MX354020B - Un antagonista del receptor h3 para uso en el tratamiento de la enfermedad de alzheimer. - Google Patents

Un antagonista del receptor h3 para uso en el tratamiento de la enfermedad de alzheimer.

Info

Publication number
MX354020B
MX354020B MX2014011992A MX2014011992A MX354020B MX 354020 B MX354020 B MX 354020B MX 2014011992 A MX2014011992 A MX 2014011992A MX 2014011992 A MX2014011992 A MX 2014011992A MX 354020 B MX354020 B MX 354020B
Authority
MX
Mexico
Prior art keywords
disease
alzheimer
treatment
receptor antagonist
ulfonamide
Prior art date
Application number
MX2014011992A
Other languages
English (en)
Other versions
MX2014011992A (es
Inventor
Barneoud Pascal
Blanchard-Bregeon Véronique
Delay-Goyet Philippe
Mary Véronique
Menager Jean
Lopez Grancha Mathilde
Schussler Nathalie
Rooney Thomas
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2014011992A publication Critical patent/MX2014011992A/es
Publication of MX354020B publication Critical patent/MX354020B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Esta descripción se refiere a métodos de uso de la 2-(ciclohexilmetil)-N-{2-[(2S)-1-metilpirrolidin-2-il]etil}-1,2,3 ,4-tetrahidroisoquinolina-7-sulfonamida en una terapia modificadora de la enfermedad para la enfermedad de Alzheimer, otras taupatías y enfermedades neurodegenerativas relacionadas.
MX2014011992A 2012-04-06 2013-04-05 Un antagonista del receptor h3 para uso en el tratamiento de la enfermedad de alzheimer. MX354020B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305415.7A EP2647377A1 (en) 2012-04-06 2012-04-06 Use of an h3 receptor antagonist for the treatment of alzheimer's disease
US201361792635P 2013-03-15 2013-03-15
PCT/EP2013/057241 WO2013150150A1 (en) 2012-04-06 2013-04-05 An h3 receptor antagonist for use in the treatment of alzheimer's disease

Publications (2)

Publication Number Publication Date
MX2014011992A MX2014011992A (es) 2015-05-08
MX354020B true MX354020B (es) 2018-02-08

Family

ID=46001073

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014011992A MX354020B (es) 2012-04-06 2013-04-05 Un antagonista del receptor h3 para uso en el tratamiento de la enfermedad de alzheimer.

Country Status (17)

