko sredstvo je antagonist receptora oksitocina.
3. Spoj za uporabu prema patentnom zahtjevu 2, naznačen time, da antagonist receptora oksitocina je atosiban, retosiban, barusiban, epelsiban, ili nolasiban.
4. Spoj za uporabu prema patentnom zahtjevu 3, naznačen time, da antagonist receptora oksitocina je atosiban.
5. Spoj za uporabu prema patentnom zahtjevu 1, naznačen time, da dodatno tokolitičko sredstvo je inhibitor kalcijevog kanala.
6. Spoj za uporabu prema patentnom zahtjevu 5, naznačen time, da inhibitor kalcijevog kanala je nifedipin ili nikardipin.
7. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-6, naznačen time, da se spoj i dodatno tokolitičko sredstvo primjenjuju kod pacijenta s betamimetikom, magnezijevom soli, donorom dušičnog oksida, progesteronom ili 17-α-hidroksiprogesteron kaproatom, ili kortikosteroidom.
8. Spoj za uporabu prema patentnom zahtjevu 7, naznačen time, da se spoj i dodatno tokolitičko sredstvo daju pacijentu s betamimetikom koji se bira iz skupine koju čine terbutalin, ritodrin, heksoprenalin, albuterol, fenoterol, nilidrin, i orciprenalin.
9. Spoj za uporabu prema patentnom zahtjevu 7, naznačen time, da se spoj i dodatno tokolitičko sredstvo daju pacijentu s magnezijevim sulfatom.
10. Spoj za uporabu prema patentnom zahtjevu 7, naznačen time, da se spoj i dodatno tokolitičko sredstvo daju pacijentu s nitroglicerinom.
11. Spoj za uporabu prema patentnom zahtjevu 7, naznačen time, da se spoj i dodatno tokolitičko sredstvo daju pacijentu s kortikosteroidom koji se bira iz skupine koju čine betametazon, deksametazon, i hidrokortizon.
12. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-11, naznačen time, da je spoj predstavljen formulom (III)
[image]
13. Spoj za uporabu prema patentnom zahtjevu 12, naznačen time, da je spoj u kristaliničnom stanju.
14. Spoj za uporabu prema patentnom zahtjevu 13, naznačen time, da spoj pokazuje maksimume 1H nuklearne magnetske rezonance (NMR), koji su centrirani na 1,1 ppm, 3,3 ppm, 4,9 ppm, 5,4 ppm, 7,1 ppm, 7,7 ppm, 7,9 ppm, i 8,0 ppm.
15. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-14, naznačen time, da se spoj daje pacijentu oralno.
16. Spoj za uporabu prema patentnom zahtjevu 15, naznačen time, da se spoj formulira kao tableta, kapsula, gel kapsula, prašak, tekuća otopina, ili tekuća suspenzija.
17. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-16, dok je pacijent, naznačen time, da se radi o gestacijskoj dobi od 24 tjedna do 34 tjedna.
18. Spoj za uporabu prema bilo kojem od patentnih zahtjeva 1-17, naznačen time, da se spoj nalazi unutar farmaceutskog pripravka koji nadalje sadrži jedno ili više farmaceutski prihvatljivih pomoćnih sredstava.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662274674P | 2016-01-04 | 2016-01-04 | |
US14/987,586 US9447055B1 (en) | 2016-01-04 | 2016-01-04 | α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
US201662395664P | 2016-09-16 | 2016-09-16 | |
US201662407918P | 2016-10-13 | 2016-10-13 | |
EP17700391.0A EP3397622B1 (en) | 2016-01-04 | 2017-01-04 | Co-administration of alpha-amino ester of hydroxypropylthiazolidine carboxamide derivative and a tocolytic agent |
PCT/EP2017/050099 WO2017118639A1 (en) | 2016-01-04 | 2017-01-04 | Alpha-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20220674T1 true HRP20220674T1 (hr) | 2022-07-22 |
Family
ID=57799697
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220674TT HRP20220674T1 (hr) | 2016-01-04 | 2017-01-04 | Zajednička primjena alfa-amino estera derivata hidroksipropiltiazolidin karboksamida i tokolitičkog sredstva |
HRP20220673TT HRP20220673T1 (hr) | 2016-01-04 | 2017-01-04 | L-valinat derivata hidroksipropiltiazolidin karboksamida, njegova sol i njegov kristalni oblik |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20220673TT HRP20220673T1 (hr) | 2016-01-04 | 2017-01-04 | L-valinat derivata hidroksipropiltiazolidin karboksamida, njegova sol i njegov kristalni oblik |
Country Status (23)
Country | Link |
---|---|
EP (4) | EP4144351A1 (hr) |
JP (5) | JP6933322B2 (hr) |
KR (2) | KR20180099708A (hr) |
CN (1) | CN108779087A (hr) |
AU (4) | AU2017205670B2 (hr) |
CA (2) | CA3009573A1 (hr) |
DK (2) | DK3400217T3 (hr) |
EA (1) | EA036990B1 (hr) |
ES (2) | ES2916835T3 (hr) |
HR (2) | HRP20220674T1 (hr) |
HU (2) | HUE058871T2 (hr) |
IL (4) | IL284912B (hr) |
LT (2) | LT3397622T (hr) |
MA (2) | MA43580A (hr) |
MX (3) | MX2018008304A (hr) |
PL (2) | PL3400217T3 (hr) |
PT (2) | PT3397622T (hr) |
RS (2) | RS63286B1 (hr) |
SG (4) | SG11201804789QA (hr) |
SI (2) | SI3400217T1 (hr) |
UA (2) | UA125377C2 (hr) |
WO (2) | WO2017118641A1 (hr) |
ZA (1) | ZA201903769B (hr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL284912B (en) * | 2016-01-04 | 2022-07-01 | Merck Serono Sa | L-Valinate derivative of hydroxypropylthiazolidine carboxamide and salt form, crystalline polymorph thereof |
RU2711615C1 (ru) * | 2019-09-12 | 2020-01-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения эндометриоза на основании экспериментальной модели у крыс |
EP4034129A4 (en) * | 2019-09-23 | 2023-11-01 | The Board of Trustees of the Leland Stanford Junior University | TREATMENT PROCEDURES FOR GESTATIONAL EXTENSION AND FOR MENSTRUAL OR GESTATIONAL COMPLICATIONS |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
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US3835175A (en) | 1971-03-15 | 1974-09-10 | Research Corp | 9-fluorenylmethanol haloformates, carbonates and thiocarbonates |
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