MD4563C1 - Produs de comicronizare cu conţinut de acetat de ulipristal - Google Patents
Produs de comicronizare cu conţinut de acetat de ulipristalInfo
- Publication number
- MD4563C1 MD4563C1 MDA20150053A MD20150053A MD4563C1 MD 4563 C1 MD4563 C1 MD 4563C1 MD A20150053 A MDA20150053 A MD A20150053A MD 20150053 A MD20150053 A MD 20150053A MD 4563 C1 MD4563 C1 MD 4563C1
- Authority
- MD
- Moldova
- Prior art keywords
- ulipristal acetate
- micronisation
- product
- micronisation product
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Abstract
Invenţia se referă la un produs de comicronizare ce conţine un ingredient activ selectat din grupul ce constă din acetat de ulipristal, un metabolit al acetatului de ulipristal şi amestecul acestora, şi un surfactant solid farmaceutic acceptabil selectat din săruri alchilsulfat C8-C20 şi amestecurile acestora.Invenţia de asemenea se referă la un procedeu de obţinere a produsului de comicronizare, la o compoziţie farmaceutică ce conţine produsul de comicronizare menţionat şi la utilizarea acesteia în calitate de contraceptiv şi în tratamentul sau prevenirea tulburărilor ginecologice.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1260603A FR2997627B1 (fr) | 2012-11-08 | 2012-11-08 | Produit de co-micronisation comprenant de l'ulipristal acetate |
PCT/FR2013/052670 WO2014072646A1 (fr) | 2012-11-08 | 2013-11-07 | Produit de co-micronisation comprenant de l'ulipristal acetate |
Publications (3)
Publication Number | Publication Date |
---|---|
MD20150053A2 MD20150053A2 (ro) | 2015-10-31 |
MD4563B1 MD4563B1 (ro) | 2018-05-31 |
MD4563C1 true MD4563C1 (ro) | 2018-12-31 |
Family
ID=47878175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150053A MD4563C1 (ro) | 2012-11-08 | 2013-11-07 | Produs de comicronizare cu conţinut de acetat de ulipristal |
Country Status (30)
Country | Link |
---|---|
US (2) | US9610293B2 (ro) |
EP (1) | EP2916871B1 (ro) |
JP (1) | JP2015536968A (ro) |
KR (1) | KR20150093170A (ro) |
CN (1) | CN104902928B (ro) |
AR (1) | AR093402A1 (ro) |
AU (1) | AU2013343320B2 (ro) |
BR (1) | BR112015010271B1 (ro) |
CA (1) | CA2890272A1 (ro) |
CR (1) | CR20150297A (ro) |
CY (1) | CY1119542T1 (ro) |
DK (1) | DK2916871T3 (ro) |
EA (1) | EA027641B1 (ro) |
EC (1) | ECSP15022442A (ro) |
ES (1) | ES2606307T3 (ro) |
FR (1) | FR2997627B1 (ro) |
GE (1) | GEP201706637B (ro) |
HR (1) | HRP20161624T1 (ro) |
HU (1) | HUE031911T2 (ro) |
LT (1) | LT2916871T (ro) |
MD (1) | MD4563C1 (ro) |
MX (1) | MX363699B (ro) |
PL (1) | PL2916871T3 (ro) |
PT (1) | PT2916871T (ro) |
RS (1) | RS55429B1 (ro) |
SI (1) | SI2916871T1 (ro) |
SM (1) | SMT201600445B (ro) |
TW (1) | TWI617325B (ro) |
UA (1) | UA117465C2 (ro) |
WO (1) | WO2014072646A1 (ro) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2997627B1 (fr) * | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant de l'ulipristal acetate |
CN103923154B (zh) * | 2013-01-16 | 2017-09-26 | 杭州容立医药科技有限公司 | 醋酸乌利司他的共晶及制备方法 |
CN105663140A (zh) * | 2014-11-21 | 2016-06-15 | 四川海思科制药有限公司 | 一种含醋酸乌利司他的药物组合物及其制备方法 |
CN104865215A (zh) * | 2015-05-16 | 2015-08-26 | 南京海纳医药科技有限公司 | 一种醋酸乌利司他片剂及其溶出度测定方法 |
CN105919150A (zh) * | 2016-05-12 | 2016-09-07 | 高洁珺 | 一种代替压片工艺中化工添加剂的方法 |
CN106265533A (zh) * | 2016-10-10 | 2017-01-04 | 朱隆娅 | 一种阿德呋啉颗粒剂及其制备方法 |
FR3060389B1 (fr) | 2016-12-20 | 2019-05-31 | Laboratoire Hra-Pharma | Comprime enrobe comprenant de l'ulipristal acetate ou un de ses metabolites |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
US4954490A (en) | 1988-06-23 | 1990-09-04 | Research Triangle Institute | 11 β-substituted progesterone analogs |
GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
FR2757397B1 (fr) * | 1996-12-23 | 1999-03-05 | Mazal Pharma | Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree |
IL127129A (en) * | 1998-11-18 | 2004-06-01 | Ferring Bv | Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared |
FR2821555B1 (fr) * | 2001-03-01 | 2003-05-16 | Besins Int Lab | Progestatif co-micronise avec un tensioactif, composition pharmaceutique le comprenant, leurs procedes de fabrication et leurs utilisations |