Country Link
US (2) US20150031893A1 (es)
EP (2) EP2647377A1 (es)
JP (1) JP6143842B2 (es)
KR (1) KR20150000490A (es)
CN (1) CN104363911A (es)
AR (1) AR090605A1 (es)
AU (1) AU2013244928B2 (es)
BR (1) BR112014024736A2 (es)
CA (1) CA2868481A1 (es)
ES (1) ES2618924T3 (es)
MX (1) MX354020B (es)
PL (1) PL2833887T3 (es)
RU (1) RU2014144615A (es)
SG (2) SG10201801200PA (es)
TW (1) TW201402119A (es)
UY (1) UY34734A (es)
WO (1) WO2013150150A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
WO2015032966A1 (en) * 2013-09-09 2015-03-12 Sanofi An h3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease
CN114053289B (zh) * 2020-08-06 2023-06-27 北京箭牧科技有限公司 瑞德西韦在制备预防和治疗神经系统退行性疾病药物中的应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002254114A1 (en) 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
JP2006512404A (ja) 2002-10-22 2006-04-13 グラクソ　グループ　リミテッド Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
NZ540148A (en) 2002-12-20 2007-11-30 Glaxo Group Ltd Benzazepine derivatives for the treatment of neurological disorders
US20050031651A1 (en) 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
US20060293298A1 (en) 2003-04-10 2006-12-28 Bamford Mark J Compounds
EP1615909B1 (en) 2003-04-23 2008-07-23 Glaxo Group Limited Piperazine derivatives and their use for the treatment of neurological and psychiatric diseases
US20060247227A1 (en) 2003-07-18 2006-11-02 Bailey James M Substituted piperidines as histamine h3 receptor ligands
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
SI1751111T1 (sl) 2004-03-01 2015-04-30 Actelion Pharmaceuticals Ltd. Substituirani 1,2,3,4-tetrahidroizokinolinski derivati
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
FR2870846B1 (fr) 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
JP2008502644A (ja) 2004-06-18 2008-01-31 グラクソ　グループ　リミテッド ヒスタミンｈ３アンタゴニストとしての３−シクロアルキルベンズアゼピン
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
GB0420831D0 (en) 2004-09-17 2004-10-20 Glaxo Group Ltd Novel compounds
SI1802307T1 (sl) 2004-10-15 2008-08-31 Glaxo Group Ltd Derivati pirolidina kot ligandi histaminskih receptorjev
RU2007125648A (ru) 2004-12-07 2009-01-20 Глэксо Груп Лимитед (GB) Инденильные производные и их применение для лечения неврологических расстройств
JP2008533117A (ja) 2005-03-14 2008-08-21 グラクソ グループ リミテッド ヒスタミンｈ３受容体に対して親和性を有する縮合チアゾール誘導体
GB0513886D0 (en) 2005-07-06 2005-08-10 Glaxo Group Ltd Novel compounds
EP1790646A1 (fr) 2005-11-24 2007-05-30 Sanofi-Aventis Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
US20100120747A1 (en) 2006-06-23 2010-05-13 Laboratorios Del Dr. Esteve, S.A. Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity
CL2008000597A1 (es) 2007-03-01 2008-09-05 Glaxo Group Ltd Forma de dosificacion que comprende 6-(3-ciclobutil-2,3,4,5-tetrahidro-1h-benzo[d]azepin-7-il oxi)-n-metil nicotinamida, un estabilizante y un excipiente; procedimiento de preparacion; y su uso para tratar enfermedades neurologicas.
ATE554081T1 (de) 2007-09-06 2012-05-15 Glaxo Group Ltd Piperazinderivate mit affinität zum histamin-h3- rezeptor
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
US20110189280A1 (en) 2008-08-29 2011-08-04 Allan James Clarke Dosage form comprising 1-isopropyl-4-hexahydro-1h-1,4-diazepine or a salt thereof
WO2010026113A1 (en) * 2008-09-03 2010-03-11 Evotec Neurosciences Gmbh Acyl- and sufonyl tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists
EP2445899B1 (en) 2009-06-26 2016-05-11 Sanofi Novel fumarate salts of a histamine h3 receptor antagonist
TW201118099A (en) 2009-08-12 2011-06-01 Boehringer Ingelheim Int New compounds for the treatment of CNS disorders
WO2011051423A1 (en) 2009-11-02 2011-05-05 Glaxo Group Limited Treatment or prophylaxis of dementia, neurodegenerative disorders, schizophrenia, adhd, somnolence or epilepsy
FR2976286B1 (fr) 2011-06-08 2013-05-24 Servier Lab 4-{3-[trans-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, son procede de preparation et les compositions pharmaceutiques qui le contiennent
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
EP2745876A1 (en) 2012-12-21 2014-06-25 Prous Institute for Biomedical Research, S.A. Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives
WO2015032966A1 (en) * 2013-09-09 2015-03-12 Sanofi An h3 receptor antagonist combined with a cholinesterase inhibitor for use in the treatment of alzheimer's disease

Also Published As

Publication number Publication date
CA2868481A1 (en) 2013-10-10
MX2014011992A (es) 2015-05-08
US20160101099A1 (en) 2016-04-14
UY34734A (es) 2013-11-29
SG11201406093VA (en) 2014-10-30
AU2013244928A1 (en) 2014-10-30
ES2618924T3 (es) 2017-06-22
KR20150000490A (ko) 2015-01-02
US20150031893A1 (en) 2015-01-29
EP2833887B1 (en) 2016-12-28
TW201402119A (zh) 2014-01-16
BR112014024736A2 (pt) 2017-07-11
EP2833887A1 (en) 2015-02-11
JP2015516963A (ja) 2015-06-18
WO2013150150A1 (en) 2013-10-10
AR090605A1 (es) 2014-11-26
CN104363911A (zh) 2015-02-18
EP2647377A1 (en) 2013-10-09
JP6143842B2 (ja) 2017-06-07
US9789102B2 (en) 2017-10-17
SG10201801200PA (en) 2018-04-27
RU2014144615A (ru) 2016-05-27
AU2013244928B2 (en) 2017-08-10
PL2833887T3 (pl) 2017-06-30

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