MA34144B1 - Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide - Google Patents

Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide

Info

Publication number
MA34144B1
MA34144B1 MA35288A MA35288A MA34144B1 MA 34144 B1 MA34144 B1 MA 34144B1 MA 35288 A MA35288 A MA 35288A MA 35288 A MA35288 A MA 35288A MA 34144 B1 MA34144 B1 MA 34144B1
Authority
MA
Morocco
Prior art keywords
tetrahydroisoquinoline
cyclohexylmethyl
sulfonamide
ethyl
preparation
Prior art date
Application number
MA35288A
Other languages
English (en)
Inventor
Steven Elenbaas
Robert Allan Farr
John Michael Kane
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44012569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34144(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA34144B1 publication Critical patent/MA34144B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'INVENTION CONCERNE UN PROCÉDÉ INDUSTRIELLEMENT APPLICABLE POUR LA PRÉPARATION DU 2-(CYCLOHEXYLMÉTHYL)-N-{2-[(2S)-1-MÉTHYLPYRROLIDIN-2-YL]ÉTHYL}-1,2,3,4- TÉTRAHYDROISOQUINOLÉINE-7-SULFONAMIDE ET DE SES SELS.
MA35288A 2010-03-05 2011-03-04 Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide MA34144B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31106910P 2010-03-05 2010-03-05
FR1059750 2010-11-25
PCT/US2011/027131 WO2011109680A2 (fr) 2010-03-05 2011-03-04 Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide

Publications (1)

Publication Number Publication Date
MA34144B1 true MA34144B1 (fr) 2013-04-03

Family

ID=44012569

Family Applications (2)

Application Number Title Priority Date Filing Date
MA35288A MA34144B1 (fr) 2010-03-05 2011-03-04 Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide
MA35286A MA34142B1 (fr) 2010-03-05 2011-03-04 Procede pour la preparation du 2-(cyclohexylmethyl)-1-methylpyrrolidin-2-yl)ethyl)-1,2,3,4-tetrahydroisoquinoleine-7-sulfonamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA35286A MA34142B1 (fr) 2010-03-05 2011-03-04 Procede pour la preparation du 2-(cyclohexylmethyl)-1-methylpyrrolidin-2-yl)ethyl)-1,2,3,4-tetrahydroisoquinoleine-7-sulfonamide

Country Status (27)

Country Link
US (2) US8748615B2 (fr)
EP (2) EP2556064B1 (fr)
JP (2) JP5927126B2 (fr)
KR (2) KR101783679B1 (fr)
CN (2) CN103221394A (fr)
AR (2) AR080374A1 (fr)
AU (2) AU2011223560A1 (fr)
BR (2) BR112012022234A2 (fr)
CA (2) CA2789669A1 (fr)
CL (2) CL2012002451A1 (fr)
CO (2) CO6630099A2 (fr)
CR (1) CR20120467A (fr)
DO (1) DOP2012000228A (fr)
EC (1) ECSP12012207A (fr)
GT (1) GT201200228A (fr)
IL (2) IL221339A0 (fr)
MA (2) MA34144B1 (fr)
MX (2) MX2012008422A (fr)
NZ (2) NZ601498A (fr)
PE (1) PE20130007A1 (fr)
RU (2) RU2012142338A (fr)
SG (2) SG183256A1 (fr)
TN (1) TN2012000361A1 (fr)
TW (2) TW201144284A (fr)
UY (2) UY33263A (fr)
WO (2) WO2011109675A2 (fr)
ZA (1) ZA201205311B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
CN102816101A (zh) * 2012-08-21 2012-12-12 江苏恒祥化工有限责任公司 一种(s)-n-甲基-2氯乙基吡咯烷的合成方法
SG11201601306QA (en) * 2013-09-09 2016-03-30 Sanofi Sa An h3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease
KR20200061363A (ko) * 2017-10-04 2020-06-02 셀진 코포레이션 시스-4-[2-｛[(3ｓ,4ｒ)-3-플루오로옥산-4-일]아미노｝-8-(2,4,6-트리클로로아닐리노)-9ｈ-퓨린-9-일]-1-메틸사이클로헥산-1-카르복스아미드의 제조 공정

