MA41038A - Composés d'aminopyridyloxypyrazole - Google Patents
Composés d'aminopyridyloxypyrazoleInfo
- Publication number
- MA41038A MA41038A MA041038A MA41038A MA41038A MA 41038 A MA41038 A MA 41038A MA 041038 A MA041038 A MA 041038A MA 41038 A MA41038 A MA 41038A MA 41038 A MA41038 A MA 41038A
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- cancer
- aminopyridylooxpyrazole
- tgfpri
- glioblastoma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne de nouveaux composés daminopyridylooxpyrazole qui inhibent l'activité du récepteur 1 du facteur du croissance transformant beta (tgfpri), des compositions pharmaceutiques comprenant les composés et des procédés d'utilisation des composés pour traiter le cancer du colon,mélanome carcinomehépatocellulaire, cancer rénal, glioblastome, cancer du pancréas, syndrome myélodysplasique, cancer du poumon et cancer gastrique et/ou la fibrose, de préference cirrhose du foie et maladie rénale chronique.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462060724P | 2014-10-07 | 2014-10-07 | |
PCT/US2015/053098 WO2016057278A1 (fr) | 2014-10-07 | 2015-09-30 | Composés d'aminopyridyloxypyrazole |
EP15777845.7A EP3204377B1 (fr) | 2014-10-07 | 2015-09-30 | Composés d'aminopyridyloxypyrazole |
Publications (2)
Publication Number | Publication Date |
---|---|
MA41038A true MA41038A (fr) | 2017-08-16 |
MA41038B1 MA41038B1 (fr) | 2018-10-31 |
Family
ID=54266692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA41038A MA41038B1 (fr) | 2014-10-07 | 2015-09-30 | Composés d'aminopyridyloxypyrazole |
Country Status (42)
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015089800A1 (fr) | 2013-12-19 | 2015-06-25 | Eli Lilly And Company | Composés fluorophényl-pyrazole |
AU2014373773C1 (en) | 2014-01-01 | 2019-06-27 | Medivation Technologies Llc | Compounds and methods of use |
JP6626885B2 (ja) * | 2014-10-31 | 2019-12-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 新しいピリジニルオキシ及びフェニルオキシピラゾリル化合物 |
EP3518926A1 (fr) | 2016-09-30 | 2019-08-07 | Eli Lilly and Company | Utilisation de 2-{4-[(4-{[1-cyclopropyl-3-tétrahydro-2h-pyrane-4-yl)-1h-pyrazole-4-yl]oxy}pyridine-2-yl)amino]pyridine-2-yl}propane-2-ol pour le traitement du cancer |
JOP20190080A1 (ar) * | 2016-10-14 | 2019-04-11 | Bayer Pharma AG | مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها |
US11124509B2 (en) | 2017-03-23 | 2021-09-21 | Clavius Pharmaceuticals, LLC. | Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment |
WO2019013790A1 (fr) * | 2017-07-12 | 2019-01-17 | Curza Global, Llc | Composés antimicrobiens et leurs utilisations |
CN107540672A (zh) * | 2017-10-10 | 2018-01-05 | 牡丹江医学院 | 一种治疗肝硬化的药物及其合成方法 |
CN107892687B (zh) * | 2018-01-21 | 2018-08-24 | 广东莱恩医药研究院有限公司 | 一种2-乙酸酯咪唑类化合物及其在防治骨质疏松药物中的应用 |
CA3103771A1 (fr) * | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | 6-aminopyridin-3-yl pyrazoles en tant que modulateurs de roryt |
CN112867724A (zh) | 2018-07-23 | 2021-05-28 | 广州噢斯荣医药技术有限公司 | 二膦酸盐药物缀合物 |
CN112512597A (zh) | 2018-07-26 | 2021-03-16 | 大日本住友制药肿瘤公司 | 用于治疗与acvr1表达异常相关的疾病的方法以及用于此的acvr1抑制剂 |
WO2020041562A1 (fr) * | 2018-08-22 | 2020-02-27 | Clavius Pharmaceuticals, Llc | Imidazoles substitués pour l'inhibition de tgf-bêta et méthodes de traitement |
WO2020078402A1 (fr) * | 2018-10-18 | 2020-04-23 | 南京圣和药业股份有限公司 | COMPOSÉ SERVANT D'INHIBITEUR DE TGF-β R1 ET SON UTILISATION |
CN112839946B (zh) * | 2018-10-31 | 2022-04-12 | 江苏奥赛康药业有限公司 | 作为TGF-βR1激酶抑制剂的双环吡唑类化合物 |
WO2020103817A1 (fr) * | 2018-11-20 | 2020-05-28 | 南京圣和药业股份有限公司 | INHIBITEUR DE TGF-βR1 ET SON UTILISATION |
