MA29757B1 - Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc - Google Patents
Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhcInfo
- Publication number
- MA29757B1 MA29757B1 MA30689A MA30689A MA29757B1 MA 29757 B1 MA29757 B1 MA 29757B1 MA 30689 A MA30689 A MA 30689A MA 30689 A MA30689 A MA 30689A MA 29757 B1 MA29757 B1 MA 29757B1
- Authority
- MA
- Morocco
- Prior art keywords
- hcv
- protease
- inhibitors
- macrocyclic peptides
- macrocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
ABREGE DE LA DESCRIPTION La présente invention concerne des composés macrocycliques de formule (I) qui sont utiles comme inhibiteurs de la protéase NS3 du virus de l'hépatite C (VHC), leur synthèse, et leur usage pour le traitement ou la prévention des infections par le VHC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70425605P | 2005-08-01 | 2005-08-01 | |
US72450905P | 2005-10-07 | 2005-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29757B1 true MA29757B1 (fr) | 2008-09-01 |
Family
ID=37404447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30689A MA29757B1 (fr) | 2005-08-01 | 2008-02-25 | Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc |
Country Status (16)
Country | Link |
---|---|
US (1) | US8278322B2 (fr) |
EP (1) | EP1913016B1 (fr) |
JP (1) | JP4705984B2 (fr) |
KR (1) | KR20080036598A (fr) |
AU (1) | AU2006275605B2 (fr) |
BR (1) | BRPI0614205A2 (fr) |
CA (1) | CA2615896C (fr) |
CR (1) | CR9731A (fr) |
EC (1) | ECSP088157A (fr) |
IL (1) | IL189166A0 (fr) |
MA (1) | MA29757B1 (fr) |
MX (1) | MX2008001588A (fr) |
NO (1) | NO20081086L (fr) |
NZ (1) | NZ565269A (fr) |
RU (1) | RU2008107972A (fr) |
WO (1) | WO2007016441A1 (fr) |
Families Citing this family (89)
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MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
CA2606195C (fr) | 2005-05-02 | 2015-03-31 | Merck And Co., Inc. | Inhibiteurs de la protease ns3 du vhc |
CN102643175B (zh) * | 2005-07-04 | 2014-12-10 | 赞南科技(上海)有限公司 | 钌络合物配体、钌络合物、固载钌络合物催化剂及其制备方法和用途 |
BRPI0614205A2 (pt) | 2005-08-01 | 2016-11-22 | Merck & Co Inc | composto, composição farmacêutica, e, uso de composto |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
GB0612423D0 (en) * | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
EP2049474B1 (fr) | 2006-07-11 | 2015-11-04 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
CA2667165A1 (fr) | 2006-10-24 | 2008-05-02 | Merck & Co., Inc. | Inhibiteurs de la protease hcv ns3 |
WO2008051514A2 (fr) | 2006-10-24 | 2008-05-02 | Merck & Co., Inc. | Inhibiteurs de la protéase ns3 du hcv |
EP2079479B1 (fr) * | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase ns3 du vhc |
CA2667032A1 (fr) | 2006-10-27 | 2008-05-15 | Merck & Co., Inc. | Inhibiteurs de protease ns3 du vhc |
KR101615500B1 (ko) * | 2006-10-27 | 2016-04-27 | 머크 샤프 앤드 돔 코포레이션 | Hcv ns3 프로테아제 억제제 |
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US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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-
2006
- 2006-07-28 BR BRPI0614205A patent/BRPI0614205A2/pt not_active IP Right Cessation
- 2006-07-28 MX MX2008001588A patent/MX2008001588A/es unknown
- 2006-07-28 CA CA2615896A patent/CA2615896C/fr not_active Expired - Fee Related
- 2006-07-28 WO PCT/US2006/029635 patent/WO2007016441A1/fr active Application Filing
- 2006-07-28 KR KR1020087002861A patent/KR20080036598A/ko not_active Application Discontinuation
- 2006-07-28 JP JP2008525069A patent/JP4705984B2/ja not_active Expired - Fee Related
- 2006-07-28 US US11/989,886 patent/US8278322B2/en active Active
- 2006-07-28 RU RU2008107972/04A patent/RU2008107972A/ru not_active Application Discontinuation
- 2006-07-28 AU AU2006275605A patent/AU2006275605B2/en not_active Ceased
- 2006-07-28 NZ NZ565269A patent/NZ565269A/en unknown
- 2006-07-28 EP EP06800513A patent/EP1913016B1/fr active Active
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2008
- 2008-01-31 IL IL189166A patent/IL189166A0/en unknown
- 2008-01-31 EC EC2008008157A patent/ECSP088157A/es unknown
- 2008-02-14 CR CR9731A patent/CR9731A/es not_active Application Discontinuation
- 2008-02-25 MA MA30689A patent/MA29757B1/fr unknown
- 2008-02-29 NO NO20081086A patent/NO20081086L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1913016B1 (fr) | 2013-01-16 |
CR9731A (es) | 2008-04-10 |
MX2008001588A (es) | 2008-02-19 |
IL189166A0 (en) | 2008-08-07 |
JP4705984B2 (ja) | 2011-06-22 |
WO2007016441A1 (fr) | 2007-02-08 |
NO20081086L (no) | 2008-04-30 |
ECSP088157A (es) | 2008-02-20 |
CA2615896C (fr) | 2012-11-13 |
AU2006275605B2 (en) | 2011-01-06 |
KR20080036598A (ko) | 2008-04-28 |
RU2008107972A (ru) | 2009-09-10 |
NZ565269A (en) | 2010-03-26 |
EP1913016A1 (fr) | 2008-04-23 |
CA2615896A1 (fr) | 2007-02-08 |
US20110028494A1 (en) | 2011-02-03 |
US8278322B2 (en) | 2012-10-02 |
JP2009503080A (ja) | 2009-01-29 |
AU2006275605A1 (en) | 2007-02-08 |
BRPI0614205A2 (pt) | 2016-11-22 |
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