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4228170A (en) 1979-08-30 1980-10-14 Smithkline Corporation 7- and/or 8-Sulfur substituted 1,2,3,4-tetrahydroisoquinoline compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
GB8717374D0 (en) 1987-07-22 1987-08-26 Smith Kline French Lab Pharmaceutically active compounds
US4857301A (en) 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
WO1994029273A1 (fr) 1993-06-09 1994-12-22 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene
GB9322976D0 (en) 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents
GB9709303D0 (en) * 1997-05-09 1997-06-25 Smithkline Beecham Plc Compounds
PL343424A1 (en) 1998-04-10 2001-08-13 Japan Tobacco Inc Amidine compounds
GB9816984D0 (en) 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
CA2347095A1 (fr) 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant
CA2366858A1 (fr) 1999-04-01 2000-10-12 Margaret Yuhua Chu-Moyer Inhibiteurs de sorbitol deshydrogenase
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
PE20010628A1 (es) 1999-10-01 2001-06-18 Takeda Chemical Industries Ltd Compuestos de amina ciclica, su produccion y su uso
CN1215059C (zh) 1999-12-03 2005-08-17 京都药品工业株式会社 新的杂环化合物及其盐和它们的医药用途
FR2804429B1 (fr) 2000-01-31 2003-05-09 Adir Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2807434B1 (fr) 2000-04-05 2002-10-18 Hoechst Marion Roussel Inc Nouveaux derives de la 1,2,3,4-tetrahydroisoquinoleine, leur procede de preparation et leur application comme fongicides
AU2001296193B2 (en) 2000-10-20 2006-04-27 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl)indoles and their use in therapy
WO2002036560A1 (fr) * 2000-10-30 2002-05-10 Warner-Lambert Company Llc Ligands des recepteurs de serotonine aminoalkylpyrrolidine et compositions, leurs utilisations pharmaceutiques, et procedes pour leur synthese
EP1379493A2 (fr) 2001-03-23 2004-01-14 Eli Lilly and Company Composes d'aryl alkylamines non imidazole comme antagonistes des recepteurs h3 de l'histamine, preparation et applications therapeutiques
CA2450856A1 (fr) * 2001-06-18 2002-12-27 Maruha Corporation Nouveau compose aliphatique, technique de synthese et technique d'utilisation
JPWO2003011812A1 (ja) 2001-08-01 2004-11-18 持田製薬株式会社 ヒト−β−トリプターゼ阻害活性を有する新規アミン誘導体およびそれを含有する医薬
US6677349B1 (en) 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
CA2469967A1 (fr) 2001-12-26 2003-07-10 Bayer Healthcare Ag Derives d'uree
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
AU2004232939A1 (en) 2003-04-17 2004-11-04 Merck Sharp & Dohme Corp. Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
FR2857695B1 (fr) 2003-07-15 2007-04-20 Saint Gobain Ct Recherches Bloc pour la filtration de particules contenues dans les gaz d'echappement d'un moteur a combustion interne
US20070117797A1 (en) 2004-01-02 2007-05-24 Goble Stephen D Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
US7410961B2 (en) 2004-01-20 2008-08-12 Merck & Co., Inc. 2,6-disubstituted piperiddines as modulators
CN1946696A (zh) 2004-04-26 2007-04-11 默克公司 四氢吡喃基环戊基1－取代的和1,1－二取代的四氢异喹啉趋化因子受体活性调节剂
CA2564499A1 (fr) 2004-04-26 2005-12-22 Merck & Co., Inc. Tetrahydropyranyl cyclopentyl tetrahy-dropyridopyridine modulant l'activite des recepteurs de la chimiokine
GEP20084519B (en) 2004-05-11 2008-10-27 Incyte Corp 3-(4-heteroarylcyclo-hexylamino) cyclopenta-necarboxamides as modulators of chemokine receptors
FR2870846B1 (fr) * 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
WO2005123089A2 (fr) 2004-06-10 2005-12-29 Kalypsys, Inc. Composes sulfonamide multicycliques inhibant l'histone desacetylase pour le traitement de maladie
ES2257168B1 (es) 2004-08-18 2007-06-01 Laboratorios Del Dr Esteve, S.A. Ligandos del receptor 5-ht7.
EP1630158A1 (fr) 2004-08-18 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Antagonistes des recepteurs 5-HT7
CA2578441C (fr) 2004-08-28 2013-01-08 Astrazeneca Ab Derives sulphonamides de pyrimidine en tant que modulateurs de l'activite du recepteur de la chimiokine
SE0403086D0 (sv) 2004-12-17 2004-12-17 Astrazeneca Ab Compounds
JP5132319B2 (ja) 2004-12-21 2013-01-30 スミスクライン ビーチャム コーポレーション ２−ピリミジニルピラゾロピリジンＥｒｂＢキナーゼ阻害剤
EP1831157A2 (fr) 2004-12-22 2007-09-12 Pfizer Limited Inhibiteurs non-nucléosidiques de la transcriptase inverse du vih-1
RU2007126951A (ru) 2005-01-26 2009-03-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные фенилметанона и их применение в качестве ингибиторов переносчика глицина 1
DE102005015040A1 (de) 2005-03-31 2006-10-05 Sanofi-Aventis Deutschland Gmbh Substituierte Tetrahydroisochinoline als MMP-Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
RU2007145434A (ru) 2005-05-10 2009-06-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бициклические производные в качестве модуляторов ионных каналов
EP1911747A1 (fr) 2006-10-11 2008-04-16 Laboratorios del Dr. Esteve S.A. Dérivés de pyrazoline substitués par un groupe sulfonamide, leur préparation et leur utlisation comme des modulateurs de CB1
JP5443975B2 (ja) 2007-04-27 2014-03-19 富山化学工業株式会社 新規なスルホンアミド誘導体またはその塩
US20110071197A1 (en) 2008-04-16 2011-03-24 Peter Nilsson Bis-aryl compounds for use as medicaments
WO2010127272A2 (fr) 2009-04-30 2010-11-04 Concert Pharmaceuticals, Inc. Dérivés hydroxyéthylamino sulfonamides
WO2010151611A1 (fr) 2009-06-26 2010-12-29 Sanofi-Aventis Nouveaux sels fumarates d'un antagoniste des récepteurs h3 de l'histamine
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida

Also Published As

Publication number Publication date
IL221341A (en) 2014-05-28
JP5927126B2 (ja) 2016-05-25
AU2011223560A1 (en) 2012-09-13
RU2012142310A (ru) 2014-04-10
US8748615B2 (en) 2014-06-10
AU2011222588B2 (en) 2016-09-08
EP2556064A2 (fr) 2013-02-13
CO6630099A2 (es) 2013-03-01
TW201144285A (en) 2011-12-16
CN103068815A (zh) 2013-04-24
UY33263A (es) 2011-09-30
RU2012142338A (ru) 2014-04-10
KR20130047685A (ko) 2013-05-08
TN2012000361A1 (en) 2014-01-30
IL221341A0 (en) 2012-10-31
EP2542530A2 (fr) 2013-01-09
NZ602009A (en) 2015-01-30
MX2012009413A (es) 2012-09-07
SG183256A1 (en) 2012-09-27
BR112012022356A2 (pt) 2016-08-30
TW201144284A (en) 2011-12-16
CO6630129A2 (es) 2013-03-01
IL221339A0 (en) 2012-10-31
WO2011109675A3 (fr) 2012-11-22
CR20120467A (es) 2012-10-05
AR080375A1 (es) 2012-04-04
AU2011222588A1 (en) 2012-08-23
WO2011109675A2 (fr) 2011-09-09
CN103221394A (zh) 2013-07-24
KR101783679B1 (ko) 2017-10-10
US8779145B2 (en) 2014-07-15
AR080374A1 (es) 2012-04-04
WO2011109680A2 (fr) 2011-09-09
WO2011109680A3 (fr) 2012-12-20
KR20130038186A (ko) 2013-04-17
PE20130007A1 (es) 2013-02-01
JP2013521309A (ja) 2013-06-10
CA2787427C (fr) 2017-10-10
SG182576A1 (en) 2012-08-30
JP2013521308A (ja) 2013-06-10
BR112012022234A2 (pt) 2015-12-15
CL2012002451A1 (es) 2012-11-30
DOP2012000228A (es) 2013-01-15
GT201200228A (es) 2013-11-21
US20130123302A1 (en) 2013-05-16
CA2787427A1 (fr) 2011-09-09
CL2012002452A1 (es) 2012-11-30
MA34142B1 (fr) 2013-04-03
NZ601498A (en) 2014-12-24
UY33262A (es) 2011-09-30
EP2556064B1 (fr) 2014-10-15
CA2789669A1 (fr) 2011-09-09
ZA201205311B (en) 2013-03-27
US20130137718A1 (en) 2013-05-30
ECSP12012207A (es) 2013-03-28
MX2012008422A (es) 2012-08-15