BR112021007006A2 (pt) * | 2018-12-27 | 2021-08-10 | Nexys Therapeutics, Inc. | derivados de (piridin-2-il)amina como inibidores de tgf-beta r1(alk5) para o tratamento de câncer |
US20200323851A1 (en) * | 2019-01-10 | 2020-10-15 | Tolero Pharmaceuticals, Inc. | Alk5 inhibitors for treating myelodysplastic syndrome |
KR20210118891A (ko) | 2019-01-24 | 2021-10-01 | 지앙수 아오사이캉 파마수티칼 씨오., 엘티디. | TGF-β R1 키나아제 억제제로서의 5-(4-피리딜옥시)피라졸 화합물 |
WO2020258006A1 (fr) * | 2019-06-25 | 2020-12-30 | Inventisbio Shanghai Ltd. | Composés hétérocycliques, leurs procédés de préparation et leurs méthodes d'utilisation |
CN112694477B (zh) * | 2019-10-22 | 2024-02-06 | 四川科伦博泰生物医药股份有限公司 | 吡唑并环类化合物,包含其的药物组合物,其制备方法及其用途 |
CN114728980A (zh) * | 2019-12-23 | 2022-07-08 | 江苏先声药业有限公司 | 吡唑类化合物 |
CN111116565B (zh) * | 2020-04-01 | 2020-07-14 | 中科利健制药(广州)有限公司 | 2-芳基-4-(4-吡唑氧基)吡啶类化合物、其制备方法、药物组合物与应用 |
CN111303135A (zh) * | 2020-04-01 | 2020-06-19 | 中科利健制药(广州)有限公司 | 4-(4-吡唑氧基)喹啉类化合物、其制备方法、药物组合物与应用 |
WO2021204626A1 (fr) | 2020-04-06 | 2021-10-14 | Almirall, S.A. | Composés hétéroaryle substitués par aryle et hétéroaryle-carboxamide utiles en tant qu'inhibiteurs de tyk2 |
CN113698395B (zh) * | 2020-05-22 | 2023-12-08 | 赛诺哈勃药业(成都)有限公司 | 转化生长因子受体拮抗剂、其制备方法和应用 |
CN114867723B (zh) * | 2020-07-23 | 2023-05-30 | 江苏奥赛康药业有限公司 | 作为TGF-βR1抑制剂的吡啶氧基连吡唑类化合物的盐型、晶型以及其药物组合物 |
WO2023182780A1 (fr) * | 2022-03-22 | 2023-09-28 | 오토텔릭바이오 주식회사 | Composé dérivé de thiazole et ses utilisations |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03010630A (es) | 2001-05-24 | 2004-03-09 | Lilly Co Eli | Nuevos derivados de pirrol como agentes farmaceuticos. |
UA80571C2 (en) | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
GB0313915D0 (en) * | 2003-06-16 | 2003-07-23 | Smithkline Beecham Corp | Compounds |
UY31281A1 (es) * | 2007-08-13 | 2009-03-31 | Aminas, benzamidas y sulfonamidas {[4-(5,6-dimetil-2-piridin-2-il-piridin-3-il) oxipiridin-2-il]amino} sustituidas, sus sales farmacéuticamente aceptables, composiciones contenniéndolas y aplicaciones. | |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
US20140296248A1 (en) | 2011-04-04 | 2014-10-02 | Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis | Methods and compositions for predicting resistance to anticancer treatment |
TW201329067A (zh) * | 2011-12-08 | 2013-07-16 | Amgen Inc | 作為gka活化劑之脲化合物 |
WO2015089800A1 (fr) | 2013-12-19 | 2015-06-25 | Eli Lilly And Company | Composés fluorophényl-pyrazole |
-
2015
- 2015-09-22 TW TW104131319A patent/TWI582083B/zh not_active IP Right Cessation
- 2015-09-22 JO JOP/2015/0235A patent/JO3336B1/ar active
- 2015-09-23 AR ARP150103058A patent/AR102003A1/es unknown
- 2015-09-30 TR TR2018/16415T patent/TR201816415T4/tr unknown
- 2015-09-30 LT LTEP15777845.7T patent/LT3204377T/lt unknown
- 2015-09-30 PL PL15777845T patent/PL3204377T3/pl unknown
- 2015-09-30 TN TN2017000046A patent/TN2017000046A1/en unknown
- 2015-09-30 PT PT15777845T patent/PT3204377T/pt unknown
- 2015-09-30 AU AU2015328553A patent/AU2015328553C1/en not_active Ceased
- 2015-09-30 JP JP2016526891A patent/JP6043894B2/ja active Active
- 2015-09-30 AP AP2017009836A patent/AP2017009836A0/en unknown
- 2015-09-30 EP EP15777845.7A patent/EP3204377B1/fr active Active
- 2015-09-30 CA CA2961262A patent/CA2961262C/fr active Active
- 2015-09-30 PE PE2017000536A patent/PE20170662A1/es unknown
- 2015-09-30 US US14/870,033 patent/US9617243B2/en active Active
- 2015-09-30 KR KR1020177009123A patent/KR101921847B1/ko active IP Right Grant
- 2015-09-30 CR CR20170072A patent/CR20170072A/es unknown
