BRPI0816304A2 - Derivado de piperazina com afinidade para o receptor da histamina h3 - Google Patents

Derivado de piperazina com afinidade para o receptor da histamina h3

Info

Publication number
BRPI0816304A2
BRPI0816304A2 BRPI0816304A BRPI0816304A2 BR PI0816304 A2 BRPI0816304 A2 BR PI0816304A2 BR PI0816304 A BRPI0816304 A BR PI0816304A BR PI0816304 A2 BRPI0816304 A2 BR PI0816304A2
Authority
BR
Brazil
Prior art keywords
histamine
affinity
receiver
piperazine derivative
piperazine
Prior art date
Application number
Other languages
English (en)
Inventor
John Desmond Best
Sing Yeung Mak
Barry Sidney Orlek
Geracimos Rassias
Pamela Joan Theobald
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39885024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0816304(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0717336A external-priority patent/GB0717336D0/en
Priority claimed from GB0814987A external-priority patent/GB0814987D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0816304A2 publication Critical patent/BRPI0816304A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
BRPI0816304 2007-09-06 2008-09-04 Derivado de piperazina com afinidade para o receptor da histamina h3 BRPI0816304A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0717336A GB0717336D0 (en) 2007-09-06 2007-09-06 Novel compound
GB0814987A GB0814987D0 (en) 2008-08-15 2008-08-15 Novel compound
PCT/EP2008/061664 WO2009030716A1 (en) 2007-09-06 2008-09-04 Piperazine derivative having affinity for the histamine h3 receptor

Publications (1)

Publication Number Publication Date
BRPI0816304A2 true BRPI0816304A2 (pt) 2015-03-17

Family

ID=39885024

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0816304 BRPI0816304A2 (pt) 2007-09-06 2008-09-04 Derivado de piperazina com afinidade para o receptor da histamina h3

Country Status (17)

Country Link
US (2) US20090170869A1 (pt)
EP (1) EP2195307B1 (pt)
JP (1) JP5379796B2 (pt)
KR (1) KR20100059944A (pt)
CN (1) CN101848903A (pt)
AR (1) AR068370A1 (pt)
AT (1) ATE554081T1 (pt)
AU (1) AU2008294708B2 (pt)
BR (1) BRPI0816304A2 (pt)
CA (1) CA2697941A1 (pt)
CL (1) CL2008002622A1 (pt)
EA (1) EA201070338A1 (pt)
ES (1) ES2384414T3 (pt)
MX (1) MX2010002606A (pt)
PE (1) PE20091199A1 (pt)
TW (1) TW200918527A (pt)
WO (1) WO2009030716A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
KR20090024811A (ko) 2006-06-23 2009-03-09 아보트 러보러터리즈 히스타민 ｈ3 수용체 조절제로서의 사이클로프로필 아민 유도체
CA2697941A1 (en) * 2007-09-06 2009-03-12 Glaxo Group Limited Piperazine derivative having affinity for the histamine h3 receptor
EP2326642A2 (en) * 2008-08-15 2011-06-01 Glaxo Group Limited Salt of, and processes for the preparation of, 1-isopropyl-4-{[4-(tetrahydro-2h-pyran- 4-yloxy)phenyl]carbonyl}hexahydro-1h-1,4-diazepine
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
CN103443093B (zh) 2011-02-23 2015-02-25 苏文生命科学有限公司 作为组胺h3受体配体的化合物
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
HUE030901T2 (en) 2012-08-23 2017-06-28 Suven Life Sciences Ltd Acrylamide compounds as histamine H3 receptor ligands
EP3623371A1 (en) 2014-12-16 2020-03-18 Axovant Sciences GmbH Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
RU2017145964A (ru) 2015-06-10 2019-07-10 Аксовант Сайенсиз Гмбх Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов
EP3334740A4 (en) 2015-08-12 2019-02-06 Axovant Sciences GmbH GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS
EP3378477A1 (en) * 2017-03-21 2018-09-26 BIOPROJET Pharma New therapeutical use of h3-ligands

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968200A1 (en) 1997-02-24 2000-01-05 ZymoGenetics, Inc. Calcitonin mimetics
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
EP1301484A2 (en) 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
DE60126785T2 (de) 2000-08-08 2007-10-25 Ortho-Mcneil Pharmaceutical, Inc. Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden
DE60234453D1 (de) 2001-07-02 2009-12-31 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
DE10144226A1 (de) 2001-09-07 2003-03-27 Henkel Kgaa Neue verbrückte p-Phenylendiamine
MXPA04002243A (es) 2001-09-19 2004-06-29 Aventis Pharma Sa Compuestos quimicos.
BR0307429A (pt) 2002-02-05 2004-12-28 Novo Nordisk As Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com receptor de histamina h3
GB0224084D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
EP1554260A1 (en) 2002-10-22 2005-07-20 Glaxo Group Limited Aryloxyalkylamine derivatives as h3 receptor ligands
ME00334B (me) 2002-10-23 2011-05-10 Janssen Pharmaceutica Nv Piperazinil i diazapanil benzamidi i benzotioamidi
RU2423353C1 (ru) 2002-12-20 2011-07-10 Глэксо Груп Лимитед Новые производные бензазепина
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
PL1615909T3 (pl) 2003-04-23 2009-01-30 Glaxo Group Ltd Pochodne piperazyny i ich zastosowanie w leczeniu chorób neurologicznych i psychicznych
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
US20080045506A1 (en) 2004-10-15 2008-02-21 Glaxo Group Limited Pyrrolidine Derivatives as Histamine Receptors Ligands
MX367916B (es) 2005-10-31 2019-09-11 Janssen Pharmaceutica N V Star Procedimientos para la preparacion de derivados de ciclopropilamida.
JP2009513702A (ja) 2005-10-31 2009-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペラジニルおよびジアザパニルベンズアミド誘導体の新規な製造方法
JP5385150B2 (ja) 2006-12-14 2014-01-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペラジニルおよびジアゼパニルベンズアミド誘導体の製造方法
PL2195293T3 (pl) 2007-08-22 2014-03-31 Astrazeneca Ab Pochodne cyklopropyloamidu
CA2697941A1 (en) 2007-09-06 2009-03-12 Glaxo Group Limited Piperazine derivative having affinity for the histamine h3 receptor
AU2008326561B2 (en) 2007-11-20 2013-12-05 Janssen Pharmaceutica N.V. Cycloalkyloxy-and heterocycloalky-loxypyridine compounds as modulators of the histamine H3 receptor
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain

Also Published As

Publication number Publication date
AR068370A1 (es) 2009-11-11
CA2697941A1 (en) 2009-03-12
EP2195307A1 (en) 2010-06-16
MX2010002606A (es) 2010-03-30
WO2009030716A1 (en) 2009-03-12
US20090170869A1 (en) 2009-07-02
EA201070338A1 (ru) 2010-10-29
AU2008294708B2 (en) 2012-03-15
US20100204242A1 (en) 2010-08-12
JP5379796B2 (ja) 2013-12-25
CL2008002622A1 (es) 2009-11-27
US8288389B2 (en) 2012-10-16
EP2195307B1 (en) 2012-04-18
CN101848903A (zh) 2010-09-29
JP2010538041A (ja) 2010-12-09
AU2008294708A1 (en) 2009-03-12
TW200918527A (en) 2009-05-01
KR20100059944A (ko) 2010-06-04
ES2384414T3 (es) 2012-07-04
PE20091199A1 (es) 2009-09-12
ATE554081T1 (de) 2012-05-15

Similar Documents

Publication Publication Date Title
BRPI0816304A2 (pt) Derivado de piperazina com afinidade para o receptor da histamina h3
BRPI0923210A2 (pt) conjunto de suspenção com compensação para ocilações.
BRPI0816149A2 (pt) Corrediça de suporte de peso de compensação
BRPI0813707A2 (pt) Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt) Derivados de isoxazol-piridina
BRPI0809992A2 (pt) Derivados de pirrolopirimidina
BRPI0820113A2 (pt) Derivados de isoxazolo-piridazina
BR112012009849A2 (pt) mola em folhas compósita
BRPI0811065A2 (pt) Indazóis 5-heteroaril substituídos como inibidores de quinase
BRPI0817110A2 (pt) Aparelho de controle para veículo
BRPI0817935A2 (pt) Derivados de biarila
BRPI0812155A2 (pt) derivados de espiroindolinona
ES2465673T9 (es) Derivados de pirimidina
BRPI0817781A2 (pt) piperazino-diidroteinopirimidinas substituídas com heterociclo
DK1948607T3 (da) Cyclopropylaminer med histamin-H3-receptormodulatorer
BRPI0914544A2 (pt) derivados de pirimidona substituídos
BRPI0812518A2 (pt) Derivados de indazolamida
BRPI0814236A2 (pt) Derivados de quinazolinamida
BRPI0820649A2 (pt) Derivados de isoxazalo-pirazina
BRPI0816914A2 (pt) Método de compensação de elevação
BRPI0820779A2 (pt) Derivados de 4-amino-pirimidina
BRPI0821258A2 (pt) Derivados de ciclopropilamina
BRPI0813354A2 (pt) Derivado de morfolina
BRPI0922023A2 (pt) unidade de amortecimento para um eixo
BRPI0814718A2 (pt) Derivados de isoxazol-imidazol

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.