Similar Documents

Publication Publication Date Title
IL211540A0 (en) Optical method for the detection of alzheimer's disease
MA41607A (fr) Sels d'un inhibiteur de pi3k et procédés de préparation de ces sels
PL2297120T3 (pl) Pochodne aminodihydrotiazyny jako inhibitory BACE do leczenia choroby Alzheimera
MA31498B1 (fr) Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EA201490493A1 (ru) Пирано[3,2-d][1,3]тиазол в качестве ингибиторов гликозидазы
IN2012DN01273A (fr)
IT1397850B1 (it) Metodo e macchina per l'etichettatura di mazzette di teli.
MX2010008226A (es) Derivados de difluorobifenilamida para el tratamiento de hipertension ocular.
MA34144B1 (fr) Procédé de préparation du 2-(cyclohexylméthyl)-n-{2-[(2s)-1-méthylpyrrolidin-2-yl]éthyl}-1,2,3,4- tétrahydroisoquinoléine-7-sulfonamide
MA34512B1 (fr) Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine
TN2011000620A1 (en) Novel fumarate salts of a histamine h3 receptor antagonist
FR2927900B1 (fr) Procede de preparation d'alpha-aminoacetals optiquement actifs.
MY183201A (en) Processes for the preparation of 2-(1-phenylethyl)isoindolin-1-one compounds
MY145122A (en) Phenylacetic acid derivatives as cox-2 inhibitors
MX354020B (es) Un antagonista del receptor h3 para uso en el tratamiento de la enfermedad de alzheimer.
MX2014001409A (es) Metodo para tratar esquizofrenia.
NI201200127A (es) Procedimiento para la preparación de 2 - ( ciclohexilmetil ) - n - { 2 - [ (2s) - 1 - metilpirrolidin - 2 - il ] etil } - 1, 2, 3, 4 - tetrahidroisoquinolin - 7 - sulfonamida.
UA106380C2 (ru) Фумаратные соли антагониста гистаминового рецептора н3
LV14037A (lv) Ftalimidoamlodipīna iegūšanas metode
UA52319U (ru) Способ интраоперационного определения дистальной границы процесса при хирургическом лечении переднего медиастинита
LV14036A (lv) Trīs komponentu metode ftalimidoamlodipīna iegūšanai jonu šķidrumu promotētās reakcijās
LV14038A (lv) Viena reaktora metode ftalimidoamlodipīna iegūšanai jonu šķidrumu promotētās reakcijās
ITRM20110013A1 (it) Metodo per la creazione di guide chirurgiche per l'intervento implantoprotesico dentale.
UA42783U (ru) Способ лечения дисбактериоза
UA60665U (en) Process for the preparation of 3-trichloromethyl-4,5-dihydro-1,2,4-benzothiadiazepin-1,1-dioxides