MA29757B1 - Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc - Google Patents

Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc

Info

Publication number
MA29757B1
MA29757B1 MA30689A MA30689A MA29757B1 MA 29757 B1 MA29757 B1 MA 29757B1 MA 30689 A MA30689 A MA 30689A MA 30689 A MA30689 A MA 30689A MA 29757 B1 MA29757 B1 MA 29757B1
Authority
MA
Morocco
Prior art keywords
hcv
protease
inhibitors
macrocyclic peptides
macrocyclic
Prior art date
Application number
MA30689A
Other languages
English (en)
Inventor
Katharine M Holloway
Nigel J Liverton
John A Mccauley
Michael T Rudd
Joseph P Vacca
Steven W Ludmerer
David B Olsen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MA29757B1 publication Critical patent/MA29757B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12Cyclic peptides with only normal peptide bonds in the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0827Tripeptides containing heteroatoms different from O, S, or N
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

ABREGE DE LA DESCRIPTION La présente invention concerne des composés macrocycliques de formule (I) qui sont utiles comme inhibiteurs de la protéase NS3 du virus de l'hépatite C (VHC), leur synthèse, et leur usage pour le traitement ou la prévention des infections par le VHC.
MA30689A 2005-08-01 2008-02-25 Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc MA29757B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70425605P 2005-08-01 2005-08-01
US72450905P 2005-10-07 2005-10-07

Publications (1)

Publication Number Publication Date
MA29757B1 true MA29757B1 (fr) 2008-09-01

Family

ID=37404447

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30689A MA29757B1 (fr) 2005-08-01 2008-02-25 Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc

Country Status (16)

