ATE554081T1 - Piperazinderivate mit affinität zum histamin-h3- rezeptor - Google Patents

Piperazinderivate mit affinität zum histamin-h3- rezeptor

Info

Publication number
ATE554081T1
ATE554081T1 AT08803634T AT08803634T ATE554081T1 AT E554081 T1 ATE554081 T1 AT E554081T1 AT 08803634 T AT08803634 T AT 08803634T AT 08803634 T AT08803634 T AT 08803634T AT E554081 T1 ATE554081 T1 AT E554081T1
Authority
AT
Austria
Prior art keywords
histamine
affinity
receptor
piperazine derivatives
piperazine
Prior art date
Application number
AT08803634T
Other languages
English (en)
Inventor
Desmond John Best
Sing Yeung Mak
Barry Sidney Orlek
Geracimos Rassias
Pamela Joan Theobald
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39885024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE554081(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0717336A external-priority patent/GB0717336D0/en
Priority claimed from GB0814987A external-priority patent/GB0814987D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE554081T1 publication Critical patent/ATE554081T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
AT08803634T 2007-09-06 2008-09-04 Piperazinderivate mit affinität zum histamin-h3- rezeptor ATE554081T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0717336A GB0717336D0 (en) 2007-09-06 2007-09-06 Novel compound
GB0814987A GB0814987D0 (en) 2008-08-15 2008-08-15 Novel compound
PCT/EP2008/061664 WO2009030716A1 (en) 2007-09-06 2008-09-04 Piperazine derivative having affinity for the histamine h3 receptor

Publications (1)

Publication Number Publication Date
ATE554081T1 true ATE554081T1 (de) 2012-05-15

Family

ID=39885024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08803634T ATE554081T1 (de) 2007-09-06 2008-09-04 Piperazinderivate mit affinität zum histamin-h3- rezeptor

Country Status (17)

Country Link
US (2) US20090170869A1 (de)
EP (1) EP2195307B1 (de)
JP (1) JP5379796B2 (de)
KR (1) KR20100059944A (de)
CN (1) CN101848903A (de)
AR (1) AR068370A1 (de)
AT (1) ATE554081T1 (de)
AU (1) AU2008294708B2 (de)
BR (1) BRPI0816304A2 (de)
CA (1) CA2697941A1 (de)
CL (1) CL2008002622A1 (de)
EA (1) EA201070338A1 (de)
ES (1) ES2384414T3 (de)
MX (1) MX2010002606A (de)
PE (1) PE20091199A1 (de)
TW (1) TW200918527A (de)
WO (1) WO2009030716A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
BRPI0712823A2 (pt) 2006-06-23 2012-07-24 Abbott Lab derivados de ciclopropil amina como moduladores de receptor de histamina h3
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
US20090170869A1 (en) * 2007-09-06 2009-07-02 Desmond John Best Piperazine derivative having affinity for the histamine h3 receptor
EP2326642A2 (de) * 2008-08-15 2011-06-01 Glaxo Group Limited Salz von, und verfahren zur herstellung von, 1-isopropyl-4-{[4-(tetrahydro-2h-pyran-4-yloxy) phenyl] carbonyl}hexahydro-1h-1,4-diazepin
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
CN103443093B (zh) 2011-02-23 2015-02-25 苏文生命科学有限公司 作为组胺h3受体配体的化合物
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (de) 2012-04-06 2013-10-09 Sanofi Verwendung eines H3-Rezeptorantagonisten zur Behandlung von Morbus Alzheimer
EP2888243B1 (de) 2012-08-23 2016-08-17 Suven Life Sciences Limited Acrylamidverbindungen als histamin-h3-rezeptorliganden
AU2015362790A1 (en) 2014-12-16 2017-07-20 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
RU2017145964A (ru) 2015-06-10 2019-07-10 Аксовант Сайенсиз Гмбх Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов
WO2017027600A1 (en) 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
EP3378477A1 (de) * 2017-03-21 2018-09-26 BIOPROJET Pharma Neue therapeutische verwendungen von h3-liganden