FR2841138B1 (fr) * | 2002-06-25 | 2005-02-25 | Cll Pharma | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation |
ES2212912B1 (es) | 2003-01-22 | 2005-10-01 | Crystal Pharma, S.A. | Procedimiento para la obtencion de 17alfa-acetoxi-11beta-(4-n,n-dimetilaminofenil)-19-norpregna-4,9-dien-3,20-diona. |
ATE497745T1 (de) | 2004-07-09 | 2011-02-15 | Population Council Inc | Zusammensetzungen mit verzögerter freisetzung mit progesteron-rezeptormodulatoren |
WO2008037044A1 (en) | 2006-09-27 | 2008-04-03 | Medley S.A. Indústria Farmacêutica | Oxcarbazepine-containing oral formulation and a process to obtain the same |
US7867515B2 (en) | 2006-12-20 | 2011-01-11 | TEVA Woman's Health, Inc. | Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof |
AU2007339820A1 (en) * | 2006-12-28 | 2008-07-10 | Repros Therapeutics Inc. | Methods and formulations for improved bioavailability of antiprogestins |
WO2009067557A1 (en) * | 2007-11-19 | 2009-05-28 | Teva Pharmaceutical Industries Ltd. | Deferasirox pharmaceutical compositions |
US8299050B2 (en) * | 2008-01-29 | 2012-10-30 | Laboratoire Hra-Pharma | Method for treating uterine fibroids |
US8512745B2 (en) | 2008-12-08 | 2013-08-20 | Laboratoire Hra Pharma | Ulipristal acetate tablets |
US9616073B2 (en) | 2009-04-14 | 2017-04-11 | Laboratoire Hra-Pharma | Method for on-demand contraception |
EP2471537A1 (en) * | 2010-12-30 | 2012-07-04 | PregLem S.A. | Treatment of pain associated with dislocation of basal endometrium |
FR2997627B1 (fr) * | 2012-11-08 | 2015-01-16 | Hra Pharma Lab | Produit de co-micronisation comprenant de l'ulipristal acetate |
-
2012
- 2012-11-08 FR FR1260603A patent/FR2997627B1/fr not_active Expired - Fee Related
-
2013
- 2013-07-11 UA UAA201505665A patent/UA117465C2/uk unknown
- 2013-11-07 KR KR1020157015210A patent/KR20150093170A/ko not_active Application Discontinuation
- 2013-11-07 HU HUE13801639A patent/HUE031911T2/en unknown
- 2013-11-07 PL PL13801639T patent/PL2916871T3/pl unknown
- 2013-11-07 BR BR112015010271A patent/BR112015010271B1/pt not_active IP Right Cessation
- 2013-11-07 SI SI201330409A patent/SI2916871T1/sl unknown
- 2013-11-07 WO PCT/FR2013/052670 patent/WO2014072646A1/fr active Application Filing
- 2013-11-07 LT LTEP13801639.9T patent/LT2916871T/lt unknown
- 2013-11-07 AR ARP130104089A patent/AR093402A1/es unknown
- 2013-11-07 JP JP2015541214A patent/JP2015536968A/ja active Pending
- 2013-11-07 US US14/441,027 patent/US9610293B2/en not_active Expired - Fee Related
- 2013-11-07 CA CA2890272A patent/CA2890272A1/fr not_active Abandoned
- 2013-11-07 ES ES13801639.9T patent/ES2606307T3/es active Active
- 2013-11-07 AU AU2013343320A patent/AU2013343320B2/en not_active Ceased
- 2013-11-07 DK DK13801639.9T patent/DK2916871T3/da active
- 2013-11-07 RS RS20161080A patent/RS55429B1/sr unknown
- 2013-11-07 CN CN201380058466.0A patent/CN104902928B/zh not_active Expired - Fee Related
- 2013-11-07 EP EP13801639.9A patent/EP2916871B1/fr active Active
- 2013-11-07 GE GEAP201313847A patent/GEP201706637B/en unknown
- 2013-11-07 MD MDA20150053A patent/MD4563C1/ro not_active IP Right Cessation
- 2013-11-07 PT PT138016399T patent/PT2916871T/pt unknown
- 2013-11-07 EA EA201500513A patent/EA027641B1/ru not_active IP Right Cessation
- 2013-11-07 MX MX2015005762A patent/MX363699B/es unknown
- 2013-11-08 TW TW102140765A patent/TWI617325B/zh not_active IP Right Cessation
-
2015
- 2015-06-05 EC ECIEPI201522442A patent/ECSP15022442A/es unknown
- 2015-06-05 CR CR20150297A patent/CR20150297A/es unknown
-
2016
- 2016-11-29 CY CY20161101236T patent/CY1119542T1/el unknown
- 2016-12-02 HR HRP20161624TT patent/HRP20161624T1/hr unknown
- 2016-12-07 SM SM201600445T patent/SMT201600445B/it unknown
-
2017
- 2017-02-16 US US15/434,650 patent/US20170157146A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG4A | Patent for invention issued | ||
KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
MM4A | Patent for invention definitely lapsed due to non-payment of fees |