Country Link
US (1) US8278322B2 (fr)
EP (1) EP1913016B1 (fr)
JP (1) JP4705984B2 (fr)
KR (1) KR20080036598A (fr)
AU (1) AU2006275605B2 (fr)
BR (1) BRPI0614205A2 (fr)
CA (1) CA2615896C (fr)
CR (1) CR9731A (fr)
EC (1) ECSP088157A (fr)
IL (1) IL189166A0 (fr)
MA (1) MA29757B1 (fr)
MX (1) MX2008001588A (fr)
NO (1) NO20081086L (fr)
NZ (1) NZ565269A (fr)
RU (1) RU2008107972A (fr)
WO (1) WO2007016441A1 (fr)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
CA2606195C (fr) 2005-05-02 2015-03-31 Merck And Co., Inc. Inhibiteurs de la protease ns3 du vhc
CN102643175B (zh) * 2005-07-04 2014-12-10 赞南科技(上海)有限公司 钌络合物配体、钌络合物、固载钌络合物催化剂及其制备方法和用途
BRPI0614205A2 (pt) 2005-08-01 2016-11-22 Merck & Co Inc composto, composição farmacêutica, e, uso de composto
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
GB0609492D0 (en) * 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
GB0612423D0 (en) * 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
EP2049474B1 (fr) 2006-07-11 2015-11-04 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
CA2667165A1 (fr) 2006-10-24 2008-05-02 Merck & Co., Inc. Inhibiteurs de la protease hcv ns3
WO2008051514A2 (fr) 2006-10-24 2008-05-02 Merck & Co., Inc. Inhibiteurs de la protéase ns3 du hcv
EP2079479B1 (fr) * 2006-10-24 2014-11-26 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase ns3 du vhc
CA2667032A1 (fr) 2006-10-27 2008-05-15 Merck & Co., Inc. Inhibiteurs de protease ns3 du vhc
KR101615500B1 (ko) * 2006-10-27 2016-04-27 머크 샤프 앤드 돔 코포레이션 Hcv ns3 프로테아제 억제제
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
JP2010513450A (ja) 2006-12-20 2010-04-30 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー 抗ウイルス性インドール
EP2118301A4 (fr) 2007-03-09 2011-04-20 Merck Sharp & Dohme Résistance in vivo du vhc à des inhibiteurs anti-viraux
AU2008277442A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis C infections
JP5433573B2 (ja) * 2007-07-19 2014-03-05 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ 抗ウイルス剤としての大環状化合物
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
CL2008003384A1 (es) * 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
JP2011503201A (ja) 2007-11-14 2011-01-27 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状テトラゾリルc型肝炎セリンプロテアーゼ阻害剤
CA2709089A1 (fr) 2007-12-14 2009-06-25 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques, de type oximyle, des proteases a serine du virus de l'hepatite c
WO2009079353A1 (fr) 2007-12-14 2009-06-25 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques contenant du triazole des protéases à sérine du vhc
EP2234977A4 (fr) 2007-12-19 2011-04-13 Boehringer Ingelheim Int Inhibiteurs de polymérase virale
WO2009085978A1 (fr) 2007-12-20 2009-07-09 Enanta Pharceuticals, Inc. Inhibiteurs de protéase de sérine de virus de l'hépatite c d'oxime carbocyclique couronnés
US8309685B2 (en) 2007-12-21 2012-11-13 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
AU2008340261C1 (en) 2007-12-21 2015-12-10 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
NZ586231A (en) * 2007-12-21 2012-12-21 Avila Therapeutics Inc HCV protease inhibitors comprising a functionalised proline derivative
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
US8591878B2 (en) 2008-02-25 2013-11-26 Merck Sharp & Dohme Corp. Therapeutic compounds
US8372802B2 (en) 2008-03-20 2013-02-12 Enanta Pharmaceuticals, Inc. Fluorinated macrocyclic compounds as hepatitis C virus inhibitors
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AU2009241445A1 (en) * 2008-04-28 2009-11-05 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044023B2 (en) 2008-05-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2491090T3 (es) 2008-07-22 2014-09-05 Merck Sharp & Dohme Corp. Combinaciones de un compuesto de quinoxalina macrocíclica que es un inhibidor de la proteasa NS3 del VHC con otros agentes del VHC
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20110114582A (ko) 2008-12-19 2011-10-19 길리애드 사이언시즈, 인코포레이티드 Hcv ns3 프로테아제 억제제
MX2011007195A (es) 2009-01-07 2013-07-12 Scynexis Inc Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih).
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
US8936781B2 (en) 2009-05-13 2015-01-20 Enanta Pharmaceuticals, Inc. Macrocyclic compounds as hepatitis C virus inhibitors
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
WO2011014487A1 (fr) 2009-07-30 2011-02-03 Merck Sharp & Dohme Corp. Inhibiteurs de protéase ns3 du virus de l'hépatite c