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968200A1 (de) 1997-02-24 2000-01-05 ZymoGenetics, Inc. Calcitonin-mimetika
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
CN1443170A (zh) 2000-07-20 2003-09-17 神经原公司 辣椒素受体配体
WO2002012190A2 (en) 2000-08-08 2002-02-14 Ortho Mcneil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
DE60234453D1 (de) 2001-07-02 2009-12-31 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
DE10144226A1 (de) 2001-09-07 2003-03-27 Henkel Kgaa Neue verbrückte p-Phenylendiamine
EP1436291B1 (de) * 2001-09-19 2009-01-14 Aventis Pharma S.A. Indolizine als kinaseproteinhemmer
MXPA04007612A (es) 2002-02-05 2004-11-10 Novo Nordisk As Aril- y heteroarilpiperazinas novedosas.
GB0224084D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
JP2006512404A (ja) 2002-10-22 2006-04-13 グラクソ　グループ　リミテッド Ｈ３受容体リガンドとしてのアリールオキシアルキルアミン誘導体
ES2335584T3 (es) * 2002-10-23 2010-03-30 Janssen Pharmaceutica Nv Piperazinil y diazepanil - benzamidas y benzotioamidas.
RU2423353C1 (ru) * 2002-12-20 2011-07-10 Глэксо Груп Лимитед Новые производные бензазепина
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
BRPI0409611A (pt) 2003-04-23 2006-04-18 Glaxo Group Ltd derivados de piperazina e uso dos mesmos para o tratamento de doenças neurológicas e psiquiátricas
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
PT1802307E (pt) 2004-10-15 2008-06-06 Glaxo Group Ltd Derivados de pirrolidina como ligandos de receptores de histamina
SI1951699T1 (sl) 2005-10-31 2013-01-31 Janssen Pharmaceutica N.V. Postopki za pripravo ciklopropil-amidnih derivatov
EA201001799A1 (ru) 2005-10-31 2011-06-30 Янссен Фармацевтика Н.В. Новые способы получения пиперазинильных и диазепанильных производных бензамида
DK2121636T3 (en) 2006-12-14 2017-04-24 Janssen Pharmaceutica Nv Process for the preparation of piperazinyl and diazepanylbenzamide derivatives
TW201446748A (zh) 2007-08-22 2014-12-16 Astrazeneca Ab 環丙基醯胺衍生物
US20090170869A1 (en) * 2007-09-06 2009-07-02 Desmond John Best Piperazine derivative having affinity for the histamine h3 receptor
CN105712977B (zh) * 2007-11-20 2021-06-29 詹森药业有限公司 作为组胺h3受体调节剂的环烷基氧基吡啶化合物和杂环烷基氧基吡啶化合物
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain

Also Published As

Publication number Publication date
US8288389B2 (en) 2012-10-16
EA201070338A1 (ru) 2010-10-29
EP2195307A1 (de) 2010-06-16
JP5379796B2 (ja) 2013-12-25
EP2195307B1 (de) 2012-04-18
AU2008294708B2 (en) 2012-03-15
WO2009030716A1 (en) 2009-03-12
ES2384414T3 (es) 2012-07-04
AR068370A1 (es) 2009-11-11
MX2010002606A (es) 2010-03-30
CA2697941A1 (en) 2009-03-12
PE20091199A1 (es) 2009-09-12
US20100204242A1 (en) 2010-08-12
CN101848903A (zh) 2010-09-29
BRPI0816304A2 (pt) 2015-03-17
US20090170869A1 (en) 2009-07-02
KR20100059944A (ko) 2010-06-04
CL2008002622A1 (es) 2009-11-27
TW200918527A (en) 2009-05-01
JP2010538041A (ja) 2010-12-09
AU2008294708A1 (en) 2009-03-12

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