RU2014147728A - Производное транс-2-деценовой кислоты и содержащее его лекарственное средство - Google Patents

Производное транс-2-деценовой кислоты и содержащее его лекарственное средство Download PDF

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RU2014147728A
RU2014147728A RU2014147728A RU2014147728A RU2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A RU 2014147728 A RU2014147728 A RU 2014147728A
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pharmaceutical agent
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pharmaceutically acceptable
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RU2014147728A
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RU2602810C2 (ru
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Мунеказу ИИНУМА
Соеи ФУРУКАВА
Мицуру НАИКИ
Томонори МАЦУМОТО
Кунихико ХИГАСИУРА
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Ниппон Дзоки Фармасьютикал Ко., Лтд.
Нагоя Индастриал Сайенс Рисерч Инститьют
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Abstract

1. Производное транс-2-деценовой кислоты, представленное следующей общей формулой (I') или его фармацевтически приемлемая соль:,где X' представляет собой:(a) 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом,(b) 3-тиазолидил,(c) пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилом, фенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом,(d) тиоморфолино,(e) 1-пиперазил, который может быть замещен алкилом, карбоксиалкилом, алкоксикарбонилалкилом, алкиламиноалкилом, циклоалкилом, пиперидиноалкилом, фенилалкилом, пиридилом, пиримидилом, карбоксифенилалкилом или алкоксикарбонилфенилалкилом,(f) 1-пиперазил, замещенный фенилом, который может быть замещен алкиламино, галогеном, алкокси, алкилом, гидрокси, карбоксиалкокси или алкоксикарбонилалкокси,(g) 1,4-диазепанил, который может быть замещен алкилом или алкиламиноалкилом, или(h) карбоксиморфолино.2. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом.3. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 3-тиазолидил, тиоморфолино или карбоксиморфолино.4. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилфенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом.5. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' пре

Claims (16)

1. Производное транс-2-деценовой кислоты, представленное следующей общей формулой (I') или его фармацевтически приемлемая соль:
Figure 00000001
,
где X' представляет собой:
(a) 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом,
(b) 3-тиазолидил,
(c) пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилом, фенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом,
(d) тиоморфолино,
(e) 1-пиперазил, который может быть замещен алкилом, карбоксиалкилом, алкоксикарбонилалкилом, алкиламиноалкилом, циклоалкилом, пиперидиноалкилом, фенилалкилом, пиридилом, пиримидилом, карбоксифенилалкилом или алкоксикарбонилфенилалкилом,
(f) 1-пиперазил, замещенный фенилом, который может быть замещен алкиламино, галогеном, алкокси, алкилом, гидрокси, карбоксиалкокси или алкоксикарбонилалкокси,
(g) 1,4-диазепанил, который может быть замещен алкилом или алкиламиноалкилом, или
(h) карбоксиморфолино.
2. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом.
3. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 3-тиазолидил, тиоморфолино или карбоксиморфолино.
4. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилфенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом.
5. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1-пиперазил, который может быть замещен алкилом, карбоксиалкилом, алкоксикарбонилалкилом, алкиламиноалкилом, циклоалкилом, пиперидиноалкилом, фенилалкилом, пиридилом, пиримидилом, карбоксифенилалкилом или алкоксикарбонилфенилалкилом.
6. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1-пиперазил, замещенный фенилом, который может быть замещен алкиламино, галогеном, алкокси, алкилом, гидрокси, карбоксиалкокси или алкоксикарбонилалкокси.
7. Производное транс-2-деценовой кислоты или его фармацевтически приемлемая соль по п. 1, где X' представляет собой 1,4-диазепанил, который может быть замещен алкилом или алкиламиноалкилом.
8. Фармацевтическое средство содержащее, в качестве активного ингредиента, по меньшей мере один член, выбранный из производного транс-2-деценовой кислоты, представленного следующей общей формулой (I), и его фармацевтически приемлемой соли:
Figure 00000002
,
где X представляет собой:
(a) 1-пирролидил, замещенный карбоксилом или алкоксикарбонилом,
(b) 3-тиазолидил,
(c) пиперидино, замещенный алкилом, оксо, гидрокси, алкокси, карбоксилом, алкоксикарбонилом, алкиламино, алкиламиноалкилом, фенилом, карбоксиалкилом, алкоксикарбонилалкилом, циано или галогенофенилом,
(d) тиоморфолино,
(e) 1-пиперазил, который может быть замещен алкилом, карбоксиалкилом, алкоксикарбонилалкилом, алкиламиноалкилом, циклоалкилом, пиперидиноалкилом, фенилалкилом, пиридилом, пиримидилом, карбоксифенилалкил или алкоксикарбонилфенилалкилом,
(f) 1-пиперазил, замещенный фенилом, который может быть замещен алкиламино, галогеном, алкокси, алкилом, гидрокси, карбоксиалкокси или алкоксикарбонилалкокси,
(g) 1,4-диазепанил, который может быть замещен алкилом или алкиламиноалкилом, или
(h) карбоксиморфолино.
9. Фармацевтическое средство по п. 8, где фармацевтическое средство представляет собой профилактическое средство или терапевтическое средство от расстройств периферической нервной системы, вызванных введением лекарственного средства, включающего по меньшей мере одно противораковое средство.
10. Фармацевтическое средство по п. 8, где фармацевтическое средство представляет собой профилактическое средство или терапевтическое средство от нейродегенеративных заболеваний.
11. Фармацевтическое средство по п. 8, где фармацевтическое средство представляет собой профилактическое средство или терапевтическое средство от психических заболеваний.
12. Фармацевтическое средство по п. 11, где психические заболевания представляют собой депрессию, тревожные расстройства (неврозы) или расстройства аутистического спектра.
13. Фармацевтическое средство по п. 8, где фармацевтическое средство представляет собой анальгетик против болевых синдромов.
14. Фармацевтическое средство по любому одному из пп. 8-13, где фармацевтическое средство представляет собой препарат для инъекций.
15. Фармацевтическое средство по любому одному из пп. 8-13, где фармацевтическое средство представляет собой пероральный препарат.
16. Фармацевтическое средство по любому одному из пп. 8-13, где фармацевтическое средство представляет собой средство для наружного применения.
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