MA34580B1 - Valsartan hautement cristallin - Google Patents
Valsartan hautement cristallinInfo
- Publication number
- MA34580B1 MA34580B1 MA35701A MA35701A MA34580B1 MA 34580 B1 MA34580 B1 MA 34580B1 MA 35701 A MA35701 A MA 35701A MA 35701 A MA35701 A MA 35701A MA 34580 B1 MA34580 B1 MA 34580B1
- Authority
- MA
- Morocco
- Prior art keywords
- valsartan
- highly crystalline
- highly
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne une forme de valsartan hautement cristalline, ses compositions pharmaceutiques et son procédé de préparation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37028510P | 2010-08-03 | 2010-08-03 | |
PCT/EP2011/063254 WO2012016969A1 (fr) | 2010-08-03 | 2011-08-01 | Valsartan hautement cristallin |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34580B1 true MA34580B1 (fr) | 2013-10-02 |
Family
ID=44645072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35701A MA34580B1 (fr) | 2010-08-03 | 2011-08-01 | Valsartan hautement cristallin |
Country Status (18)
Country | Link |
---|---|
US (1) | US20130137737A1 (fr) |
EP (1) | EP2601180A1 (fr) |
JP (1) | JP2013532707A (fr) |
KR (1) | KR20130139863A (fr) |
CN (1) | CN103052630A (fr) |
AR (1) | AR082435A1 (fr) |
AU (1) | AU2011287616A1 (fr) |
BR (1) | BR112013002589A2 (fr) |
CA (1) | CA2806657A1 (fr) |
CL (1) | CL2013000335A1 (fr) |
CO (1) | CO6670580A2 (fr) |
EC (1) | ECSP13012459A (fr) |
MA (1) | MA34580B1 (fr) |
MX (1) | MX2013001251A (fr) |
RU (1) | RU2013109365A (fr) |
SG (1) | SG187007A1 (fr) |
TW (1) | TW201206428A (fr) |
WO (1) | WO2012016969A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103739564A (zh) * | 2012-02-20 | 2014-04-23 | 中国科学院上海药物研究所 | 缬沙坦的多晶型及其制备方法 |
CN103435567B (zh) * | 2013-09-09 | 2015-08-26 | 山东新华制药股份有限公司 | 缬沙坦的精制方法 |
CN105801506A (zh) * | 2014-12-30 | 2016-07-27 | 天津法莫西医药科技有限公司 | 缬沙坦新晶型及其制备方法 |
JP2016150917A (ja) * | 2015-02-17 | 2016-08-22 | 株式会社トクヤマ | バルサルタンの結晶の製造方法 |
CN105777660A (zh) * | 2016-03-29 | 2016-07-20 | 潍坊盛瑜药业有限公司 | 缬沙坦晶型e的诱导结晶工艺及应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
CN1137887C (zh) * | 2000-04-07 | 2004-02-11 | 常州四药制药有限公司 | 一种合成缬沙坦的改进方法 |
HU229280B1 (en) | 2000-07-19 | 2013-10-28 | Novartis Ag | Valsartan salts |
US6869970B2 (en) | 2002-02-04 | 2005-03-22 | Novartis Ag | Crystalline salt forms of valsartan |
WO2003089417A1 (fr) * | 2002-04-15 | 2003-10-30 | Dr. Reddy's Laboratories Limited | Nouvelles formes cristallines de (s)-n-(1-carboxy-2-methyl-prop-1-yl) -n-pentanoyl-n- [2'-(1h-tetrazol-5-yl-)- biphenyl-4-yl methyl] amine (valsartan) |
GB0222056D0 (en) * | 2002-09-23 | 2002-10-30 | Novartis Ag | Process for the manufacture of organic compounds |
US20040242661A1 (en) | 2003-03-17 | 2004-12-02 | Igor Rukhman | Polymorphs of valsartan |
CN101265239A (zh) * | 2003-03-17 | 2008-09-17 | 特瓦制药工业有限公司 | 缬沙坦的多晶型 |
CZ298685B6 (cs) * | 2003-05-15 | 2007-12-19 | Zentiva, A.S. | Zpusob výroby N-(1-oxopentyl)-N-[[2´-(1H-tetrazol-5-yl)[1,1´-bifenyl]-4-yl]methyl]-L-valinu (valsartanu) |
ITMI20032267A1 (it) * | 2003-11-21 | 2005-05-22 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procdimento per la preparzione di valsartan e suoi intermedi |
CN101103006A (zh) | 2005-01-11 | 2008-01-09 | 特瓦制药工业有限公司 | 无定形缬沙坦的制备方法 |
EP1896433A4 (fr) | 2005-05-25 | 2010-06-02 | Ipca Lab Ltd | Nouvelles formes cristallines de (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)bi-phenyl-4-ylmethyl]-amine |
ITMI20051989A1 (it) * | 2005-10-20 | 2007-04-21 | Dipharma Spa | Procedimerntyo per la preparazione di composti antagonisti di angiotensina ii |
WO2007069271A2 (fr) * | 2005-10-31 | 2007-06-21 | Alembic Limited | Procede de purification d'une (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine |
CN1844110B (zh) * | 2005-12-09 | 2010-07-14 | 浙江天宇药业有限公司 | 高光学纯度的缬沙坦的合成方法 |
CN101270096B (zh) * | 2007-03-22 | 2011-08-03 | 浙江华海药业股份有限公司 | 一种合成缬沙坦的方法 |
CN100522953C (zh) * | 2007-04-03 | 2009-08-05 | 浙江天宇药业有限公司 | 一种缬沙坦的新合成方法 |
ES2316281B1 (es) * | 2007-05-14 | 2010-02-09 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de valsartan. |
CN101362728B (zh) * | 2008-08-22 | 2011-07-20 | 北京赛科药业有限责任公司 | 一种缬沙坦的合成方法 |
CN101768128B (zh) * | 2009-01-05 | 2012-10-10 | 浙江华海药业股份有限公司 | 一种含10%以上异构体的缬沙坦的精制方法 |
CN101475540B (zh) * | 2009-01-22 | 2011-05-11 | 江苏德峰药业有限公司 | 一种缬沙坦的制备方法 |
CN101735164A (zh) * | 2009-12-22 | 2010-06-16 | 北京赛科药业有限责任公司 | 缬沙坦中杂质f的研究及控制方法 |
-
2011
- 2011-08-01 AU AU2011287616A patent/AU2011287616A1/en not_active Abandoned
- 2011-08-01 EP EP11752132.8A patent/EP2601180A1/fr not_active Withdrawn
- 2011-08-01 MA MA35701A patent/MA34580B1/fr unknown
- 2011-08-01 US US13/813,181 patent/US20130137737A1/en not_active Abandoned
- 2011-08-01 SG SG2013001888A patent/SG187007A1/en unknown
- 2011-08-01 WO PCT/EP2011/063254 patent/WO2012016969A1/fr active Application Filing
- 2011-08-01 BR BR112013002589A patent/BR112013002589A2/pt not_active IP Right Cessation
- 2011-08-01 RU RU2013109365/04A patent/RU2013109365A/ru not_active Application Discontinuation
- 2011-08-01 CN CN2011800380433A patent/CN103052630A/zh active Pending
- 2011-08-01 JP JP2013522227A patent/JP2013532707A/ja not_active Withdrawn
- 2011-08-01 KR KR1020137005256A patent/KR20130139863A/ko not_active Application Discontinuation
- 2011-08-01 AR ARP110102771A patent/AR082435A1/es unknown
- 2011-08-01 MX MX2013001251A patent/MX2013001251A/es not_active Application Discontinuation
- 2011-08-01 CA CA2806657A patent/CA2806657A1/fr not_active Abandoned
- 2011-08-02 TW TW100127455A patent/TW201206428A/zh unknown
-
2013
- 2013-02-01 CL CL2013000335A patent/CL2013000335A1/es unknown
- 2013-02-01 CO CO13019553A patent/CO6670580A2/es not_active Application Discontinuation
- 2013-02-25 EC ECSP13012459 patent/ECSP13012459A/es unknown
Also Published As
Publication number | Publication date |
---|---|
RU2013109365A (ru) | 2014-09-10 |
CA2806657A1 (fr) | 2012-02-09 |
CL2013000335A1 (es) | 2013-06-14 |
AR082435A1 (es) | 2012-12-05 |
ECSP13012459A (es) | 2013-03-28 |
JP2013532707A (ja) | 2013-08-19 |
SG187007A1 (en) | 2013-02-28 |
EP2601180A1 (fr) | 2013-06-12 |
US20130137737A1 (en) | 2013-05-30 |
WO2012016969A1 (fr) | 2012-02-09 |
BR112013002589A2 (pt) | 2019-09-24 |
AU2011287616A1 (en) | 2013-02-28 |
TW201206428A (en) | 2012-02-16 |
CN103052630A (zh) | 2013-04-17 |
MX2013001251A (es) | 2013-03-18 |
KR20130139863A (ko) | 2013-12-23 |
CO6670580A2 (es) | 2013-05-15 |
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