MA31695B1 - Anticorps humains a affinite elevee pour le facteur de croissance nerveuse humain - Google Patents

Anticorps humains a affinite elevee pour le facteur de croissance nerveuse humain

Info

Publication number
MA31695B1
MA31695B1 MA32679A MA32679A MA31695B1 MA 31695 B1 MA31695 B1 MA 31695B1 MA 32679 A MA32679 A MA 32679A MA 32679 A MA32679 A MA 32679A MA 31695 B1 MA31695 B1 MA 31695B1
Authority
MA
Morocco
Prior art keywords
pain
human
growth factor
ngf
binds
Prior art date
Application number
MA32679A
Other languages
Arabic (ar)
English (en)
Inventor
Joel C Reinhardt
Lynn Macdonald
Richard Torres
Marc R Morra
Joel H Martin
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MA31695B1 publication Critical patent/MA31695B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un anticorps humain, ou un fragment d'anticorps se liant à l'antigène, qui se lie spécifiquement au facteur humain de croissance nerveuse (ngf) à un kd de 5 pm ou moins, n'a pas de réaction croisée avec la neurotrophine-3 (nt-3), et se lie au ngf humain à un kd d'environ 2 à environ 10 fois supérieur à celui auquel l'anticorps ou le fragment se lie au ngf de rat et de souris. Les anticorps sont utiles pour traiter la douleur, comprenant la douleur inflammatoire, la douleur d'incision post-opératoire, la douleur névralgique, la douleur de fracture, la douleur de fracture ostéoporotique, la névralgie post-herpétique, l'arthrose, la polyarthrite rhumatoïde, la douleur du cancer, la douleur consécutive à un choc, la douleur articulaire de la goutte, ainsi que les maladies, telles que le carcinome hépatocellulaire, le cancer du sein, et la cirrhose du foie.
MA32679A 2007-08-10 2010-03-08 Anticorps humains a affinite elevee pour le facteur de croissance nerveuse humain MA31695B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96422407P 2007-08-10 2007-08-10
US99452607P 2007-09-20 2007-09-20
US6286008P 2008-01-28 2008-01-28
US7925908P 2008-07-09 2008-07-09
PCT/US2008/072561 WO2009023540A1 (fr) 2007-08-10 2008-08-08 Anticorps humains anti-facteur de croissance nerveux humain de haute affinité

Publications (1)

Publication Number Publication Date
MA31695B1 true MA31695B1 (fr) 2010-09-01

Family

ID=39951432

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32679A MA31695B1 (fr) 2007-08-10 2010-03-08 Anticorps humains a affinite elevee pour le facteur de croissance nerveuse humain

Country Status (32)

Country Link
US (3) US7988967B2 (fr)
EP (2) EP2572729A3 (fr)
JP (1) JP5632744B2 (fr)
KR (2) KR101709488B1 (fr)
CN (1) CN101827609B (fr)
AU (1) AU2008287037B2 (fr)
BR (1) BRPI0815370B8 (fr)
CA (1) CA2695997C (fr)
CO (1) CO6261383A2 (fr)
CR (1) CR11298A (fr)
CY (1) CY1116072T1 (fr)
DK (1) DK2187964T3 (fr)
DO (1) DOP2010000054A (fr)
EC (1) ECSP10010029A (fr)
ES (1) ES2517872T3 (fr)
HK (1) HK1144379A1 (fr)
HR (1) HRP20141025T1 (fr)
IL (1) IL203558A (fr)
MA (1) MA31695B1 (fr)
ME (2) ME00977B (fr)
MX (1) MX2010001395A (fr)
MY (2) MY161564A (fr)
NI (1) NI201000021A (fr)
NZ (1) NZ583200A (fr)
PL (1) PL2187964T3 (fr)
PT (1) PT2187964E (fr)
RS (1) RS53661B1 (fr)
RU (1) RU2473564C2 (fr)
SI (1) SI2187964T1 (fr)
TN (1) TN2010000059A1 (fr)
WO (1) WO2009023540A1 (fr)
ZA (1) ZA201000725B (fr)

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