TW201117812A (en) 2009-08-05 2011-06-01 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
WO2011049908A2 (fr) 2009-10-19 2011-04-28 Enanta Pharmaceuticals, Inc. Composés bismacrocycliques à titre d'inhibiteurs du virus de l'hépatite c
MX2013000242A (es) 2010-06-24 2014-04-14 Panmed Ltd Tratamiento de enfermedades relacionadas con el virus de hepatitis c que usa hidroxicloroquina o una combinacion de hidroxicloroquina y un agente antiviral.
WO2012016186A1 (fr) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Inhibiteurs de kinases macrocycliques et leurs utilisations
NZ608720A (en) 2010-09-21 2015-03-27 Enanta Pharm Inc Macrocyclic proline derived hcv serine protease inhibitors
EP2635570B1 (fr) 2010-11-01 2017-12-13 RFS Pharma, LLC. Nouveaux inhibiteurs spécifiques de la protéase ns3 du vhc
BR112013010372A2 (pt) 2010-12-14 2016-07-05 Merck Sharp & Dohme composto, e, método para preparar um composto
CA2822556A1 (fr) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc Inhibiteurs macrocycliques de serine protease d'hepatite c
CN103380132B (zh) 2010-12-30 2016-08-31 益安药业 菲啶大环丙型肝炎丝氨酸蛋白酶抑制剂
WO2012109398A1 (fr) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Inhibiteurs macrocycliques de sérine protéase, compositions pharmaceutiques les contenant et leur utilisation pour le traitement des infections par le vhc
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2723337A1 (fr) 2011-06-23 2014-04-30 Panmed Ltd. Traitement du virus de l'hépatite c
EP2726467A4 (fr) 2011-07-01 2015-01-21 Harvard College Inhibiteurs macrocycliques de l'enzyme de dégradation de l'insuline (ide) et leurs utilisations
EP2744331A4 (fr) 2011-08-19 2015-01-21 Merck Sharp & Dohme Procédés et intermédiaires pouvant être utilisés pour la préparation de macrolactames
UA119315C2 (uk) * 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
WO2014064534A2 (fr) 2012-10-05 2014-05-01 Chrontech Pharma Ab Aiguille d'injection, dispositif, compositions immunogènes et procédé d'utilisation
EA025560B1 (ru) 2012-10-19 2017-01-30 Бристол-Майерс Сквибб Компани Ингибиторы вируса гепатита с
WO2014070964A1 (fr) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014071007A1 (fr) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
EP2914614B1 (fr) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2014137869A1 (fr) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
SG11201507223TA (en) 2013-03-15 2015-10-29 Gilead Sciences Inc Macrocyclic and bicyclic inhibitors of hepatitis c virus
US9873707B2 (en) 2013-10-18 2018-01-23 Merck Sharp & Dohme Corp. Methods and intermediates for preparing macrolactams
WO2015103490A1 (fr) 2014-01-03 2015-07-09 Abbvie, Inc. Formes galéniques antivirales solides
WO2016172631A2 (fr) 2015-04-24 2016-10-27 President And Fellows Of Harvard College Inhibiteurs sélectifs de substrats d'enzyme dégradant l'insuline (ide) et utilisations associées
WO2017197036A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères spirocycliques pour la dégradation de protéines cibles
EP3454856B1 (fr) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Dégronimères hétérocycliques pour la dégradation de protéines cibles
EP3455218A4 (fr) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles
TWI658568B (zh) * 2017-01-03 2019-05-01 Leadtrend Technology Corporation 高壓半導體元件以及同步整流控制器
WO2019168654A2 (fr) * 2018-02-09 2019-09-06 President And Fellows Of Harvard College Bibliothèque de macrocycles à matrice d'adn
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3480613A (en) * 1967-07-03 1969-11-25 Merck & Co Inc 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
US6128582A (en) 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
ES2234144T3 (es) 1997-08-11 2005-06-16 Boehringer Ingelheim (Canada) Ltd. Analogos de peptidos inhibidores de la hepatitis c.
ES2241157T3 (es) 1997-08-11 2005-10-16 Boehringer Ingelheim (Canada) Ltd. Peptidos inhibidores de la hepatitis c.
IT1299134B1 (it) 1998-02-02 2000-02-29 Angeletti P Ist Richerche Bio Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
ES2276515T3 (es) 1998-02-25 2007-06-16 Emory University 2'-fluoronucleosidos.
GB9806815D0 (en) 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
EP1066247B1 (fr) 1998-03-31 2006-11-22 Vertex Pharmaceuticals Incorporated Inhibiteurs de serine protease, particulierement de la protease ns3 du virus de l'hepatite c
