MA29757B1 - Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc - Google Patents
Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhcInfo
- Publication number
- MA29757B1 MA29757B1 MA30689A MA30689A MA29757B1 MA 29757 B1 MA29757 B1 MA 29757B1 MA 30689 A MA30689 A MA 30689A MA 30689 A MA30689 A MA 30689A MA 29757 B1 MA29757 B1 MA 29757B1
- Authority
- MA
- Morocco
- Prior art keywords
- hcv
- protease
- inhibitors
- macrocyclic peptides
- macrocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
ABREGE DE LA DESCRIPTION La présente invention concerne des composés macrocycliques de formule (I) qui sont utiles comme inhibiteurs de la protéase NS3 du virus de l'hépatite C (VHC), leur synthèse, et leur usage pour le traitement ou la prévention des infections par le VHC.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70425605P | 2005-08-01 | 2005-08-01 | |
US72450905P | 2005-10-07 | 2005-10-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29757B1 true MA29757B1 (fr) | 2008-09-01 |
Family
ID=37404447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30689A MA29757B1 (fr) | 2005-08-01 | 2008-02-25 | Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc |
Country Status (16)
Country | Link |
---|---|
US (1) | US8278322B2 (fr) |
EP (1) | EP1913016B1 (fr) |
JP (1) | JP4705984B2 (fr) |
KR (1) | KR20080036598A (fr) |
AU (1) | AU2006275605B2 (fr) |
BR (1) | BRPI0614205A2 (fr) |
CA (1) | CA2615896C (fr) |
CR (1) | CR9731A (fr) |
EC (1) | ECSP088157A (fr) |
IL (1) | IL189166A0 (fr) |
MA (1) | MA29757B1 (fr) |
MX (1) | MX2008001588A (fr) |
NO (1) | NO20081086L (fr) |
NZ (1) | NZ565269A (fr) |
RU (1) | RU2008107972A (fr) |
WO (1) | WO2007016441A1 (fr) |
Families Citing this family (88)
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JP5406525B2 (ja) * | 2005-07-04 | 2014-02-05 | ツァナン・サイテック・カンパニー・リミテッド | ルテニウム錯体配位子、ルテニウム錯体、固定化ルテニウム錯体触媒及びその調製方法と用途 |
WO2007016441A1 (fr) | 2005-08-01 | 2007-02-08 | Merck & Co., Inc. | Peptides macrocycliques en tant qu’inhibiteurs de la protéase ns3 du vhc |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
GB0612423D0 (en) * | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2008051475A2 (fr) | 2006-10-24 | 2008-05-02 | Merck & Co., Inc. | Inhibiteurs de la protéase ns3 du vhc |
WO2008051477A2 (fr) | 2006-10-24 | 2008-05-02 | Merck & Co., Inc. | Inhibiteurs de la protéase hcv ns3 |
CN101583372A (zh) | 2006-10-24 | 2009-11-18 | 默克公司 | Hcv ns3蛋白酶抑制剂 |
CN101568346B (zh) | 2006-10-27 | 2015-11-25 | 默沙东公司 | Hcv ns3蛋白酶抑制剂 |
BRPI0718161A2 (pt) * | 2006-10-27 | 2013-11-26 | Merck & Co Inc | Composto, composição farmacêutica, e, uso do composto. |
US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
GB0625345D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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-
2006
- 2006-07-28 WO PCT/US2006/029635 patent/WO2007016441A1/fr active Application Filing
- 2006-07-28 AU AU2006275605A patent/AU2006275605B2/en not_active Ceased
- 2006-07-28 JP JP2008525069A patent/JP4705984B2/ja not_active Expired - Fee Related
- 2006-07-28 RU RU2008107972/04A patent/RU2008107972A/ru not_active Application Discontinuation
- 2006-07-28 CA CA2615896A patent/CA2615896C/fr not_active Expired - Fee Related
- 2006-07-28 US US11/989,886 patent/US8278322B2/en active Active
- 2006-07-28 BR BRPI0614205A patent/BRPI0614205A2/pt not_active IP Right Cessation
- 2006-07-28 EP EP06800513A patent/EP1913016B1/fr active Active
- 2006-07-28 KR KR1020087002861A patent/KR20080036598A/ko not_active Application Discontinuation
- 2006-07-28 NZ NZ565269A patent/NZ565269A/en unknown
- 2006-07-28 MX MX2008001588A patent/MX2008001588A/es unknown
-
2008
- 2008-01-31 EC EC2008008157A patent/ECSP088157A/es unknown
- 2008-01-31 IL IL189166A patent/IL189166A0/en unknown
- 2008-02-14 CR CR9731A patent/CR9731A/es not_active Application Discontinuation
- 2008-02-25 MA MA30689A patent/MA29757B1/fr unknown
- 2008-02-29 NO NO20081086A patent/NO20081086L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2615896C (fr) | 2012-11-13 |
EP1913016B1 (fr) | 2013-01-16 |
AU2006275605A1 (en) | 2007-02-08 |
IL189166A0 (en) | 2008-08-07 |
NZ565269A (en) | 2010-03-26 |
KR20080036598A (ko) | 2008-04-28 |
MX2008001588A (es) | 2008-02-19 |
AU2006275605B2 (en) | 2011-01-06 |
RU2008107972A (ru) | 2009-09-10 |
US8278322B2 (en) | 2012-10-02 |
US20110028494A1 (en) | 2011-02-03 |
EP1913016A1 (fr) | 2008-04-23 |
CA2615896A1 (fr) | 2007-02-08 |
JP4705984B2 (ja) | 2011-06-22 |
BRPI0614205A2 (pt) | 2016-11-22 |
ECSP088157A (es) | 2008-02-20 |
JP2009503080A (ja) | 2009-01-29 |
WO2007016441A1 (fr) | 2007-02-08 |
NO20081086L (no) | 2008-04-30 |
CR9731A (es) | 2008-04-10 |
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