- 2015-09-30 MX MX2017004457A patent/MX367360B/es active IP Right Grant
- 2015-09-30 SG SG11201702481UA patent/SG11201702481UA/en unknown
- 2015-09-30 MY MYPI2017701190A patent/MY190541A/en unknown
- 2015-09-30 UA UAA201702921A patent/UA118807C2/uk unknown
- 2015-09-30 BR BR112017005453-1A patent/BR112017005453B1/pt active IP Right Grant
- 2015-09-30 SI SI201530417T patent/SI3204377T1/sl unknown
- 2015-09-30 ES ES15777845T patent/ES2700376T3/es active Active
- 2015-09-30 RS RS20181372A patent/RS58094B1/sr unknown
- 2015-09-30 CN CN201580054343.9A patent/CN106795139B/zh active Active
- 2015-09-30 DK DK15777845.7T patent/DK3204377T3/en active
- 2015-09-30 MA MA41038A patent/MA41038B1/fr unknown
- 2015-09-30 WO PCT/US2015/053098 patent/WO2016057278A1/fr active Application Filing
- 2015-09-30 NZ NZ729800A patent/NZ729800A/en unknown
- 2015-09-30 EA EA201790476A patent/EA031830B1/ru not_active IP Right Cessation
-
2017
- 2017-02-09 IL IL250543A patent/IL250543B/en active IP Right Grant
- 2017-02-16 ZA ZA2017/01175A patent/ZA201701175B/en unknown
- 2017-03-10 CO CONC2017/0002233A patent/CO2017002233A2/es unknown
- 2017-03-24 SV SV2017005411A patent/SV2017005411A/es unknown
- 2017-03-30 CL CL2017000765A patent/CL2017000765A1/es unknown
- 2017-03-30 DO DO2017000090A patent/DOP2017000090A/es unknown
- 2017-04-04 GT GT201700067A patent/GT201700067A/es unknown
- 2017-04-06 PH PH12017500635A patent/PH12017500635B1/en unknown
- 2017-04-06 EC ECIEPI201721097A patent/ECSP17021097A/es unknown
-
2018
- 2018-10-30 HR HRP20181797TT patent/HRP20181797T1/hr unknown
- 2018-11-13 CY CY20181101193T patent/CY1120903T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA41038A (fr) | Composés d'aminopyridyloxypyrazole | |
EA201792047A1 (ru) | Новые соединения | |
MX2021006615A (es) | Proteinas de union triespecificas y metodos de uso. | |
MX2019006045A (es) | Proteinas triespecificas dirigidas a psma y metodos de uso. | |
PH12019502576A1 (en) | Bis-octahydrophenanthrene carboxamides and protein conjugates thereof | |
SG10201909796PA (en) | Chemosensory receptor ligand-based therapies | |
NZ737399A (en) | Ccr2 modulators | |
MX2021012205A (es) | Anticuerpos de cadena pesada que se unen al psma. | |
EA201790765A1 (ru) | Производные спиродиамина в качестве ингибиторов альдостерон-синтазы | |
TW200714290A (en) | Anti-M-CSF antibody compositions having reduced levels of endotoxin | |
MX2022005404A (es) | Compuestos de fijación a il-2r e il-7r dual. | |
MX2014004074A (es) | Metodo de tratamiento de condiciones del higado utilizando antagonistas de notch2. | |
EA201791227A1 (ru) | РЕЖИМ ДОЗИРОВАНИЯ АНТАГОНИСТОВ MAdCAM | |
EA201891710A1 (ru) | Терапевтические соединения | |
MX2022003671A (es) | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. | |
SG10201805646WA (en) | Angiopoietin-like 4 antibodies and methods of use | |
MX2019009847A (es) | Proteínas que se unen a cd123, nkg2d y cd16. | |
PH12019502717A1 (en) | Recombinant robo2 proteins, compositions, methods and uses thereof | |
MX2022000317A (es) | Anticuerpos altamente potentes que se unen al receptor de muerte 4 y al receptor de muerte 5. | |
MA44558B1 (fr) | Dérivé du glucagon, conjugué de celui-ci, composition le comprenant et utilisation thérapeutique de celui-ci | |
EA202190787A1 (ru) | Пиридазиноны и способы их применения | |
PL426662A1 (en) | Composition for intravitreal administration of therapeutic protein | |
EA201990927A1 (ru) | Антитела против lag-3 и способы их применения | |
EA201792460A1 (ru) | Связывающие tigit агенты и варианты их применения |