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
EP1106626B1 (fr) 1998-08-10 2003-05-28 Hokkaido Electric Power Company, Incorporated Preparation de glycopeptides ordinaires
WO2000025780A1 (fr) 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
CA2377278C (fr) 1999-06-25 2010-03-23 Vertex Pharmaceuticals Incorporated Promedicaments a base d'inhibiteurs carbamates de l'impdh
CN1623984A (zh) 1999-12-27 2005-06-08 日本烟草产业株式会社 稠环化合物及其药物用途
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
US6455508B1 (en) 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
CN1427722A (zh) * 2000-02-18 2003-07-02 希拉生物化学股份有限公司 用核苷类似物治疗或预防黄病毒感染的方法
KR20030036152A (ko) * 2000-04-05 2003-05-09 쉐링 코포레이션 N-사이클릭 p2 잔기를 포함하는 c형 간염 바이러스의매크로사이클릭 ns3-세린 프로테아제 억제제
WO2001077091A2 (fr) 2000-04-05 2001-10-18 Tularik Inc. Inhibiteurs de polymerases ns5b vhc
BR0110023A (pt) 2000-04-13 2003-12-30 Pharmasset Ltd Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) 2000-05-26 2013-07-10 イデニクス(ケイマン)リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
US6921735B2 (en) * 2000-08-10 2005-07-26 The Trustees Of Boston College Recyclable metathesis catalysts
US6955174B2 (en) * 2000-08-18 2005-10-18 Uryovascular Systems, Inc. Cryotherapy method for detecting and treating vulnerable plaque
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
AU2001282528A1 (en) 2000-09-01 2002-03-22 Shionogi And Co., Ltd. Compounds having anti-hepatitis c virus effect
EP1411954B1 (fr) 2000-10-18 2010-12-15 Pharmasset, Inc. Nucleosides modifies pour traiter des infections virales et une proliferation cellulaire anormale
CN1301994C (zh) 2000-12-12 2007-02-28 先灵公司 作为c型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的二芳基肽
AU2002230763A1 (en) 2000-12-13 2008-01-03 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
US20040266723A1 (en) 2000-12-15 2004-12-30 Otto Michael J. Antiviral agents for treatment of Flaviviridae infections
EP1346724A4 (fr) 2000-12-26 2004-11-17 Mitsubishi Pharma Corp Remedes pour l'hepatite c
EP1539188B1 (fr) * 2001-01-22 2015-01-07 Merck Sharp & Dohme Corp. Derives de nucleoside comme inhibiteurs de l'arn polymerase virale arn-dependante
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
ES2607802T3 (es) 2001-08-14 2017-04-04 Tel Aviv University Future Technology Development L.P. Partículas lipidadas de glicosaminoglicano y su uso en el suministro de fármacos y genes para diagnóstico y terapia
EP1435974A4 (fr) 2001-09-28 2006-09-06 Idenix Cayman Ltd Procedes et compositions pour le traitement du virus de l'hepatite c au moyen de nucleosides modifies en 4'
JP2005536440A (ja) 2001-09-28 2005-12-02 イデニクス(ケイマン)リミテツド 4’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
WO2003062192A1 (fr) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k
GB0201179D0 (en) 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
CA2369711A1 (fr) * 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Peptides macrocycliques qui agissent contre le virus de l'hepatite c
AU2003209045B2 (en) 2002-02-13 2006-12-14 Isis Pharmaceuticals, Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
KR20050006221A (ko) * 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 C형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
MY140680A (en) * 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
WO2004000858A2 (fr) 2002-06-21 2003-12-31 Merck & Co., Inc. Derives nucleosidiques utilises comme inhibiteurs de l'arn polymerase virale arn-dependante
EP1572945A2 (fr) 2002-06-27 2005-09-14 Merck & Co., Inc. Derives nucleosidiques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale
TW200500374A (en) 2002-06-28 2005-01-01 Idenlx Cayman Ltd 2' and 3' -nucleoside produrgs for treating flavivridae infections
WO2004002422A2 (fr) 2002-06-28 2004-01-08 Idenix (Cayman) Limited Ester 3'-l-valine de ?-d-2'-c-methyl-ribofuranosyl cytidine pour le traitement d'infections par des flaviviridae
JP5087211B2 (ja) 2002-06-28 2012-12-05 イデニクス(ケイマン)リミテツド フラビウィルス感染治療のための2′および3′−ヌクレオシドプロドラッグ
AU2003269902A1 (en) 2002-07-16 2004-02-02 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2003254657A1 (en) 2002-07-25 2004-02-16 Micrologix Biotech Inc. Anti-viral 7-deaza d-nucleosides and uses thereof
CA2494340C (fr) 2002-08-01 2012-01-24 Pharmasset Inc. Composes contenant un bicyclo[4.2.1]nonane, utilises dans le traitement des infections causees par les flaviviridae
WO2004028481A2 (fr) 2002-09-30 2004-04-08 Genelabs Technologies, Inc. Derives nucleosidiques servant au traitement d'une infection par le virus de l'hepatite c
EA009943B1 (ru) 2002-11-01 2008-04-28 Вирофарма Инкорпорейтед Соединения бензофурана, композиции и способы лечения и профилактики инфекций, вызванных вирусом гепатита с, и связанных с ним заболеваний
US20040254159A1 (en) * 2003-02-27 2004-12-16 Hasvold Lisa A. Heterocyclic kinase inhibitors
WO2004101605A1 (fr) * 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Composes d'inhibition de l'hepatite c
JP2006522017A (ja) * 2003-04-02 2006-09-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング C型肝炎ウイルスプロテアーゼインヒビターのための医薬組成物
GB0307891D0 (en) 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
US7173004B2 (en) * 2003-04-16 2007-02-06 Bristol-Myers Squibb Company Macrocyclic isoquinoline peptide inhibitors of hepatitis C virus
US7176208B2 (en) * 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
UY28323A1 (es) * 2003-05-21 2004-12-31 Boehringer Ingelheim Int Compuestos inhibidores de la hepatitis c
WO2005003147A2 (fr) 2003-05-30 2005-01-13 Pharmasset, Inc. Analogues de nucleosides fluores modifies
GB0313250D0 (en) 2003-06-09 2003-07-16 Angeletti P Ist Richerche Bio Therapeutic agents
KR20060026426A (ko) * 2003-06-19 2006-03-23 에프. 호프만-라 로슈 아게 4'-아지도 뉴클레오사이드 유도체의 제조 방법
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
GB0321003D0 (en) 2003-09-09 2003-10-08 Angeletti P Ist Richerche Bio Compounds, compositions and uses
GB0323845D0 (en) 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2358333T3 (es) 2004-01-21 2011-05-09 Boehringer Ingelheim International Gmbh Péptidos macrocíclicos con acción contra el virus de la hepatitis c.
SI1719773T1 (sl) 2004-02-24 2009-08-31 Japan Tobacco Inc Kondenzirane heterotetraciklične spojine in njihova uporaba kot inhibitorji polimeraze HCV
GB0413087D0 (en) 2004-06-11 2004-07-14 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0416396D0 (en) 2004-07-22 2004-08-25 Angeletti P Ist Richerche Bio Therapeutic agents
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
GB0419850D0 (en) 2004-09-07 2004-10-13 Angeletti P Ist Richerche Bio Therapeutic agents
CA2585084A1 (fr) 2004-10-26 2006-05-04 Immacolata Conte Derives d'indole tetracyclique utilises en tant qu'agents antiviraux
CA2606195C (fr) 2005-05-02 2015-03-31 Merck And Co., Inc. Inhibiteurs de la protease ns3 du vhc
GB0509326D0 (en) 2005-05-09 2005-06-15 Angeletti P Ist Richerche Bio Therapeutic compounds
AR057456A1 (es) * 2005-07-20 2007-12-05 Merck & Co Inc Inhibidores de la proteasa ns3 del vhc
BRPI0614205A2 (pt) 2005-08-01 2016-11-22 Merck & Co Inc composto, composição farmacêutica, e, uso de composto
WO2007028789A1 (fr) 2005-09-07 2007-03-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Dérivés de quinazoline en tant qu'agents antiviraux
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0519797D0 (en) 2005-09-29 2005-11-09 Istituto Di Ricerche D Biolog Therapeutic agents
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
WO2007145894A2 (fr) 2006-06-08 2007-12-21 Merck & Co., Inc. Procédé rapide pour déterminer la sensibilité aux inhibiteurs de séquences de protéase ns3/4a clonées à partir d'échantillons cliniques
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
WO2008051514A2 (fr) 2006-10-24 2008-05-02 Merck & Co., Inc. Inhibiteurs de la protéase ns3 du hcv
EP2079479B1 (fr) 2006-10-24 2014-11-26 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase ns3 du vhc
CA2667165A1 (fr) 2006-10-24 2008-05-02 Merck & Co., Inc. Inhibiteurs de la protease hcv ns3
CA2667032A1 (fr) 2006-10-27 2008-05-15 Merck & Co., Inc. Inhibiteurs de protease ns3 du vhc
KR101615500B1 (ko) 2006-10-27 2016-04-27 머크 샤프 앤드 돔 코포레이션 Hcv ns3 프로테아제 억제제
WO2008057028A1 (fr) 2006-11-09 2008-05-15 Twinblade Technologies Holding Sweden Ab Dispositif moyeu
EP2118301A4 (fr) 2007-03-09 2011-04-20 Merck Sharp & Dohme Résistance in vivo du vhc à des inhibiteurs anti-viraux
TWI434849B (zh) 2007-06-29 2014-04-21 Gilead Sciences Inc 類鐸(Toll-like)受體7之調節劑
JP5433573B2 (ja) 2007-07-19 2014-03-05 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ 抗ウイルス剤としての大環状化合物
CL2008003384A1 (es) 2007-11-14 2009-12-11 Enanta Pharm Inc Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c.
JP2011503201A (ja) 2007-11-14 2011-01-27 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状テトラゾリルc型肝炎セリンプロテアーゼ阻害剤

