BRPI0816304A2 - Derivado de piperazina com afinidade para o receptor da histamina h3 - Google Patents
Derivado de piperazina com afinidade para o receptor da histamina h3Info
- Publication number
- BRPI0816304A2 BRPI0816304A2 BRPI0816304A BRPI0816304A2 BR PI0816304 A2 BRPI0816304 A2 BR PI0816304A2 BR PI0816304 A BRPI0816304 A BR PI0816304A BR PI0816304 A2 BRPI0816304 A2 BR PI0816304A2
- Authority
- BR
- Brazil
- Prior art keywords
- histamine
- affinity
- receiver
- piperazine derivative
- piperazine
- Prior art date
Links
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 title 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229960001340 histamine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0717336A GB0717336D0 (en) | 2007-09-06 | 2007-09-06 | Novel compound |
GB0814987A GB0814987D0 (en) | 2008-08-15 | 2008-08-15 | Novel compound |
PCT/EP2008/061664 WO2009030716A1 (en) | 2007-09-06 | 2008-09-04 | Piperazine derivative having affinity for the histamine h3 receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0816304A2 true BRPI0816304A2 (pt) | 2015-03-17 |
Family
ID=39885024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0816304 BRPI0816304A2 (pt) | 2007-09-06 | 2008-09-04 | Derivado de piperazina com afinidade para o receptor da histamina h3 |
Country Status (17)
Country | Link |
---|---|
US (2) | US20090170869A1 (pt) |
EP (1) | EP2195307B1 (pt) |
JP (1) | JP5379796B2 (pt) |
KR (1) | KR20100059944A (pt) |
CN (1) | CN101848903A (pt) |
AR (1) | AR068370A1 (pt) |
AT (1) | ATE554081T1 (pt) |
AU (1) | AU2008294708B2 (pt) |
BR (1) | BRPI0816304A2 (pt) |
CA (1) | CA2697941A1 (pt) |
CL (1) | CL2008002622A1 (pt) |
EA (1) | EA201070338A1 (pt) |
ES (1) | ES2384414T3 (pt) |
MX (1) | MX2010002606A (pt) |
PE (1) | PE20091199A1 (pt) |
TW (1) | TW200918527A (pt) |
WO (1) | WO2009030716A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
KR20090024811A (ko) | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 h3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
CA2697941A1 (en) * | 2007-09-06 | 2009-03-12 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine h3 receptor |
EP2326642A2 (en) * | 2008-08-15 | 2011-06-01 | Glaxo Group Limited | Salt of, and processes for the preparation of, 1-isopropyl-4-{[4-(tetrahydro-2h-pyran- 4-yloxy)phenyl]carbonyl}hexahydro-1h-1,4-diazepine |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
CN103443093B (zh) | 2011-02-23 | 2015-02-25 | 苏文生命科学有限公司 | 作为组胺h3受体配体的化合物 |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
HUE030901T2 (en) | 2012-08-23 | 2017-06-28 | Suven Life Sciences Ltd | Acrylamide compounds as histamine H3 receptor ligands |
EP3623371A1 (en) | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
RU2017145964A (ru) | 2015-06-10 | 2019-07-10 | Аксовант Сайенсиз Гмбх | Аминобензизоксазольные соединения в качестве агонистов α7-никотиновых ацетилхолиновых рецепторов |
EP3334740A4 (en) | 2015-08-12 | 2019-02-06 | Axovant Sciences GmbH | GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF ALPHA 7-NICOTINIC ACETYLCHOLINE RECEPTORS |
EP3378477A1 (en) * | 2017-03-21 | 2018-09-26 | BIOPROJET Pharma | New therapeutical use of h3-ligands |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0968200A1 (en) | 1997-02-24 | 2000-01-05 | ZymoGenetics, Inc. | Calcitonin mimetics |
US6268367B1 (en) | 1998-02-23 | 2001-07-31 | Zymogenetics, Inc. | Piperazine derivatives for treating bone deficit conditions |
EP1301484A2 (en) | 2000-07-20 | 2003-04-16 | Neurogen Corporation | Capsaicin receptor ligands |
DE60126785T2 (de) | 2000-08-08 | 2007-10-25 | Ortho-Mcneil Pharmaceutical, Inc. | Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden |
DE60234453D1 (de) | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
DE10144226A1 (de) | 2001-09-07 | 2003-03-27 | Henkel Kgaa | Neue verbrückte p-Phenylendiamine |
MXPA04002243A (es) | 2001-09-19 | 2004-06-29 | Aventis Pharma Sa | Compuestos quimicos. |
BR0307429A (pt) | 2002-02-05 | 2004-12-28 | Novo Nordisk As | Composto, uso do mesmo, composição farmacêutica, e, método para o tratamento de distúrbios ou doenças relacionadas com receptor de histamina h3 |
GB0224084D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
EP1554260A1 (en) | 2002-10-22 | 2005-07-20 | Glaxo Group Limited | Aryloxyalkylamine derivatives as h3 receptor ligands |
ME00334B (me) | 2002-10-23 | 2011-05-10 | Janssen Pharmaceutica Nv | Piperazinil i diazapanil benzamidi i benzotioamidi |
RU2423353C1 (ru) | 2002-12-20 | 2011-07-10 | Глэксо Груп Лимитед | Новые производные бензазепина |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
PL1615909T3 (pl) | 2003-04-23 | 2009-01-30 | Glaxo Group Ltd | Pochodne piperazyny i ich zastosowanie w leczeniu chorób neurologicznych i psychicznych |
GB0324159D0 (en) * | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
US20080045506A1 (en) | 2004-10-15 | 2008-02-21 | Glaxo Group Limited | Pyrrolidine Derivatives as Histamine Receptors Ligands |
MX367916B (es) | 2005-10-31 | 2019-09-11 | Janssen Pharmaceutica N V Star | Procedimientos para la preparacion de derivados de ciclopropilamida. |
JP2009513702A (ja) | 2005-10-31 | 2009-04-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペラジニルおよびジアザパニルベンズアミド誘導体の新規な製造方法 |
JP5385150B2 (ja) | 2006-12-14 | 2014-01-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペラジニルおよびジアゼパニルベンズアミド誘導体の製造方法 |
PL2195293T3 (pl) | 2007-08-22 | 2014-03-31 | Astrazeneca Ab | Pochodne cyklopropyloamidu |
CA2697941A1 (en) | 2007-09-06 | 2009-03-12 | Glaxo Group Limited | Piperazine derivative having affinity for the histamine h3 receptor |
AU2008326561B2 (en) | 2007-11-20 | 2013-12-05 | Janssen Pharmaceutica N.V. | Cycloalkyloxy-and heterocycloalky-loxypyridine compounds as modulators of the histamine H3 receptor |
US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
-
2008
- 2008-09-04 CA CA2697941A patent/CA2697941A1/en not_active Abandoned
- 2008-09-04 JP JP2010523502A patent/JP5379796B2/ja not_active Expired - Fee Related
- 2008-09-04 EA EA201070338A patent/EA201070338A1/ru unknown
- 2008-09-04 KR KR1020107007395A patent/KR20100059944A/ko not_active Application Discontinuation
- 2008-09-04 PE PE2008001550A patent/PE20091199A1/es not_active Application Discontinuation
- 2008-09-04 MX MX2010002606A patent/MX2010002606A/es not_active Application Discontinuation
- 2008-09-04 CN CN200880115043A patent/CN101848903A/zh active Pending
- 2008-09-04 US US12/203,946 patent/US20090170869A1/en not_active Abandoned
- 2008-09-04 AU AU2008294708A patent/AU2008294708B2/en not_active Expired - Fee Related
- 2008-09-04 CL CL2008002622A patent/CL2008002622A1/es unknown
- 2008-09-04 ES ES08803634T patent/ES2384414T3/es active Active
- 2008-09-04 WO PCT/EP2008/061664 patent/WO2009030716A1/en active Application Filing
- 2008-09-04 US US12/676,158 patent/US8288389B2/en not_active Expired - Fee Related
- 2008-09-04 BR BRPI0816304 patent/BRPI0816304A2/pt not_active IP Right Cessation
- 2008-09-04 AT AT08803634T patent/ATE554081T1/de active
- 2008-09-04 TW TW097133837A patent/TW200918527A/zh unknown
- 2008-09-04 AR ARP080103850A patent/AR068370A1/es unknown
- 2008-09-04 EP EP08803634A patent/EP2195307B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
AR068370A1 (es) | 2009-11-11 |
CA2697941A1 (en) | 2009-03-12 |
EP2195307A1 (en) | 2010-06-16 |
MX2010002606A (es) | 2010-03-30 |
WO2009030716A1 (en) | 2009-03-12 |
US20090170869A1 (en) | 2009-07-02 |
EA201070338A1 (ru) | 2010-10-29 |
AU2008294708B2 (en) | 2012-03-15 |
US20100204242A1 (en) | 2010-08-12 |
JP5379796B2 (ja) | 2013-12-25 |
CL2008002622A1 (es) | 2009-11-27 |
US8288389B2 (en) | 2012-10-16 |
EP2195307B1 (en) | 2012-04-18 |
CN101848903A (zh) | 2010-09-29 |
JP2010538041A (ja) | 2010-12-09 |
AU2008294708A1 (en) | 2009-03-12 |
TW200918527A (en) | 2009-05-01 |
KR20100059944A (ko) | 2010-06-04 |
ES2384414T3 (es) | 2012-07-04 |
PE20091199A1 (es) | 2009-09-12 |
ATE554081T1 (de) | 2012-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0816304A2 (pt) | Derivado de piperazina com afinidade para o receptor da histamina h3 | |
BRPI0923210A2 (pt) | conjunto de suspenção com compensação para ocilações. | |
BRPI0816149A2 (pt) | Corrediça de suporte de peso de compensação | |
BRPI0813707A2 (pt) | Derivados de pirimidinil-piridazinona | |
BRPI0820112A2 (pt) | Derivados de isoxazol-piridina | |
BRPI0809992A2 (pt) | Derivados de pirrolopirimidina | |
BRPI0820113A2 (pt) | Derivados de isoxazolo-piridazina | |
BR112012009849A2 (pt) | mola em folhas compósita | |
BRPI0811065A2 (pt) | Indazóis 5-heteroaril substituídos como inibidores de quinase | |
BRPI0817110A2 (pt) | Aparelho de controle para veículo | |
BRPI0817935A2 (pt) | Derivados de biarila | |
BRPI0812155A2 (pt) | derivados de espiroindolinona | |
ES2465673T9 (es) | Derivados de pirimidina | |
BRPI0817781A2 (pt) | piperazino-diidroteinopirimidinas substituídas com heterociclo | |
DK1948607T3 (da) | Cyclopropylaminer med histamin-H3-receptormodulatorer | |
BRPI0914544A2 (pt) | derivados de pirimidona substituídos | |
BRPI0812518A2 (pt) | Derivados de indazolamida | |
BRPI0814236A2 (pt) | Derivados de quinazolinamida | |
BRPI0820649A2 (pt) | Derivados de isoxazalo-pirazina | |
BRPI0816914A2 (pt) | Método de compensação de elevação | |
BRPI0820779A2 (pt) | Derivados de 4-amino-pirimidina | |
BRPI0821258A2 (pt) | Derivados de ciclopropilamina | |
BRPI0813354A2 (pt) | Derivado de morfolina | |
BRPI0922023A2 (pt) | unidade de amortecimento para um eixo | |
BRPI0814718A2 (pt) | Derivados de isoxazol-imidazol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |