MA29805B1 - Derives de phenyl-1.2.4-oxadiazolone, leurs procedes de preparation et leur utilisation comme produits pharmaceutiques - Google Patents
Derives de phenyl-1.2.4-oxadiazolone, leurs procedes de preparation et leur utilisation comme produits pharmaceutiquesInfo
- Publication number
- MA29805B1 MA29805B1 MA30781A MA30781A MA29805B1 MA 29805 B1 MA29805 B1 MA 29805B1 MA 30781 A MA30781 A MA 30781A MA 30781 A MA30781 A MA 30781A MA 29805 B1 MA29805 B1 MA 29805B1
- Authority
- MA
- Morocco
- Prior art keywords
- disorders
- phenyl
- processes
- preparation
- pharmaceutical products
- Prior art date
Links
- INVHTFJJZGBKTM-UHFFFAOYSA-N 5-phenyl-1,2,4-oxadiazol-3-one Chemical class OC1=NOC(C=2C=CC=CC=2)=N1 INVHTFJJZGBKTM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05021277 | 2005-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA29805B1 true MA29805B1 (fr) | 2008-09-01 |
Family
ID=35788653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30781A MA29805B1 (fr) | 2005-09-29 | 2008-03-24 | Derives de phenyl-1.2.4-oxadiazolone, leurs procedes de preparation et leur utilisation comme produits pharmaceutiques |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7709481B2 (es) |
| EP (1) | EP1931337B1 (es) |
| JP (1) | JP2009509988A (es) |
| KR (1) | KR20080048504A (es) |
| CN (1) | CN101272784A (es) |
| AR (1) | AR056095A1 (es) |
| AU (1) | AU2006299091A1 (es) |
| BR (1) | BRPI0617207A2 (es) |
| CA (1) | CA2624102A1 (es) |
| CR (1) | CR9785A (es) |
| DO (1) | DOP2006000203A (es) |
| EC (1) | ECSP088322A (es) |
| IL (1) | IL190231A0 (es) |
| MA (1) | MA29805B1 (es) |
| NO (1) | NO20081369L (es) |
| NZ (1) | NZ566877A (es) |
| PE (1) | PE20070620A1 (es) |
| RU (1) | RU2008112198A (es) |
| TN (1) | TNSN08148A1 (es) |
| TW (1) | TW200806658A (es) |
| UY (1) | UY29831A1 (es) |
| WO (1) | WO2007039177A2 (es) |
| ZA (1) | ZA200801629B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| CA2693169C (en) | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| TW201002705A (en) * | 2008-03-31 | 2010-01-16 | Metabolex Inc | Oxymethylene aryl compounds and uses thereof |
| CN102216296B (zh) * | 2008-10-01 | 2015-03-18 | 拜耳作物科学公司 | 作为作物保护剂的杂环取代的噻唑类 |
| WO2010066353A1 (de) | 2008-12-11 | 2010-06-17 | Bayer Cropscience Ag | Thiazolyoximether und -hydrazone asl pflanzenschutzmittel |
| EP2198710A1 (de) | 2008-12-19 | 2010-06-23 | Bayer CropScience AG | Verwendung von 5-Pyridin-4yl-(1,3)Thiazole zur Bekämpfung phytopathogener Pilze |
| AP2799A (en) * | 2009-06-05 | 2013-11-30 | Pfizer | 1-(Piperidin-4-YL)-pyrazole derivatives as GPR 119modulators |
| CN102666553B (zh) | 2009-10-01 | 2015-05-06 | 赛马拜制药公司 | 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 |
| PH12012500676A1 (en) | 2009-10-08 | 2015-06-03 | Sanofi Sa | Phenyloxadiazole derivatives as pgds inhibitors |
| ES2613066T3 (es) | 2010-04-28 | 2017-05-22 | Bayer Intellectual Property Gmbh | Derivados de cetoheteroarilpiperidina y -piperazina como fungicidas |
| ES2676209T3 (es) | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| EP2532233A1 (en) | 2011-06-07 | 2012-12-12 | Bayer CropScience AG | Active compound combinations |
| MX2014012454A (es) | 2012-04-26 | 2015-03-13 | Bristol Myers Squibb Co | Derivados de imidazotiadiazol como inhibidores del receptor 4 activado de proteasa (par4) para el tratamiento de agregacion plaquetaria. |
| EA201491954A1 (ru) | 2012-04-26 | 2015-01-30 | Бристол-Майерс Сквибб Компани | Производные имидазотиадиазола и имидазопиридазина в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов |
| PT2841437T (pt) | 2012-04-26 | 2017-09-28 | Univ Montreal | Derivados de imidazotiadiazol e imidazopirazina como inibidores de recetor 4 ativado por protease (par4) para o tratamento de agregação plaquetária |
| JP2019527693A (ja) | 2016-08-03 | 2019-10-03 | サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783593A (en) | 1993-11-04 | 1998-07-21 | Abbott Laboratories | Inhibitors of squalene synthetase and protein farnesyltransferase |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
| AU2381397A (en) | 1996-04-19 | 1997-11-12 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| RU2200161C2 (ru) | 1996-12-31 | 2003-03-10 | Др. Редди'З Рисерч Фаундейшн | Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение |
| EP1053227B1 (en) | 1998-01-29 | 2008-11-05 | Amgen Inc. | Ppar-gamma modulators |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| HRP20010688B1 (en) | 1999-03-29 | 2008-10-31 | F. Hoffmann - La Roche Ag | Glucokinase activators |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| WO2000064876A1 (en) | 1999-04-28 | 2000-11-02 | Aventis Pharma Deutschland Gmbh | Tri-aryl acid derivatives as ppar receptor ligands |
| EP1177187B1 (en) | 1999-04-28 | 2007-07-25 | Sanofi-Aventis Deutschland GmbH | Di-aryl acid derivatives as ppar receptor ligands |
| CA2377246A1 (en) * | 1999-06-18 | 2000-12-28 | Ranjit C. Desai | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
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-
2006
- 2006-09-26 JP JP2008532647A patent/JP2009509988A/ja not_active Abandoned
- 2006-09-26 NZ NZ566877A patent/NZ566877A/en not_active IP Right Cessation
- 2006-09-26 CN CNA2006800359361A patent/CN101272784A/zh active Pending
- 2006-09-26 EP EP06792251.8A patent/EP1931337B1/en active Active
- 2006-09-26 KR KR1020087007393A patent/KR20080048504A/ko not_active Withdrawn
- 2006-09-26 RU RU2008112198/04A patent/RU2008112198A/ru not_active Application Discontinuation
- 2006-09-26 BR BRPI0617207-5A patent/BRPI0617207A2/pt not_active IP Right Cessation
- 2006-09-26 CA CA002624102A patent/CA2624102A1/en not_active Abandoned
- 2006-09-26 AU AU2006299091A patent/AU2006299091A1/en not_active Abandoned
- 2006-09-26 WO PCT/EP2006/009303 patent/WO2007039177A2/en not_active Ceased
- 2006-09-27 DO DO2006000203A patent/DOP2006000203A/es unknown
- 2006-09-27 PE PE2006001170A patent/PE20070620A1/es not_active Application Discontinuation
- 2006-09-27 AR ARP060104223A patent/AR056095A1/es not_active Application Discontinuation
- 2006-09-27 TW TW095135658A patent/TW200806658A/zh unknown
- 2006-09-29 UY UY29831A patent/UY29831A1/es not_active Application Discontinuation
-
2008
- 2008-02-19 ZA ZA200801629A patent/ZA200801629B/xx unknown
- 2008-02-29 CR CR9785A patent/CR9785A/es not_active Application Discontinuation
- 2008-03-14 NO NO20081369A patent/NO20081369L/no not_active Application Discontinuation
- 2008-03-17 IL IL190231A patent/IL190231A0/en unknown
- 2008-03-24 MA MA30781A patent/MA29805B1/fr unknown
- 2008-03-26 US US12/055,780 patent/US7709481B2/en not_active Expired - Fee Related
- 2008-03-27 EC EC2008008322A patent/ECSP088322A/es unknown
- 2008-03-28 TN TNP2008000148A patent/TNSN08148A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200806658A (en) | 2008-02-01 |
| EP1931337A2 (en) | 2008-06-18 |
| ZA200801629B (en) | 2009-03-25 |
| JP2009509988A (ja) | 2009-03-12 |
| EP1931337B1 (en) | 2013-10-23 |
| ECSP088322A (es) | 2008-04-28 |
| KR20080048504A (ko) | 2008-06-02 |
| AR056095A1 (es) | 2007-09-19 |
| BRPI0617207A2 (pt) | 2011-07-19 |
| TNSN08148A1 (en) | 2009-07-14 |
| WO2007039177B1 (en) | 2007-11-01 |
| NZ566877A (en) | 2010-05-28 |
| WO2007039177A3 (en) | 2007-09-07 |
| WO2007039177A2 (en) | 2007-04-12 |
| AU2006299091A1 (en) | 2007-04-12 |
| NO20081369L (no) | 2008-05-28 |
| US20080261979A1 (en) | 2008-10-23 |
| DOP2006000203A (es) | 2007-06-30 |
| CA2624102A1 (en) | 2007-04-12 |
| US7709481B2 (en) | 2010-05-04 |
| UY29831A1 (es) | 2007-04-30 |
| RU2008112198A (ru) | 2009-10-10 |
| PE20070620A1 (es) | 2007-07-10 |
| CN101272784A (zh) | 2008-09-24 |
| IL190231A0 (en) | 2008-11-03 |
| CR9785A (es) | 2008-05-21 |
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