Also Published As

Publication number Publication date
EP1913016B1 (fr) 2013-01-16
CR9731A (es) 2008-04-10
MX2008001588A (es) 2008-02-19
IL189166A0 (en) 2008-08-07
JP4705984B2 (ja) 2011-06-22
WO2007016441A1 (fr) 2007-02-08
NO20081086L (no) 2008-04-30
ECSP088157A (es) 2008-02-20
CA2615896C (fr) 2012-11-13
AU2006275605B2 (en) 2011-01-06
KR20080036598A (ko) 2008-04-28
RU2008107972A (ru) 2009-09-10
NZ565269A (en) 2010-03-26
EP1913016A1 (fr) 2008-04-23
CA2615896A1 (fr) 2007-02-08
US20110028494A1 (en) 2011-02-03
US8278322B2 (en) 2012-10-02
JP2009503080A (ja) 2009-01-29
AU2006275605A1 (en) 2007-02-08
BRPI0614205A2 (pt) 2016-11-22

Similar Documents

Publication Publication Date Title
MA29757B1 (fr) Peptides macrocycliques en tant qu'inhibiteurs de la protease ns3 du vhc
MA30198B1 (fr) Inhibiteurs de la protease ns3 du vhc
MA30893B1 (fr) Inhibiteurs de la protease ns3 du vhc
WO2006119061A3 (fr) Inhibiteurs de la protease ns3 du vhc
MA33209B1 (fr) Inhibiteurs de la replication du virus de l'hepatite c
WO2008051514A3 (fr) Inhibiteurs de la protéase ns3 du hcv
TNSN06071A1 (en) Use of modified cyclosporins for the treatment of hcv disorders
TW200718422A (en) 1,6-Dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
ATE512976T1 (de) Hemmer des hepatitis-c-virus
MA32502B1 (fr) Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv)
MXPA04000293A (es) Inhibidores de serina proteasa biciclica de puente.
NO20091704L (no) Inhibitorer av hepatitt C virus
NO20091707L (no) Inhibitorer av hepatitt C virus
MA33360B1 (fr) Composés antiviraux hétérocycliques
MA29240B1 (fr) Derives d'indole pour le traitement d'infections virales
ES2240446T3 (es) Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c.
EA201101492A1 (ru) Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
NO20091706L (no) Inhibitorer av hepatitt C virus
WO2005035525A3 (fr) Inhibiteurs des serines proteases, en particulier de la protease ns3-ns4a du virus de l'hepatite c (vhc)
WO2004041201A3 (fr) Composes de benzofurane, compositions et methodes utilisees pour le traitement et la prophylaxie des infections virales induites par l'hepatite c et des maladies associees
WO2004106293A3 (fr) Composes tricycliques a base d'oxazolo[4,5-b]pyridine condensee a un imidazo et de thiazolo[4,5-b]pyridine condensee a un imidazo, et compositions pharmaceutiques renfermant ceux-ci
WO2010034105A8 (fr) Composés inhibiteurs de l'hépatite c
WO2006055434A3 (fr) Inhibiteurs de la beta-secretase formes d'amines tertiaires macrocycliques pour le traitement de la maladie d'alzheimer
WO2005084315A3 (fr) Derives de pyranoindole et utilisation de ceux-ci pour le traitement d'une maladie ou d'une infection provoquee par le virus de l'hepatite c
ATE368040T1 (de) Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren